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E3 ligase MIB1 regulates STAT1/P21 signaling via regulation of FGFR1 in colorectal cancer
E3 ligase MIB1 regulates STAT1/P21 signaling via regulation of FGFR1 in colorectal cancer
Mind bomb 1 (MIB1) is an E3 ubiquitin ligase that promotes the polyubiquitination-mediated degradation of NOTCH ligands an...
RepID depletion enhances TWS119-induced erythropoiesis through chromatin reprogramming and transcription factor recruitment
RepID depletion enhances TWS119-induced erythropoiesis through chromatin reprogramming and transcription factor recruitment
Erythrocytes, derived from hematopoietic stem cells, are essential for oxygen transport, ensuring survival in all vertebra...
Exploring the role of alternative splicing in the pathogenesis of Sjögren’s syndrome: identification of novel isoforms associated with salivary gland immune infiltration
Exploring the role of alternative splicing in the pathogenesis of Sjögren’s syndrome: identification of novel isoforms associated with salivary gland immune infiltration
Sjögren's syndrome (SS) is an autoimmune disorder affecting exocrine glands, causing dry mouth and eyes, with no ...
Molecular cloning, expression analysis, and functional characterization of Intelectin-1 from Chinese giant salamanders ()
Molecular cloning, expression analysis, and functional characterization of Intelectin-1 from Chinese giant salamanders ()
Intelectin (ITLN) plays a pivotal role in innate immunity, inflammatory responses, and tumor progression. However, its phy...
Backtracking identification techniques for predicting unclear bacterial taxonomy at species level: molecular diagnosis-based bacterial classification
Backtracking identification techniques for predicting unclear bacterial taxonomy at species level: molecular diagnosis-based bacterial classification
Bacterial 16S rRNA genes are widely used to classify bacterial communities within interesting environments (e.g., plants, ...
Whole transcriptome profiling of cardiac injury: insights from a neonatal mouse sepsis model
Whole transcriptome profiling of cardiac injury: insights from a neonatal mouse sepsis model
Neonatal sepsis is characterized by an excessive immune response, often leading to multiple organ failure, including cardi...
Alternative splicing of CHI3L1 regulates protein secretion through conformational changes
Alternative splicing of CHI3L1 regulates protein secretion through conformational changes
Alternative splicing (AS) plays a crucial role in regulating protein function through the generation of structurally disti...
Whole exome sequencing of 80 cases of sporadic mitral valve prolapse reveals novel disease-associated genes and variants in a Southern Chinese population
Whole exome sequencing of 80 cases of sporadic mitral valve prolapse reveals novel disease-associated genes and variants in a Southern Chinese population
Mitral valve prolapse (MVP) is a common valvular disorder with a complex genetic basis. While familial MVP-related genes h...
Ectopic expression of and induces green tissue formation in non-green organs of
Ectopic expression of and induces green tissue formation in non-green organs of
A dominant mutant, green root-dominant (grt-D), which exhibits a green-root phenotype, was identified using the GAL4-UAS a...
RNA-binding protein expression based machine learning model predicts metastasis and treatment outcome of testicular cancer
RNA-binding protein expression based machine learning model predicts metastasis and treatment outcome of testicular cancer
RNA-binding proteins (RBPs) are key regulators of cellular transcription and are associated with the occurrence and develo...
Gene expression profile in ulcerative colitis patients: , , , genes as potential biomarkers
Gene expression profile in ulcerative colitis patients: , , , genes as potential biomarkers
Ulcerative colitis (UC) is a complex, chronic inflammatory disease that primarily impacts the colon mucosa. One of the key...
Genome-wide identification of NAC transcription factors in and their expression dynamics during leaf aging
Genome-wide identification of NAC transcription factors in and their expression dynamics during leaf aging
The NAC family (consisting of NAM, ATAF1/2, and CUC2) represents a crucial plant-specific transcription factor family, con...
Transcriptomic analysis revealed that short-day treatment of seedlings promotes flowering in maize ( L.)
Transcriptomic analysis revealed that short-day treatment of seedlings promotes flowering in maize ( L.)
In this study, blockage of transition from vegetative to reproductive growth was observed in short-day maize (Zea mays L.)...
The GPR4 antagonist NE 52-QQ57 prevents ox-LDL-induced cellular senescence by promoting the expression of SIRT1
The GPR4 antagonist NE 52-QQ57 prevents ox-LDL-induced cellular senescence by promoting the expression of SIRT1
Cell senescence-associated endothelia dysfunction is a vital point in the pathological progression of atherosclerosis (AS)...
RalB promotes lymph node metastasis in tongue squamous cell carcinoma
RalB promotes lymph node metastasis in tongue squamous cell carcinoma
Lymph nodes metastasis is the main metastasis mode of tongue squamous cell carcinoma (TSCC). Ras related GTP binding prote...
Perillic acid disrupts the specification of germ layers by upregulating the FGF/MAPK pathway
Perillic acid disrupts the specification of germ layers by upregulating the FGF/MAPK pathway
Xenopus embryo is an ideal model for teratogenesis assays to assess the effects of any compounds on the cellular processes...
Hippocampal MCT4 as a key regulator in excessive exercise-induced cognitive impairment: involvement of neuroinflammation
Hippocampal MCT4 as a key regulator in excessive exercise-induced cognitive impairment: involvement of neuroinflammation
As human life expectancy increases, maintaining a healthy lifestyle has become crucial. However, excessive exercise (EE) c...
De novo somatic mosaicisms of and in patients with Charcot-Marie-Tooth disease
De novo somatic mosaicisms of and in patients with Charcot-Marie-Tooth disease
Somatic mosaicism is caused by a postzygotic de novo mutation. It is a very rare genetic event, and mosaic cases have been...
Comparison of unique Dong Tao chickens from Vietnam and Thailand: genetic background and differences for resource management
Comparison of unique Dong Tao chickens from Vietnam and Thailand: genetic background and differences for resource management
Rare Dong Tao (DT) chickens are a unique and highly productive poultry breed introduced from Vietnam to Thailand ~&#...
Summarizing Online Patient Conversations Using Generative Language Models: Experimental and Comparative Study
Summarizing Online Patient Conversations Using Generative Language Models: Experimental and Comparative Study
Background: Social media is acknowledged by regulatory bodies (eg, the Food and Drug Administration) as an important sourc...
Optimizing an Electronic Health Record System Used to Help Health Care Professionals Comply With a Standardized Care Pathway for Heart Failure During the Transition From Hospital To Chronic Care: Qualitative Semistructured Interview Study
Optimizing an Electronic Health Record System Used to Help Health Care Professionals Comply With a Standardized Care Pathway for Heart Failure During the Transition From Hospital To Chronic Care: Qualitative Semistructured Interview Study
Background: In Spain, the prevalence of heart failure is twice the European average, partly due to inadequate patient mana...
Ensuring General Data Protection Regulation Compliance and Security in a Clinical Data Warehouse From a University Hospital: Implementation Study
Ensuring General Data Protection Regulation Compliance and Security in a Clinical Data Warehouse From a University Hospital: Implementation Study
Background: The digital transformation of health data has enabled the utilization of advanced data analytics and Artificia...
Effect of Smartphone-Based Messaging on Interns and Nurses at an Academic Medical Center: Observational Study
Effect of Smartphone-Based Messaging on Interns and Nurses at an Academic Medical Center: Observational Study
Background: The increasing use of secure messaging in medical centers has led to concerns about alert fatigue and the impa...
Effect of Uncertainty-Aware AI Models on Pharmacists’ Reaction Time and Decision-Making in a Web-Based Mock Medication Verification Task: Randomized Controlled Trial
Effect of Uncertainty-Aware AI Models on Pharmacists’ Reaction Time and Decision-Making in a Web-Based Mock Medication Verification Task: Randomized Controlled Trial
Background: Artificial intelligence (AI)-based clinical decision support systems are increasingly used in healthcare. Unce...
Daily Automated Prediction of Delirium Risk in Hospitalized Patients: Model Development and Validation
Daily Automated Prediction of Delirium Risk in Hospitalized Patients: Model Development and Validation
Background: Delirium is common in hospitalized patients and is correlated with increased morbidity and mortality. Despite ...
The Anemia Risk Warning Model Based on a Noninvasive Method: Key Insights and Clarifications
The Anemia Risk Warning Model Based on a Noninvasive Method: Key Insights and Clarifications
We recently read with great interest the article by Zhang et al [], which presents a noninvasive technique for diagnosing ...
Authors’ Reply: The Anemia Risk Warning Model Based on a Noninvasive Method: Key Insights and Clarifications
Authors’ Reply: The Anemia Risk Warning Model Based on a Noninvasive Method: Key Insights and Clarifications
JMIR Med Inform 2025;13:e74333doi:10.2196/74333KeywordsWe sincerely appreciate your thoughtful and constructive comments o...
Prediction of Snacking Behavior Involving Snacks Having High Levels of Saturated Fats, Salt, or Sugar Using Only Information on Previous Instances of Snacking: Survey- and App-Based Study
Prediction of Snacking Behavior Involving Snacks Having High Levels of Saturated Fats, Salt, or Sugar Using Only Information on Previous Instances of Snacking: Survey- and App-Based Study
Background: Consuming high amounts of foods or beverages with high levels of saturated fats, salt, or sugar (HFSS) can be ...
Expectations of Intensive Care Physicians Regarding an AI-Based Decision Support System for Weaning From Continuous Renal Replacement Therapy: Predevelopment Survey Study
Expectations of Intensive Care Physicians Regarding an AI-Based Decision Support System for Weaning From Continuous Renal Replacement Therapy: Predevelopment Survey Study
Background: Critically ill patients in Intensive Care Units (ICU) require continuous monitoring, generating vast amounts o...
Association of Circulating Robo4 with Obesity, Hypertension and Atherosclerotic Plaque Burden
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