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SCI Abstract
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ALL
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Epigenetic regulation of inflammation by CxxC domain‐containing proteins*
Abstract Epigenetic regulation of gene transcription in the immune system is important for proper control of protective an...
Immunological Reviews
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Chromodomain helicase DNA‐binding 4 (CHD4) regulates early B cell identity and V(D)J recombination*
Summary B lymphocytes develop from uncommitted precursors into immunoglobulin (antibody)-producing B cells, a major arm of...
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ZAP70, too little, too much can lead to autoimmunity*
Abstract Establishing both central and peripheral tolerance requires the appropriate TCR signaling strength to discriminat...
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Epigenetics and CD8+ T cell memory*
Abstract Following antigen recognition, CD8+ T lymphocytes can follow different patterns of differentiation, with the gene...
Immunological Reviews
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Understanding immunity in a tissue‐centric context: Combining novel imaging methods and mathematics to extract new insights into function and dysfunction*
Abstract A central question in immunology is what features allow the immune system to respond in a timely manner to a vari...
Immunological Reviews
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Silencing and activating anergic B cells*
Abstract Despite the existence of central tolerance mechanisms, including clonal deletion and receptor editing to eliminat...
Immunological Reviews
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Epigenetic regulation of natural killer cell memory*
Abstract Immunological memory is the underlying mechanism by which the immune system remembers previous encounters with pa...
Immunological Reviews
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Spatial determinates of effector and memory CD8+ T cell fates
Abstract The lymph node plays a critical role in mounting an adaptive immune response to infection, clearance of foreign p...
Immunological Reviews
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Imaging dendritic cell functions*
Abstract Dendritic cells (DCs) are crucial for the appropriate initiation of adaptive immune responses. During inflammatio...
Immunological Reviews
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Visualization and functional characterization of lymphoid organ fibroblasts*
Abstract Fibroblastic reticular cells (FRCs) are specialized stromal cells of lymphoid organs that generate the structural...
Immunological Reviews
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Skin‐ny deeping: Uncovering immune cell behavior and function through imaging techniques*
Abstract As the largest organ of the body, the skin is a key barrier tissue with specialized structures where ongoing immu...
Immunological Reviews
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T cell activation niches—Optimizing T cell effector function in inflamed and infected tissues*
Abstract Successful immunity to infection, malignancy, and tissue damage requires the coordinated recruitment of numerous ...
Immunological Reviews
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Information flow in the spatiotemporal organization of immune responses
Abstract Immune responses must be rapid, tightly orchestrated, and tailored to the encountered stimulus. Lymphatic vessels...
Immunological Reviews
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Imaging innate immunity*
Abstract Innate immunity is the first line of defense against infectious intruders and also plays a major role in the deve...
Immunological Reviews
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Imaging the different timescales of germinal center selection*
Abstract Germinal centers (GCs) are the site of antibody affinity maturation, a fundamental immunological process that inc...
Immunological Reviews
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Autoimmunity in motion: Mechanisms of immune regulation and destruction revealed by in vivo imaging*
Abstract Autoimmunity arises when mechanisms of immune tolerance fail. Here we discuss mechanisms of T cell activation and...
Immunological Reviews
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Epigenetics and tissue immunity—Translating environmental cues into functional adaptations*
Abstract There is an increasing appreciation that many innate and adaptive immune cell subsets permanently reside within n...
Immunological Reviews
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Micro but mighty—Micronutrients in the epigenetic regulation of adaptive immune responses*
Abstract Micronutrients are essential small molecules required by organisms in minute quantity for survival. For instance,...
Immunological Reviews
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Emerging roles for endogenous retroviruses in immune epigenetic regulation*
Abstract In recent years, there has been significant progress toward understanding the transcriptional networks underlying...
Immunological Reviews
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Imaging reveals novel innate immune responses in lung, liver, and beyond*
Abstract Highly dynamic immune responses are generated toward pathogens or injuries, in vivo. Multiple immune cell types p...
Immunological Reviews
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RNA regulation in immunity
RNAs scaffold complex molecular machines that regulate their stability, translation, modification, and subcellular localiz...
Immunological Reviews
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Heterogeneity in antiviral B cell responses: Lessons from the movies*
Abstract Humoral and cellular responses to viral infections coexist in a dynamic equilibrium that often results in efficie...
Immunological Reviews
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Imaging viral infection in vivo to gain unique perspectives on cellular antiviral immunity*
Abstract The past decade has seen near continual global public health crises caused by emerging viral infections. Extraord...
Immunological Reviews
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Moving beyond velocity: Opportunities and challenges to quantify immune cell behavior
Abstract The analysis of cellular behavior using intravital multi-photon microscopy has contributed substantially to our u...
Immunological Reviews
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What sequencing technologies can teach us about innate immunity*
Abstract For years, we have taken a reductionist approach to understanding gene regulation through the study of one gene i...
Immunological Reviews
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Transcriptional and epigenetic regulation in thymic epithelial cells
Abstract The thymus is required for the development of both adaptive and innate-like T cell subsets. There is keen interes...
Immunological Reviews
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Diving into the mechanism of action of tumor immunotherapies with intravital imaging*
Abstract The clinical successes and tremendous hopes raised by tumor immunotherapies such as tumor-targeting monoclonal an...
Immunological Reviews
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Imaging leukocyte migration through afferent lymphatics*
Abstract Afferent lymphatics mediate the transport of antigen and leukocytes, especially of dendritic cells (DCs) and T ce...
Immunological Reviews
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Regulation of airway immunity by epithelial miRNAs*
Abstract The airway epithelium is essential to protect the host from inhaled pathogens and particles. It maintains immune ...
Immunological Reviews
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Cell‐intrinsic and ‐extrinsic roles of miRNAs in regulating T cell immunity
Summary T cells are crucial to generate an effective response against numerous invading microbial pathogens and play a piv...
Immunological Reviews
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