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Efficacy and mechanism of inhibition of the GPR30-PI3K pathway by 4-phenylbutyric acid in the treatment of intrahepatic cholestasis of pregnancy
Efficacy and mechanism of inhibition of the GPR30-PI3K pathway by 4-phenylbutyric acid in the treatment of intrahepatic cholestasis of pregnancy
Intrahepatic cholestasis of pregnancy (ICP) is a liver disease that manifests predominantly in the later stages of pregnan...
Mitochondrial transplantation via injection of exogenous mitochondria into blood reduces bleomycin-induced oxidative damages and mitochondrial dysfunction in lung tissue
Mitochondrial transplantation via injection of exogenous mitochondria into blood reduces bleomycin-induced oxidative damages and mitochondrial dysfunction in lung tissue
Mechanistic studies have been suggested that adverse effect of bleomycin is attributed to formation of free radicals, mito...
Combined skin injury model from airblast overpressure and seawater immersion in rats: establishment, characterization, and mechanistic insights
Combined skin injury model from airblast overpressure and seawater immersion in rats: establishment, characterization, and mechanistic insights
In maritime operations, individuals often face the threat of combined injury caused by airblast overpressure and seawater ...
Exogenous mitochondria added on benefits for cellular prion protein overexpression in adipose-derived mesenchymal stem cells treatment on intracranial hemorrhage rat
Exogenous mitochondria added on benefits for cellular prion protein overexpression in adipose-derived mesenchymal stem cells treatment on intracranial hemorrhage rat
We examined whether combined exogenous mitochondria (ExMito) and cellular prion protein overexpression (Ove-PrPC) in adipo...
Ciliary neurotrophic factor (CNTF) contributes to pelvic organ prolapse by modulating collagen expression via the JAK2–STAT3 pathway
Ciliary neurotrophic factor (CNTF) contributes to pelvic organ prolapse by modulating collagen expression via the JAK2–STAT3 pathway
Pelvic organ prolapse (POP) is a prevalent condition that affects postmenopausal women and significantly impacts their qua...
Nell-1 inhibits lipopolysaccharide-activated macrophages into M1 phenotype through the modulation of NF-κB pathway
Nell-1 inhibits lipopolysaccharide-activated macrophages into M1 phenotype through the modulation of NF-κB pathway
Nel-like molecule-1 (Nell-1), as a novel osteo-inductive molecule with great potential for clinical applications, has vari...
Curcumin protects rat endplate chondrocytes against IL-1β-induced apoptosis via Bcl-2/Bax regulation
Curcumin protects rat endplate chondrocytes against IL-1β-induced apoptosis via Bcl-2/Bax regulation
The study aims to investigate the protective effect of curcumin on intervertebral disc degeneration by examining its influ...
Protective effects of -acetylcysteine against titanium dioxide nanoparticles-induced kidney damage in rats
Protective effects of -acetylcysteine against titanium dioxide nanoparticles-induced kidney damage in rats
The objective of this study was to evaluate the potential protective effect of N-acetylcysteine (NAC) against kidney damag...
Serum proteomic profiling reveals potential predictive indicators for coronary artery calcification in stable ischemic heart disease
Serum proteomic profiling reveals potential predictive indicators for coronary artery calcification in stable ischemic heart disease
Coronary artery calcification (CAC) is a common complication in patients with stable ischemic heart disease (SIHD). Howeve...
Notch 2 from bone marrow mesenchymal stem cells alleviates smoke inhalation-induced lung injury by mediating alveolar cell differentiation
Notch 2 from bone marrow mesenchymal stem cells alleviates smoke inhalation-induced lung injury by mediating alveolar cell differentiation
Smoke inhalation-induced lung injury (SILI) is the major fatality in fire- and blast-related accidents. Bone marrow mesenc...
Direct exposure with exogenous mitochondria reduce colistin-induced mitochondrial dysfunction and cellular damages in isolated rat renal proximal tubular cells
Direct exposure with exogenous mitochondria reduce colistin-induced mitochondrial dysfunction and cellular damages in isolated rat renal proximal tubular cells
Kidney damage caused by colistin (polymyxin E) can bring about a decrease in creatinine clearance, potential proteinuria, ...
Taraxasterol attenuates inflammatory responses in a 2,4-dinitrochlorobenzene-induced atopic dermatitis mouse model via inactivation of the MAPK and NF-κB pathways
Taraxasterol attenuates inflammatory responses in a 2,4-dinitrochlorobenzene-induced atopic dermatitis mouse model via inactivation of the MAPK and NF-κB pathways
Atopic dermatitis (AD) is an inflammatory skin disease. Taraxasterol has anti-inflammatory effects in various pathological...
miR-378d suppresses gastric cancer metastasis by targeting METTL4 to inhibit epithelial-mesenchymal transition
miR-378d suppresses gastric cancer metastasis by targeting METTL4 to inhibit epithelial-mesenchymal transition
Metastasis is a major determinant of prognosis in gastric cancer (GC), and microRNAs (miRNAs) play crucial roles in drivin...
In vivo and analysis of anti inflammatory, antipyretic and analgesic activity of methanolic extract of
In vivo and analysis of anti inflammatory, antipyretic and analgesic activity of methanolic extract of
Nigella Sativa (N. sativa) belongs to the family of Ranunculaceae and is an annual herb which is also known as black cumin...
Electron microscopic analysis of pomegranate and black chokeberry effects on acute pancreatitis in rats
Electron microscopic analysis of pomegranate and black chokeberry effects on acute pancreatitis in rats
Despite numerous experimental and clinical studies in terms of novel therapeutic strategies, the treatment of acute pancre...
Efficacy of curcumin-selenium nanoemulsion in alleviating oxidative damage induced by aluminum chloride in a rat model of Alzheimer’s disease
Efficacy of curcumin-selenium nanoemulsion in alleviating oxidative damage induced by aluminum chloride in a rat model of Alzheimer’s disease
Alzheimer’s disease (AD) is a common neurological disorder primarily affecting older adults. A hallmark of this cond...
Localization and function of APC15 during mouse oocyte meiotic progression
Localization and function of APC15 during mouse oocyte meiotic progression
The Anaphase-Promoting Complex/Cyclosome (APC/C) is a critical regulator of cell cycle progression, with APC15 serving as ...
RING box protein-1 promotes the metastasis of cervical cancer through regulating matrix metalloproteinases via PI3K/AKT signaling pathway
RING box protein-1 promotes the metastasis of cervical cancer through regulating matrix metalloproteinases via PI3K/AKT signaling pathway
Cervical cancer (CC) remains a leading cause of cancer mortality amongst females worldwide. Some of the CC patients may ex...
Fetal adnexa-derived allogeneic mesenchymal stem cells for cardiac regeneration: the future trend of cell-based therapy for age-related adverse conditions
Fetal adnexa-derived allogeneic mesenchymal stem cells for cardiac regeneration: the future trend of cell-based therapy for age-related adverse conditions
Heart failure is known as the leading cause of mortality and morbidity in adults, not only in USA but worldwide. Since the...
CircTBCK protects against osteoarthritis by regulating extracellular matrix and autophagy
CircTBCK protects against osteoarthritis by regulating extracellular matrix and autophagy
Osteoarthritis (OA) is a widespread chronic bone and joint disease for which there is currently no effective preventive or...
MTHFD2 stabilizes LOX expression through RNA methylation modification to promote sepsis-induced acute kidney injury progression
MTHFD2 stabilizes LOX expression through RNA methylation modification to promote sepsis-induced acute kidney injury progression
Myofibroblasts combine features of fibroblasts and smooth muscle cells, and they are reactive cells present under injury c...
Poly(I:C) signaling induces robust CXCL10 production and apoptosis in human esophageal squamous cell carcinoma cells
Poly(I:C) signaling induces robust CXCL10 production and apoptosis in human esophageal squamous cell carcinoma cells
We previously reported that high tumoral expression of Toll-like receptor 3 (TLR3) and CXCL10, a member of the CXC chemoki...
Novel CRISPR-Cas9 iPSC knockouts for and genes: advancing propionic acidemia research
Novel CRISPR-Cas9 iPSC knockouts for and genes: advancing propionic acidemia research
Propionic acidemia (PA) is a rare autosomal recessive metabolic disorder caused by mutations in the PCCA and PCCB genes, w...
Replication factor C4, which is regulated by insulin-like growth factor 2 mRNA binding protein 2, enhances the radioresistance of breast cancer by promoting the stemness of tumor cells
Replication factor C4, which is regulated by insulin-like growth factor 2 mRNA binding protein 2, enhances the radioresistance of breast cancer by promoting the stemness of tumor cells
Radiotherapy resistance, is usually caused by enhanced tumor stemness and poses a significant challenge in treating breast...
STX1A regulates ferroptosis and chemoresistance in gastric cancer through mitochondrial function modulation
STX1A regulates ferroptosis and chemoresistance in gastric cancer through mitochondrial function modulation
Gastric cancer is one of the leading causes of cancer-related deaths worldwide, and chemoresistance remains a major obstac...
Circ_0090100 induces AHNAK expression to inhibit trophoblast cell proliferation and invasion and accelerate cell apoptosis by segregating miR-139-5p in preeclampsia
Circ_0090100 induces AHNAK expression to inhibit trophoblast cell proliferation and invasion and accelerate cell apoptosis by segregating miR-139-5p in preeclampsia
The etiology of preeclampsia (PE) is complex and is known to involve the expression of circular RNAs (circRNAs). Among the...
In vitro generation of spiral ganglion neurons from embryonic stem cells
In vitro generation of spiral ganglion neurons from embryonic stem cells
Spiral ganglion neurons (SGNs) are crucial for transmitting auditory signals from the inner ear to the brainstem, playing ...
Derivation of functional neurons from induced pluripotent stem cells using a simple neuromesodermal progenitor generation and rapid spinal cord neuron differentiation process
Derivation of functional neurons from induced pluripotent stem cells using a simple neuromesodermal progenitor generation and rapid spinal cord neuron differentiation process
To generate spinal cord neurons from pluripotent stem cells via neuromesodermal progenitors (NMPs) is not only an importan...
Role of hepatocellular senescence in the development of hepatocellular carcinoma and the potential for therapeutic manipulation
Role of hepatocellular senescence in the development of hepatocellular carcinoma and the potential for therapeutic manipulation
Accumulation of senescent hepatocytes is universal in chronic liver disease (CLD). This study investigates an association ...
Establishment and characterization of novel patient-derived esophageal tumoroids with long-term cultivability
Establishment and characterization of novel patient-derived esophageal tumoroids with long-term cultivability
Esophageal cancer is an aggressive and fatal disease classified into two distinct histologic types: esophageal squamous ce...
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