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Fetal adnexa-derived allogeneic mesenchymal stem cells for cardiac regeneration: the future trend of cell-based therapy for age-related adverse conditions
Fetal adnexa-derived allogeneic mesenchymal stem cells for cardiac regeneration: the future trend of cell-based therapy for age-related adverse conditions
Heart failure is known as the leading cause of mortality and morbidity in adults, not only in USA but worldwide. Since the...
CircTBCK protects against osteoarthritis by regulating extracellular matrix and autophagy
CircTBCK protects against osteoarthritis by regulating extracellular matrix and autophagy
Osteoarthritis (OA) is a widespread chronic bone and joint disease for which there is currently no effective preventive or...
MTHFD2 stabilizes LOX expression through RNA methylation modification to promote sepsis-induced acute kidney injury progression
MTHFD2 stabilizes LOX expression through RNA methylation modification to promote sepsis-induced acute kidney injury progression
Myofibroblasts combine features of fibroblasts and smooth muscle cells, and they are reactive cells present under injury c...
Poly(I:C) signaling induces robust CXCL10 production and apoptosis in human esophageal squamous cell carcinoma cells
Poly(I:C) signaling induces robust CXCL10 production and apoptosis in human esophageal squamous cell carcinoma cells
We previously reported that high tumoral expression of Toll-like receptor 3 (TLR3) and CXCL10, a member of the CXC chemoki...
Novel CRISPR-Cas9 iPSC knockouts for and genes: advancing propionic acidemia research
Novel CRISPR-Cas9 iPSC knockouts for and genes: advancing propionic acidemia research
Propionic acidemia (PA) is a rare autosomal recessive metabolic disorder caused by mutations in the PCCA and PCCB genes, w...
Replication factor C4, which is regulated by insulin-like growth factor 2 mRNA binding protein 2, enhances the radioresistance of breast cancer by promoting the stemness of tumor cells
Replication factor C4, which is regulated by insulin-like growth factor 2 mRNA binding protein 2, enhances the radioresistance of breast cancer by promoting the stemness of tumor cells
Radiotherapy resistance, is usually caused by enhanced tumor stemness and poses a significant challenge in treating breast...
STX1A regulates ferroptosis and chemoresistance in gastric cancer through mitochondrial function modulation
STX1A regulates ferroptosis and chemoresistance in gastric cancer through mitochondrial function modulation
Gastric cancer is one of the leading causes of cancer-related deaths worldwide, and chemoresistance remains a major obstac...
Circ_0090100 induces AHNAK expression to inhibit trophoblast cell proliferation and invasion and accelerate cell apoptosis by segregating miR-139-5p in preeclampsia
Circ_0090100 induces AHNAK expression to inhibit trophoblast cell proliferation and invasion and accelerate cell apoptosis by segregating miR-139-5p in preeclampsia
The etiology of preeclampsia (PE) is complex and is known to involve the expression of circular RNAs (circRNAs). Among the...
In vitro generation of spiral ganglion neurons from embryonic stem cells
In vitro generation of spiral ganglion neurons from embryonic stem cells
Spiral ganglion neurons (SGNs) are crucial for transmitting auditory signals from the inner ear to the brainstem, playing ...
Derivation of functional neurons from induced pluripotent stem cells using a simple neuromesodermal progenitor generation and rapid spinal cord neuron differentiation process
Derivation of functional neurons from induced pluripotent stem cells using a simple neuromesodermal progenitor generation and rapid spinal cord neuron differentiation process
To generate spinal cord neurons from pluripotent stem cells via neuromesodermal progenitors (NMPs) is not only an importan...
Role of hepatocellular senescence in the development of hepatocellular carcinoma and the potential for therapeutic manipulation
Role of hepatocellular senescence in the development of hepatocellular carcinoma and the potential for therapeutic manipulation
Accumulation of senescent hepatocytes is universal in chronic liver disease (CLD). This study investigates an association ...
Establishment and characterization of novel patient-derived esophageal tumoroids with long-term cultivability
Establishment and characterization of novel patient-derived esophageal tumoroids with long-term cultivability
Esophageal cancer is an aggressive and fatal disease classified into two distinct histologic types: esophageal squamous ce...
Generation of iPSCs line from patient with Singleton-Merten syndrome
Generation of iPSCs line from patient with Singleton-Merten syndrome
Singleton-Merten syndrome (SMS) is a rare genetic condition associated with abnormal calcification and skeletal anomalies....
Azoramide, a novel regulator, favors adipogenesis against osteogenesis through inhibiting the GLP-1 receptor-PKA-β-catenin pathway
Azoramide, a novel regulator, favors adipogenesis against osteogenesis through inhibiting the GLP-1 receptor-PKA-β-catenin pathway
The reciprocal fate decision of mesenchymal stem cells (MSCs) to either bone or adipocytes is determined by Wnt-related si...
Generation and characterization of human-induced pluripotent stem cell lines from patients with autism spectrum disorder and variants
Generation and characterization of human-induced pluripotent stem cell lines from patients with autism spectrum disorder and variants
Autism spectrum disorders (ASD) comprise a group of complex neurodevelopmental disorders that affect communication and soc...
Correlation between levels of clock protein expression and effects on temozolomide-resistant glioblastoma and tumor progression
Correlation between levels of clock protein expression and effects on temozolomide-resistant glioblastoma and tumor progression
Glioblastoma (GBM) is the most common malignant intracranial neoplasm. Treatment with surgical resection and concurrent ch...
Establishment and characterization of NCC-dCS2-C1: a novel patient-derived cell line of dedifferentiated chondrosarcoma
Establishment and characterization of NCC-dCS2-C1: a novel patient-derived cell line of dedifferentiated chondrosarcoma
Dedifferentiated chondrosarcoma (dCS) is a rare, aggressive subtype of chondrosarcoma, characterized by an abrupt transiti...
Advances in the study of single-walled carbon nanotubes in ophthalmology
Advances in the study of single-walled carbon nanotubes in ophthalmology
With the rapid development of nanotechnology, the application of nanomaterials in the medical field shows unprecedented po...
The causal dance: trimethylamine N-oxide, obesity, and acute pancreatitis in pathophysiological harmony
The causal dance: trimethylamine N-oxide, obesity, and acute pancreatitis in pathophysiological harmony
Trimethylamine N-oxide (TMAO), a compound generated by the gut microbiota, may be associated with acute pancreatitis (AP)....
Generation of CRISPR/Cas9 modified human iPSC line with correction of heterozygous mutation in exon 6 of the CaSR gene
Generation of CRISPR/Cas9 modified human iPSC line with correction of heterozygous mutation in exon 6 of the CaSR gene
The calcium-sensing receptor (CaSR) gene encodes a cell membrane G protein-coupled receptor (GPCR) which has a key role in...
Assessment of non-myelotoxic agents as a preparatory regimen for hematopoietic stem cell gene therapy
Assessment of non-myelotoxic agents as a preparatory regimen for hematopoietic stem cell gene therapy
RAG2 deficiency is characterized by a lack of B and T lymphocytes, causing severe lethal infections. Currently, RAG2 defic...
MiR-124-3p inhibits cell stemness in glioblastoma via targeting EPHA2 through ALKBH5-mediated m6A modification
MiR-124-3p inhibits cell stemness in glioblastoma via targeting EPHA2 through ALKBH5-mediated m6A modification
Glioblastoma (GBM) is the most aggressive form of glioma, characterized by high mortality and poor prognosis. Dysregulatio...
Adiponectin-induced activation of ERK1/2 drives fibrosis in retinal pigment epithelial cells
Adiponectin-induced activation of ERK1/2 drives fibrosis in retinal pigment epithelial cells
Adiponectin (APN), a vasoactive cytokine produced by adipocytes, has emerged as a critical player in retinal diseases. Ren...
Brain inflammaging in the pathogenesis of late-life depression
Brain inflammaging in the pathogenesis of late-life depression
Late-life depression (LLD) is a prevalent mental disorder among older adults. Previous studies revealed that many patholog...
Inhibition of the AP-1/TFPI2 axis contributes to alleviating cerebral ischemia/reperfusion injury by improving blood–brain barrier integrity
Inhibition of the AP-1/TFPI2 axis contributes to alleviating cerebral ischemia/reperfusion injury by improving blood–brain barrier integrity
Reperfusion after cerebral ischemia leads to secondary damage to the nervous system, called cerebral ischemia/reperfusion ...
Establishment and characterization of NCC-SS6-C1: a novel patient-derived cell line of synovial sarcoma
Establishment and characterization of NCC-SS6-C1: a novel patient-derived cell line of synovial sarcoma
Synovial sarcoma (SS) is identified as a sarcoma with monomorphic blue spindle cells that display variable epithelial diff...
Transcription repression of estrogen receptor alpha by ghrelin/Gq/11/YAP signaling in granulosa cells promotes polycystic ovary syndrome
Transcription repression of estrogen receptor alpha by ghrelin/Gq/11/YAP signaling in granulosa cells promotes polycystic ovary syndrome
Polycystic ovarian syndrome (PCOS) is a prevalent endocrinological disorder affected by ghrelin. This study aimed to inves...
GABAA receptor modulation by the endocannabinoid system: insights into the regulatory mechanisms involving glutamine synthetase and MAPK mediators
GABAA receptor modulation by the endocannabinoid system: insights into the regulatory mechanisms involving glutamine synthetase and MAPK mediators
Baur R, Gertsch J, Sigel E. Do N-arachidonyl-glycine (NA-glycine) and 2-arachidonoyl glycerol (2-AG) share mode of action ...
Exploring the relationship between ulcerative colitis, colorectal cancer, and prostate cancer
Exploring the relationship between ulcerative colitis, colorectal cancer, and prostate cancer
Chronic systemic inflammation caused by diseases such as ulcerative colitis (UC) and Crohn’s disease (CD) increases ...
The role of monoglyceride lipase gene in promoting proliferation, metastasis, and free fatty acid accumulation in uveal melanoma cells
The role of monoglyceride lipase gene in promoting proliferation, metastasis, and free fatty acid accumulation in uveal melanoma cells
Uveal melanoma is a malignant tumor originating from melanocytes in the eye's uvea, often detected during routine opht...
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