Live News

Safety and efficacy of different rotational speed during rotational atherectomy in coronary heart disease patients (RACE): study protocol for a randomized controlled trial

The increasing incidence of coronary heart disease, driven by socio-economic development and population aging, poses signi...

Trials

0 0

Core outcome sets in cancer clinical trials: current status and future opportunities—an EORTC perspective

Inconsistent, varied and selective outcome reporting is problematic in clinical trials. Core outcome sets (COS) standardis...

Trials

0 0

SUV39H1 maintains cancer stem cell chromatin state and properties in glioblastoma

Research ArticleCell biologyOncologyStem cells Open Access | 10.1172/jci.insight.186344 Chuny...

Jci Insight

0 0

Altered inflammatory mucosal signatures within their spatial and cellular context during active ileal Crohn’s disease

Research ArticleGastroenterologyInflammation Open Access | 10.1172/jci.insight.171783 Vasanth...

Jci Insight

0 0

Permanent defects in renal medullary structure and function after reversal of urinary obstruction

Persistent decline in renal function and UCC To study the effects of prolonged ureteric obstruction on the kidney, male B...

Jci Insight

0 0

Impaired axonal transport contributes to neurodegeneration in a Cre-inducible mouse model of myocilin-associated glaucoma

Research ArticleGeneticsNeuroscienceOphthalmology Open Access | 10.1172/jci.insight.188710 Ba...

Jci Insight

0 0

Multimodal integration of blood RNA and ctDNA reflects response to immunotherapy in metastatic urothelial cancer

Clinical Research and Public HealthImmunologyOncology Open Access | 10.1172/jci.insight.186062 ...

Jci Insight

0 0

Neutrophils initiate proinflammatory immune responses in early endometriosis lesion development

Aged neutrophil populations in menstrual effluent from women with endometriosis. Previous findings using our in vivo SDME...

Jci Insight

0 0

Leveraging complementary multi-omics data integration methods for mechanistic insights in kidney diseases

Research ArticleNephrology Open Access | 10.1172/jci.insight.186070 Fadhl Alakwaa,1 Vivek...

Jci Insight

0 0

Metabolic shifts in tryptophan pathways during acute pancreatitis infections

Research ArticleGastroenterology Open Access | 10.1172/jci.insight.186745 Daosheng Wang,1,2 ...

Jci Insight

0 0

APOBEC3A drives ovarian cancer metastasis by altering epithelial-mesenchymal transition

Research ArticleCell biologyOncology Open Access | 10.1172/jci.insight.186409 Jessica M. Deve...

Jci Insight

0 0

Orchestrated response from heterogenous fibroblast subsets contributes to repair from surgery-induced stress after airway reconstruction

SIS results in Fb accumulation in the reconstructed airway. In our previous work, we showed that ECM turnover and remodel...

Jci Insight

0 0

Fibroblast growth factor–inducible 14 regulates satellite cell self-renewal and expansion during skeletal muscle repair

Activation of Fn14 signaling in satellite cells during muscle regeneration. We first investigated how the expression of F...

Jci Insight

0 0

The AURKA inhibitor alters the immune microenvironment and enhances targeting B7-H3 immunotherapy in glioblastoma

Increased B7-H3 expression in GBM and the correlation between AURKA and B7-H3. First, we investigated the differentially ...

Jci Insight

0 0

A single-cell atlas of normal and KRASG12D-malformed lymphatic vessels

Sex as a biological variable. Our study examined male and female animals, and similar findings are reported for both sexe...

Jci Insight

0 0

Characterization of cognitive decline in long-duration type 1 diabetes by cognitive, neuroimaging, and pathological examinations

Clinical Research and Public HealthAgingEndocrinology Open Access | 10.1172/jci.insight.180226 ...

Jci Insight

0 0

Aerobic exercise prevents renal osteodystrophy via irisin-activated osteoblasts

Research ArticleBone biologyCell biologyMetabolism Open Access | 10.1172/jci.insight.184468 M...

Jci Insight

0 0

NAD+ prevents chronic kidney disease by activating renal tubular metabolism

Research ArticleNephrology Open Access | 10.1172/jci.insight.181443 Bryce A. Jones,1 Debo...

Jci Insight

0 0

Neurofilament accumulation disrupts autophagy in giant axonal neuropathy

Proteomic analysis of mouse dorsal root ganglia with gigaxonin silenced. Gan-null mice recapitulate the neurofilament agg...

Jci Insight

0 0

ROCK1 promotes B cell differentiation and proteostasis under stress through the heme-regulated proteins, BACH2 and HRI

Research ArticleAgingImmunology Open Access | 10.1172/jci.insight.180507 Juan Rivera-Correa,1...

Jci Insight

0 0

Involvement of lncRNA MIR205HG in idiopathic pulmonary fibrosis and IL-33 regulation via Alu elements

Research ArticleInflammationPulmonology Open Access | 10.1172/jci.insight.187172 Tsuyoshi Tak...

Jci Insight

0 0

Map2k6 is a potent genetic modifier of arterial rupture in vascular Ehlers-Danlos syndrome mice

Research ArticleCardiologyGeneticsVascular biology Open Access | 10.1172/jci.insight.187315 C...

Jci Insight

0 0

Does H3K27me3 expression play a role in patients with Blastic plasmacytoid dendritic cell neoplasm? A clinicopathologic analysis of 14 patients