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Re-evaluating the relevance of extensive intraductal component (EIC) in modern breast cancer management
Re-evaluating the relevance of extensive intraductal component (EIC) in modern breast cancer management
The concept of extensive intraductal component (EIC), currently defined by the presence of a prominent ductal carcinoma in...
Real-time histological evaluation of gastrointestinal tissue using non-linear microscopy
Real-time histological evaluation of gastrointestinal tissue using non-linear microscopy
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Breast phyllodes tumour with epithelioid feature predisposes to malignant transformation
Breast phyllodes tumour with epithelioid feature predisposes to malignant transformation
WHAT IS ALREADY KNOWN ON THIS TOPICThe stromal cells of classic phyllodes tumour (PT) exhibit a spindle cell morphology, w...
Partial regression of conventional renal cell carcinoma displays markers of wound repair
Partial regression of conventional renal cell carcinoma displays markers of wound repair
WHAT IS ALREADY KNOWN ON THIS TOPICHOW THIS STUDY MIGHT AFFECT RESEARCH, PRACTICE OR POLICYIntroductionSpontaneous regress...
IASLC grading system predicts distant metastases for resected lung adenocarcinoma
IASLC grading system predicts distant metastases for resected lung adenocarcinoma
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Time trends in Gleason score distribution among Gleason score 8 and 9-10 cancers
Time trends in Gleason score distribution among Gleason score 8 and 9-10 cancers
Reporting of prostate cancer grade has drifted to higher reported grades over the past decades. In prostate cancers diagno...
Retraction: Estimation of associations between 10 common gene polymorphisms and gastric cancer: evidence from a meta-analysis
Retraction: Estimation of associations between 10 common gene polymorphisms and gastric cancer: evidence from a meta-analysis
This article1 has been retracted by the Journal of Clinical Pathology due to apparent peer review manipulation.An individu...
Core outcome sets in cancer clinical trials: current status and future opportunities—an EORTC perspective
Core outcome sets in cancer clinical trials: current status and future opportunities—an EORTC perspective
Inconsistent, varied and selective outcome reporting is problematic in clinical trials. Core outcome sets (COS) standardis...
SUV39H1 maintains cancer stem cell chromatin state and properties in glioblastoma
Research ArticleCell biologyOncologyStem cells Open Access | 10.1172/jci.insight.186344 Chuny...
Permanent defects in renal medullary structure and function after reversal of urinary obstruction
Persistent decline in renal function and UCC To study the effects of prolonged ureteric obstruction on the kidney, male B...
Neutrophils initiate proinflammatory immune responses in early endometriosis lesion development
Aged neutrophil populations in menstrual effluent from women with endometriosis. Previous findings using our in vivo SDME...
Metabolic shifts in tryptophan pathways during acute pancreatitis infections
Research ArticleGastroenterology Open Access | 10.1172/jci.insight.186745 Daosheng Wang,1,2 ...
APOBEC3A drives ovarian cancer metastasis by altering epithelial-mesenchymal transition
Research ArticleCell biologyOncology Open Access | 10.1172/jci.insight.186409 Jessica M. Deve...
Orchestrated response from heterogenous fibroblast subsets contributes to repair from surgery-induced stress after airway reconstruction
SIS results in Fb accumulation in the reconstructed airway. In our previous work, we showed that ECM turnover and remodel...
Fibroblast growth factor–inducible 14 regulates satellite cell self-renewal and expansion during skeletal muscle repair
Activation of Fn14 signaling in satellite cells during muscle regeneration. We first investigated how the expression of F...
The AURKA inhibitor alters the immune microenvironment and enhances targeting B7-H3 immunotherapy in glioblastoma
Increased B7-H3 expression in GBM and the correlation between AURKA and B7-H3. First, we investigated the differentially ...
A single-cell atlas of normal and KRASG12D-malformed lymphatic vessels
Sex as a biological variable. Our study examined male and female animals, and similar findings are reported for both sexe...
Aerobic exercise prevents renal osteodystrophy via irisin-activated osteoblasts
Research ArticleBone biologyCell biologyMetabolism Open Access | 10.1172/jci.insight.184468 M...
NAD+ prevents chronic kidney disease by activating renal tubular metabolism
Research ArticleNephrology Open Access | 10.1172/jci.insight.181443 Bryce A. Jones,1 Debo...