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Exploring castleman disease in a cohort of hispanic patients: a recognition to its histopathology
Exploring castleman disease in a cohort of hispanic patients: a recognition to its histopathology
Castleman disease is a clinicopathological entity that shares features with hematological, rheumatological, and infectious...
CD5-positive B-cell acute lymphoblastic leukemia/lymphoma with mimicking aggressive mature B-cell lymphoma: a case report of a newly described entity and potential diagnostic pitfall
CD5-positive B-cell acute lymphoblastic leukemia/lymphoma with mimicking aggressive mature B-cell lymphoma: a case report of a newly described entity and potential diagnostic pitfall
Here, we present a challenging diagnostic case of a B-cell acute lymphoblastic leukemia (B-ALL) presenting as a rare extra...
Primary myelofibrosis with concurrent and atypical mutations
Primary myelofibrosis with concurrent and atypical mutations
Distinct bone marrow morphology is considered the primary basis for the diagnosis of BCR::ABL1-negative myeloprol...
Evaluation of CD200 marker variations and its correlation with clinicopathological features of chronic lymphocytic leukemia patients: a case–control study
Evaluation of CD200 marker variations and its correlation with clinicopathological features of chronic lymphocytic leukemia patients: a case–control study
Given its strong correlation with disease progression and risk stratification, CD200 has emerged as a pivotal biomarker in...
A novel homozygous frameshift mutation (p.Lys365Glnfs*69) in a family with hereditary factor XII deficiency: a case report
A novel homozygous frameshift mutation (p.Lys365Glnfs*69) in a family with hereditary factor XII deficiency: a case report
Factor XII (FXII) deficiency is a rare autosomal recessive disorder characterized by prolonged activated partial thrombopl...
EGLN1-positive familial erythrocytosis: a rare variant with an unusually aggressive clinical course
EGLN1-positive familial erythrocytosis: a rare variant with an unusually aggressive clinical course
Familial erythrocytosis type 3 (ECYT3) is a rare condition caused by loss of function germline mutations in the prolyl hyd...
Unicentric Castleman disease following POEMS syndrome remission
Unicentric Castleman disease following POEMS syndrome remission
POEMS syndrome is a rare paraneoplastic disorder characterized by polyneuropathy, organomegaly, endocrinopathy, monoclonal...
Granulomas in bone marrow: is it always tuberculosis?
Granulomas in bone marrow: is it always tuberculosis?
Granulomas in a bone marrow biopsy are like gold dust. Numerous studies have reported that the incidence of granu...
Masked by eosinophils: a cryptic presentation of pediatric B-ALL with IGH rearrangement
Masked by eosinophils: a cryptic presentation of pediatric B-ALL with IGH rearrangement
Hypereosinophilia is uncommon in the pediatric population and may be associated with either primary or secondary condition...
Discovery of a germline deletion in a B-lymphoblastic leukemia post-induction bone marrow specimen: a case report and review of the literature
Discovery of a germline deletion in a B-lymphoblastic leukemia post-induction bone marrow specimen: a case report and review of the literature
Somatic IKZF1 alterations are common in B-lymphoblastic leukemia (B-ALL) and are generally associated with poor outcomes. ...
Plasmablastic plasmacytoma followed by a plasmacytic plasma cell myeloma: insights into discordant extramedullary transformation—a case report and literature review
Plasmablastic plasmacytoma followed by a plasmacytic plasma cell myeloma: insights into discordant extramedullary transformation—a case report and literature review
Plasma cell neoplasms encompass a spectrum of disorders characterized by the clonal proliferation of plasma cells. Plasmab...
A rare alpha globin chain variant hemoglobin Fontainebleau poses diagnostic challenges by yielding different results in two different HPLC systems
A rare alpha globin chain variant hemoglobin Fontainebleau poses diagnostic challenges by yielding different results in two different HPLC systems
Alpha globin chain variants constitute a very small fraction of the total hemoglobinopathy cases. Their rarity and the oft...
A rare case of Hodgkin lymphoma transformed from follicular lymphoma demonstrating 14;18 translocation
A rare case of Hodgkin lymphoma transformed from follicular lymphoma demonstrating 14;18 translocation
Ethical approval Following the institutional ethical guidel...
Where are the immunoglobulins? A review of non-secretory multiple myeloma
Where are the immunoglobulins? A review of non-secretory multiple myeloma
Multiple myeloma (MM) is a malignant neoplasm of clonal plasma cells, typically associated with the production of a monocl...
Application of capillary gel electrophoresis in detection of Factor VIII gene intron 22 inversion of hemophilia A
Application of capillary gel electrophoresis in detection of Factor VIII gene intron 22 inversion of hemophilia A
Intron 22 inversion (Inv22) of the factor VIII gene (F8) accounts for approximately 45% of severe hemophilia A (HA) cases....
Immune cell subset variations in immune thrombocytopenia: a prospective observational study
Immune cell subset variations in immune thrombocytopenia: a prospective observational study
This study evaluated immune cell subset variations in immune thrombocytopenia (ITP) by comparing frequencies at diagnosis ...
Validation of clinicopathologic features of a genetic myelodysplastic syndrome classification in an independent cohort
Validation of clinicopathologic features of a genetic myelodysplastic syndrome classification in an independent cohort
Current classification systems for myelodysplastic syndromes (MDS) incorporate morphologic findings, blast percentage, and...
A rare case of in situ follicular B-cell neoplasm involving sebaceous lymphadenoma
A rare case of in situ follicular B-cell neoplasm involving sebaceous lymphadenoma
In situ follicular neoplasia (ISFN) is characterized by a monoclonal proliferation of BCL2-positive B cells harboring the ...
Clinical features and outcomes of primary ocular adnexal follicular lymphoma: a retrospective analysis
Clinical features and outcomes of primary ocular adnexal follicular lymphoma: a retrospective analysis
Extranodal follicular lymphoma (FL) demonstrates unique clinicopathological features and prognostic implications, and the ...
Post-transplant changes in physical functioning and quality of life in patients undergoing two allogeneic hematopoietic stem cell transplants
Post-transplant changes in physical functioning and quality of life in patients undergoing two allogeneic hematopoietic stem cell transplants
This study retrospectively examined changes in physical functioning and quality of life (QOL) in allogeneic hematopoietic ...
Real-world safety and effectiveness of alemtuzumab as a conditioning regimen for hematopoietic stem cell transplantation
Real-world safety and effectiveness of alemtuzumab as a conditioning regimen for hematopoietic stem cell transplantation
Alemtuzumab, a humanized monoclonal antibody directed against CD52, is indicated for administration prior to allogeneic he...
Growth differentiation factor-15 as a non-invasive biomarker of liver fibrosis in sickle cell disease
Growth differentiation factor-15 as a non-invasive biomarker of liver fibrosis in sickle cell disease
This study aimed to evaluate the relationship between growth differentiation factor-15 (GDF-15) levels and liver fibrosis ...
Discovering the hidden link: hematological disorders caused by copper deficiency
Discovering the hidden link: hematological disorders caused by copper deficiency
Copper deficiency can lead to anemia, leukopenia, or thrombocytopenia, often mimicking vitamin B12 deficiency or myelodysp...
Intravenous umbilical cord-derived mesenchymal stromal cell therapy may improve overall survival in Japanese patients with idiopathic pneumonia syndrome after hematopoietic stem cell transplantation: a multicenter, single-arm, phase II trial
Intravenous umbilical cord-derived mesenchymal stromal cell therapy may improve overall survival in Japanese patients with idiopathic pneumonia syndrome after hematopoietic stem cell transplantation: a multicenter, single-arm, phase II trial
Idiopathic pneumonia syndrome (IPS) is a serious complication of allogeneic hematopoietic stem cell transplantation (HSCT)...
Efficacy and safety of momelotinib in Janus kinase inhibitor-experienced Asian patients with myelofibrosis and anemia
Efficacy and safety of momelotinib in Janus kinase inhibitor-experienced Asian patients with myelofibrosis and anemia
This post hoc analysis investigated the efficacy and safety of momelotinib in the Asian subpopulation of MOMENTUM (NCT0417...
Cardiovascular toxicity from tyrosine kinase inhibitors in chronic myeloid leukemia with severe dilated cardiomyopathy
Cardiovascular toxicity from tyrosine kinase inhibitors in chronic myeloid leukemia with severe dilated cardiomyopathy
Tyrosine kinase inhibitors (TKIs) have significantly improved the prognosis of patients with chronic myeloid leukemia (CML...
Expression profiling of Epstein–Barr virus-derived microRNA in systemic chronic active EBV disease
Expression profiling of Epstein–Barr virus-derived microRNA in systemic chronic active EBV disease
Systemic chronic active Epstein–Barr virus disease (sCAEBV) is an intractable disorder characterized by clonal proli...
Humoral immunity after hematopoietic stem cell transplantation: evaluation by B-cell receptor repertoire analysis
Humoral immunity after hematopoietic stem cell transplantation: evaluation by B-cell receptor repertoire analysis
Immunity acquired before hematopoietic stem cell transplantation (HSCT) may decrease or disappear following HSCT, and it i...
Treatment of post-transplant lymphoproliferative disorders in kidney transplant recipients: a single-center retrospective analysis
Treatment of post-transplant lymphoproliferative disorders in kidney transplant recipients: a single-center retrospective analysis
Post-transplant lymphoproliferative disorder (PTLD) is a significant complication of immunosuppression after kidney transp...
Andrographolide drives dual apoptosis and ferroptosis via caspase-3 and FACL4 in T-ALL cell lines
Andrographolide drives dual apoptosis and ferroptosis via caspase-3 and FACL4 in T-ALL cell lines
This study investigated the anti-tumor effects of andrographolide, a diterpene lactone derived from Andrographis paniculat...
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