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TLR-4/Notch1/NF-κB pathway modulation by dapagliflozin: a novel mechanism for neuroprotection in hepatic encephalopathy
TLR-4/Notch1/NF-κB pathway modulation by dapagliflozin: a novel mechanism for neuroprotection in hepatic encephalopathy
Acute or chronic liver damage can result in Hepatic Encephalopathy (HE), a potentially fatal neuropsychiatric condition th...
Multimodal evaluation of nitazoxanide as an antidepressant: behavioral, biochemical, and molecular docking insights
Multimodal evaluation of nitazoxanide as an antidepressant: behavioral, biochemical, and molecular docking insights
This study aimed to evaluate the antidepressant potential of Nitazoxanide (NTZ), an antiprotozoal drug with known anti-inf...
The therapeutic effects of various tonic traditional Chinese medicines on demyelinating diseases
The therapeutic effects of various tonic traditional Chinese medicines on demyelinating diseases
Demyelinating diseases, a prevalent group of neurological disorders, lead to impaired nerve conduction and sensorimotor dy...
Transformations in plasma metabolic profiles of patients with major depression disorder during treatment
Transformations in plasma metabolic profiles of patients with major depression disorder during treatment
Major depression disorder (MDD) is a mental condition that significantly threatens both physical and psychological health....
Simple scoring model for predicting overt hepatic encephalopathy in geriatric cirrhosis: A multicenter retrospective cohort study
Simple scoring model for predicting overt hepatic encephalopathy in geriatric cirrhosis: A multicenter retrospective cohort study
Identifying the risk of overt hepatic encephalopathy (OHE) in geriatric patients with cirrhosis remains challenging. This ...
4-aminopyridine exerts anxiolytic and pro-cognitive effects in mice model of medial prefrontal cortex ischemia
4-aminopyridine exerts anxiolytic and pro-cognitive effects in mice model of medial prefrontal cortex ischemia
Brain ischemia is a major global cause of disability, frequently leading to psychoneurological issues. This study investig...
Impact of agmatine on cerebral astrocyte reactivity, neurodegeneration, and oxidative stress in bile duct-ligated rats
Impact of agmatine on cerebral astrocyte reactivity, neurodegeneration, and oxidative stress in bile duct-ligated rats
Hepatic encephalopathy (HE) is a severe neurological disorder arising from liver disease, often studied using the bile duc...
Curcumin treatment reduces motor impairments and protects against rotenone-induced neurodegeneration in a rat model of Parkinson disease
Curcumin treatment reduces motor impairments and protects against rotenone-induced neurodegeneration in a rat model of Parkinson disease
Parkinson’s disease (PD) is a progressive neurodegenerative disorder characterized by degeneration of dopaminergic n...
A novel modulator of the Axin/β-Catenin interaction to restore EAAT2 expression in alzheimer’s disease: an in-silico and in-vitro approach
A novel modulator of the Axin/β-Catenin interaction to restore EAAT2 expression in alzheimer’s disease: an in-silico and in-vitro approach
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder marked by synaptic dysfunction and neuronal los...
Correction to: Regulation of oxygen–glucose deprivation/reperfusion‑induced inflammatory responses and M1‑M2 phenotype switch of BV2 microglia by Lobetyolin
Correction to: Regulation of oxygen–glucose deprivation/reperfusion‑induced inflammatory responses and M1‑M2 phenotype switch of BV2 microglia by Lobetyolin
Correction to: Veterinary Research CommunicationsThe following errors are listed as f...
Prospective observational study on systemic inflammation and prognostic significance of hepatic encephalopathy
Prospective observational study on systemic inflammation and prognostic significance of hepatic encephalopathy
Hepatic encephalopathy (HE) is a common decompensating event in liver cirrhosis, with a prevalence of 10–14% in newl...
Bay leaves: the neuroprotective dietary spice inhibition of amyloid-like aggregation
Bay leaves: the neuroprotective dietary spice inhibition of amyloid-like aggregation
Aguzzi A, O’connor T (2010) Protein aggregation diseases: pathogenicity and therapeutic perspectives. Nat Rev Drug Discov ...
Umbelliferone reverses neuronal damage induced by chronic Chlorpyrifos exposure via suppressing NF-κB/STAT3/NLRP3 and boosting Keap-1/Nrf2/HO-1 signals
Umbelliferone reverses neuronal damage induced by chronic Chlorpyrifos exposure via suppressing NF-κB/STAT3/NLRP3 and boosting Keap-1/Nrf2/HO-1 signals
Chlorpyrifos (CPF), an organophosphate pesticide, is a widely used pest control chemical. Unfortunately, pesticides are kn...
Exercise training enhances myokine release and reduces brain insulin resistance: insights into muscle-CNS metabolic cross-talk
Exercise training enhances myokine release and reduces brain insulin resistance: insights into muscle-CNS metabolic cross-talk
Recent studies have demonstrated that insulin and its receptors play a vital role in the central nervous system, supportin...
Portacaval anastomosis promotes fragmentation of mitochondrial network in the cerebellum of male rats
Portacaval anastomosis promotes fragmentation of mitochondrial network in the cerebellum of male rats
Portacaval anastomosis (PCA) is a model for hypometabolic liver dysfunction. Spongiform neurodegeneration has been detecte...
Nitisinone treatment protect hereditary tyrosinemia type I patients against inflammation, DNA and protein oxidative damage by decreasing succinylacetone levels
Nitisinone treatment protect hereditary tyrosinemia type I patients against inflammation, DNA and protein oxidative damage by decreasing succinylacetone levels
Hereditary tyrosinemia type I (HT1) is an inborn error of metabolism (IEM), caused by deficiency of the enzyme fumarylacet...
From metabolic dysregulation to neurodegenerative pathology: the role of hyperglycemia, oxidative stress, and blood-brain barrier breakdown in T2D-driven Alzheimer’s disease
From metabolic dysregulation to neurodegenerative pathology: the role of hyperglycemia, oxidative stress, and blood-brain barrier breakdown in T2D-driven Alzheimer’s disease
Type 2 Diabetes (T2D) and Alzheimer’s Disease (AD) share common risk factors that can be seen through T2D nearly dou...
Impaired Synaptic Plasticity Mechanisms in Alzheimer’s Disease
Impaired Synaptic Plasticity Mechanisms in Alzheimer’s Disease
Alzheimer’s disease (AD) is the most common form of dementia, characterized by progressive cognitive decline driven ...
Epstein-Barr virus infection and vitamin D deficiency are both “causal” for multiple sclerosis (MS) - could the common denominator be their effects on hepcidin levels?
Epstein-Barr virus infection and vitamin D deficiency are both “causal” for multiple sclerosis (MS) - could the common denominator be their effects on hepcidin levels?
Multiple sclerosis (MS) is a neurological disorder characterized by damage to the myelin sheaths surrounding axons in the ...
Protective effects of against thioacetamide-induced hepatic encephalopathy: a focus on antioxidant and neuroprotective mechanisms
Protective effects of against thioacetamide-induced hepatic encephalopathy: a focus on antioxidant and neuroprotective mechanisms
Hepatic encephalopathy (HE) is a multifaceted neuropsychiatric syndrome frequently observed in patients with liver dysfunc...
Association of the triglyceride-glucose index combined with a body shape index with all-cause and cardiovascular mortality in individuals with cardiovascular-kidney-metabolic syndrome stage 0–3: findings from two prospective cohorts
Association of the triglyceride-glucose index combined with a body shape index with all-cause and cardiovascular mortality in individuals with cardiovascular-kidney-metabolic syndrome stage 0–3: findings from two prospective cohorts
The triglyceride-glucose (TyG) index, as a measure of insulin resistance, has been confirmed to be associated with adverse...
Fixed-dose vs loose-dose combination antidiabetic therapy and cardiorenal outcomes in type 2 diabetes: a nationwide comparative effectiveness study
Fixed-dose vs loose-dose combination antidiabetic therapy and cardiorenal outcomes in type 2 diabetes: a nationwide comparative effectiveness study
Combination therapy is gaining attention in type 2 diabetes management due to its potential to reach glycaemic goals withi...
Treatment and associated outcomes of type 2 diabetes mellitus patients with a cardiovascular comorbidity and comparison with guideline recommendations: a German claims data analysis
Treatment and associated outcomes of type 2 diabetes mellitus patients with a cardiovascular comorbidity and comparison with guideline recommendations: a German claims data analysis
Type 2 diabetes mellitus (T2DM) patients are at high risk for micro- and macrovascular complications, and cardiovascular (...
The association between triglyceride-glucose index and all-cause/cardiovascular mortality in patients with different glucose metabolism statuses
The association between triglyceride-glucose index and all-cause/cardiovascular mortality in patients with different glucose metabolism statuses
The triglyceride-glucose index (TyG) is an emerging marker of metabolic health, yet its association with mortality across ...
Bone Mineral Density During Treatment with The Janus Kinase Inhibitor Baricitinib in Patients with Rheumatoid Arthritis: A Monocentric Observational Study
Bone Mineral Density During Treatment with The Janus Kinase Inhibitor Baricitinib in Patients with Rheumatoid Arthritis: A Monocentric Observational Study
Rheumatoid arthritis (RA) is associated with systemic bone loss and thus an established risk factor for osteoporosis. Janu...
The Role of Heparan Sulfate in Bone Repair and Regeneration
The Role of Heparan Sulfate in Bone Repair and Regeneration
Heparan sulfate (HS) is synthesized in majority of cells in the human body and is typically released as an extension of po...
Impacts of Nonenzymatic Glycation Crosslinks in Bone Matrix on the Mechanosensitivity of Osteocyte
Impacts of Nonenzymatic Glycation Crosslinks in Bone Matrix on the Mechanosensitivity of Osteocyte
The products of nonenzymatic glycation (NEG) are a key contributor to various types of osteoporosis, as they affect both t...
Effect of Oral Semaglutide on Volumetric BMD and Bone Microarchitecture in Overweight/Obese Individuals with Type 2 Diabetes
Effect of Oral Semaglutide on Volumetric BMD and Bone Microarchitecture in Overweight/Obese Individuals with Type 2 Diabetes
Obesity, type 2 diabetes, and therapeutic weight loss are all associated with impaired bone quantity and microarchitecture...
Effectiveness of Radiotherapy in Preventing Heterotopic Ossification: A Meta-analysis of Randomized Controlled Trials Beyond Total Hip Arthroplasty
Effectiveness of Radiotherapy in Preventing Heterotopic Ossification: A Meta-analysis of Randomized Controlled Trials Beyond Total Hip Arthroplasty
Heterotopic ossification (HO) frequently occurs after procedures such as hip replacements, acetabular fractures, and elbow...
Consensus-Based Recommendations for the Diagnosis, Treatment, and Monitoring of Hypoparathyroidism: Insights from the DACH Region
Consensus-Based Recommendations for the Diagnosis, Treatment, and Monitoring of Hypoparathyroidism: Insights from the DACH Region
Hypoparathyroidism (HypoPT) is a rare endocrine disorder characterized by low parathyroid hormone (PTH) levels, hypocalcem...
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