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DLL3 Expression in Neuroendocrine Carcinomas and Neuroendocrine Tumours: Insights From a Multicentric Cohort of 1294 Pulmonary and Extrapulmonary Neuroendocrine Neoplasms
DLL3 Expression in Neuroendocrine Carcinomas and Neuroendocrine Tumours: Insights From a Multicentric Cohort of 1294 Pulmonary and Extrapulmonary Neuroendocrine Neoplasms
Delta-like ligand 3 (DLL3) is frequently expressed in pulmonary small cell neuroendocrine carcinoma (SCNEC) and has emerge...
Impact of Tissue Thickness on Computational Quantification of Features in Whole Slide Images for Diagnostic Pathology
Impact of Tissue Thickness on Computational Quantification of Features in Whole Slide Images for Diagnostic Pathology
Tissue section thickness (TST) is an understudied variable in digital pathology that significantly impacts both visual ass...
Multicentric Retrospective Analysis of Oncocytic Adrenocortical Carcinoma: Insights into Clinical and Management Strategies
Multicentric Retrospective Analysis of Oncocytic Adrenocortical Carcinoma: Insights into Clinical and Management Strategies
Oncocytic adrenocortical carcinoma (OAC) is a rare variant of conventional adrenocortical carcinoma (ACC), characterized b...
Subclassifying "Atypia of Undetermined Significance (AUS)" Category in the 2023 Bethesda System for Thyroid Cytopathology: Analyzing K-TIRADS, V600E Mutation, and Risk of Malignancy
Subclassifying "Atypia of Undetermined Significance (AUS)" Category in the 2023 Bethesda System for Thyroid Cytopathology: Analyzing K-TIRADS, V600E Mutation, and Risk of Malignancy
The 2023 Bethesda System for Reporting Thyroid Cytopathology (TBSRTC) update refines the atypia of undetermined significan...
Prevalence and Clinical Impact of p.V600E Mutation in Papillary Thyroid Carcinoma
Prevalence and Clinical Impact of p.V600E Mutation in Papillary Thyroid Carcinoma
Identifying risk factors in papillary thyroid carcinoma (PTC) that warrant more aggressive treatment is paramount. Importa...
Identification of Specific Biomarkers for Anaplastic Thyroid Carcinoma Through Spatial Transcriptomic and Immunohistochemical Profiling
Identification of Specific Biomarkers for Anaplastic Thyroid Carcinoma Through Spatial Transcriptomic and Immunohistochemical Profiling
Anaplastic thyroid carcinoma (ATC) is an aggressive malignancy with a poor prognosis. Despite its rarity, identifying pred...
Amplification a Risk Stratification Marker in Papillary Thyroid Carcinoma, Significantly Correlated with Tumor Recurrence and Survival
Amplification a Risk Stratification Marker in Papillary Thyroid Carcinoma, Significantly Correlated with Tumor Recurrence and Survival
Few studies have analyzed the prevalence of TERT amplification in thyroid cancer, showing discrepancies in various topics....
Is Ectopic Cushing Syndrome Commonly Associated with Small Cell Lung Cancer (SCLC)? Critical Review of the Literature and ACTH Expression in Resected SCLC
Is Ectopic Cushing Syndrome Commonly Associated with Small Cell Lung Cancer (SCLC)? Critical Review of the Literature and ACTH Expression in Resected SCLC
The literature emphasizes that pulmonary ectopic Cushing syndrome (ECS) is associated not only with neuroendocrine tumors ...
ABCC3 Is a Differential Marker of CYP11B2-Negative Zona Glomerulosa Cells in Human Adrenal Cortex
ABCC3 Is a Differential Marker of CYP11B2-Negative Zona Glomerulosa Cells in Human Adrenal Cortex
ATP Binding Cassette Subfamily C Member 3 (ABCC3) is a membrane transporter that exports diverse compounds, influencing dr...
Clinicopathological Correlates of Hormone Expression-Based Subtypes of Non-Functioning Duodenal/Ampullary Neuroendocrine Tumors: A Multicenter Study of 151 Cases
Clinicopathological Correlates of Hormone Expression-Based Subtypes of Non-Functioning Duodenal/Ampullary Neuroendocrine Tumors: A Multicenter Study of 151 Cases
Duodenal neuroendocrine tumors (Duo-NETs) may arise in the ampullary and non-ampullary duodenum. Non-functioning Duo-NETs ...
Three Synchronous Pituitary Neuroendocrine Tumors—Epigenomics Confirm an Exceptional Triple PitNET
Three Synchronous Pituitary Neuroendocrine Tumors—Epigenomics Confirm an Exceptional Triple PitNET
Histopathology revealed three distinct tumor components (Fig. 1C). The first component was characterized by scant infiltra...
Focal High-Grade Areas with a Tumor-in-Tumor Pattern: Another Feature of Pediatric -Associated Thyroid Carcinoma?
Focal High-Grade Areas with a Tumor-in-Tumor Pattern: Another Feature of Pediatric -Associated Thyroid Carcinoma?
In the thyroid gland, during childhood or adolescence, DICER1-driven tumors include differentiated follicular thyroid carc...
Reticulin Framework Assessment in Neoplastic Endocrine Pathology
Reticulin Framework Assessment in Neoplastic Endocrine Pathology
The reticulin framework, composed mainly of type III collagen, is an essential structural component of biological tissues....
A Novel Three-Stage AI-Assisted Approach for Accurate Differential Diagnosis and Classification of NIFTP and Thyroid Neoplasms
A Novel Three-Stage AI-Assisted Approach for Accurate Differential Diagnosis and Classification of NIFTP and Thyroid Neoplasms
The recent introduction of the term non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) ...
Extended Hormone Profiling Identifies a Wider Network of Duodenal Neuroendocrine Tumor Subtypes
Extended Hormone Profiling Identifies a Wider Network of Duodenal Neuroendocrine Tumor Subtypes
We studied transcription factors and hormones expressed by duodenal neuroendocrine cells in a consecutively diagnosed seri...
Roadmap to Challenges in Limited Cellularity Specimens from Pancreatic Neuroendocrine Neoplasms: Diagnostic Tools for the Most Appropriate Management of Limited Material
Roadmap to Challenges in Limited Cellularity Specimens from Pancreatic Neuroendocrine Neoplasms: Diagnostic Tools for the Most Appropriate Management of Limited Material
Fine needle aspiration (FNA) and fine needle biopsy (FNB) procedures are increasingly employed in the diagnostic work-up o...
Expression of DLL3 and SEZ6 in the Spectrum of Neuroendocrine Neoplasia
Expression of DLL3 and SEZ6 in the Spectrum of Neuroendocrine Neoplasia
Delta-like protein 3 (DLL3), a Notch ligand, has been identified in high-grade small- and large-cell lung carcinomas and p...
Reappraisal of Neuroendocrine Tumor Classification of the Prostate Gland: Translating Molecular Insights into Clinical Practice
Reappraisal of Neuroendocrine Tumor Classification of the Prostate Gland: Translating Molecular Insights into Clinical Practice
Neuroendocrine tumors (NETs) of the prostate gland represent a distinct entity within the spectrum of prostate cancer, cha...
Consensus Statement: Recommendations on Actionable Biomarker Testing for Thyroid Cancer Management
Consensus Statement: Recommendations on Actionable Biomarker Testing for Thyroid Cancer Management
Thyroid cancer management is rapidly changing. The identification of actionable biomarkers through both germline and somat...
Clinicopathological Features of Epstein-Barr Virus-Positive Neuroendocrine Carcinoma: Analysis of Twenty-Two Cases
Clinicopathological Features of Epstein-Barr Virus-Positive Neuroendocrine Carcinoma: Analysis of Twenty-Two Cases
Epstein-Barr Virus (EBV)–positive neuroendocrine carcinoma (NEC) is a rare neoplasm with limited histopathological a...
Effective Preparation of FFPE Tissue Samples for Preserving Appropriate Nucleic Acid Quality for Genomic Analysis in Thyroid Carcinoma
Effective Preparation of FFPE Tissue Samples for Preserving Appropriate Nucleic Acid Quality for Genomic Analysis in Thyroid Carcinoma
Formalin-fixed paraffin-embedded (FFPE) tissue samples are important for genomic analysis of thyroid carcinomas, particula...
Unravelling the Reasons Behind Limited Response to Anti-PD Therapy in ATC: A Comprehensive Evaluation of Tumor-Infiltrating Immune Cells and Checkpoints
Unravelling the Reasons Behind Limited Response to Anti-PD Therapy in ATC: A Comprehensive Evaluation of Tumor-Infiltrating Immune Cells and Checkpoints
Inhibiting the immune checkpoint (ICP) PD-1 based on PD-L1 expression status has revolutionized the treatment of various c...
Insights into Biologic Evolution of Grade 3 Neuroendocrine Tumors Reflect Classification Challenges
Insights into Biologic Evolution of Grade 3 Neuroendocrine Tumors Reflect Classification Challenges
In the IARC/WHO classification framework of neuroendocrine neoplasms (NENs), high-gra...
Cauda Equina Neuroendocrine Tumors with Ganglioneuromatous Elements are Best Classified as Composite Gangliocytoma/Neuroma and Neuroendocrine Tumor (COGNET)
Cauda Equina Neuroendocrine Tumors with Ganglioneuromatous Elements are Best Classified as Composite Gangliocytoma/Neuroma and Neuroendocrine Tumor (COGNET)
Ethics Approval For this article, an ethic approval is not ...
Rapid Evolution of Metastases in Patients with Treated G3 Neuroendocrine Tumors Associated with NEC-Like Transformation and TP53 Mutation
Rapid Evolution of Metastases in Patients with Treated G3 Neuroendocrine Tumors Associated with NEC-Like Transformation and TP53 Mutation
Little is known about the morphomolecular features of G3 neuroendocrine tumors (G3NETs) under prolonged systemic treatment...
Multilineage Pituitary Neuroendocrine Tumors Expressing TPIT and SF1: A Clinicopathological Series of Six Tumors
Multilineage Pituitary Neuroendocrine Tumors Expressing TPIT and SF1: A Clinicopathological Series of Six Tumors
Tumors of adenohypophysial hormone-secreting cells, now classified as pituitary neuroendocrine tumors (PitNETs), have been...
The Potential Utility of RAS Q61R Immunohistochemistry as a Screening Tool in Pre-operative Fine Needle Aspirates of Medullary Thyroid Carcinoma
The Potential Utility of RAS Q61R Immunohistochemistry as a Screening Tool in Pre-operative Fine Needle Aspirates of Medullary Thyroid Carcinoma
Medullary thyroid carcinoma (MTC) can either be sporadic, often via mutually exclusive RET or RAS alterations, or inherite...
Mitochondrial Proteome Defined Molecular Pathological Characteristics of Oncocytic Thyroid Tumors
Mitochondrial Proteome Defined Molecular Pathological Characteristics of Oncocytic Thyroid Tumors
Oncocytic thyroid tumors are characterized by an elevated mitochondrial density within the cells, distinguishing them from...
High-Grade Progression, Sarcomatous Transformation, and/or Metastasis of Pituitary Neuroendocrine Neoplasms (PitNENs): The UCSF Experience
High-Grade Progression, Sarcomatous Transformation, and/or Metastasis of Pituitary Neuroendocrine Neoplasms (PitNENs): The UCSF Experience
Pituitary neuroendocrine tumors (PitNET) that metastasize comprise ~ 0.2% of adenohypophyseal tumors are aggre...
The Molecular Classification of Pheochromocytomas and Paragangliomas: Discovering the Genomic and Immune Landscape of Metastatic Disease
The Molecular Classification of Pheochromocytomas and Paragangliomas: Discovering the Genomic and Immune Landscape of Metastatic Disease
Pheochromocytomas (PCCs) and paragangliomas (PGLs, together PPGLs) are the most hereditary tumors known. PPGLs were consid...
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