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Nitrogen-inversion-based racemate aggregation and interenantiomer -stacking-caused solid-state fluorescence enhancement
The solid-state fluorescence of fluorophores is usually weakened or quenched by strong π-π interactions. Here, the solid-s...
Photoinduced Co-catalyzed dehydrogenative cyclization of 2-alkenylphenyl carbonyl compounds and mechanistic insights
In this work, we present a UV-induced 6π-cyclization protocol enabling the synthesis of polysubstituted naphthol skeletons...
Dearomative 2,3-Diamination of Indoles Triggered by Rh(III)-Catalyzed Csp2-H Activation
A Rh(III)-catalyzed dearomative 2,3-diamination of indoles with N-alkoxyamides has been developed. The method provides an ...
An Unexpected Lewis Acid-Catalyzed Cascade Reaction of Bicyclo[1.1.0]butanes with Triazinanes to Biscyclobutenyl Amines
An unexpected In(OTf)3-catalyzed cascade reaction of bicyclo[1.1.0]butanes with triazinanes is reported, providing a serie...
Remodelling Molecular Frameworks via Atom-Level Surgery: Recent Advances in Skeletal Editing of (Hetero)Cycles
Skeletal editing is an emerging approach in synthetic chemistry that enables precise atom-level modifications within molec...
Bridged Rings from Phenolic Feedstocks: Regio- and Diastereoselective Substitution-Hemiketalization Cyclization of Bridged Benzoxocin-4-ones with Grignard Reagents
The efficient and controllable generation of bridged polycycles of structural complexity and diversity from readily avaial...
Access to (Bridged) Bicyclic Ureas through Azocarboxamide-Enabled Enantioselective 1,2-Diamination of α-Branched Cyclic Ketones
Chiral bicyclic ureas are important multi-nitrogen-containing polycyclic frameworks and valuable building blocks in organi...
Palladium-Catalyzed Multicomponent [4+2] Cycloaddtion of 1, 4-Enynes with CO and Arylamines to Access Polycyclic γ-Lactams via Dearomative Rearrangement
Herein we report a novel palladium-catalyzed intermolecular dearomative [4+2] cycloaddition of 1, 4-enynes with CO and ary...
Supramolecular Chiroptical Sensing by Achiral AIE-active Thiols
Rapid and sensitive chiroptical sensing is of great significance for practical applications. Here, a novel rapid supramole...
Synthesis of 2-arylchromeno[2,3,4,5-lmna]phenanthridines through a sequential multicomponent assembly, oxygenation and 6πe electrocyclization reactions
A novel metal-free synthetic method is presented for the 2-arylchromeno[2,3,4,5-lmna]phenanthridines from the one-pot reac...
Giese Reaction of Alkyl Bromides using Amine Carboxyboranes
Amine carboxyborane enabled an efficient halogen atom transfer (XAT) with 1o, 2o, and 3o alkyl bromides, resulting in Gies...
Computational Study on Pd-Catalyzed ipso,meta-Dimethylation of ortho-Substituted Iodoarene: Mechanisms and the Role of Base
Density functional theory (DFT) calculations were performed to study Pd-catalyzed ipso,meta-dimethylation reaction of orth...
Progress in Catalytic Enantioselective Construction of Difluoroalkylated Stereogenic Center
Molecules bearing the difluoroalkyl groups were very important in pharmaceuticals, argrochemicals and materials. In recent...
Synthesis of a cross-chain bridging cryptand
We present two methodologies for synthesizing cross–chain bridging cryptand 1 that incorporates tri- and tetra(ethylene gl...
Rapid and Visual Detection of Hepatitis B Virus Using the ERA/Cas12f1_ge4.1-Based Lateral Flow Assay System
Hepatitis B virus (HBV) is a major pathogen posing significant challenges to global public health, making early diagnosis ...
Optical biosensor array based on nanozyme for environmental monitoring and food safety detection: Principle, design, and application
Typical biosensing platforms are built on the 'lock-and-key' approach, providing high specificity and sensitivity ...
Glycan Profiling of Multiple Sclerosis Oligoclonal Bands with MALDI-TOF
Multiple sclerosis (MS) is a common autoimmune disease that primarily affects young adults. In this condition, the immune ...
Combining Digital Imaging and Quantum Dots for Analytical Purposes
This review details recent advances in digital imaging (DI) methods for the development of analytical methodologies combin...
Enabling simultaneous photoluminescence spectroscopy and X-ray Footprinting Mass Spectrometry to study protein conformation and interactions
X-ray Footprinting Mass Spectrometry (XFMS) is a structural biology method that uses broadband X-rays for in situ hydroxyl...
Rapid Mimetic Micro-Contact Nano Fluorosensor based on Molecularly Imprinted Polymers for Detection of Amygdalin in Biological Matrix
In this study, mimetic fluorescence nano-sensor based on molecularly imprinted polymer was designed for detection of amygd...
Facile preparation of a hydrophilic Eu-based ratiometric fluorescence nanosensor for Cu2+ ion detection and living cells imaging
In this work, a hydrophilic Eu-based ratiometric fluorescence nanosensor (PAAC-Eu) was developed for Cu2+ ion detection in...
Advances in Human Papillomavirus Detection for Cervical Cancer Screening and Diagnosis: Challenges of Conventional Methods and Opportunities for Emergent Tools
Human papillomavirus (HPV) infection is the main cause of cervical cancer and other cancers such as anogenital and orophar...
A rapid and highly sensitive fluorescence immunochromatographic test strip for pepsin detection in human hypopharyngeal saliva
Pepsin serves as a potential biomarker for laryngopharyngeal reflux disease (LPRD). The reported methods for detecting pep...
Qualitative and quantitative nondestructive determination of cyanide in water and distilled spirits by Raman integrating sphere
Cyanide often forms as a byproduct during the fermentation process of distilled spirits, and excessive amounts can cause d...
A paclobutrazol determination by square wave voltammetry based on molecularly imprinting polymer and boron doped copper oxide/graphene nanocomposite
In this research paper, a novel voltammetric sensor based on boron doped copper oxide/graphene (B-CuO-Gr) nanocomposite an...
Tungsten disulphide nanosheet modulated fluorescent gold nanoclusters immunoprobe for the Detection of Tau peptide: Alzheimer's disease Biomarker
Neuronal tau peptide serves as a key biomarker for neurodegenerative diseases, in specific Alzheimer’s disease, a conditio...
Thin film microextraction of PAHs from wastewater samples using an oxine modified iron mesh followed by dispersive liquid-liquid microextraction prior to gas chromatography analysis
In the present research, an attempt has been made to develop a new thin film microextraction method for the extraction of ...
Preliminary Studies for the Standardization of a pXRF Analyzer via ICP-OES for the Accurate Quantification of Pb in New Paint
Determining lead (Pb) concentrations in new paints using spectroscopic methods like Inductively Coupled Plasma-Optical Emi...
Galactose Oxidase Oxidation and Glycosidase Digestion for GlycoRNA Analysis
Ribonucleic acid (RNA), essential for protein production and immune function, undergoes glycosylation, a process that atta...
Development of a novel and affordable point-of-care kit for rapid detection of urea and glucose adulteration in cow milk
The increasing global population has raised the demand for cow milk, leading to its adulteration with harmful substances, ...
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