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Advances in hybrid hydrogel design for biomedical applications: innovations in drug delivery and tissue engineering for gynecological cancers
Advances in hybrid hydrogel design for biomedical applications: innovations in drug delivery and tissue engineering for gynecological cancers
Hybrid hydrogels have emerged as multifunctional biomaterials for targeted drug delivery and tissue engineering in gynecol...
Epi-nutrients for cancer prevention: Molecular mechanisms and emerging insights
Epi-nutrients for cancer prevention: Molecular mechanisms and emerging insights
The burgeoning field of epigenetics holds considerable potential in cancer prevention and management, as it targets mechan...
ZMIZ1 lactylation induces tamoxifen resistance in breast cancer through increasing transcriptional activity of Nanog to impact cell stemness and cholesterol uptake
ZMIZ1 lactylation induces tamoxifen resistance in breast cancer through increasing transcriptional activity of Nanog to impact cell stemness and cholesterol uptake
Tamoxifen is a critical drug for the treatment of oestrogen receptor (ER)-positive breast cancer (BC), which represents th...
The SDF-1α/MTDH axis inhibits ferroptosis and promotes the formation of anti-VEGF-resistant choroidal neovascularization by facilitating the nuclear translocation of SREBP1
The SDF-1α/MTDH axis inhibits ferroptosis and promotes the formation of anti-VEGF-resistant choroidal neovascularization by facilitating the nuclear translocation of SREBP1
Age-related macular degeneration (AMD) has been well recognized as the first ranked blinding ocular fundus diseases among ...
Intersection of ferroptosis and nanomaterials brings benefits to breast cancer
Intersection of ferroptosis and nanomaterials brings benefits to breast cancer
Breast cancer (BC) is the most frequently diagnosed malignancy among women worldwide, with a high incidence and mortality ...
Asperosaponin VI mitigates mitochondrial dysfunction and chondrocyte apoptosis in osteoarthritis by modulating the AMPK-SIRT3 pathway
Asperosaponin VI mitigates mitochondrial dysfunction and chondrocyte apoptosis in osteoarthritis by modulating the AMPK-SIRT3 pathway
To investigate the therapeutic potential of Asperosaponin VI (ASA VI) from Clematis chinensis in mitigating osteoarthritis...
Targeting PTK2 by vaccarin alleviates osteoporosis through inhibiting ferroptosis via modulating P53 acetylation/succinylation
Targeting PTK2 by vaccarin alleviates osteoporosis through inhibiting ferroptosis via modulating P53 acetylation/succinylation
Osteoporosis (OP) is a systemic skeletal disorder marked by reduced bone density and deterioration of trabecular microstru...
CD44-targeted therapy using mP6/Rg3 micelles inhibits oral cancer stem cell proliferation and migration
CD44-targeted therapy using mP6/Rg3 micelles inhibits oral cancer stem cell proliferation and migration
This study investigates how mP6/Rg3 micelles modulate ABCB1 expression to induce ferroptosis in oral cancer stem cells (CS...
FTO-mediated the destabilization of mRNA impedes thyroid cancer progression and suppresses macrophage M2 polarization
FTO-mediated the destabilization of mRNA impedes thyroid cancer progression and suppresses macrophage M2 polarization
The guanine nucleotide exchange factor RASGRF1 actively acts in a broad range of human cancers, including thyroid cancer (...
METTL1 promotes cadmium-induced stress granules formation via enhancing translation of G3BP1 and expression of mG- 3' tiRNA Met
METTL1 promotes cadmium-induced stress granules formation via enhancing translation of G3BP1 and expression of mG- 3' tiRNA Met
Methyltransferase 1 (METTL1) is currently regarded as a key tRNA m7G writer. Recent studies indicate its potential role in...
NAT10 Mediates Cardiac Fibrosis Induced by Myocardial Infarction Through ac4C Modification of TGFBR1 mRNA
NAT10 Mediates Cardiac Fibrosis Induced by Myocardial Infarction Through ac4C Modification of TGFBR1 mRNA
Cardiac fibrosis is a critical pathological process following myocardial infarction (MI), contributing to adverse cardiac ...
USP18 promotes ferroptosis in lipopolysaccharide-induced human kidney organoids by stabilizing STING1
USP18 promotes ferroptosis in lipopolysaccharide-induced human kidney organoids by stabilizing STING1
Sepsis-induced acute kidney injury (SI-AKI) is a severe condition with limited therapeutic options, resulting in poor prog...
Correction to: LINC00858 promotes colorectal cancer by sponging miR-4766-5p to regulate PAK2
Correction to: LINC00858 promotes colorectal cancer by sponging miR-4766-5p to regulate PAK2
Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4...
DNMT1 recruits RUNX1 and represses FOXO1 transcription to inhibit anti-inflammatory activity of regulatory T cells and augments sepsis-induced lung injury
DNMT1 recruits RUNX1 and represses FOXO1 transcription to inhibit anti-inflammatory activity of regulatory T cells and augments sepsis-induced lung injury
Sepsis-induced lung injury (ALI) is a critical condition characterized by excessive immune responses and tissue damage. Pr...
Celastrol modulates IRS1 expression to alleviate ovarian aging and to enhance follicular development
Celastrol modulates IRS1 expression to alleviate ovarian aging and to enhance follicular development
Ovarian aging significantly contributes to the decline of the female reproductive system, adversely affecting fertility an...
SP1 and p23 play a crucial role in the circadian target gene induction of activated aryl hydrocarbon receptor in human breast cells
SP1 and p23 play a crucial role in the circadian target gene induction of activated aryl hydrocarbon receptor in human breast cells
The Aryl Hydrocarbon Receptor (AHR) is a crucial mediator of cellular responses upon exposure to environmental pollutants....
Repeated exposure to CoCr28Mo6 particles leads to activation of NLRP3 inflammasome signaling in human osteoblasts
Repeated exposure to CoCr28Mo6 particles leads to activation of NLRP3 inflammasome signaling in human osteoblasts
Interleukin (IL)-1β and IL-18 are involved in the inflammatory response of wear-induced osteolysis. The production an...
METTL3-driven m⁶A epigenetics in gastric cancer: unveiling oncogenic networks and clinical translation from tumorigenesis to therapy resistance
METTL3-driven m⁶A epigenetics in gastric cancer: unveiling oncogenic networks and clinical translation from tumorigenesis to therapy resistance
Globally, gastric cancer (GC) ranks among the deadliest malignancies due to frequent late-stage detection, metastatic diss...
scRNA-seq deciphers molecular mechanisms of endocrine disruptor 4-nonylphenol impairing spermatogenesis in mice
scRNA-seq deciphers molecular mechanisms of endocrine disruptor 4-nonylphenol impairing spermatogenesis in mice
4-Nonylphenol (NP) is an environmental endocrine disruptor widely used in consumer products. Previous studies have shown t...
A computational framework for agent-based assessment of multiple environmental exposures
A computational framework for agent-based assessment of multiple environmental exposures
Agent-based assessment of long-term personal exposure to environmental factors accounts for spatio-temporal variation in e...
Post-fire soil hazards: recommendations for updated soil testing protocols and clearance thresholds
Urban wildfires in Los Angeles have highlighted the increased risk of soil lead exposure, especially for children. Current...
Neighborhood built environment, psychosocial stressors, and telomere length of birth parents and their newborns from San Francisco, California
Neighborhood built environment, psychosocial stressors, and telomere length of birth parents and their newborns from San Francisco, California
Shorter telomere length is a biomarker of cellular aging influenced in early life. Exposure to environmental hazards and p...
Application of a computer vision algorithm to quantify the frequency and duration of children’s microactivities in different play scenarios
Application of a computer vision algorithm to quantify the frequency and duration of children’s microactivities in different play scenarios
Microactivity rates, including hand- and object-to-mouth contacts, are inputs for modeling children’s exposure to ch...
Abstracts of the Joint Annual Meeting of the International Society of Exposure Science and the International Society for Environmental Epidemiology 2025
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which...
Accuracy of LexisNexis-derived retrospective address histories in the Sister Study cohort
Commercial address data can help reconstruct detailed residential histories, which are crucial for accurate assessment of ...
Identifying the known and unknown health hazard information for chemical disasters: a phased scoping review of the East Palestine, Ohio train derailment
Identifying the known and unknown health hazard information for chemical disasters: a phased scoping review of the East Palestine, Ohio train derailment
In February 2023, people residing in the village of East Palestine (EP, Ohio, USA) and surrounding areas were exposed to t...
Longitudinal relationships between changes in post-COVID mental fatigue and neuropsychiatric symptoms across distinct recovery trajectories
Longitudinal relationships between changes in post-COVID mental fatigue and neuropsychiatric symptoms across distinct recovery trajectories
Persistent fatigue, often accompanied by neuropsychiatric symptoms (e.g., cognitive impairment, sleep disorders, depressio...
COVID-19 in comorbid chronic diseased patients, pregnant and lactating women: pathophysiology, available drug treatment, and the most suitable protocol regimen in each group
COVID-19 in comorbid chronic diseased patients, pregnant and lactating women: pathophysiology, available drug treatment, and the most suitable protocol regimen in each group
Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Comorbiditi...
Therapeutic efficacy of celastrol in experimental polyarthritis: insights from a meta-analysis of in vivo studies
Therapeutic efficacy of celastrol in experimental polyarthritis: insights from a meta-analysis of in vivo studies
Celastrol, a bioactive compound derived from Tripterygium wilfordii, has shown potent anti-inflammatory and immunomodulato...
Cucurbitacin B alleviates DSS-induced experimental colitis by targeting ZNF70 to suppress the NLRP3/STAT3 signaling axis
Cucurbitacin B alleviates DSS-induced experimental colitis by targeting ZNF70 to suppress the NLRP3/STAT3 signaling axis
Ulcerative colitis (UC) is an inflammatory disease characterized by lifelong involvement and a complex pathogenesis. Due t...
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