Aanniz T, Bouyahya A, Balahbib A, El Kadri K, Khalid A, Makeen HA, Alhazmi HA, El Omari N, Zaid Y, Wong RS-Y, Yeo CI, Goh BH, Bakrim S. Natural bioactive compounds targeting DNA methyltransferase enzymes in cancer: mechanisms insights and efficiencies. Chem Biol Interact. 2024;392:110907. https://doi.org/10.1016/j.cbi.2024.110907.

Article  CAS  PubMed  Google Scholar 

Abbasi IHR, Abbasi F, Wang L, Abd El Hack ME, Swelum AA, Hao R, Yao J, Cao Y. Folate promotes S-adenosyl methionine reactions and the microbial methylation cycle and boosts ruminants production and reproduction. AMB Express. 2018;8:65. https://doi.org/10.1186/s13568-018-0592-5.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Abdul QA, Yu BP, Chung HY, Jung HA, Choi JS. Epigenetic modifications of gene expression by lifestyle and environment. Arch Pharmacal Res. 2017;40(11):1219–37. https://doi.org/10.1007/s12272-017-0973-3.

Article  CAS  Google Scholar 

Adkins Y, Kelley DS. Mechanisms underlying the cardioprotective effects of omega-3 polyunsaturated fatty acids. J Nutr Biochem. 2010;21(9):781–92. https://doi.org/10.1016/j.jnutbio.2009.12.004.

Article  CAS  PubMed  Google Scholar 

Addissouky T. Next generation of colorectal cancer management: integrating omics, targeted therapies, and smart technologies. Avicenna J Med Biochem. 2025;12:131–43. https://doi.org/10.34172/ajmb.2530.

Article  Google Scholar 

Allison J, Kaliszewska A, Uceda S, Reiriz M, Arias N. Targeting DNA Methylation in the Adult Brain through Diet. Nutrients. 2021;13(11):11. https://doi.org/10.3390/nu13113979.

Article  CAS  Google Scholar 

Alvarez MC, Maso V, Torello CO, Ferro KP, Saad STO. The polyphenol quercetin induces cell death in leukemia by targeting epigenetic regulators of pro-apoptotic genes. Clin Epigenetics. 2018;10(1):139. https://doi.org/10.1186/s13148-018-0563-3.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Al-Yousef N, Shinwari Z, Al-Shahrani B, Al-Showimi M, Al-Moghrabi N. Curcumin induces re-expression of BRCA1 and suppression of γ synuclein by modulating DNA promoter methylation in breast cancer cell lines. Oncol Rep. 2020;43(3):827–38. https://doi.org/10.3892/or.2020.7473.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Alzeer J. Personalized health through epigenetics: the lifestylopathy approach. Med Res Arch. 2025;13(4). https://doi.org/10.18103/mra.v13i4.6435.

Anderson OS, Sant KE, Dolinoy DC. Nutrition and epigenetics: An interplay of dietary methyl donors, one-carbon metabolism and DNA methylation. J Nutr Biochem. 2012;23(8):853–9.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Andreescu, N., Puiu, M., & Niculescu, M. (2018). Effects of Dietary Nutrients on Epigenetic Changes in Cancer. In R. G. Dumitrescu & M. Verma (Eds.), Cancer Epigenetics for Precision Medicine (Vol. 1856, pp. 121–139). Springer New York. https://doi.org/10.1007/978-1-4939-8751-1_7

Arand J, Chiang HR, Martin D, Snyder MP, Sage J, Reijo Pera RA, Wossidlo M. Tet enzymes are essential for early embryogenesis and completion of embryonic genome activation. EMBO Rep. 2022;23(2):e53968. https://doi.org/10.15252/embr.202153968.

Article  CAS  PubMed  Google Scholar 

Asgharian P, Tazekand AP, Hosseini K, Forouhandeh H, Ghasemnejad T, Ranjbar M, Hasan M, Kumar M, Beirami SM, Tarhriz V, Soofiyani SR, Kozhamzharova L, Sharifi-Rad J, Calina D, Cho WC. Potential mechanisms of quercetin in cancer prevention: focus on cellular and molecular targets. Cancer Cell Int. 2022;22:257. https://doi.org/10.1186/s12935-022-02677-w.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ayissi VBO, Ebrahimi A, Schluesenner H. Epigenetic effects of natural polyphenols: A focus on SIRT1-mediated mechanisms. Mol Nutr Food Res. 2014;58(1):22–32. https://doi.org/10.1002/mnfr.201300195.

Article  CAS  PubMed  Google Scholar 

Babar Q, Saeed A, Tabish TA, Pricl S, Townley H, Thorat N. Novel epigenetic therapeutic strategies and targets in cancer. BBA-Mol Basis Dis. 2022;1868(12):166552. https://doi.org/10.1016/j.bbadis.2022.166552.

Article  CAS  Google Scholar 

Baek SH, Kim KI. Epigenetic Control of Autophagy: Nuclear Events Gain More Attention. Mol Cell. 2017;65(5):781–5. https://doi.org/10.1016/j.molcel.2016.12.027.

Article  CAS  PubMed  Google Scholar 

Bakrim S, Aboulaghras S, Aanniz T, Benali T, El Omari N, El-Shazly M, Lee L-H, Mustafa SK, Sahib N, Rebezov M, Ali Shariati M, Lorenzo JM, Bouyahya A. Effects of Mediterranean diets and nutrigenomics on cardiovascular health. Crit Rev Food Sci Nutr. 2023;64(21):7589–608. https://doi.org/10.1080/10408398.2023.2187622.

Article  CAS  PubMed  Google Scholar 

Bannoura SF, Khan HY, Azmi AS. KRAS G12D targeted therapies for pancreatic cancer: Has the fortress been conquered? Front Oncol. 2022;12:1013902. https://doi.org/10.3389/fonc.2022.1013902.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Batra S, Sahu RP, Kandala PK, Srivastava SK. Benzyl isothiocyanate-mediated inhibition of histone deacetylase leads to NF-kappaB turnoff in human pancreatic carcinoma cells. Mol Cancer Ther. 2010;9(6):1596–608. https://doi.org/10.1158/1535-7163.MCT-09-1146.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bekdash RA. Methyl donors, epigenetic alterations, and brain health: Understanding the connection. Int J Mol Sci. 2023;24(3):2346.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Beklemisheva AA, Fang Y, Feng J, Ma X, Dai W, Chiao JW. Epigenetic mechanism of growth inhibition induced by phenylhexyl isothiocyanate in prostate cancer cells. Anticancer Res. 2006;26(2A):1225–30.

CAS  PubMed  Google Scholar 

Bhat MI, Kapila R. Dietary metabolites derived from gut microbiota: Critical modulators of epigenetic changes in mammals. Nutr Rev. 2017;75(5):374–89.

Article  PubMed  Google Scholar 

Biel M, Wascholowski V, Giannis A. Epigenetics—An Epicenter of Gene Regulation: Histones and Histone-Modifying Enzymes. Angew Chem Int Ed. 2005;44(21):3186–216. https://doi.org/10.1002/anie.200461346.

Article  CAS  Google Scholar 

Bishop K, Ferguson L. The Interaction between Epigenetics, Nutrition and the Development of Cancer. Nutrients. 2015;7(2):922–47. https://doi.org/10.3390/nu7020922.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Blanco E, González-Ramírez M, Alcaine-Colet A, Aranda S, Di Croce L. The Bivalent Genome: Characterization, Structure, and Regulation. Trends in Genetics: TIG. 2020;36(2):118–31. https://doi.org/10.1016/j.tig.2019.11.004.

Article  CAS  PubMed  Google Scholar 

Block LG, Grier SA, Childers TL, Davis B, Ebert JEJ, Kumanyika S, Laczniak RN, Machin JE, Motley CM, Peracchio L, Pettigrew S, Scott M, Bieshaar MNGG. From Nutrients to Nurturance: A Conceptual Introduction to Food Well-Being. J Public Policy Mark. 2011;30(1):5–13. https://doi.org/10.1509/jppm.30.1.5.

Article  Google Scholar 

Bordoni L, Gabbianelli R. Primers on nutrigenetics and nutri(epi)genomics: Origins and development of precision nutrition. Biochimie. 2019;160:156–71. https://doi.org/10.1016/j.biochi.2019.03.006.

Article  CAS  PubMed  Google Scholar 

Bordoni L, Agostinho de Sousa J, Zhuo J, von Meyenn F. Evaluating the connection between diet quality, EpiNutrient intake and epigenetic age: An observational study. Am J Clin Nutr. 2024;120(5):1143–55. https://doi.org/10.1016/j.ajcnut.2024.08.033.

Article  CAS  PubMed  Google Scholar 

Bouyahya A, Hachlafi NE, Aanniz T, Bourais I, Mechchate H, Benali T, Shariati MA, Burkov P, Lorenzo JM, Wilairatana P, Mubarak MS, Omari NE. Natural Bioactive Compounds Targeting Histone Deacetylases in Human Cancers: Recent Updates. Mol. 2022a;27(8):8. https://doi.org/10.3390/molecules27082568.

Article  CAS  Google Scholar 

Bouyahya A, Mechchate H, Oumeslakht L, Zeouk I, Aboulaghras S, Balahbib A, Zengin G, Kamal MA, Gallo M, Montesano D, El Omari N. The Role of Epigenetic Modifications in Human Cancers and the Use of Natural Compounds as Epidrugs: Mechanistic Pathways and Pharmacodynamic Actions. Biomolecules. 2022b;12(3):3. https://doi.org/10.3390/biom12030367.

Article