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Longitudinal relationships between changes in post-COVID mental fatigue and neuropsychiatric symptoms across distinct recovery trajectories
Longitudinal relationships between changes in post-COVID mental fatigue and neuropsychiatric symptoms across distinct recovery trajectories
Persistent fatigue, often accompanied by neuropsychiatric symptoms (e.g., cognitive impairment, sleep disorders, depressio...
COVID-19 in comorbid chronic diseased patients, pregnant and lactating women: pathophysiology, available drug treatment, and the most suitable protocol regimen in each group
COVID-19 in comorbid chronic diseased patients, pregnant and lactating women: pathophysiology, available drug treatment, and the most suitable protocol regimen in each group
Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Comorbiditi...
Therapeutic efficacy of celastrol in experimental polyarthritis: insights from a meta-analysis of in vivo studies
Therapeutic efficacy of celastrol in experimental polyarthritis: insights from a meta-analysis of in vivo studies
Celastrol, a bioactive compound derived from Tripterygium wilfordii, has shown potent anti-inflammatory and immunomodulato...
Cucurbitacin B alleviates DSS-induced experimental colitis by targeting ZNF70 to suppress the NLRP3/STAT3 signaling axis
Cucurbitacin B alleviates DSS-induced experimental colitis by targeting ZNF70 to suppress the NLRP3/STAT3 signaling axis
Ulcerative colitis (UC) is an inflammatory disease characterized by lifelong involvement and a complex pathogenesis. Due t...
Insights into ion channels to identify drug target for neuropathic pain management
Insights into ion channels to identify drug target for neuropathic pain management
Neuropathic pain (NP) is a debilitating condition resulting from maladaptive changes in the nervous system, characterised ...
A systematic review of the role of interleukin inhibitors in lichen planus: therapeutic and paradoxical effects
A systematic review of the role of interleukin inhibitors in lichen planus: therapeutic and paradoxical effects
Lichen planus (LP) is a group of chronic inflammatory disorders of the skin, mucous membranes, scalp, and nails that mainl...
The renin–angiotensin system (RAS) and arthritic diseases: therapeutic potential for RAS inhibitors
The renin–angiotensin system (RAS) and arthritic diseases: therapeutic potential for RAS inhibitors
The renin–angiotensin system (RAS) is a pivotal hormonal regulator of cardiovascular and renal homeostasis, recently...
The link between oral health and neurodegeneration: a review of periodontitis in Alzheimer’s and Parkinson’s disease and dementia
The link between oral health and neurodegeneration: a review of periodontitis in Alzheimer’s and Parkinson’s disease and dementia
This review aims to explore the relationship between periodontitis and neurodegenerative diseases, such as Alzheimer’...
Deciphering the iridoids' boundaries: from soil ecology to anti-inflammatory medicines
Deciphering the iridoids' boundaries: from soil ecology to anti-inflammatory medicines
Iridoid glycosides (IGs) are monoterpenoids that protect against stress and modulate the immune system. A comprehensive an...
Mitigation of inflammation and oxidative stress in FCA-induced arthritic rat model through gum acacia intervention: a comprehensive in‑vivo study
Mitigation of inflammation and oxidative stress in FCA-induced arthritic rat model through gum acacia intervention: a comprehensive in‑vivo study
Rheumatoid arthritis is a persistent immune-mediated inflammatory disorder that primarily affects joint bones, impacting a...
The IL-12 family cytokines in neurodegenerative diseases: dual roles in neurotoxicity and neuroprotection
The IL-12 family cytokines in neurodegenerative diseases: dual roles in neurotoxicity and neuroprotection
Neurodegenerative diseases (NDs) such as Alzheimer’s disease (AD), Parkinson’s disease (PD), multiple sclerosi...
Transforming advancing autosomal dominant polycystic kidney disease care: investigating new horizons in treatment and research
Transforming advancing autosomal dominant polycystic kidney disease care: investigating new horizons in treatment and research
A hereditary disorder called autosomal dominant polycystic kidney disease (ADPKD) results from changes in the PKD1 and PKD...
Therapeutic potential of in arthritis management: mechanistic insights into COX-2, 5-LOX, and NFĸB modulation
Therapeutic potential of in arthritis management: mechanistic insights into COX-2, 5-LOX, and NFĸB modulation
Arthritis is a chronic inflammatory disorder characterized by joint pain, stiffness, and progressive cartilage degeneratio...
Recent advances in the therapeutics and modes of action of a range of agents used to treat ulcerative colitis and related inflammatory conditions
Recent advances in the therapeutics and modes of action of a range of agents used to treat ulcerative colitis and related inflammatory conditions
Ulcerative colitis (UC) is a chronic, relapsing form of an inflammatory bowel disease characterized by epithelial barrier ...
Modulation of inflammatory and oxidative stress pathways by polyphenol-rich  extract in carrageenan-induced paw edema in rats
Modulation of inflammatory and oxidative stress pathways by polyphenol-rich  extract in carrageenan-induced paw edema in rats
Pleurospermum candollei is a locally used vegetable traditionally known for its medicinal properties in alleviating pain a...
The protective effects of coenzyme Q10 on blood pressure: a narrative review of anti-inflammatory and antioxidant mechanisms
The protective effects of coenzyme Q10 on blood pressure: a narrative review of anti-inflammatory and antioxidant mechanisms
The consequences of uncontrolled hypertension, often referred to as the "silent killer," encompass end-organ dam...
Protective effects of ozone therapy on cartilage degeneration in temporomandibular joint osteoarthritis
Protective effects of ozone therapy on cartilage degeneration in temporomandibular joint osteoarthritis
Temporomandibular joint osteoarthritis (TMJ-OA) is a condition characterized by progressive cartilage degradation and infl...
Unlocking the molecular pathway of atopic dermatitis: journey so far and roads ahead
Unlocking the molecular pathway of atopic dermatitis: journey so far and roads ahead
Atopic Dermatitis (AD) is a skin-associated disorder involving hyperactivation of inflammatory cascades. The attributing r...
Leukotriene signaling in neurodegeneration: implications for treatment strategies
Leukotriene signaling in neurodegeneration: implications for treatment strategies
Leukotrienes (LTs) are a group of substances that cause inflammation. They are produced by the enzyme 5-lipoxygenase (5-LO...
Preoperative versus postoperative nonsteroidal anti-inflammatory drugs in femoroacetabular impingement patients undergoing hip arthroscopy surgery: analgesic effect, joint function, patients’ satisfaction, and quality of life
Preoperative versus postoperative nonsteroidal anti-inflammatory drugs in femoroacetabular impingement patients undergoing hip arthroscopy surgery: analgesic effect, joint function, patients’ satisfaction, and quality of life
Nonsteroidal anti-inflammatory drugs (NSAIDs) have analgesic effects on femoroacetabular impingement (FAI) patients underg...
Essential oils: a potential alternative with promising active ingredients for pharmaceutical formulations in chronic wound management
Essential oils: a potential alternative with promising active ingredients for pharmaceutical formulations in chronic wound management
Chronic wound is a major clinical challenge that complicates wound healing, mainly associated with bacterial biofilms. Bac...
Vitexin mitigates oxidative stress, mitochondrial damage, pyroptosis and regulates small nucleolar RNA host gene 1/DNA methyltransferase 1/microRNA-495 axis in sepsis-associated acute lung injury
Vitexin mitigates oxidative stress, mitochondrial damage, pyroptosis and regulates small nucleolar RNA host gene 1/DNA methyltransferase 1/microRNA-495 axis in sepsis-associated acute lung injury
This study examined vitexin’s effect on sepsis-induced acute lung injury. We used network pharmacology and ...
Prooxidant state in anticancer drugs and prospect use of mitochondrial cofactors and anti-inflammatory agents in cancer prevention
Prooxidant state in anticancer drugs and prospect use of mitochondrial cofactors and anti-inflammatory agents in cancer prevention
An extensive body of literature has associated cancer with redox imbalance and inflammatory conditions. Thus, several stud...
Pharmaceutical aspects of JAK inhibitors: a comparative review
Pharmaceutical aspects of JAK inhibitors: a comparative review
Janus kinase inhibitors (JAKIs) are a new class of drugs used in the treatment of a heterogeneous group of diseases, mainl...
Effects of tranexamic acid on postoperative knee activity and stress, and inflammation cytokines in patients undergoing total knee arthroplasty
Effects of tranexamic acid on postoperative knee activity and stress, and inflammation cytokines in patients undergoing total knee arthroplasty
Total knee arthroplasty (TKA) is an effective treatment for knee osteoarthritis, with postoperative bleeding and the infla...
Epidural injection of varying doses of capsaicin alleviates inflammatory pain in rats via the TLR4/AKT/NF-κB pathway
Epidural injection of varying doses of capsaicin alleviates inflammatory pain in rats via the TLR4/AKT/NF-κB pathway
Capsaicin (CAP) induces transient pain sensation by activating transient receptor potential vanilloid-1 (TRPV1). However, ...
Mechanisms of action of ethyl acetate fractions of Liparis nervosa (Thunb.) Lindl. as potential central anti-nociceptive agents
Mechanisms of action of ethyl acetate fractions of Liparis nervosa (Thunb.) Lindl. as potential central anti-nociceptive agents
Opioids/non-steroidal anti-inflammatory drugs are used to alleviate pain; however, they are expensive and can have adverse...
Anti-inflammatory effect of nestorone in a lipopolysaccharide-induced acute lung injury model through regulation of the TLR-4/Myd88/NF-κB signaling pathway
Anti-inflammatory effect of nestorone in a lipopolysaccharide-induced acute lung injury model through regulation of the TLR-4/Myd88/NF-κB signaling pathway
Progesterone plays a crucial and indispensable role in regulating immunity and attenuating inflammation. Nestorone® (...
Carvone-loaded chitosan nanoparticles alleviate joint destruction by downregulating the expression of pro, inflammatory cytokines and MMP-13 in adjuvant-induced rat model
Carvone-loaded chitosan nanoparticles alleviate joint destruction by downregulating the expression of pro, inflammatory cytokines and MMP-13 in adjuvant-induced rat model
Rheumatoid arthritis is an autoimmune illness causing deformity, edema, and joint tenderness. Its long-term treatment burd...
Examining the role of antioxidant supplementation in mitigating oxidative stress markers in Alzheimer’s disease: a comprehensive review
Examining the role of antioxidant supplementation in mitigating oxidative stress markers in Alzheimer’s disease: a comprehensive review
Alzheimer’s disease is a devastating neurodegenerative disorder that affects millions of people worldwide. One of th...
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