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Evaluation of acute, repeated dose 28-day and 13-week oral toxicity and genotoxicity of a standardized fraction (HemoHIM) from Angelica gigas, Cnidium officinale, and Paeonia lactiflora
Evaluation of acute, repeated dose 28-day and 13-week oral toxicity and genotoxicity of a standardized fraction (HemoHIM) from Angelica gigas, Cnidium officinale, and Paeonia lactiflora
HemoHIM is a functional food ingredient comprising a triple herbal combination of extracts from Angelica gigas Nakai, Cnid...
Upregulation of YPEL3 expression and induction of human breast cancer cell death by microRNAs
Upregulation of YPEL3 expression and induction of human breast cancer cell death by microRNAs
MicroRNAs (miRNAs), molecules comprising 18–22 nucleotides, regulate expression of genes post-transcriptionally at t...
The impact of manganese on vascular endothelium
The impact of manganese on vascular endothelium
Manganese (Mn) is an essential trace element involved in various physiological processes, but excessive exposure may lead ...
Evaluation of acute, 28-day, 13-week repeated dose oral toxicity and genotoxicity of a herbal extract (HemoHIM G) from Angelica sinensis, Ligusticum chuanxiong, and Peaonia lactiflora
Evaluation of acute, 28-day, 13-week repeated dose oral toxicity and genotoxicity of a herbal extract (HemoHIM G) from Angelica sinensis, Ligusticum chuanxiong, and Peaonia lactiflora
HemoHIM G is a functional food ingredient composed of a triple herbal combination of Angelica sinensis, Ligusticum chuanxi...
Protective effect of cilostazol on vascular injury in rats with acute ischemic stroke complicated with chronic renal failure
Protective effect of cilostazol on vascular injury in rats with acute ischemic stroke complicated with chronic renal failure
Chronic renal failure (CRF) resulting in vascular calcification, which does damage to blood vessels and endothelium, is an...
Pulmonary toxicity assessment of polypropylene, polystyrene, and polyethylene microplastic fragments in mice
Pulmonary toxicity assessment of polypropylene, polystyrene, and polyethylene microplastic fragments in mice
Polypropylene (PP), polystyrene (PS), and polyethylene (PE) plastics are commonly used in household items such as electron...
Toxicity of a novel antifungal agent (ATB1651 gel) in Yucatan minipigs (Sus scrofa) following 4 weeks of daily dermal administration
Toxicity of a novel antifungal agent (ATB1651 gel) in Yucatan minipigs (Sus scrofa) following 4 weeks of daily dermal administration
ATB1651 gel is an antifungal drug candidate that enhances antifungal activity through substitution of several aryl rings, ...
Pathological changes in various organs in HLA-B*57:01 transgenic mice with abacavir-induced skin eruption
Pathological changes in various organs in HLA-B*57:01 transgenic mice with abacavir-induced skin eruption
Several patients with cutaneous adverse drug reactions exhibit extracutaneous organ damages, and it becomes severe in a fe...
Distribution of molybdenum in soft tissues and blood of rats after intratracheal instillation of molybdenum(IV) sulfide nano- and microparticles
Distribution of molybdenum in soft tissues and blood of rats after intratracheal instillation of molybdenum(IV) sulfide nano- and microparticles
There is still little literature data on the toxicity and safety of the commonly used molybdenum (Mo) disulfide which is p...
Molecular mechanism of empagliflozin cardioprotection in 5-fluorouracil (5-FU)-induced cardiotoxicity via modulation of SGLT2 and TNFα/TLR/NF-κB signaling pathway in rats
Molecular mechanism of empagliflozin cardioprotection in 5-fluorouracil (5-FU)-induced cardiotoxicity via modulation of SGLT2 and TNFα/TLR/NF-κB signaling pathway in rats
One of the commoly used chemotherapeutic agents is 5-Fluorouracil (5-FU). Unfortunately, the clinical administration of 5-...
Assessment of reproductive toxicity of gold nanoparticles and its reversibility in male albino rats
Assessment of reproductive toxicity of gold nanoparticles and its reversibility in male albino rats
Nanotechnology has become a trending area in science all over the world. Although gold nanoparticles (AuNPs) have been uti...
Potential role of inducible nitric oxide synthase (iNOS) activity in testicular dysfunction following co-administration of alcohol and combination antiretroviral therapy (cART) in diabetic rats: an immunohistochemistry study
Potential role of inducible nitric oxide synthase (iNOS) activity in testicular dysfunction following co-administration of alcohol and combination antiretroviral therapy (cART) in diabetic rats: an immunohistochemistry study
Diabetes, alcohol abuse, and combination antiretroviral therapy (cART) use have been reported to cause multi-organ complic...
Re-evaluation of a microbiological acceptable daily intake for tylosin based on its impact on human intestinal microflora
Re-evaluation of a microbiological acceptable daily intake for tylosin based on its impact on human intestinal microflora
As veterinary drugs available for fish is very restricted, there is growing trials for repurposing livestock drugs as aqua...
Acute toxicity assessment of nine organic UV filters using a set of biotests
Acute toxicity assessment of nine organic UV filters using a set of biotests
UV filters in environmental compartments are a source of concern related to their ecotoxicological effects. However, littl...
Impacts of PAH accumulation on reproductive hormones, indices of oxidative stress and BPDE-albumin adduct in women with recurrent pregnancy loss
Impacts of PAH accumulation on reproductive hormones, indices of oxidative stress and BPDE-albumin adduct in women with recurrent pregnancy loss
Chronic exposure to Poly aromatic hydrocarbons (PAHs) may be associated with adverse pregnancy outcomes. Disruption of hor...
Comparison of structural characteristics and molecular markers of rabbit skin, pig skin, and reconstructed human epidermis for an ex vivo human skin model
Comparison of structural characteristics and molecular markers of rabbit skin, pig skin, and reconstructed human epidermis for an ex vivo human skin model
The Organization for Economic Co-operation and Development approved a reconstructed human epidermis (RHE) model for in vit...
A comparative study on the implementation of deep learning algorithms for detection of hepatic necrosis in toxicity studies
A comparative study on the implementation of deep learning algorithms for detection of hepatic necrosis in toxicity studies
Deep learning has recently become one of the most popular methods of image analysis. In non-clinical studies, several tiss...
Effects of stabilizer magnesium nirate on CMIT/MIT-induced respiratory toxicity
Effects of stabilizer magnesium nirate on CMIT/MIT-induced respiratory toxicity
Despite a humidifier disinfectant (HD) product containing chloromethylisothiazolinone (CMIT) and methylisothiazolinone (MI...
In vitro toxicological assessment of PhSeZnCl in human liver cells
In vitro toxicological assessment of PhSeZnCl in human liver cells
Phenylselenenylzinc chloride (PhSeZnCl) is an air-stable selenolate, easily synthesizable through oxidative insertion of e...
The effects of co-exposure to methyl paraben and dibutyl phthalate on cell line derived from human skin
The effects of co-exposure to methyl paraben and dibutyl phthalate on cell line derived from human skin
Data on the cumulative effects of chemical substances are necessary for the proper risk assessment, but their availability...
Theracurmin (Highly Bioavailable Curcumin) Prevents High Fat Diet-Induced Hepatic Steatosis Development in Mice
Theracurmin (Highly Bioavailable Curcumin) Prevents High Fat Diet-Induced Hepatic Steatosis Development in Mice
Curcumin, a hydrophobic polyphenol isolated from the Curcuma longa L. plant, has many pharmacological properties, includin...
Extrapolation of Hepatic Concentrations of Industrial Chemicals Using Pharmacokinetic Models to Predict Hepatotoxicity
Extrapolation of Hepatic Concentrations of Industrial Chemicals Using Pharmacokinetic Models to Predict Hepatotoxicity
In this review, we describe the absorption rates (Caco-2 cell permeability) and hepatic/plasma pharmacokinetics of 53 dive...
Alleviation of Ultraviolet B-Induced Photoaging by 7-MEGATM 500 in Hairless Mouse Skin
Alleviation of Ultraviolet B-Induced Photoaging by 7-MEGATM 500 in Hairless Mouse Skin
The purpose of this study was to investigate the effect of 7-MEGA™ 500 on the improvement of skin aging in an UVB-in...
Study on Consumer Exposure to Sun Spray and Sun Cream in South Korea
Study on Consumer Exposure to Sun Spray and Sun Cream in South Korea
When conducting risk assessments of cosmetic ingredients, it is important that reliable exposure information is obtained f...
Intracutaneous Delivery of Gelatins Reduces Fat Accumulation in Subcutaneous Adipose Tissue
Intracutaneous Delivery of Gelatins Reduces Fat Accumulation in Subcutaneous Adipose Tissue
Subcutaneous adipose tissue (SAT) accumulation is a constitutional disorder resulting from metabolic syndrome. Although su...
Molecular Markers in Sex Differences in Cancer
Molecular Markers in Sex Differences in Cancer
Cancer is one of the common causes of death with a high degree of mortality, worldwide. In many types of cancers, if not a...
Implications for the Predictivity of Cell-Based Developmental Toxicity Assays Developed Two Decades Apart
Implications for the Predictivity of Cell-Based Developmental Toxicity Assays Developed Two Decades Apart
Many in vitro developmental toxicity assays have been proposed over several decades. Since the late 1980s, we have made in...
1,2-Dichloropropane (1,2-DCP)-Induced Angiogenesis in Dermatitis
1,2-Dichloropropane (1,2-DCP)-Induced Angiogenesis in Dermatitis
1,2-Dichloropropane (1,2-DCP) has been used as an industrial solvent and a chemical intermediate, as well as in soil fumig...
A general toxicity and biodistribution study of human natural killer cells by single or repeated intravenous dose in severe combined immune deficient mice
A general toxicity and biodistribution study of human natural killer cells by single or repeated intravenous dose in severe combined immune deficient mice
Natural killer (NK) cells are a part of the innate immune system and represent the first line of defense against infection...
Semi-automated approach for generation of biological networks on drug-induced cholestasis, steatosis, hepatitis, and cirrhosis
Semi-automated approach for generation of biological networks on drug-induced cholestasis, steatosis, hepatitis, and cirrhosis
Drug-induced liver injury (DILI) is one of the leading reasons for discontinuation of a new drug development project. Dive...
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