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A Matching-Adjusted Indirect Comparison of Guselkumab and Secukinumab in Patients with Psoriatic Arthritis Over 52 Weeks

Studies evaluating the long-term comparative efficacy between biologic therapies for psoriatic arthritis (PsA) are scarce....

Rheumatology And Therapy

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Prophylaxis of Gout Flares in Patients with Renal Impairment: Dosing Adjustments with Colchicine Oral Solution Informed by a Pharmacokinetic Model

Patients receiving the standard prophylaxis dose of colchicine for gout flares are at increased risk for developing toxici...

Rheumatology And Therapy

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Summary of Research: Immunogenicity of Adalimumab Reference Product and Adalimumab-adbm in Patients with Rheumatoid Arthritis, Crohn’s Disease, and Chronic Plaque Psoriasis: A Pooled Analysis of the VOLTAIRE trials

This summary-of-research article presents the findings of a post hoc analysis comparing immunogenicity across the VOLTAIRE...

Rheumatology And Therapy

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Clinical Outcomes of Patients with SLE Treated with Belimumab, Without Versus With Prior Immunosuppressant Use: a US Claims Database Study

This study examined the benefit of belimumab as standard treatment in patients with systemic lupus erythematosus (SLE) tre...

Rheumatology And Therapy

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The Efficacy and Safety of Single Injections of Hybrid HA in the Treatment of Symptomatic Knee Osteoarthritis: A Case Series

The prevalence of knee osteoarthritis (OA) is rising worldwide, leading to disability and a reduced quality of life, parti...

Rheumatology And Therapy

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Real-World Analysis of Patient Characteristics, Adverse Events, and Economic Burden Among Patients with Giant Cell Arteritis Treated with Glucocorticoids

Giant cell arteritis (GCA) typically requires long-term treatment with glucocorticoids (GC). However, prolonged use of GCs...

Rheumatology And Therapy

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Efficacy and Safety of Deucravacitinib, a Selective, Allosteric TYK2 Inhibitor, by Baseline DMARD Use in a Phase 2 Psoriatic Arthritis Study: A Post Hoc Analysis

This study aimed to evaluate the influence of background conventional synthetic disease-modifying antirheumatic drug (csDM...

Rheumatology And Therapy

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Efficacy of Intravenous Immunoglobulin for Systemic Manifestations of Dermatomyositis Beyond Muscular and Cutaneous: Sub-analysis of the ProDERM Study

Muscle and skin involvement are well defined in dermatomyositis but other symptoms contribute significantly to the disease...

Rheumatology And Therapy

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Patient Profile and Outcomes Among Patients with Rheumatoid Arthritis Treated with Baricitinib Versus Other Therapies in Spain: The RA-BE-REAL Study

Rheumatoid arthritis (RA) is a chronic autoimmune disorder characterized by joint inflammation and pain. Baricitinib, a ta...

Rheumatology And Therapy

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Saudi Clinical Practice Guidelines for Management of Axial Spondyloarthritis Disease

This guideline offers evidence-based recommendations for physicians and policymakers on managing axial spondyloarthritis (...

Rheumatology And Therapy

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Risk of Major Adverse Cardiovascular Events and Thromboembolism Events in Patients with Psoriatic Arthritis on JAK Inhibitors: A Network Meta-Analysis

Our objective was to evaluate the comparative effects of five Janus kinase inhibitors (JAKis) with ten interventions, comp...

Rheumatology And Therapy

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A Real-World Comparison of Clinical Effectiveness of Upadacitinib, Tumor Necrosis Factor Inhibitors or Interleukin-17 Inhibitors in Patients with Axial Spondyloarthritis After Switching from an Initial Tumor Necrosis Factor Inhibitor Treatment

Tumor necrosis factor inhibitors (TNFi) may have insufficient efficacy in 40% of patients with axial spondyloarthritis (ax...

Rheumatology And Therapy

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Treatment Strategies for Acute Exacerbation of Interstitial Lung Disease Associated with Systemic Autoimmune Rheumatic Diseases in Chinese Patients: A Scoping Review

Connective tissue disease-related interstitial lung disease (CTD-ILD) refers to a range of pulmonary complications arising...

Rheumatology And Therapy

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Guselkumab Efficacy in Biologic-Naïve Participants with Psoriatic Arthritis and Severe Disease Activity: Post Hoc Analysis of a Phase 3 Study

The aim of this study was to evaluate guselkumab efficacy through week 100 in participants with psoriatic arthrit...

Rheumatology And Therapy

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The Impact of Sex on the Pattern and Clinical Response of Early Psoriatic Arthritis: Real-life Data from the Italian Prospective SIRENA Study

Limited data are available on sex differences in the disease characteristics, burden and treatment outcomes of early psori...

Rheumatology And Therapy

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Real-World Effectiveness of Bimekizumab in Predominantly Difficult-to-Treat Patients with Psoriatic Arthritis Followed in a Combined Dermatology–Rheumatology Clinic: A 24-Week Multicenter Study

Bimekizumab (BKZ), a monoclonal antibody targeting interleukin (IL)-17A and IL-17F, has shown high efficacy in clinical tr...

Rheumatology And Therapy

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Efficacy and Safety of Firsekibart Compared to Etoricoxib for Gout Flares: A Phase 2, Multicenter, Open-label, Active-controlled, Randomized Non-inferiority Trial

Firsekibart, an anti-interleukin (IL)-1β monoclonal antibody, has demonstrated more sustained control of gout flares ...

Rheumatology And Therapy

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Patient Diagnostic Journey and Time to Diagnosis in Axial Spondyloarthritis: A Retrospective Cohort Study Using US Claims Data

The journey to axial spondyloarthritis (axSpA) diagnosis is often prolonged, and delayed diagnosis has been associated wit...

Rheumatology And Therapy

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RE: Response to Goyal & Santhanam best practice & research clinical rheumatology