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Denatonium benzoate promotes IgE-mediated mast celldegranulation and ovalbumin-induced allergic diarrheain BALB/c mice
Ju Liu,1† Huaping Xu,2† Shaotong Feng,1 Xiaoyun Shi,3 Xin Li,4 Jiexin Zou,1 Linbo Shi1 Affiliations: 1 Schoo...
Effect of exposure to ambient air volatile organiccompounds on the severity of atopic dermatitisand lag-day effect
Hui-Wen Tseng1,2,3,4 Affiliations: 1 Department of Dermatology, Ministry of Health and Welfare Pingtung Hosp...
Effect of budesonide nasal irrigationon Hypothalamic-Pituitary-Adrenal Axis in patientswith chronic rhinosinusitis post endoscopic sinus surgery: A prospective study
Jesada Kanjanaumporn,1,2 Sorranut Thaweboon,1 Songklot Aeumjaturapat,1,2 Kornkiat Snidvongs,1,2Supinda Chusakul...
Impact of pre-existing immunity on humoraland cellular responses to CoronaVac in SARS-CoV-2 variants: A focus on common human Coronaviruses
Nawamin Pinpathomrat,1 Bunya Seeyankem,1 Ratchanon Sophonmanee,1 Jomkwan Ongarj,1 Smonrapat Surasombatpattana2 ...
Analysis of daily aspirin intake on platelet-associated factors and aggregation in nonsteroidal anti-inflammatory drugexacerbated respiratory disease: A cross-sectional study
Selcan Genc,1* Basak Ezgi Sarac,1* Ozge Can Bostan,2 Gulseren Tuncay,2 Hayriye Akel Bilgic,1 Baran Erman,3,4 Um...
Frequency of Biological Drug Use in Older Patients with Immune-Mediated Inflammatory Diseases: Results from the Large-Scale Italian VALORE Distributed Database Network
Frequency of Biological Drug Use in Older Patients with Immune-Mediated Inflammatory Diseases: Results from the Large-Scale Italian VALORE Distributed Database Network
Limited real-world data on biological drug use in older patients with immune-mediated inflammatory diseases (IMIDs) exist ...
First-in-Human Study on Tolerability, Pharmacokinetics, and Pharmacodynamics of Single Escalating Doses of HEC88473, a Novel Dual GLP-1 and FGF21 Receptor Agonist in Healthy and Obese Chinese Subjects
First-in-Human Study on Tolerability, Pharmacokinetics, and Pharmacodynamics of Single Escalating Doses of HEC88473, a Novel Dual GLP-1 and FGF21 Receptor Agonist in Healthy and Obese Chinese Subjects
HEC88473 is a novel long-acting dual agonist of glucagon-like peptide 1 (GLP-1) and fibroblast growth factor 21 (FGF21) re...
Translational Investigation of CM326 from Preclinical Studies to Randomized Phase I Clinical Trials in Healthy Adults
Translational Investigation of CM326 from Preclinical Studies to Randomized Phase I Clinical Trials in Healthy Adults
Thymic stromal lymphopoietin (TSLP) plays a pivotal role in immune responses. CM326 is a humanized monoclonal antibody tar...
The Fomivirsen, Patisiran, and Givosiran Odyssey: How the Success Stories May Pave the Way for Future Clinical Translation of Nucleic Acid Drugs
The Fomivirsen, Patisiran, and Givosiran Odyssey: How the Success Stories May Pave the Way for Future Clinical Translation of Nucleic Acid Drugs
Over the past 25 years, the approval of several nucleic acid-based drugs by the US Food and Drug Administration (FDA) has ...
Understanding IgM Structure and Biology to Engineer New Antibody Therapeutics
Understanding IgM Structure and Biology to Engineer New Antibody Therapeutics
Immunoglobulin M (IgM) antibodies are an essential and conserved part of adaptive immunity. IgMs assemble into pentamers a...
Interrogation of Structure–Activity Relationships in Charge Variants of Therapeutic IgG2s Enabled by Free-Flow Isoelectric Focusing Fractionation
Interrogation of Structure–Activity Relationships in Charge Variants of Therapeutic IgG2s Enabled by Free-Flow Isoelectric Focusing Fractionation
Recombinant immunoglobulin G2 (IgG2) antibodies are effective neutralization agents or antagonists with high medical value...
Progress and Challenges in the Treatment of Fabry Disease
Progress and Challenges in the Treatment of Fabry Disease
Fabry disease is a rare but life-threatening, X-linked, inherited lysosomal storage disorder in which globotriaosylceramid...
Characterization of Biosimilar Monoclonal Antibodies and Their Reference Products Approved in Japan to Reveal the Quality Characteristics in Post-approval Phase
Characterization of Biosimilar Monoclonal Antibodies and Their Reference Products Approved in Japan to Reveal the Quality Characteristics in Post-approval Phase
Promoting the use of biosimilars is a global issue from the perspective of reducing medical costs. In Japan, the replaceme...
Demand- Versus Supply-Side Policies in Market Penetration of Biosimilars: Which is More Effective?
Demand- Versus Supply-Side Policies in Market Penetration of Biosimilars: Which is More Effective?
To evaluate the impact of demand- and supply-side policies on the biosimilar market penetration and identify effective str...
Emerging Therapy in Osteoarthritis: Mesenchymal Stem Cells, Secretomes, and Using Hydrogels to Enhance Efficacy
Emerging Therapy in Osteoarthritis: Mesenchymal Stem Cells, Secretomes, and Using Hydrogels to Enhance Efficacy
Osteoarthritis is a prevalent condition among middle-aged and elderly populations characterized primarily by the progressi...
Beyond Cost: Observations on Clinical and Patient Benefits of Biosimilars in Real-World Settings
Beyond Cost: Observations on Clinical and Patient Benefits of Biosimilars in Real-World Settings
The introduction of biosimilars into healthcare systems globally is recognized by many as a healthcare success. Despite th...
The Use of Biologics for Thyroid Eye Disease
The Use of Biologics for Thyroid Eye Disease
Thyroid eye disease (TED) is the most common extrathyroidal manifestation of Graves’ disease. It is an autoimmune di...
Emerging Role of Targeted Monoclonal Antibodies in Neuromyelitis Optica Spectrum Disorders
Emerging Role of Targeted Monoclonal Antibodies in Neuromyelitis Optica Spectrum Disorders
Neuromyelitis optica spectrum disorder (NMOSD) is a rare, autoimmune disease that results in recurring, often severe attac...
Influence of Pharmacokinetic-Pharmacodynamic Failure Mechanisms on Outcomes in Biologic Therapy Sequencing in Inflammatory Bowel Disease: A Retrospective Cohort Study
Influence of Pharmacokinetic-Pharmacodynamic Failure Mechanisms on Outcomes in Biologic Therapy Sequencing in Inflammatory Bowel Disease: A Retrospective Cohort Study
Increasing therapeutic options for inflammatory bowel disease calls for tools to aid choice of sequencing. We investigated...
Lipid-Lowering RNA Therapeutics for Atherosclerotic Cardiovascular Disease Prevention: A State−of−the−Art Review
Lipid-Lowering RNA Therapeutics for Atherosclerotic Cardiovascular Disease Prevention: A State−of−the−Art Review
Despite the modern era of effective and safe high-intensity statins and non-statin agents, a significant portion of patien...
Analytical Data and Single-Dose PK are Sufficient to Conclude Comparable Immunogenicity for Biosimilars: An Ustekinumab Case Study
Analytical Data and Single-Dose PK are Sufficient to Conclude Comparable Immunogenicity for Biosimilars: An Ustekinumab Case Study
Comparative immunogenicity is a key regulatory requirement for biosimilars. In a streamlined biosimilar development proces...
Impact of a standardized emergency department asthma care pathway on health services utilization
Impact of a standardized emergency department asthma care pathway on health services utilization
An evidence-based standardized ED asthma care pathway (EDACP) was developed and implemented in Ontario, Canada. To determi...
Sputum immunoglobulin E levels correlate with eosinophilic airway regardless of atopy
Sputum immunoglobulin E levels correlate with eosinophilic airway regardless of atopy
Immunoglobulin E (IgE) is a key molecule that induces mast cell activation in allergic inflammation and contributes to typ...
Online food allergy and anaphylaxis education for school personnel is effective and scalable: experience with the allergyaware e-learning portal from 2015 to 2022
Online food allergy and anaphylaxis education for school personnel is effective and scalable: experience with the allergyaware e-learning portal from 2015 to 2022
Providing training to school personnel on how to prevent, recognize, and manage anaphylaxis is critical. Asynchronous e-le...
Prevalence trends and risk factors for allergic rhinoconjunctivitis, asthma and eczema in the UK
Prevalence trends and risk factors for allergic rhinoconjunctivitis, asthma and eczema in the UK
Allergic rhinoconjunctivitis (ARC), asthma and eczema carry a substantial morbidity. These conditions often co-exist withi...
Newborn Screening Followed By Early Treatment is Essential to Improve Survival in SCID
Newborn Screening Followed By Early Treatment is Essential to Improve Survival in SCID
Severe combined immunodeficiency (SCID) is a heterogeneous genetic disease characterized by severe T-cell lymphopenia with...
Chronic Kidney Disease in Common Variable Immunodeficiency: a Multicenter Study
Chronic Kidney Disease in Common Variable Immunodeficiency: a Multicenter Study
There are few reports of renal involvement in Common Variable Immunodeficiencies (CVID) and, when present, is due to infec...
Complete CD16A Deficiency and Defective NK Cell Function in a Man Living with HIV
Complete CD16A Deficiency and Defective NK Cell Function in a Man Living with HIV
A man living with HIV was found to lack expression of CD16A on his natural killer (NK) cells and monocytes. Genetic analys...
Mosaicism in Two Patients with COPA Syndrome
Mosaicism in Two Patients with COPA Syndrome
The authors would like to express their gratitude to the patients and their families for their participation to this study...
From Rare to Common: Genetic Insights into Variants in a Multicentric Spanish Study on COVID-19 Severity
From Rare to Common: Genetic Insights into Variants in a Multicentric Spanish Study on COVID-19 Severity
TLR7, which encodes a key receptor for single-stranded RNA (ssRNA) virus of the innate immune system, was recently associa...
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