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SCI Abstract
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Mucosal immunization with a delta-inulin adjuvanted recombinant spike vaccine elicits lung-resident immune memory and protects mice against SARS-CoV-2
Multiple SARS-CoV-2 vaccine candidates have been approved for use and have had a major impact on the COVID-19 pandemic. Th...
Mucosal Immunology
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Intestinal epithelium in early life
Rapid development of the fetal and neonatal intestine is required to meet the growth requirements of early life and form a...
Mucosal Immunology
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Epithelial dysfunction is prevented by IL-22 treatment in a Citrobacter rodentium-induced colitis model that shares similarities with inflammatory bowel disease
Inflammatory bowel disease (IBD) is characterized by a dysregulated intestinal epithelial barrier leading to breach of bar...
Mucosal Immunology
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Severity of neonatal influenza infection is driven by type I interferon and oxidative stress
Neonates exhibit increased susceptibility to respiratory viral infections, attributed to inflammation at the developing pu...
Mucosal Immunology
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Resistance is futile? Mucosal immune mechanisms in the context of microbial ecology and evolution
In the beginning it was simple: we injected a protein antigen and studied the immune responses against the purified protei...
Mucosal Immunology
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Hermansky-Pudlak syndrome type 1 causes impaired anti-microbial immunity and inflammation due to dysregulated immunometabolism
Hermansky-Pudlak syndrome (HPS) types 1 and 4 are caused by defective vesicle trafficking. The mechanism for Crohn’s...
Mucosal Immunology
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A new age for (mucosal) NeuroImmunology
Dantzer, R., O’Connor, J. C., Freund, G. G., Johnson, R. W. & Kelley, K. W. From inflammation to sickness and depressi...
Mucosal Immunology
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John Bienenstock Obituary
On the 25th of July, disheartening news of the untimely demise of our distinguished colleague and dear fr...
Mucosal Immunology
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Vaccine protection by Cryptococcus neoformans Δsgl1 is mediated by γδ T cells via TLR2 signaling
We previously reported that administration of Cryptococcus neoformans Δsgl1 mutant vaccine, accumulating sterylglucos...
Mucosal Immunology
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The urothelium: a multi-faceted barrier against a harsh environment
All mucosal surfaces must deal with the challenge of exposure to the outside world. The urothelium is a highly specialized...
Mucosal Immunology
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Role of the humoral immune response during COVID-19: guilty or not guilty?
Systemic and mucosal humoral immune responses are crucial to fight respiratory viral infections in the current pandemic of...
Mucosal Immunology
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Microbiome-based interventions to modulate gut ecology and the immune system
The gut microbiome lies at the intersection between the environment and the host, with the ability to modify host response...
Mucosal Immunology
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Food for thought – ILC metabolism in the context of helminth infections
Helminths are multicellular ancient organisms residing as parasites at mucosal surfaces of their host. Through adaptation ...
Mucosal Immunology
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Trained immunity in type 2 immune responses
Immunological memory of innate immune cells, also termed “trained immunity”, allows for cross-protection again...
Mucosal Immunology
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B-cell receptor physical properties affect relative IgG1 and IgE responses in mouse egg allergy
Mutated and unmutated IgE and IgG play different and partly opposing roles in allergy development, but the mechanisms cont...
Mucosal Immunology
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Correction to: Trained immunity in type 2 immune responses
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which...
Mucosal Immunology
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A lentiviral vector expressing a dendritic cell-targeting multimer induces mucosal anti-mycobacterial CD4+ T-cell immunity
Most viral vectors, including the potently immunogenic lentiviral vectors (LVs), only poorly direct antigens to the MHC-II...
Mucosal Immunology
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Enteric glial cells favor accumulation of anti-inflammatory macrophages during the resolution of muscularis inflammation
Monocyte-derived macrophages (Mφs) are crucial regulators during muscularis inflammation. However, it is unclear whic...
Mucosal Immunology
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From germ-free to wild: modulating microbiome complexity to understand mucosal immunology
The gut microbiota influences host responses at practically every level, and as research into host-microbe interactions ex...
Mucosal Immunology
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Timing is everything: impact of development, ageing and circadian rhythm on macrophage functions in urinary tract infections
The bladder supports a diversity of macrophage populations with functional roles related to homeostasis and host defense, ...
Mucosal Immunology
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Single-cell RNA transcriptomic analysis identifies Creb5 and CD11b-DCs as regulator of asthma exacerbations
Immune responses that result in asthma exacerbation are associated with allergen or viral exposure. Identification of comm...
Mucosal Immunology
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Microbial antigen in human milk: a natural vaccine?
A few studies shed light on the possible ways breast milk vaccination may work and provide the optimal route to activate t...
Mucosal Immunology
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IκBζ controls IL-17-triggered gene expression program in intestinal epithelial cells that restricts colonization of SFB and prevents Th17-associated pathologies
Control of gut microbes is crucial for not only local defense in the intestine but also proper systemic immune responses. ...
Mucosal Immunology
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Ocular microbiota promotes pathological angiogenesis and inflammation in sterile injury-driven corneal neovascularization
Microbiota promotes or inhibits the pathogenesis of a range of immune-mediated disorders. Although recent studies have elu...
Mucosal Immunology
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Lessons from helminths: what worms have taught us about mucosal immunology
Ogilvie, B. M. Reagin-like antibodies in animals immune to helminth parasites. Nature 204, 91–92 (1964).CAS Article ...
Mucosal Immunology
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Mucosal immunology of the ocular surface
The eye is a sensory organ exposed to the environment and protected by a mucosal tissue barrier. While it shares a number ...
Mucosal Immunology
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Moving beyond descriptive studies: harnessing metabolomics to elucidate the molecular mechanisms underpinning host-microbiome phenotypes
Advances in technology and software have radically expanded the scope of metabolomics studies and allow us to monitor a br...
Mucosal Immunology
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The rise to power of the microbiome: power and sample size calculation for microbiome studies
A priori power and sample size calculations are crucial to appropriately test null hypotheses and obtain valid conclusions...
Mucosal Immunology
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Enteric glial adenosine 2B receptor signaling mediates persistent epithelial barrier dysfunction following acute DSS colitis
Intestinal epithelial barrier function is compromised in inflammatory bowel disease and barrier dysfunction contributes to...
Mucosal Immunology
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The impact of biological sex on diseases of the urinary tract
Biological sex, being female or male, broadly influences diverse immune phenotypes, including immune responses to diseases...
Mucosal Immunology
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