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The prognostic value of IgA anti-citrullinated protein antibodies and rheumatoid factor in an early arthritis population with a treat-to-target approach
The prognostic value of IgA anti-citrullinated protein antibodies and rheumatoid factor in an early arthritis population with a treat-to-target approach
The mucosal origin hypothesis of rheumatoid arthritis has renewed the interest in IgA autoantibodies, but their added valu...
A novel MALT1 variant in an Egyptian patient presenting with exfoliative dermatitis: a case-based review
A novel MALT1 variant in an Egyptian patient presenting with exfoliative dermatitis: a case-based review
Inborn errors of the CARD11-BCL10-MALT1 (CBM) signalosome have recently been shown to underlie severe combined immunodefic...
miR-141-3p attenuates inflammation and oxidative stress–induced pulmonary fibrosis in ARDS via the Keap1/Nrf2/ARE signaling pathway
miR-141-3p attenuates inflammation and oxidative stress–induced pulmonary fibrosis in ARDS via the Keap1/Nrf2/ARE signaling pathway
The present research aimed to investigate the effects and mechanisms of microRNA (miR)-141-3p on pulmonary fibrosis of acu...
Analysis of binding and authentic virus-neutralizing activities of immune sera induced by various monkeypox virus antigens
Analysis of binding and authentic virus-neutralizing activities of immune sera induced by various monkeypox virus antigens
Monkeypox cases continue to increase globally, and there is an urgent need to develop a highly effective vaccine against m...
Thymic microenvironment’s impact on immunosenescence
Thymic microenvironment’s impact on immunosenescence
Age-related thymic involution is characterized by the loss of T cell development and the supporting epithelial network, wh...
SPDYC serves as a prognostic biomarker related to lipid metabolism and the immune microenvironment in breast cancer
SPDYC serves as a prognostic biomarker related to lipid metabolism and the immune microenvironment in breast cancer
Breast cancer remains the most common malignant carcinoma among women globally and is resistant to several therapeutic age...
HLA-E-expressing macrophage polarization and increased NKG2A/CD94 expression in adult-onset Still’s disease
HLA-E-expressing macrophage polarization and increased NKG2A/CD94 expression in adult-onset Still’s disease
We investigated the phenotypic characteristics of human leukocyte antigen (HLA)-E-expressing macrophages, NKG2A/CD94 expre...
Endogenous innate sensor NLRP3 is a key component in peritoneal macrophage dynamics required for cestode establishment
Endogenous innate sensor NLRP3 is a key component in peritoneal macrophage dynamics required for cestode establishment
The NLRP3 receptor can assemble inflammasome platforms to trigger inflammatory responses; however, accumulating evidence s...
Exploring CCR5 + T regulatory cell subset dysfunction in type 1 diabetes patients: implications for immune regulation
Exploring CCR5 + T regulatory cell subset dysfunction in type 1 diabetes patients: implications for immune regulation
T regulatory lymphocytes (Treg) expressing CCR5 exhibit strong suppression activity in various autoimmune disorders. Howev...
Investigation of the relationship of tissue-resident γδ T cells and IL-17 gene expression with the pathogenesis of autoimmune hepatitis
Investigation of the relationship of tissue-resident γδ T cells and IL-17 gene expression with the pathogenesis of autoimmune hepatitis
Autoimmune hepatitis (AIH) is a chronic inflammatory liver disease. Elevated serum immunoglobulin G (IgG) levels, autoanti...
Belimumab 10 years later: how drug positioning has changed
Belimumab 10 years later: how drug positioning has changed
We analysed the change in the positioning of belimumab (BLM) in systemic lupus erythematosus (SLE) treatment in the first ...
Differential analysis of sorting nexin 10 and sterol regulatory element–binding protein 2 expression in inflammatory bowel disease
Differential analysis of sorting nexin 10 and sterol regulatory element–binding protein 2 expression in inflammatory bowel disease
Sorting nexin 10 (SNX10) expression induces intestinal barrier dysfunction and inflammatory responses; in contrast, its in...
Clinical relevance and frequency of cytoplasmic patterns observed in ANA-Hep-2: experience of Cairo University Hospitals
Clinical relevance and frequency of cytoplasmic patterns observed in ANA-Hep-2: experience of Cairo University Hospitals
Antinuclear antibodies (ANA) are the most common biomarkers observed in autoimmune diseases. Cytoplasmic staining patterns...
Phillyrin inhibits oxidative stress and neutrophil extracellular trap formation through the KEAP1/NRF2 pathway in gouty arthritis
Phillyrin inhibits oxidative stress and neutrophil extracellular trap formation through the KEAP1/NRF2 pathway in gouty arthritis
Gouty arthritis (GA) is an inflammatory disorder characterized by deposition of monosodium urate (MSU) crystal in joints. ...
Impaired inducibility of immune regulatory capacity of peripheral B cells of patients with recurrent pregnancy loss
Impaired inducibility of immune regulatory capacity of peripheral B cells of patients with recurrent pregnancy loss
The pathogenesis of recurrent pregnancy loss (RPL) is unclear. RPL may have an association with disruption of immune toler...
cGAS-STING pathway in systemic lupus erythematosus: biological implications and therapeutic opportunities
cGAS-STING pathway in systemic lupus erythematosus: biological implications and therapeutic opportunities
The cyclic GMP-AMP synthase (cGAS)–stimulator of interferon genes (STING) signaling pathway has been identified as a...
Artificial intelligence applications for immunology laboratory: image analysis and classification study of IIF photos
Artificial intelligence applications for immunology laboratory: image analysis and classification study of IIF photos
Artificial intelligence (AI) is increasingly being used in medicine to enhance the speed and accuracy of disease diagnosis...
T cell receptor clonotype in tumor microenvironment contributes to intratumoral signaling network in patients with colorectal cancer
T cell receptor clonotype in tumor microenvironment contributes to intratumoral signaling network in patients with colorectal cancer
Single-cell RNA sequencing (scRNA-seq) has contributed to understanding cellular heterogeneity and immune profiling in can...
New mutations and new phenotypes: a case of Major Histocompatibility Complex Class II Deficiency
New mutations and new phenotypes: a case of Major Histocompatibility Complex Class II Deficiency
Major Histocompatibility Complex Class II Deficiency is a rare primary immunodeficiency disease with autosomal recessive i...
In silico and experimental potentials of 6-shogaol and meglumine antimoniate on Leishmania major: multiple synergistic combinations through modulation of biological properties
In silico and experimental potentials of 6-shogaol and meglumine antimoniate on Leishmania major: multiple synergistic combinations through modulation of biological properties
Conventional therapeutic agents are no longer adequate against leishmaniasis. This complex condition continues to have a h...
EBV + B cell-derived exosomes promote EBV-associated T/NK-cell lymphoproliferative disease immune evasion by STAT3/IL-10/PD-L1 pathway
EBV + B cell-derived exosomes promote EBV-associated T/NK-cell lymphoproliferative disease immune evasion by STAT3/IL-10/PD-L1 pathway
EBV-associated T/NK-cell lymphoproliferative diseases (EBV-T/NK-LPDs) are characterized by the clonal proliferation of EBV...
Good syndrome combined with multiple microbial pulmonary infections: case report and review of the literature
Good syndrome combined with multiple microbial pulmonary infections: case report and review of the literature
Good syndrome (GS), a rare acquired immunodeficiency disorder characterized by thymoma and hypogammaglobulinemia, predispo...
MYOCD and SRF-mediated MLCK transcription prevents polymorphonuclear neutrophils from ferroptosis in sepsis-related acute lung injury
MYOCD and SRF-mediated MLCK transcription prevents polymorphonuclear neutrophils from ferroptosis in sepsis-related acute lung injury
Persistent activation of polymorphonuclear neutrophils (PMNs) plays a crucial role in the development of sepsis-related ac...
Predictive biomarkers of response to tocilizumab in giant cell arteritis (GCA): correlations with imaging activity
Predictive biomarkers of response to tocilizumab in giant cell arteritis (GCA): correlations with imaging activity
In the recent EULAR recommendations, ultrasound examination is now recommended as a first-line imaging test in all patient...
Amphotericin B for injection triggers degranulation of human LAD2 mast cells by MRGPRX2 and pseudo-allergic reactions in mice via MRGPRB2 activation
Amphotericin B for injection triggers degranulation of human LAD2 mast cells by MRGPRX2 and pseudo-allergic reactions in mice via MRGPRB2 activation
Amphotericin B, a polyene macrolide antifungal agent, still plays an important role in the management of serious systemic ...
The dysregulation of mitochondrial homeostasis–related genes could be involved in the decrease of mtDNA copy number in systemic lupus erythematosus patients
The dysregulation of mitochondrial homeostasis–related genes could be involved in the decrease of mtDNA copy number in systemic lupus erythematosus patients
Systemic lupus erythematosus (SLE) is a chronic multifactorial autoimmune disease. It is now widely demonstrated that oxid...
NK/DC crosstalk-modulating antitumor activity via Sema3E/PlexinD1 axis for enhanced cancer immunotherapy
NK/DC crosstalk-modulating antitumor activity via Sema3E/PlexinD1 axis for enhanced cancer immunotherapy
The complex relationship between natural killer (NK) cells and dendritic cells (DCs) within the tumor microenvironment sig...
Changes in immune subsets during chemotherapy as prognosis biomarkers for multiple myeloma patients by longitudinal monitoring
Changes in immune subsets during chemotherapy as prognosis biomarkers for multiple myeloma patients by longitudinal monitoring
Multiple myeloma (MM) is a malignancy of plasma cells accompanied by immune dysfunction. This study aimed to provide a com...
Tumour-associated macrophages in diffuse large B-cell lymphoma: the prognostic and therapeutic impact in a South African centre with high HIV seroprevalence
Tumour-associated macrophages in diffuse large B-cell lymphoma: the prognostic and therapeutic impact in a South African centre with high HIV seroprevalence
Diffuse large B-cell lymphoma (DLBCL) is a common malignancy among people living with HIV. Macrophage enrichment of the tu...
Serum soluble interleukin-2 receptor alpha may predict tubulointerstitial inflammatory cell infiltration and short-term disease progression in immunoglobin A nephropathy
Serum soluble interleukin-2 receptor alpha may predict tubulointerstitial inflammatory cell infiltration and short-term disease progression in immunoglobin A nephropathy
This study aims to explore the relationship between serum soluble interleukin-2 receptor alpha (sIL-2Rα) lev...
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