Luan R, Ding D, Yang J. The protective effect of natural medicines against excessive inflammation and oxidative stress in acute lung injury by regulating the Nrf2 signaling pathway. Front Pharmacol. 2022;13:1039022. https://doi.org/10.3389/fphar.2022.1039022.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Parzibut G, Henket M, Moermans C, Struman I, Louis E, Malaise M, et al. A blood exosomal miRNA signature in acute respiratory distress syndrome. Front Mol Biosci. 2021;8:640042. https://doi.org/10.3389/fmolb.2021.640042.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hu X, Huang X. Alleviation of inflammatory response of pulmonary fibrosis in acute respiratory distress syndrome by puerarin via transforming growth factor (TGF-beta1). Med Sci Monit. 2019;25:6523–31. https://doi.org/10.12659/MSM.915570.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hamon A, Scemama U, Bourenne J, Daviet F, Coiffard B, Persico N, et al. Chest CT scan and alveolar procollagen III to predict lung fibroproliferation in acute respiratory distress syndrome. Ann Intensive Care. 2019;9(1):42. https://doi.org/10.1186/s13613-019-0516-9.

Article  PubMed  PubMed Central  Google Scholar 

Mu X, Wang H, Li H. Silencing of long noncoding RNA H19 alleviates pulmonary injury, inflammation, and fibrosis of acute respiratory distress syndrome through regulating the microRNA-423-5p/FOXA1 axis. Exp Lung Res. 2021;47(4):183–97. https://doi.org/10.1080/01902148.2021.1887967.

Article  CAS  PubMed  Google Scholar 

Cao Y, Liu Y, Ping F, Yi L, Zeng Z, Li Y. miR-200b/c attenuates lipopolysaccharide-induced early pulmonary fibrosis by targeting ZEB1/2 via p38 MAPK and TGF-beta/smad3 signaling pathways. Lab Invest. 2018;98(3):339–59. https://doi.org/10.1038/labinvest.2017.123.

Article  CAS  PubMed  Google Scholar 

Fang X, Wang H, Zhuo Z, Tian P, Chen Z, Wang Y, et al. miR-141-3p inhibits the activation of astrocytes and the release of inflammatory cytokines in bacterial meningitis through down-regulating HMGB1. Brain Res. 2021;1770:147611. https://doi.org/10.1016/j.brainres.2021.147611.

Article  CAS  PubMed  Google Scholar 

Yan R, Liang X, Hu J. miR-141-3p alleviates ulcerative colitis by targeting SUGT1 to inhibit colonic epithelial cell pyroptosis. Autoimmunity. 2023;56(1):2220988. https://doi.org/10.1080/08916934.2023.2220988.

Article  CAS  PubMed  Google Scholar 

Wang J, Wang Y, Zhang H, Chang J, Lu M, Gao W, et al. Identification of a novel microRNA-141-3p/Forkhead box C1/beta-catenin axis associated with rheumatoid arthritis synovial fibroblast function in vivo and in vitro. Theranostics. 2020;10(12):5412–34. https://doi.org/10.7150/thno.45214.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ji J, Wu S, Bao X, Liu S, Ye Y, Liu J, et al. Mediating oxidative stress through the palbociclib/miR-141-3p/STAT4 axis in osteoporosis: a bioinformatics and experimental validation study. Sci Rep. 2023;13(1):19560. https://doi.org/10.1038/s41598-023-46813-6.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li T, Chen Q, Dai J, Huang Z, Luo Y, Mou T, et al. MicroRNA-141-3p attenuates oxidative stress-induced hepatic ischemia reperfusion injury via Keap1/Nrf2 pathway. Mol Biol Rep. 2022;49(8):7575–85. https://doi.org/10.1007/s11033-022-07570-3.

Article  CAS  PubMed  Google Scholar 

Chen H, Zeng L, Zheng W, Li X, Lin B. Increased expression of microRNA-141-3p improves necrotizing enterocolitis of neonates through targeting MNX1. Front Pediatr. 2020;8:385. https://doi.org/10.3389/fped.2020.00385.

Article  PubMed  PubMed Central  Google Scholar 

Jin Y, Liu W, Liu X, Ma T, Yang C, Cai Q, et al. Transplantation of endothelial progenitor cells attenuated paraquat-induced acute lung injury via mir-141-3p-Notch-Nrf2 axis. Cell Biosci. 2018;8:21. https://doi.org/10.1186/s13578-018-0219-1.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Qian W, Cai X, Qian Q, Peng W, Yu J, Zhang X, et al. lncRNA ZEB1-AS1 promotes pulmonary fibrosis through ZEB1-mediated epithelial-mesenchymal transition by competitively binding miR-141-3p. Cell Death Dis. 2019;10(2):129. https://doi.org/10.1038/s41419-019-1339-1.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Long G, Zhang Q, Yang X, Sun H, Ji C. Diagnostic and predictive significance of serum miR-141-3p in acute respiratory distress syndrome patients with pulmonary fibrosis. Tohoku J Exp Med. 2024;262(3):157–62. https://doi.org/10.1620/tjem.2023.J093.

Article  CAS  PubMed  Google Scholar 

Hu LY, Cui JB, Xu XM, Huang ZH, Jiao HT. Expression of Nrf2-Keap1-ARE signal pathway in traumatic lung injury and functional study. Eur Rev Med Pharmacol Sci. 2018;22(5):1402–8. https://doi.org/10.26355/eurrev_201803_14486.

Article  PubMed  Google Scholar 

Reddy NM, Suryanaraya V, Yates MS, Kleeberger SR, Hassoun PM, Yamamoto M, et al. The triterpenoid CDDO-imidazolide confers potent protection against hyperoxic acute lung injury in mice. Am J Respir Crit Care Med. 2009;180(9):867–74. https://doi.org/10.1164/rccm.200905-0670OC.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang Y, Ren F, Sun D, Liu J, Liu B, He Y, et al. CircKEAP1 suppresses the progression of lung adenocarcinoma via the miR-141-3p/KEAP1/NRF2 Axis. Front Oncol. 2021;11:672586. https://doi.org/10.3389/fonc.2021.672586.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhang C, Kong X, Ma D. Mir-141-3p inhibits vascular smooth muscle cell proliferation and migration via regulating Keap1/Nrf2/HO-1 pathway. IUBMB Life. 2020;72(10):2167–79. https://doi.org/10.1002/iub.2374.

Article  CAS  PubMed  Google Scholar 

Zheng L, Su J, Zhang Z, Jiang L, Wei J, Xu X, et al. Salidroside regulates inflammatory pathway of alveolar macrophages by influencing the secretion of miRNA-146a exosomes by lung epithelial cells. Sci Rep. 2020;10(1):20750. https://doi.org/10.1038/s41598-020-77448-6.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhang C, Yu S, Zheng B, Liu D, Wan F, Ma Y, et al. miR-30c-5p reduces renal ischemia-reperfusion involving macrophage. Med Sci Monit. 2019;25:4362–9. https://doi.org/10.12659/MSM.914579.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li P, Gu L, Bian Q, Jiao D, Xu Z, Wang L. Long non-coding RNA MALAT1 enhances the protective effect of dexmedetomidine on acute lung injury by sponging miR-135a-5p to downregulate the ratio of X-box binding proteins XBP-1S/XBP-1U. Bioengineered. 2021;12(1):6377–89. https://doi.org/10.1080/21655979.2021.1967579.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gao Y, Xie D, Wang Y, Niu L, Jiang H. Short-chain fatty acids reduce oligodendrocyte precursor cells loss by inhibiting the activation of astrocytes via the SGK1/IL-6 signalling pathway. Neurochem Res. 2022;47(11):3476–89. https://doi.org/10.1007/s11064-022-03710-0.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Pan A, Tan Y, Wang Z, Xu G. STAT4 silencing underlies a novel inhibitory role of microRNA-141-3p in inflammation response of mice with experimental autoimmune myocarditis. Am J Physiol Heart Circ Physiol. 2019;317(3):H531–40. https://doi.org/10.1152/ajpheart.00048.2019.

Article  CAS  PubMed  Google Scholar 

Gonzalez-Rodriguez A, Reibert B, Amann T, Constien R, Rondinone CM, Valverde AM. In vivo siRNA delivery of Keap1 modulates death and survival signaling pathways and attenuates concanavalin-A-induced acute liver injury in mice. Dis Model Mech. 2014;7(9):1093–100. https://doi.org/10.1242/dmm.015537.

Article  CAS  PubMed  PubMed Central