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Histone H1 deamidation regulates DNA double-strand break repair
Histone H1 deamidation regulates DNA double-strand break repair
Repair of DNA double-strand breaks requires chromatin opening; however, the mechanisms involved were unclear. This work sh...
Molecular machineries shaping the mitochondrial inner membrane
Molecular machineries shaping the mitochondrial inner membrane
Mitochondria display intricately shaped deep invaginations of the mitochondrial inner membrane (MIM) termed cristae. This ...
N-glycan-dependent protein maturation and quality control in the ER
N-glycan-dependent protein maturation and quality control in the ER
The vast majority of proteins that traverse the mammalian secretory pathway become N-glycosylated in the endoplasmic retic...
Mechanisms of auxin action in plant growth and development
Mechanisms of auxin action in plant growth and development
The phytohormone auxin is a major signal coordinating growth and development in plants. The variety of its effects arises ...
Functions and therapeutic applications of pseudouridylation
Functions and therapeutic applications of pseudouridylation
The success of using pseudouridine (Ψ) and its methylation derivative in mRNA vaccines against SARS-CoV-2 has sparked...
Uncovering mRNA sequences that control translation initiation
Uncovering mRNA sequences that control translation initiation
In this Tools of the Trade article, Abdallah (Gilbert lab) describes the development of direct analysis of ribosome target...
Enabling RNA-compatible synthetic receptors through RNA editing
Enabling RNA-compatible synthetic receptors through RNA editing
In this Tools of the Trade article, Zhang and Mille-Fragoso (Gao lab) describe a synthetic receptor platform that is activ...
Structure, regulation and assembly of the photosynthetic electron transport chain
Structure, regulation and assembly of the photosynthetic electron transport chain
The electron transfer chain of chloroplast thylakoid membranes uses solar energy to split water into electrons and protons...
Polycystin-1 regulates tendon-derived mesenchymal stem cells fate and matrix organization in heterotopic ossification
Polycystin-1 regulates tendon-derived mesenchymal stem cells fate and matrix organization in heterotopic ossification
Mechanical stress modulates bone formation and organization of the extracellular matrix (ECM), the interaction of which af...
FGFR antagonists restore defective mandibular bone repair in a mouse model of osteochondrodysplasia
FGFR antagonists restore defective mandibular bone repair in a mouse model of osteochondrodysplasia
Gain-of-function mutations in fibroblast growth factor receptor (FGFR) genes lead to chondrodysplasia and craniosynostoses...
GnIH secreted by green light exposure, regulates bone mass through the activation of Gpr147
GnIH secreted by green light exposure, regulates bone mass through the activation of Gpr147
Reproductive hormones associated with the hypothalamic-pituitary-gonadal (HPG) axis are closely linked to bone homeostasis...
Role of macrophage in intervertebral disc degeneration
Role of macrophage in intervertebral disc degeneration
Intervertebral disc degeneration is a degenerative disease where inflammation and immune responses play significant roles....
Isovitexin targets SIRT3 to prevent steroid-induced osteonecrosis of the femoral head by modulating mitophagy-mediated ferroptosis
Isovitexin targets SIRT3 to prevent steroid-induced osteonecrosis of the femoral head by modulating mitophagy-mediated ferroptosis
The death of osteoblasts induced by glucocorticoid (GC)-mediated oxidative stress plays a crucial role in the development ...
Skeletal progenitor LRP1 deficiency causes severe and persistent skeletal defects with Wnt pathway dysregulation
Skeletal progenitor LRP1 deficiency causes severe and persistent skeletal defects with Wnt pathway dysregulation
Low-density lipoprotein receptor-related protein 1 (LRP1) is a multifunctional endocytic receptor whose dysfunction is lin...
Enhancer-driven Shh signaling promotes glia-to-mesenchyme transition during bone repair
Enhancer-driven Shh signaling promotes glia-to-mesenchyme transition during bone repair
Plp1-lineage Schwann cells (SCs) of peripheral nerve play a critical role in vascular remodeling and osteogenic differenti...
Stem Cell Therapy as a Potential Treatment of Non-Alcoholic Steatohepatitis-Related End-Stage Liver Disease: A Narrative Review
Stem Cell Therapy as a Potential Treatment of Non-Alcoholic Steatohepatitis-Related End-Stage Liver Disease: A Narrative Review
To review recent research using various stem cell-related therapies, including bone marrow, adipose tissue, hematopoietic ...
Leading Edge Techniques in the Quest for Characterizing Rare Hematopoietic Stem Cells
Leading Edge Techniques in the Quest for Characterizing Rare Hematopoietic Stem Cells
Hematopoietic stem cells (HSCs) occupy the summit of the intricate hematopoiesis hierarchy, constituting a mere 0.01% of t...
Transcription regulation by biomolecular condensates
Transcription regulation by biomolecular condensates
Biomolecular condensates regulate transcription by dynamically compartmentalizing the transcription machinery. Classic mod...
Author Correction: All the sites we cannot see: Sources and mitigation of false negatives in RNA modification studies
Authors and AffiliationsLaboratory of Receptor Biology and Gene Expression, Center for Cancer Research, National Cancer In...
The intraflagellar transport cycle
The intraflagellar transport cycle
Primary and motile cilia are eukaryotic organelles that perform crucial roles in cellular signalling and motility. Intrafl...
Grand roles for microproteins
Grand roles for microproteins
Valerie Tornini discusses two studies that identified functional roles for small proteins encoded by short open reading fr...
RNA communication between organisms inspires innovative eco-friendly strategies for disease control
Evidence shows that RNA trafficking is a key communication mechanism across kingdoms and species, but how RNAs are secrete...
Connecting cells through TNT
Connecting cells through TNT
Tunnelling nanotubes, which are actin-based protrusions different from filopodia and cytokinetic bridges, connect cells in...
Paleoproteomics sheds light on million-year-old fossils
It is now well established that ancient proteins endure, and remain informative, much longer than DNA. Accordingly, sequen...
Exploiting cell cycle-dependent dephosphorylation for mitosis-specific protein recruitment
Exploiting cell cycle-dependent dephosphorylation for mitosis-specific protein recruitment
In this Tools of the Trade article, Cao (Baskin lab) discusses the development of MARS, which enables mitosis-specific rec...
Targeting Fascin1 maintains chondrocytes phenotype and attenuates osteoarthritis development
Targeting Fascin1 maintains chondrocytes phenotype and attenuates osteoarthritis development
Osteoarthritis (OA) is the most common form of arthritic disease, and phenotypic modification of chondrocytes is an import...
Bone targeted nano-drug and nano-delivery
Bone targeted nano-drug and nano-delivery
There are currently no targeted delivery systems to satisfactorily treat bone-related disorders. Many clinical drugs consi...
Hydroxychloroquine and a low antiresorptive activity bisphosphonate conjugate prevent and reverse ovariectomy-induced bone loss in mice through dual antiresorptive and anabolic effects
Hydroxychloroquine and a low antiresorptive activity bisphosphonate conjugate prevent and reverse ovariectomy-induced bone loss in mice through dual antiresorptive and anabolic effects
Osteoporosis remains incurable. The most widely used antiresorptive agents, bisphosphonates (BPs), also inhibit bone forma...
Osteopontin deficiency promotes cartilaginous endplate degeneration by enhancing the NF-κB signaling to recruit macrophages and activate the NLRP3 inflammasome
Osteopontin deficiency promotes cartilaginous endplate degeneration by enhancing the NF-κB signaling to recruit macrophages and activate the NLRP3 inflammasome
Intervertebral disc degeneration (IDD) is a major cause of discogenic pain, and is attributed to the dysfunction of nucleu...
Pharmacologic or genetic targeting of peripheral nerves prevents peri-articular traumatic heterotopic ossification
Pharmacologic or genetic targeting of peripheral nerves prevents peri-articular traumatic heterotopic ossification
Heterotopic ossification (HO) is a pathological process that commonly arises following severe polytrauma, characterized by...
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