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Transcription regulation by biomolecular condensates
Transcription regulation by biomolecular condensates
Biomolecular condensates regulate transcription by dynamically compartmentalizing the transcription machinery. Classic mod...
Author Correction: All the sites we cannot see: Sources and mitigation of false negatives in RNA modification studies
Authors and AffiliationsLaboratory of Receptor Biology and Gene Expression, Center for Cancer Research, National Cancer In...
The intraflagellar transport cycle
The intraflagellar transport cycle
Primary and motile cilia are eukaryotic organelles that perform crucial roles in cellular signalling and motility. Intrafl...
Grand roles for microproteins
Grand roles for microproteins
Valerie Tornini discusses two studies that identified functional roles for small proteins encoded by short open reading fr...
RNA communication between organisms inspires innovative eco-friendly strategies for disease control
Evidence shows that RNA trafficking is a key communication mechanism across kingdoms and species, but how RNAs are secrete...
Connecting cells through TNT
Connecting cells through TNT
Tunnelling nanotubes, which are actin-based protrusions different from filopodia and cytokinetic bridges, connect cells in...
Paleoproteomics sheds light on million-year-old fossils
It is now well established that ancient proteins endure, and remain informative, much longer than DNA. Accordingly, sequen...
Exploiting cell cycle-dependent dephosphorylation for mitosis-specific protein recruitment
Exploiting cell cycle-dependent dephosphorylation for mitosis-specific protein recruitment
In this Tools of the Trade article, Cao (Baskin lab) discusses the development of MARS, which enables mitosis-specific rec...
Cellular and pathological functions of tau
Cellular and pathological functions of tau
Tau protein is involved in various cellular processes, including having a canonical role in binding and stabilization of m...
Regulation of and challenges in targeting NAD+ metabolism
Regulation of and challenges in targeting NAD+ metabolism
Nicotinamide adenine dinucleotide, in its oxidized (NAD+) and reduced (NADH) forms, is a reduction–oxidation (redox)...
What does it take to build a nucleus?
What does it take to build a nucleus?
Abigail Buchwalter recounts what happened to the nuclei of cells lacking all lamin genes.
MYB-related proteins make chloroplasts
MYB-related proteins make chloroplasts
MYB-related transcription factors are found to function in chloroplast biogenesis alongside GLK in the distantly related s...
Structural biology and molecular pharmacology of voltage-gated ion channels
Structural biology and molecular pharmacology of voltage-gated ion channels
Voltage-gated ion channels (VGICs), including those for Na+, Ca2+ and K+, selectively permeate ions across the cell membra...
Mechanisms of autophagy–lysosome dysfunction in neurodegenerative diseases
Mechanisms of autophagy–lysosome dysfunction in neurodegenerative diseases
Autophagy is a lysosome-based degradative process used to recycle obsolete cellular constituents and eliminate damaged org...
Far from the cytoplasmic crowd
Far from the cytoplasmic crowd
Stresses induce de-crowding and fluidization of the cytoplasm, which promotes the formation of biomolecular condensates.
Profiling cell identity and tissue architecture with single-cell and spatial transcriptomics
Profiling cell identity and tissue architecture with single-cell and spatial transcriptomics
Single-cell transcriptomics has broadened our understanding of cellular diversity and gene expression dynamics in healthy ...
A novel photosystem assembly line worker
A novel photosystem assembly line worker
The assembly of large protein–pigment photosystem supercomplexes relies on several assembly factors. Zhang et al. de...
Fibroblast and myofibroblast activation in normal tissue repair and fibrosis
Fibroblast and myofibroblast activation in normal tissue repair and fibrosis
The term ‘fibroblast’ often serves as a catch-all for a diverse array of mesenchymal cells, including perivasc...
Modelling tauopathies
Modelling tauopathies
This study presents a new iPS cell-based model to study the mechanisms of tau propagation in 4R tauopathies.
Mechanical state transitions in the regulation of tissue form and function
Mechanical state transitions in the regulation of tissue form and function
From embryonic development, postnatal growth and adult homeostasis to reparative and disease states, cells and tissues und...
Early insights into co-translational assembly of protein complexes
Early insights into co-translational assembly of protein complexes
The first evidence that the formation of protein complexes is linked to protein synthesis was already provided in the earl...
In memoriam Judy Campisi: spreading cellular senescence
In memoriam Judy Campisi: spreading cellular senescence
In the Journal Club, Fabrizio d’Adda di Fagagna remembers how the work of Judy Campisi changed our understanding of ...
Relaying gasdermin D to the membrane
Relaying gasdermin D to the membrane
Reversible S-palmitoylation regulates gasdermin D cleavage, membrane translocation and pore formation to control pyroptosi...
Is endocytosis by caveolae dependent on dynamin?
Is endocytosis by caveolae dependent on dynamin?
The large GTPase dynamin has a crucial role in endocytosis, working at the neck of clathrin-coated pits to drive vesicular...
The molecular basis of translation initiation and its regulation in eukaryotes
The molecular basis of translation initiation and its regulation in eukaryotes
The regulation of gene expression is fundamental for life. Whereas the role of transcriptional regulation of gene expressi...
Does species-specific alternative splicing make us human?
Florian Heyd describes a paper that pointed towards alternative splicing as a driver of human cognitive abilities.
Lysosomes as coordinators of cellular catabolism, metabolic signalling and organ physiology
Lysosomes as coordinators of cellular catabolism, metabolic signalling and organ physiology
Every cell must satisfy basic requirements for nutrient sensing, utilization and recycling through macromolecular breakdow...
Local and systemic mechanisms that control the hair follicle stem cell niche
Local and systemic mechanisms that control the hair follicle stem cell niche
Hair follicles are essential appendages of the mammalian skin, as hair performs vital functions of protection, thermoregul...
Extended heterochronic parabiosis as an approach to study rejuvenation
In this Tools of the Trade article, Bohan Zhang (Gladyshev lab) discusses how the use of extended heterochronic parabiosis...
Senescent cells support limb regeneration
Yu et al. identify senescent cells as important players in the regeneration of complex structures.
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