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Synthesis and antibacterial evaluation of 5-(3-nitrophenyl)-N′-arylisoxazole-3-carbohydrazide derivatives against carbapenem-resistant Acinetobacter baumannii
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Design, synthesis and in vitro assessment of di-/tri-methoxy-aryl-substituted mono-spiro-1,2,4,5-tetraoxanes for antiplasmodial and anticancer use
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Assessing the anti-leukemic efficacy of a curcuminoid in cellular and animal models
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Microwave-assisted one-pot green synthesis, ADMET profiling, DFT, and molecular docking of novel 3-cyano-2-pyridone derivatives as dual EGFR and cytokine (TNF-α, IL-6) inhibitors
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Synthesis and biological evaluation of C-28-modified pyrazole-fused betulinic acid derivatives as potent antiosteoporosis agents
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SAR studies of chabrolonaphthoquinone B via rational design and synthesis of analogues - Cytotoxicity evaluation uncovers anticancer activity via mRNA splicing modulation
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Design, synthesis, and biological evaluation of arctigenin derivatives as novel GPX4 inhibitors in colorectal cancer cells
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PyaiVS unifies AI workflows to accelerate ligand discovery and yields ABCG2 inhibitors
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Discovery of novel benzylaniline derivatives containing chloroacetamide as GPX4 inhibitors with potential efficacy in triple-negative breast cancer
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Ring systems in medicinal chemistry: A cheminformatics analysis of ring popularity in drug discovery over time
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Structure-based virtual screening identifies potent CD28 inhibitors that suppress T cell co-stimulation in cellular and mucosal models
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A novel AIE photosensitizer for combination photodynamic immunotherapy via autophagy activation and tumor microenvironment modulation
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Structural optimization and biological evaluation of ferrocene-appended RSL3 derivatives as potent ferroptosis inducers
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Discovery of fluorescent theranostic molecular glues for real-time visualization and target degradation toward eEF2K
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Discovery of lipidated cysteine-based amphiphiles as bioinspired antimicrobial peptidomimetics against drug-resistant bacteria
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Design and synthesis of novel cyclin-dependent kinase 4/6(CDK4/6) and histone deacetylase (HDAC) dual inhibitors: In vitro and in vivo anticancer activity
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Bufalin targeting METTL17 inhibits the occurrence and metastasis of oral cancer through JAK1/STAT3 signaling pathway
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(N)-Methanocarba-adenosines as monoamine transporter allosteric inhibitors: Extended N6 groups for bitopic stabilization
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Photooxidation of biomolecules in cancer cells with a viscosity-dependent fluorescent Rhodamine derivative decorated with a naphthoimidazole rotor
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Kuoxin Decoction Alleviated Left Ventricular Remodeling by Inhibiting Cardiomyocyte Apoptosis Through ASK1/JNK/Cx43 Signaling Pathway in cTnTR141W Transgenic Mice and in vitro
Kuoxin Decoction Alleviated Left Ventricular Remodeling by Inhibiting Cardiomyocyte Apoptosis Through ASK1/JNK/Cx43 Signaling Pathway in cTnTR141W Transgenic Mice and in vitro
To explore the potential of KXD in mitigating gap junction remodeling and apoptosis in DCM and to elucidate the complex mo...
Ursolic Acid Ameliorates Diabetic Nephropathy by Inhibiting JAK2/STAT3-Driven Ferroptosis: Mechanistic Insights from Network Pharmacology and Experimental Validation
Ursolic Acid Ameliorates Diabetic Nephropathy by Inhibiting JAK2/STAT3-Driven Ferroptosis: Mechanistic Insights from Network Pharmacology and Experimental Validation
Exploring the underlying mechanism of UA protection against DN by blocking JAK2/STAT3-mediated ferroptosis. Read more
Comparison of Oliceridine and Morphine in Postoperative Analgesia in Laparoscopic Total Hysterectomy, a Randomized Double-Blind Controlled Trial
Comparison of Oliceridine and Morphine in Postoperative Analgesia in Laparoscopic Total Hysterectomy, a Randomized Double-Blind Controlled Trial
To identify safer and more effective postoperative analgesic methods for patients undergoing laparoscopic total hysterecto...
Synergistic Potential of Trikatu Essential Oil as an Aromatherapy Agent: A Chemical and Mechanistic Review
Synergistic Potential of Trikatu Essential Oil as an Aromatherapy Agent: A Chemical and Mechanistic Review
Reviewing the antioxidant, anti-inflammatory, anxiolytic, and neuroprotective properties of the bioactive compounds in Tri...
Effects of Remimazolam-Propofol with Flumazenil Reversal on the Emergence Time and Hemodynamics of Patients Undergoing Laparoscopic Partial Hepatectomy: A Prospective Randomized Controlled Trial
Effects of Remimazolam-Propofol with Flumazenil Reversal on the Emergence Time and Hemodynamics of Patients Undergoing Laparoscopic Partial Hepatectomy: A Prospective Randomized Controlled Trial
Evaluating remimazolam-propofol with flumazenil reversal on the emergence time and hemodynamics of patients undergoing lap...
Therapeutic Implications of Traditional Chinese Medicine in Clinically Relevant Diseases: Perspectives From microRNA-Modulated Apoptotic Signaling
Therapeutic Implications of Traditional Chinese Medicine in Clinically Relevant Diseases: Perspectives From microRNA-Modulated Apoptotic Signaling
We comprehensively examine contemporary research investigating the correlation between miRNAs and anti-tumor TCMs alongsid...
Phase I Trial of Pegylated Liposomal Doxorubicin Combined with Ifosfamide for Advanced Soft Tissue Sarcoma
Phase I Trial of Pegylated Liposomal Doxorubicin Combined with Ifosfamide for Advanced Soft Tissue Sarcoma
This phase I study aimed to determine the MTD and to assess the safety of escalated doses of PLD in combination with a fix...
Stimuli-Responsive Drug Delivery Systems for Enhanced Melanoma Immunotherapy
Stimuli-Responsive Drug Delivery Systems for Enhanced Melanoma Immunotherapy
To clarify how stimuli-responsive DDSs enhance melanoma immunotherapy and guide their use as therapeutic agents. Read more
Determining the Preventive Effect of Topical Magnesium Sulfate Administration on Postoperative Sore Throat [Letter]
Determining the Preventive Effect of Topical Magnesium Sulfate Administration on Postoperative Sore Throat [Letter]
Letter for the article Comparison of Preoperative Topical Magnesium Sulfate Spraying and Magnesium Sulfate Gargling for th...
Bibliometric Analysis of Exosome Research in Spinal Cord Injury (2000–May 2024). Trends, Collaborations, and Emerging Insights
Bibliometric Analysis of Exosome Research in Spinal Cord Injury (2000–May 2024). Trends, Collaborations, and Emerging Insights
The present study was conducted to provide a systematic bibliometric analysis of research trends related to SCI and exosomes.
Wedelolactone Ameliorates Ischemic Stroke by Inhibiting Oxidative Damage and Ferroptosis via HIF-1α/SLC7A11/GPX4 Signaling
Wedelolactone Ameliorates Ischemic Stroke by Inhibiting Oxidative Damage and Ferroptosis via HIF-1α/SLC7A11/GPX4 Signaling
Revealing that the Wel could alleviate ischemic stroke by inhibiting oxidative damage and ferroptosis via HIF-1α/ SL...
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