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A new diterpenoid, carneadiol, isolated from IFM 12324
A new diterpenoid, carneadiol, isolated from IFM 12324
A new diterpenoid, carneadiol (1), with an unprecedented tricyclic carbon skeleton, was isolated from the culture extracts...
Potent SARS-CoV-2 3C-like protease inhibitor ( +)-eupenoxide-3,6-diketone (IC: 0.048 μM) was synthesized based on ( +)-eupenoxide; lead from ( +)-eupenoxide analogs study by endophytic fermentation
Potent SARS-CoV-2 3C-like protease inhibitor ( +)-eupenoxide-3,6-diketone (IC: 0.048 μM) was synthesized based on ( +)-eupenoxide; lead from ( +)-eupenoxide analogs study by endophytic fermentation
Since the coronavirus disease 2019 (COVID-19) outbreak, research has been conducted on treatment and countermeasures again...
Biosynthesis of unique natural product scaffolds by Fe(II)/αKG-dependent oxygenases
Biosynthesis of unique natural product scaffolds by Fe(II)/αKG-dependent oxygenases
Fe(II)/αKG-dependent oxygenases are multifunctional oxidases responsible for the formation of unique natural product ...
Four new acylated glycosidic acid methyl esters and a new glycosidic acid from seeds
Four new acylated glycosidic acid methyl esters and a new glycosidic acid from seeds
Resin glycosides, characteristic of plants of the Convolvulaceae family, are well-known purgative constituents found in tr...
Fungal protein D1 inhibits the proliferation of A549 cells via activating the p53/miR-34a signaling pathway
Fungal protein D1 inhibits the proliferation of A549 cells via activating the p53/miR-34a signaling pathway
Boletus bicolor is a kind of wild edible boletus, which is widely distributed in China. We have isolated the protein D1 fr...
Meroterpenes and prenylated acylphloroglucinol from the aerial parts of
Meroterpenes and prenylated acylphloroglucinol from the aerial parts of
Two previously undescribed specialized metabolites, erecricins F (1) and G (2), along with two known metabolites, erectumi...
SIRT5: a potential target for discovering bioactive natural products
SIRT5: a potential target for discovering bioactive natural products
Silent information regulator 5 (SIRT5) is the fifth member of the sirtuin family, which is mainly expressed in mi...
Potential -glucosidase inhibitors from cultures of SWUF15-40 fungus
Potential -glucosidase inhibitors from cultures of SWUF15-40 fungus
The search for a potent α-glucosidase inhibitor from the fungus Biscogniauxia capnodes SWUF15-40 yielded eighteen com...
New abietane-type diterpenoids from roots of and their cytotoxicity in human cancer cell
New abietane-type diterpenoids from roots of and their cytotoxicity in human cancer cell
Two new abietane-type diterpenoids, 6β-(3-furoyloxy)ferruginol (1) and 6-chloro-6,7-dehydroferruginol (2), were isola...
Grandifolins A–D: three 6/6/5 abietane diterpenes and an abietane diterpene from
Grandifolins A–D: three 6/6/5 abietane diterpenes and an abietane diterpene from
The genus Salvia is a well-established source of biologically active compounds with beneficial health effects. In this stu...
Leptomonines A and B, two novel rare benzyltetrahydroisoquinoline -oxides from the aerial parts of as potential COX-2 inhibitors: in vitro and in silico studies
Leptomonines A and B, two novel rare benzyltetrahydroisoquinoline -oxides from the aerial parts of as potential COX-2 inhibitors: in vitro and in silico studies
Leptomonines A and B, two novel rare benzyltetrahydroisoquinoline N-oxides, were isolated from the aerial parts of Leptopy...
Growth characteristics, optimal harvest timing, and quality assessment of three species cultivated in Japan
Growth characteristics, optimal harvest timing, and quality assessment of three species cultivated in Japan
Immature Evodia fruits are used in herbal medicine for their analgesic properties; however, determining the appropriate ti...
New oxepin and dihydrobenzofuran derivatives from roots and their anti-inflammatory, cytotoxic, and antioxidant activities
New oxepin and dihydrobenzofuran derivatives from roots and their anti-inflammatory, cytotoxic, and antioxidant activities
Four new oxepin and dihydrobenzofuran derivatives, saccoxepins A–C (1–3) and saccobenzofurin A (4), along with...
Correlation between the metabolic profile of Nelumbo Seed, a component of Seishinrenshiin, and its inhibitory activity on bladder smooth muscle contraction
Correlation between the metabolic profile of Nelumbo Seed, a component of Seishinrenshiin, and its inhibitory activity on bladder smooth muscle contraction
Seishinrenshiin (SRI), a Kampo formula, is often used for frequent urination. Nelumbo Seed, a crude-drug component of SRI ...
Multi-omics analysis reveals tissue-specific biosynthesis and accumulation of diterpene alkaloids in
Multi-omics analysis reveals tissue-specific biosynthesis and accumulation of diterpene alkaloids in
Aconitum japonicum, native to the mountainous regions of Japan, is a toxic perennial plant widely recognized for its thera...
Extraction, characterization, and biological activities of a novel polysaccharide extract from
Extraction, characterization, and biological activities of a novel polysaccharide extract from
This study showed that Polysaccharide-rich Fructus caryophylli extracts (FCE) were prepared for investigation through hot ...
Amide and phenylpropanoid glycosides from the fruits of L. and their anti-inflammatory activity
Amide and phenylpropanoid glycosides from the fruits of L. and their anti-inflammatory activity
Ten glycosidic compounds (1–10), including two novel amide glycosides and one new phenylpropanoid glycoside, were is...
Berberine diminishes the malignant progression of non-small cell lung cancer cells by targeting CDCA5 and CCNA2
Berberine diminishes the malignant progression of non-small cell lung cancer cells by targeting CDCA5 and CCNA2
Berberine (BBR), an isoquinoline alkaloid from Coptidis Rhizoma, possesses powerful activities against diverse human malig...
Anti-tumor effects of artemisinin-based oligomers: From monomer to trimer as a novel drug-enhancing strategy
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Synthesis and evaluation of triazole-containing aryl/acyloxy prodrugs of a BTN3A1 ligand
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Different chemical scaffolds bind to L-phe site in Mycobacterium tuberculosis Phe-tRNA synthetase
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Synthesis and evaluation of novel ebselen derivatives as urease inhibitors for combating Helicobacter pylori infections
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Discovery of 2,4-quinazolinedione derivatives as LC3B recruiters in the facilitation of protein complex degradations
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Structure-based design, synthesis and biological evaluation of a novel d-amino acid-containing peptide inhibitor by blocking the RAD51-BRCA2 interaction for the treatment of kidney cancer
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Anticancer activity promoted by ligand diversity in diiron thiocarbyne complexes
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Single or double lipid-modified ultra-short antimicrobial peptides for treating infections caused by resistant bacteria
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Structural optimization and characterization of highly potent and selective STAT3 inhibitors for the treatment of triple negative breast cancer
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Discovery of novel thiazole-pleuromutilin derivatives with potent antibacterial activity
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Discovery of naphthoquinone-furo-piperidone derivatives as dual targeting agents of STAT3 and NQO1 for the treatment of breast cancer
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Vitexin alleviates lipid metabolism disorders and hepatic injury in obese mice through the PI3K/AKT/mTOR/SREBP-1c pathway
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