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Structure–function insights of natural polysaccharides: advances in biosynthesis and functional food applications
Structure–function insights of natural polysaccharides: advances in biosynthesis and functional food applications
Ganoderma polysaccharides (GPs), derived from various species of the Ganoderma genus, exhibit diverse bioactivities, inclu...
Advanced RPL19-TRAP-seq method reveals mechanism of action of bioactive compounds
Advanced RPL19-TRAP-seq method reveals mechanism of action of bioactive compounds
Natural products play a crucial role in new drug development, but their druggability is often limited by uncertain molecul...
Emestrin-type epipolythiodioxopiperazines from with cytotoxic activities by regulating PI3K/AKT and mitochondrial apoptotic pathways
Emestrin-type epipolythiodioxopiperazines from with cytotoxic activities by regulating PI3K/AKT and mitochondrial apoptotic pathways
Five novel emestrin-type epipolythiodioxopiperazines (ETPs), prenylemestrins C−G (1–5), along with two known E...
Asprecosides A–J, ten new pentacyclic triterpenoid glycosides with cytotoxic activity from the roots of
Asprecosides A–J, ten new pentacyclic triterpenoid glycosides with cytotoxic activity from the roots of
Phytochemical study of the n-BuOH extract of Ilex asprella resulted in the discovery of ten new pentacyclic triterpenoid g...
Newly isolated terpenoids (covering 2019–2024) from species and their potential for the discovery of novel antimicrobials
Newly isolated terpenoids (covering 2019–2024) from species and their potential for the discovery of novel antimicrobials
The rapid emergence of drug-resistant microbial pathogens has posed challenges to global health in the twenty-first centur...
Vibralactone derivatives isolated from co-cultures of the basidiomycetes and
Vibralactone derivatives isolated from co-cultures of the basidiomycetes and
The basidiomycetes Stereum hirsutum and Boreostereum vibrans are two fungi of the same genus. In this study, chemical inve...
Identification and verification of methylenetetrahydrofolate dehydrogenase 1-like protein as the binding target of natural product pseudolaric acid A
Identification and verification of methylenetetrahydrofolate dehydrogenase 1-like protein as the binding target of natural product pseudolaric acid A
Natural product pseudolaric acid A (PAA), the main bioactive component from Traditional Chinese Medicine Pseudolarix corte...
Structurally diverse polyketides and alkaloids produced by a plant-derived fungus L1
Structurally diverse polyketides and alkaloids produced by a plant-derived fungus L1
A series of structurally diverse polyketides (1–3), sesterterpenoids (24 and 25), and alkaloids (26–34) were i...
Xylariaides A and B, novel cytochalasans with a unique 5/6/5/3 ring system from a soil fungus sp. Y01
Xylariaides A and B, novel cytochalasans with a unique 5/6/5/3 ring system from a soil fungus sp. Y01
Two new cytochalasans, xylariaides A (1) and B (2), were isolated and identified from a soil fungus Xylaria sp. Y01. Their...
Activation of SIK1 by phanginin A regulates skeletal muscle glucose uptake by phosphorylating HADC4/5/7 and enhancing GLUT4 expression and translocation
Activation of SIK1 by phanginin A regulates skeletal muscle glucose uptake by phosphorylating HADC4/5/7 and enhancing GLUT4 expression and translocation
Salt-inducible kinase 1 (SIK1) participates in various physiological processes, yet its involvement in regulating skeletal...
Natural anticancer agents: prospection of medicinal and aromatic plants in modern chemoprevention and chemotherapy
Natural anticancer agents: prospection of medicinal and aromatic plants in modern chemoprevention and chemotherapy
Natural products obtained from medicinal and aromatic plants are increasingly recognized as promising anticancer agents du...
Phthalide mono- and dimers from the rhizomes of and their anti-inflammatory activities
Phthalide mono- and dimers from the rhizomes of and their anti-inflammatory activities
Three pairs of enantiomeric phthalide dimers, including two new ones, angesicolides A (1) and B (2), and a new phthalide m...
Inhibitory effects of corylin derived from aerial part of on melanin synthesis and potential applications in skin whitening and photoaging management
Inhibitory effects of corylin derived from aerial part of on melanin synthesis and potential applications in skin whitening and photoaging management
This study aimed to investigate the potential of corylin, a bioactive compound isolated from the aerial part of Pueraria l...
Rational search for natural antimicrobial compounds: relevance of sesquiterpene lactones
Rational search for natural antimicrobial compounds: relevance of sesquiterpene lactones
Antimicrobial resistance is one of the most pressing global health challenges, as many pathogens are rapidly evolving to e...
New sesquiterpenoids with anti-inflammatory effects from phytopathogenic fungus 11134
New sesquiterpenoids with anti-inflammatory effects from phytopathogenic fungus 11134
Sesquiterpenoids represent a structurally diverse class of natural products widely recognized for their ecological signifi...
Therapeutic targeting of ocular diseases with emphasis on PI3K/Akt, and OPRL pathways by L. saponins: a new approach for the treatment of -induced bacterial keratitis
Therapeutic targeting of ocular diseases with emphasis on PI3K/Akt, and OPRL pathways by L. saponins: a new approach for the treatment of -induced bacterial keratitis
Pseudomonas aeruginosa-induced bacterial keratitis is one of the most sight-threatening corneal infections associated with...
Concise syntheses of natural diarylheptanoids containing a 1,4-pentadiene unit
Concise syntheses of natural diarylheptanoids containing a 1,4-pentadiene unit
Two concise and efficient synthetic routes were developed for the synthesis of three 1,7-diarylheptanoids (1–3) cont...
Six pairs of enantiomeric prenylated flavonoids with cytotoxic activities from Maxim
Six pairs of enantiomeric prenylated flavonoids with cytotoxic activities from Maxim
In this work, six pairs of undescribed enantiomeric prenylated flavonoids, ( ±)-epimesatines J–O (1a/1b&#...
Enantiomeric diarylheptanoids from var. and their -glucosidase inhibitory activity
Enantiomeric diarylheptanoids from var. and their -glucosidase inhibitory activity
Otteacumienes G–K (1–5), five pairs of enantiomeric diarylheptanoids, along with one undescribed diarylheptano...
Polyprenylated acylphloroglucinols from species and structural revision of seven analogues
Polyprenylated acylphloroglucinols from species and structural revision of seven analogues
Our continuous study of the fruits of Garcinia xanthochymus and Garcinia subelliptica led to the isolation and structural ...
A new diterpenoid, carneadiol, isolated from IFM 12324
A new diterpenoid, carneadiol, isolated from IFM 12324
A new diterpenoid, carneadiol (1), with an unprecedented tricyclic carbon skeleton, was isolated from the culture extracts...
Potent SARS-CoV-2 3C-like protease inhibitor ( +)-eupenoxide-3,6-diketone (IC: 0.048 μM) was synthesized based on ( +)-eupenoxide; lead from ( +)-eupenoxide analogs study by endophytic fermentation
Potent SARS-CoV-2 3C-like protease inhibitor ( +)-eupenoxide-3,6-diketone (IC: 0.048 μM) was synthesized based on ( +)-eupenoxide; lead from ( +)-eupenoxide analogs study by endophytic fermentation
Since the coronavirus disease 2019 (COVID-19) outbreak, research has been conducted on treatment and countermeasures again...
Biosynthesis of unique natural product scaffolds by Fe(II)/αKG-dependent oxygenases
Biosynthesis of unique natural product scaffolds by Fe(II)/αKG-dependent oxygenases
Fe(II)/αKG-dependent oxygenases are multifunctional oxidases responsible for the formation of unique natural product ...
Four new acylated glycosidic acid methyl esters and a new glycosidic acid from seeds
Four new acylated glycosidic acid methyl esters and a new glycosidic acid from seeds
Resin glycosides, characteristic of plants of the Convolvulaceae family, are well-known purgative constituents found in tr...
Fungal protein D1 inhibits the proliferation of A549 cells via activating the p53/miR-34a signaling pathway
Fungal protein D1 inhibits the proliferation of A549 cells via activating the p53/miR-34a signaling pathway
Boletus bicolor is a kind of wild edible boletus, which is widely distributed in China. We have isolated the protein D1 fr...
Meroterpenes and prenylated acylphloroglucinol from the aerial parts of
Meroterpenes and prenylated acylphloroglucinol from the aerial parts of
Two previously undescribed specialized metabolites, erecricins F (1) and G (2), along with two known metabolites, erectumi...
SIRT5: a potential target for discovering bioactive natural products
SIRT5: a potential target for discovering bioactive natural products
Silent information regulator 5 (SIRT5) is the fifth member of the sirtuin family, which is mainly expressed in mi...
Potential -glucosidase inhibitors from cultures of SWUF15-40 fungus
Potential -glucosidase inhibitors from cultures of SWUF15-40 fungus
The search for a potent α-glucosidase inhibitor from the fungus Biscogniauxia capnodes SWUF15-40 yielded eighteen com...
New abietane-type diterpenoids from roots of and their cytotoxicity in human cancer cell
New abietane-type diterpenoids from roots of and their cytotoxicity in human cancer cell
Two new abietane-type diterpenoids, 6β-(3-furoyloxy)ferruginol (1) and 6-chloro-6,7-dehydroferruginol (2), were isola...
Grandifolins A–D: three 6/6/5 abietane diterpenes and an abietane diterpene from
Grandifolins A–D: three 6/6/5 abietane diterpenes and an abietane diterpene from
The genus Salvia is a well-established source of biologically active compounds with beneficial health effects. In this stu...
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