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Synthesis and antibacterial activity of environmentally friendly sulfonium compounds
Synthesis and antibacterial activity of environmentally friendly sulfonium compounds
The abuse and overuse of antibacterial drugs have caused the increasing drug resistance of pathogenic bacteria, which thre...
Design, synthesis and insecticidal activities of novel m-diamide compounds containing n-propyl group
Design, synthesis and insecticidal activities of novel m-diamide compounds containing n-propyl group
To develop a structurally novel and efficient insecticide, a series of meta-diamide compounds incorporating n-propyl group...
Design, synthesis and antifungal study of novel 2-aryl-3,4-dihydroisoquinolin-2-ium salts containing benzoate moieties
Design, synthesis and antifungal study of novel 2-aryl-3,4-dihydroisoquinolin-2-ium salts containing benzoate moieties
To discover natural-derived fungicides, three series of 2-aryl-3,4-dihydroisoquinolinium salts (6–8) containing benz...
Uncaria-derived compounds for cancer treatment: mechanistic insights and therapeutic potential
Uncaria-derived compounds for cancer treatment: mechanistic insights and therapeutic potential
Uncaria is a traditional medicinal plant belonging to the Rubiaceae family, with a particularly strong presence in Asia, C...
Evaluation of cholinesterase enzyme inhibitory potential of dipterocarpol derivatives
Evaluation of cholinesterase enzyme inhibitory potential of dipterocarpol derivatives
Acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) - are depression and neurodegenerative diseases that target e...
Phytochemical constituents isolated from Silene popovii Schischk
Phytochemical constituents isolated from Silene popovii Schischk
In this work, with the aim to find new and biologically active natural compounds, the chemical content of the apolar and p...
Integrating omics data for personalized medicine in treating psoriasis
Integrating omics data for personalized medicine in treating psoriasis
Psoriasis is a chronic, multifactorial skin disorder characterized by the hyperproliferation of keratinocytes and persiste...
Thiophene ring-opening reactions. Part VII: synthesis and antitumor, anti-inflammatory, and antioxidant properties of 1,3,4‒thiadiazoline‒6-sulfanylthiopyran-4(1H)-one hybrids
Thiophene ring-opening reactions. Part VII: synthesis and antitumor, anti-inflammatory, and antioxidant properties of 1,3,4‒thiadiazoline‒6-sulfanylthiopyran-4(1H)-one hybrids
The reaction of N′’(aryl)benzothiohydrazides with 2-chloro-6-((substituted)amino)-3-nitro-4-oxo-4H-thieno[2,3-...
Triphenylphosphonium (TPP) conjugates of 1,2,3-triazolyl nucleoside analogues. Synthesis, cytotoxicity and antimicrobial activity
Triphenylphosphonium (TPP) conjugates of 1,2,3-triazolyl nucleoside analogues. Synthesis, cytotoxicity and antimicrobial activity
A series of new triphenylphosphonium (TPP) conjugates of 1,2,3-triazolyl nucleoside analogues were synthesised by coupling...
A guide for asymmetric synthesis of morphine alkaloids
A guide for asymmetric synthesis of morphine alkaloids
A collection of structurally related natural compounds derived from Papaver somniferum, the opium poppy, are known as the ...
Design and synthesis of aminothiazole-benzazole based amide: antiproliferative, antimigration activity and molecular docking studies
Design and synthesis of aminothiazole-benzazole based amide: antiproliferative, antimigration activity and molecular docking studies
In this study, we synthesized a series of amide-functionalized aminothiazole-benzazole analogs for potential application i...
Synthesis and biological assessment of triazolo-quinazoline carbothioamide derivatives for p38 MAP kinase inhibition: in-silico and in-vitro approaches
Synthesis and biological assessment of triazolo-quinazoline carbothioamide derivatives for p38 MAP kinase inhibition: in-silico and in-vitro approaches
A series of 4-Alkyl-5-oxo-N-(pyridin-3-yl)-4,5-dihydro [1,2,3] triazolo[1,5-a] quinazoline-3-carbothioamide compounds (8a-...
Synthesis, bacteria activity and molecular simulation of D-galactose-conjugated thiosemicarbazones of 3-aryl-4-formylsydnones
Synthesis, bacteria activity and molecular simulation of D-galactose-conjugated thiosemicarbazones of 3-aryl-4-formylsydnones
A series of D-galactose-conjugated substituted 4-formylsydnone thiosemicarbazones 4a-j were designed and synthesized from ...
α-Glucosidase inhibitory activities of aromatic compounds from the rhizomes of Alpinia galanga
α-Glucosidase inhibitory activities of aromatic compounds from the rhizomes of Alpinia galanga
Inhibition of α-glucosidase is a widely recognized approach for managing hyperglycemia, particularly postprandial glu...
Antivirulence therapy: type IV pilus as a druggable target for bacterial infections
Antivirulence therapy: type IV pilus as a druggable target for bacterial infections
Virulence is an organism’s ability to infect the host and cause disease, and this ability is determined by the prese...
Review: Chemical and biological features of genus Paralemnalia soft corals
Review: Chemical and biological features of genus Paralemnalia soft corals
Marine soft corals are plentiful sources of a wide range of natural products. They include an extensive array of chemical ...
Exploration of potential antihypertensive peptides derived from farmed Chinese giant salamander (Andrias davidianus)
Exploration of potential antihypertensive peptides derived from farmed Chinese giant salamander (Andrias davidianus)
The alcalase digestate of farmed Chinese giant salamander meat powder (FCGSMP) demonstrated antihypertensive properties th...
Characterization of Allium tuberosum Rottl. peptides with dual inhibitory activities against angiotensin I converting enzyme and dipeptidyl peptidase-IV
Characterization of Allium tuberosum Rottl. peptides with dual inhibitory activities against angiotensin I converting enzyme and dipeptidyl peptidase-IV
Two peptides with dual functionality, namely LLPSY and NAPALVY, exhibit inhibitory effects on both angiotensin-I-convertin...
Extraction and purification, pharmacological action, synthesis and product development of salidroside: a review
Extraction and purification, pharmacological action, synthesis and product development of salidroside: a review
Salidroside (Sal), a natural phenolic glycoside ubiquitous across all species of the Rhodiola genus, has garnered consider...
Design, synthesis and evaluation of imidazo[1,2-a]pyrazin-8(7H)-one derivatives as acetylcholinesterase inhibitors and antioxidants
Design, synthesis and evaluation of imidazo[1,2-a]pyrazin-8(7H)-one derivatives as acetylcholinesterase inhibitors and antioxidants
A series of 8-(piperazin-1-yl)imidazo[1,2-a]pyrazine derivatives were designed and synthesized as acetylcholinesterase inh...
Design and discovery of monopolar spindle kinase 1 (MPS1/TTK) inhibitors by computational approaches
Design and discovery of monopolar spindle kinase 1 (MPS1/TTK) inhibitors by computational approaches
Monopolar spindle kinase 1 (MPS1, also called TTK) is an attractive target for the treatment of cancers. Five MPS1 inhibit...
Anticancer potential of delphinidin and its derivatives: therapeutic and mechanistic insights
Anticancer potential of delphinidin and its derivatives: therapeutic and mechanistic insights
Anthocyanins are water-soluble naturally occurring flavonoids present in fruits, flowers, leaves, and roots of fruit plant...
Targeting selective inhibitors of PARPs in drug discovery and development
Targeting selective inhibitors of PARPs in drug discovery and development
Poly(ADP-ribose)polymerases (PARPs) have emerged as promising targets for the treatment of diseases, particularly in cance...
Synthesis and evaluation of novel biaryl oxazolidinones effective against gram-positive bacterial infections
Synthesis and evaluation of novel biaryl oxazolidinones effective against gram-positive bacterial infections
Oxazolidinones are synthetic antibiotic class of compounds characterized by chemical structure, cyclic carbamate with R...
Synthesis and antiproliferative activity of 7-substituted amide estradiol derivatives
Synthesis and antiproliferative activity of 7-substituted amide estradiol derivatives
The modification of the 7-position in the estradiol structure has drawn significant attention from pharmacologists. In thi...
Facile access to novel furoyl-based amide retroisoster inhibitors of LuxR-regulated quorum sensing: conformation analysis and docking studies
Facile access to novel furoyl-based amide retroisoster inhibitors of LuxR-regulated quorum sensing: conformation analysis and docking studies
A series of N-alkylfuran-2-carboxamide derivatives was easily prepared through direct acylation of diverse amines with 2-f...
Nafithromycin (MIQNAF®): ultramodern lactone ketolide designed to treat community acquired bacterial pneumonia (CABP)
Nafithromycin (MIQNAF®): ultramodern lactone ketolide designed to treat community acquired bacterial pneumonia (CABP)
Community acquired bacterial pneumoniae (CABP) infections is the major cause of mortality and morbidity, especially in eld...
Dauricine: a review of natural observation, pharmacology, and pharmacokinetics
Dauricine: a review of natural observation, pharmacology, and pharmacokinetics
Menispermum dauricum DC (the moonseed family Menispermaceae) was used to treat various diseases, such as inflammatory diso...
Design, synthesis and evaluation of sesamol-derived acetamides as dual inhibitors of monoamine oxidases and cholinesterases
Design, synthesis and evaluation of sesamol-derived acetamides as dual inhibitors of monoamine oxidases and cholinesterases
A set of sesamol-derived acetamides was designed, synthesized, and evaluated against monoamine oxidases (MAO-A and MAO-B) ...
Synthesis and evaluation of 2-methylbenzothiazole derivatives as monoamine oxidase inhibitors
Synthesis and evaluation of 2-methylbenzothiazole derivatives as monoamine oxidase inhibitors
Neurodegenerative disorders are caused by the progressive death of neuronal cells in specific regions of the brain and spi...
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