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Partner’s dual use of new tobacco products and combustible cigarettes in early pregnancy was associated with hypertensive disorders of pregnancy: a cross-sectional study
Partner’s dual use of new tobacco products and combustible cigarettes in early pregnancy was associated with hypertensive disorders of pregnancy: a cross-sectional study
It is an urgent issue to clarify whether new tobacco products have adverse pregnancy effects. As far as we know, however, ...
Sodium-glucose co-transporter 2 inhibitor-induced increase in adenosine promotes lipolysis and weight reduction by activating reno-adipose autonomic neurocircuitry
Sodium-glucose co-transporter 2 inhibitor-induced increase in adenosine promotes lipolysis and weight reduction by activating reno-adipose autonomic neurocircuitry
Sodium-glucose co-transporter 2 (SGLT2) inhibitors promote weight loss in patients with type 2 diabetes mellitus; however,...
From binary to gradient: EUS-RFA redefines primary aldosteronism therapy
From binary to gradient: EUS-RFA redefines primary aldosteronism therapy
EUS-RFA redefines PA treatment, shifting from a binary (surgery or drugs) to a gradient paradigm (ablation, drugs, surgery...
Synchronizing science and society: JSH2025 Guidelines × “Asakatsu BP” action – Morning Blood Pressure 130 Campaign
Synchronizing science and society: JSH2025 Guidelines × “Asakatsu BP” action – Morning Blood Pressure 130 Campaign
The “Asakatsu BP” action - Morning Blood Pressure 130 Campaign is a society-wide awareness initiative spearheaded by JSH, ...
South Korea vs. Japan: participation in the 10th Annual Meeting of the Korean Society of Clinical Hypertension
South Korea vs. Japan: participation in the 10th Annual Meeting of the Korean Society of Clinical Hypertension
We would like to express our sincere gratitude to Dr. Tomohiro Katsuya (Chairman of Practitioners Subcommittee in the JSH)...
JSH2025 guidelines new viewpoints
Ohya Y, et al. Japanes Society of Hypertension Guidelines for the management of elevated blood pressure and hypertension 2...
Urinary sodium-to-potassium ratio as a marker for apparent treatment-resistant hypertension in patients with chronic kidney disease
Urinary sodium-to-potassium ratio as a marker for apparent treatment-resistant hypertension in patients with chronic kidney disease
Adrogué HJ, Madias NE. Sodium and potassium in the pathogenesis of hypertension. N Engl J Med. 2007;356:1966–78.PubMed  ...
Blood pressure control and treatment status at 1 year after the first health check-up in individuals with observed referral-level blood pressure
Blood pressure control and treatment status at 1 year after the first health check-up in individuals with observed referral-level blood pressure
Hypertension is a major risk factor for cardiovascular diseases. This study aimed to clarify blood pressure (BP) managemen...
Endothelial transcriptomic, epigenomic and proteomic data challenge the proposed role for TSAd in vascular permeability
Endothelial transcriptomic, epigenomic and proteomic data challenge the proposed role for TSAd in vascular permeability
The vascular endothelial growth factor VEGF drives excessive vascular permeability to cause tissue-damaging oedema in neov...
Microvascular and cerebrovascular alterations in Raynaud’s phenomenon and fibromyalgia
Microvascular and cerebrovascular alterations in Raynaud’s phenomenon and fibromyalgia
Consent for publication Written informed consent was obtain...
Endothelial USP11 drives VEGFR2 signaling and angiogenesis via PRDX2/c-MYC axis
Endothelial USP11 drives VEGFR2 signaling and angiogenesis via PRDX2/c-MYC axis
Angiogenesis is a crucial component of various physiological and pathological processes, including embryonic development, ...
ApoM-bound S1P acts via endothelial S1PR1 to suppress choroidal neovascularization and vascular leakage
ApoM-bound S1P acts via endothelial S1PR1 to suppress choroidal neovascularization and vascular leakage
Neovascular age-related macular degeneration (nAMD) is a major cause of vision loss worldwide. Current standard of care is...
G protein-coupled receptor GPR182 negatively regulates sprouting angiogenesis via modulating CXCL12-CXCR4 axis signaling
G protein-coupled receptor GPR182 negatively regulates sprouting angiogenesis via modulating CXCL12-CXCR4 axis signaling
Angiogenesis is a critical process for tumor progression, regulated by various signaling pathways. Although antiangiogenic...
The VEGF decoy receptor soluble Fms-like tyrosine kinase 1 binds to macrophages
The VEGF decoy receptor soluble Fms-like tyrosine kinase 1 binds to macrophages
Soluble Fms-like Tyrosine kinase-1 (sFLT1) is a native inhibitor of VEGF, best known for its antiangiogenic effects in pre...
SDF-1α mRNA therapy in peripheral artery disease
SDF-1α mRNA therapy in peripheral artery disease
Stromal cell-derived factor-1 alpha (SDF-1α) is a promising target for therapeutic angiogenesis in ischemic diseases ...
Acute aortic dissection in a patient with Hereditary Hemorrhagic Telangiectasia associated with Juvenile Polyposis due to SMAD4 mutation: case report and literature review
Acute aortic dissection in a patient with Hereditary Hemorrhagic Telangiectasia associated with Juvenile Polyposis due to SMAD4 mutation: case report and literature review
We present a novel case of concurrent Hereditary Hemorrhagic Telangiectasia-Juvenile Polyposis Syndrome (HHT-JP), resultin...
Mixed lineage kinase (MLK) controls tumor development and angiogenesis
Mixed lineage kinase (MLK) controls tumor development and angiogenesis
Cancer is among the leading causes of death in the USA and worldwide. Solid tumors require the formation of new blood vess...
Human endothelial colony forming cells (ECFCs) require endothelial protein C receptor (EPCR) for cell cycle progression and angiogenic activity
Human endothelial colony forming cells (ECFCs) require endothelial protein C receptor (EPCR) for cell cycle progression and angiogenic activity
Vascular repair and regeneration are critical for tissue homeostasis. Endothelial colony forming cells (ECFCs) are vessel-...
Polysialic acid regulates glomerular microvasculature formation by interaction with VEGF-A188 in mice
Polysialic acid regulates glomerular microvasculature formation by interaction with VEGF-A188 in mice
Vascular endothelial growth factor A (VEGF-A) is a key signalling protein that stimulates blood vessel development and rep...
High-throughput differentiation of human blood vessel organoids reveals overlapping and distinct functions of the cerebral cavernous malformation proteins
High-throughput differentiation of human blood vessel organoids reveals overlapping and distinct functions of the cerebral cavernous malformation proteins
Cerebral cavernous malformations (CCMs) are clusters of thin-walled enlarged blood vessels in the central nervous system t...
An endothelial specific mouse model for the capillary malformation mutation p.R183Q
An endothelial specific mouse model for the capillary malformation mutation p.R183Q
Capillary malformation (CM) is a congenital, non-hereditary lesion composed of enlarged and tortuous blood vessels. CM is ...
Diversity of extracellular vesicle sources in atherosclerosis: role and therapeutic application
Diversity of extracellular vesicle sources in atherosclerosis: role and therapeutic application
Extracellular vesicles (EVs) are phospholipid bilayer membrane structures secreted by cells and widely present in blood or...
Genetic deletion of microRNA-15a/16-1 in pericytes stimulates cerebral angiogenesis and promotes functional recovery after ischemic stroke
Genetic deletion of microRNA-15a/16-1 in pericytes stimulates cerebral angiogenesis and promotes functional recovery after ischemic stroke
Stroke is a leading cause of mortality and disability globally. Despite advancements in acute stroke therapies, patient ou...
Endothelial GTPBP3 directs developmental angiogenesis and neovascularization after limb ischemia via the mtROS/HRl/ATF4/mTORC1 axis
Endothelial GTPBP3 directs developmental angiogenesis and neovascularization after limb ischemia via the mtROS/HRl/ATF4/mTORC1 axis
GTP binding protein 3 (GTPBP3) is a highly conserved enzyme involved in tRNA modification, is essential for 5-taurinomethy...
Proteoglycans and glycosaminoglycans: critical regulators in angiogenesis, vasculogenesis, and vascularized tissue engineering
Proteoglycans and glycosaminoglycans: critical regulators in angiogenesis, vasculogenesis, and vascularized tissue engineering
Reconstruction of the microvascular network is essential for tissue regeneration and functional repair. However, inadequat...
Mechanistic insights into endometriosis: roles of and L-carnitine in lesion development and angiogenesis
Mechanistic insights into endometriosis: roles of and L-carnitine in lesion development and angiogenesis
Retrograde menstruation is a widely recognized etiological factor for endometriosis (EMs); however, it is not the sole cau...
Semaphorin 3A protects against thoracic aortic aneurysm dissection by suppressing aortic angiogenesis
Semaphorin 3A protects against thoracic aortic aneurysm dissection by suppressing aortic angiogenesis
Thoracic aortic aneurysm (TAA) is life-threatening once developing to sudden dissection (TAAD) or rupture. The pathogenesi...
In vivo profiling of the endothelium using ‘AngioTag’ zebrafish
In vivo profiling of the endothelium using ‘AngioTag’ zebrafish
Vascular endothelial cells in vivo are exquisitely regulated by their local environment, which is disrupted or absent when...
Baroreceptor sensitivity, kidney function and cardiovascular risk in prepubescent boys with normal versus elevated blood pressure
Baroreceptor sensitivity, kidney function and cardiovascular risk in prepubescent boys with normal versus elevated blood pressure
In children reduced baroreceptor sensitivity (BRS) has been linked to obesity but not blood pressure (BP). Offspring of hy...
Long-term effect of continuous positive airway pressure on blood pressure in patients with resistant hypertension and obstructive sleep apnea
Long-term effect of continuous positive airway pressure on blood pressure in patients with resistant hypertension and obstructive sleep apnea
Continuous Positive Airway Pressure (CPAP) is the gold standard treatment for Obstructive Sleep Apnea (OSA). Its long-term...
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