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Impact of Selective Peroxisome Proliferator-Activated Receptor (PPAR)-α Modulators and Fibrates on Microvascular Disease: Is There Still Room?
Impact of Selective Peroxisome Proliferator-Activated Receptor (PPAR)-α Modulators and Fibrates on Microvascular Disease: Is There Still Room?
This review examines the role of fibrates and the selective PPAR-alpha modulators (SPPARM-α), pemafibrate, in diabeti...
Insight into the Mechanistic role of Colchicine in Atherosclerosis
Insight into the Mechanistic role of Colchicine in Atherosclerosis
Globally, the prevalence of atherosclerosis (AS) is rising. Currently, there is no specific drug for AS. Therefore, this r...
Managing Dyslipidemia in Chronic Kidney Disease: Implications for Cardiovascular and Renal Risk
Managing Dyslipidemia in Chronic Kidney Disease: Implications for Cardiovascular and Renal Risk
The review aims to address the complex relationship between dyslipidemia and chronic kidney disease (CKD), emphasizing its...
Inflammation-Driven Plaque Erosion in Atherosclerosis: A Focus on Complement System Pathways
Inflammation-Driven Plaque Erosion in Atherosclerosis: A Focus on Complement System Pathways
Complement system activation is implicated in various stages of atherogenesis, from fatty streak formation to plaque desta...
Remnant Cholesterol: Should it be a Target for Prevention of ASCVD?
Remnant Cholesterol: Should it be a Target for Prevention of ASCVD?
To summarize studies analyzing whether remnant cholesterol should be a target for prevention of atherosclerotic cardiovasc...
Familial Combined Hyperlipidemia: Myth or Reality?
Familial Combined Hyperlipidemia: Myth or Reality?
Familial combined hyperlipidemia (FCHL) was first described by Goldstein and co-workers in 1973 as a multiple-type hyperli...
The Atherosclerotic Plaque Microenvironment as a Therapeutic Target
The Atherosclerotic Plaque Microenvironment as a Therapeutic Target
Atherosclerosis is traditionally viewed as a disease triggered by lipid accumulation, but growing evidence underscores the...
Role of Aspirin in Reducing Risk for Atherosclerotic Cardiovascular Disease in Individuals with Elevated Lipoprotein(a)
Role of Aspirin in Reducing Risk for Atherosclerotic Cardiovascular Disease in Individuals with Elevated Lipoprotein(a)
Elevated Lp(a) is associated with increased risk for atherosclerotic cardiovascular disease (ASCVD), and there is currentl...
Anti-Inflammatory Lipid Mediators from Polyunsaturated Fatty Acids: Insights into their Role in Atherosclerosis Microenvironments
Anti-Inflammatory Lipid Mediators from Polyunsaturated Fatty Acids: Insights into their Role in Atherosclerosis Microenvironments
Inflammation has become a major residual risk factor for atherosclerotic cardiovascular disease (ASCVD). Certain lipid med...
Novel Therapeutics for Familial Chylomicronemia Syndrome
Novel Therapeutics for Familial Chylomicronemia Syndrome
This review discusses new treatment approaches for familial chylomicronemia syndrome (FCS), a rare disorder affecting trig...
Statin Use in Special Populations for the Prevention of Cardiovascular Disease in Adults
Statin Use in Special Populations for the Prevention of Cardiovascular Disease in Adults
Outcome benefits for HMG-CoA reductase inhibitor (statin) use in the prevention of atherosclerotic cardiovascular disease ...
Diagnosis and Management of Genetic Lipodystrophy Syndromes and its Implications for Atherosclerosis
Diagnosis and Management of Genetic Lipodystrophy Syndromes and its Implications for Atherosclerosis
This paper explores the diagnostic and management challenges associated with genetic lipodystrophy syndromes (LDs) and the...
Arteries and Hearts in Motion: Sex Differences in Exercise-Mediated Protection Against Atherosclerotic Cardiovascular Disease Risk
Arteries and Hearts in Motion: Sex Differences in Exercise-Mediated Protection Against Atherosclerotic Cardiovascular Disease Risk
This review summarizes the current knowledge on the benefits of various exercise training modalities on subclinical athero...
Myeloid Cells in Abdominal Aortic Aneurysm
Myeloid Cells in Abdominal Aortic Aneurysm
Abdominal aortic aneurysm (AAA) is a life-threatening vascular disorder with high mortality upon rupture, yet effective ph...
Health Data Sciences and Cardiovascular Disease in Africa: Needs and the Way Forward
Health Data Sciences and Cardiovascular Disease in Africa: Needs and the Way Forward
The rising burden of cardiovascular disease (CVD) in Africa is of great concern. Health data sciences is a rapidly develop...
Health Data Sciences and Cardiovascular Diseases in South Asia: Innovations and Challenges in Digital Health
Health Data Sciences and Cardiovascular Diseases in South Asia: Innovations and Challenges in Digital Health
Health data sciences can help mitigate high burden of cardiovascular disease (CVD) management in South Asia by increasing ...
Do Statins Affect Cognitive Health? A Narrative Review and Critical Analysis of the Evidence
Do Statins Affect Cognitive Health? A Narrative Review and Critical Analysis of the Evidence
Statins are the first-line treatment for hypercholesterolemia and play a key role in the prevention of cardiovascular dise...
The Role of Iron in Atherosclerosis and its Association with Related Diseases
The Role of Iron in Atherosclerosis and its Association with Related Diseases
This review aims to elucidate the multifaceted role of iron in the pathogenesis of atherosclerosis. The primary objective ...
The Emerging Potential of Apolipoprotein C-III Inhibition for ASCVD Prevention: A State-of-the-Art Review
The Emerging Potential of Apolipoprotein C-III Inhibition for ASCVD Prevention: A State-of-the-Art Review
Multiple agents are being developed that inhibit apolipoprotein (apo) C-III. This state-of-the-art review examines their p...
Erosion of the Atheroma: Wicked T Cells at the Culprit Site
Erosion of the Atheroma: Wicked T Cells at the Culprit Site
There is a growing recognition of plaque erosion as a cause of acute coronary syndrome. This review aims to examine the po...
Statin-Associated Muscle Symptoms: Identification and Recommendations for Management
Statin-Associated Muscle Symptoms: Identification and Recommendations for Management
Statins are first-line pharmacotherapy for the treatment of elevated low-density lipoprotein cholesterol and are generally...
Inhibition of the ANGPTL3/8 Complex for the Prevention and Treatment of Atherosclerotic Cardiovascular Disease
Inhibition of the ANGPTL3/8 Complex for the Prevention and Treatment of Atherosclerotic Cardiovascular Disease
Dyslipidemia is a casual risk factor for atherosclerotic cardiovascular disease (ASCVD). There is an unmet need for more e...
Role of RNA-binding Proteins in Regulating Cell Adhesion and Progression of the Atherosclerotic Plaque and Plaque Erosion
Role of RNA-binding Proteins in Regulating Cell Adhesion and Progression of the Atherosclerotic Plaque and Plaque Erosion
RNA-binding proteins (RBPs) have emerged as crucial regulators of post-transcriptional processes, influencing the fate of ...
Bridging the Gap: How Accounting for Social Determinants of Health Can Improve Digital Health Equity in Cardiovascular Medicine
Bridging the Gap: How Accounting for Social Determinants of Health Can Improve Digital Health Equity in Cardiovascular Medicine
In this review, we discuss the importance of digital health equity and how social determinants of health (and intersection...
Lp(a): A Rapidly Evolving Therapeutic Landscape
Lp(a): A Rapidly Evolving Therapeutic Landscape
Elevated lipoprotein(a) (Lp[a]) is a genetically determined cardiovascular risk factor, causally linked to both atheroscle...
Pericoronary Fat Attenuation: Diagnosis and Clinical Implications
Pericoronary Fat Attenuation: Diagnosis and Clinical Implications
The purpose of this review is to evaluate the current state of knowledge regarding the technical challenges associated wit...
PCSK9 Monoclonal Antibodies Have Come a Long Way
PCSK9 Monoclonal Antibodies Have Come a Long Way
This review examines the pivotal role of monoclonal antibodies against PCSK9 in lipid-lowering therapy, emphasizing their ...
Targeting Inflammatory Pathways in Atherosclerosis: Exploring New Opportunities for Treatment
Targeting Inflammatory Pathways in Atherosclerosis: Exploring New Opportunities for Treatment
This review discusses the molecular mechanisms involved in the immuno-pathogenesis of atherosclerosis, the pleiotropic ant...
Psychological Health and Ischemic Heart Disease in Women: A Review of Current Evidence and Clinical Considerations across the Healthspan
Psychological Health and Ischemic Heart Disease in Women: A Review of Current Evidence and Clinical Considerations across the Healthspan
Psychological health encompasses a constellation of negative and positive factors—i.e., psychosocial stress, depress...
How Will Our Practice Change After the CLEAR Outcomes Trial?
How Will Our Practice Change After the CLEAR Outcomes Trial?
Bempedoic acid is a novel therapeutic agent that is designed to reduce levels of low-density lipoprotein cholesterol (LDL-...
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