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Differential effects of young and old hematopoietic stem cell niches on bone marrow-derived dendritic cells
Differential effects of young and old hematopoietic stem cell niches on bone marrow-derived dendritic cells
Aging is linked to various dysfunctions of the immune system, including the decline of its primary developmental source: t...
Aging modulates the immunosuppressive, polarizing and metabolic functions of blood-derived myeloid-derived suppressor cells (MDSCs)
Aging modulates the immunosuppressive, polarizing and metabolic functions of blood-derived myeloid-derived suppressor cells (MDSCs)
Immunosenescence describes the gradual remodeling of immune responses, leading to disturbed immune homeostasis and increas...
p38 mitogen-activated protein kinase drives senescence in CD4+ T lymphocytes and increases their pathological potential
p38 mitogen-activated protein kinase drives senescence in CD4+ T lymphocytes and increases their pathological potential
In several diseases, senescent T lymphocytes increase in number and release a senescence-associated secretory phenotype (S...
Ageing and dysregulated lung immune responses in fatal COVID-19
Ageing and dysregulated lung immune responses in fatal COVID-19
Elderly individuals were disproportionally affected during the COVID-19 pandemic, and more than 80% of the global COVID-19...
Qifuyin against CCL11-Induced cognitive impairment by inhibiting microglial senescence via CCR3 signaling
Qifuyin against CCL11-Induced cognitive impairment by inhibiting microglial senescence via CCR3 signaling
The chemokine CCL11 is negatively correlated with cognitive function and is able to cause dysfunctions of synaptic plastic...
Impact of lifestyle factors on quantitative motor and cognitive performance: insights from a longitudinal study on healthy ageing
Impact of lifestyle factors on quantitative motor and cognitive performance: insights from a longitudinal study on healthy ageing
The process of ageing is extremely variable in progression and phenotypic features including significant variations in dis...
Synaptic pruning genes networks in Alzheimer’s disease: correlations with neuropathology and cognitive decline
Synaptic pruning genes networks in Alzheimer’s disease: correlations with neuropathology and cognitive decline
Synaptic pruning (SP) is a critical process in brain development and maintenance, essential for refining neural circuits b...
Linking sleep microstructure, blood markers of inflammation and metabolism, and cognition: mediation analysis in the osteoporotic fractures in men study
Linking sleep microstructure, blood markers of inflammation and metabolism, and cognition: mediation analysis in the osteoporotic fractures in men study
The sleep electroencephalographic (EEG) microstructure is explicitly related to brain functions, such as sleep spindle and...
Age-independent anti-angiogenic therapy for choroidal neovascularization by targeting secretogranin III
Age-independent anti-angiogenic therapy for choroidal neovascularization by targeting secretogranin III
Recent studies reported that anti-angiogenic drugs targeting vascular endothelial growth factor (VEGF) alleviate choroidal...
HealthAge: evaluation of intrinsic capacity changes in humans, mice, and killifish to explore the biology of aging
HealthAge: evaluation of intrinsic capacity changes in humans, mice, and killifish to explore the biology of aging
HealthAge was devised by a conglomerate of research groups in Toulouse, France, with the combined goal of narrowing the li...
Associations of physical frailty and polygenic score with incident heart failure in cardiovascular patients: unraveling the mediating role of inflammation
Associations of physical frailty and polygenic score with incident heart failure in cardiovascular patients: unraveling the mediating role of inflammation
Older adults with established cardiovascular diseases (CVD) are at elevated risk of heart failure (HF). Frailty, a hallmar...
Plasma p-tau231 and NfL differently associate with functional connectivity patterns in cognitively unimpaired individuals
Plasma p-tau231 and NfL differently associate with functional connectivity patterns in cognitively unimpaired individuals
Amid the rising relevance of early and non-invasive markers for neurodegenerative diseases, such as Alzheimer’s dise...
Proteoglycan-4 (PRG4) serum concentration is lower in aged mice, and genetic deficiency impacts survival probability, blood parameters, and bone during aging
Proteoglycan-4 (PRG4) serum concentration is lower in aged mice, and genetic deficiency impacts survival probability, blood parameters, and bone during aging
Proteoglycan 4 (PRG4) is a mucin-like glycoprotein best known as a boundary lubricant of articular cartilage; however, it ...
NRF2 pathway activation predicts poor prognosis in lung cancer: a cautionary note on antioxidant interventions
NRF2 pathway activation predicts poor prognosis in lung cancer: a cautionary note on antioxidant interventions
Lung cancer is a leading cause of cancer-related mortality worldwide. As an age-related disease, its pathogenesis is shape...
Cognitive decline before and after incident chronic respiratory disease
Cognitive decline before and after incident chronic respiratory disease
Few studies have comprehensively measured the changes in cognition occurring in the years before and after the onset of sp...
Rapid repetitive syllable sounds associate with episodic memory, executive function, and working memory in cognitively healthy and subjectively impaired older adults
Rapid repetitive syllable sounds associate with episodic memory, executive function, and working memory in cognitively healthy and subjectively impaired older adults
Non-invasive screening tools for Alzheimer’s disease (AD) risk are needed. Decline in episodic memory and subjective...
Indicators of mortality risk in ageing horses
Indicators of mortality risk in ageing horses
Clinical care for patients with limited life expectancy often requires adjustments, prioritizing immediate benefits over l...
Misalignment of age clocks
Misalignment of age clocks
Biological aging is a complex non-linear process, with markedly distinct starting and end points, yet the biomarkers of it...
Quinacrine and rimonabant prolong the life span of
Quinacrine and rimonabant prolong the life span of
Aging and age-related disorders are significant global health concerns, driving interest in potential preventative strateg...
Admission of Older Patients to Geriatric Inpatient Care from the Emergency Department Compared with Admission through Acute Medical Unit: Cost and Length of Stay Outcomes
Admission of Older Patients to Geriatric Inpatient Care from the Emergency Department Compared with Admission through Acute Medical Unit: Cost and Length of Stay Outcomes
To investigate whether direct admission to geriatric inpatient care from the emergency department (EMD) was associated wit...
Most Hospital-Acquired Complications among Older Adults Are Associated with Frailty: The South-Western Sydney Frailty and Hospital-Acquired Complications Study
Most Hospital-Acquired Complications among Older Adults Are Associated with Frailty: The South-Western Sydney Frailty and Hospital-Acquired Complications Study
People live longer, and frailty has become an important problem in the acute hospital setting. Increasingly the associatio...
Evaluation of Handgrip Strength Asymmetry to Assess Sarcopenia in Older Patients with Chronic Low Back Pain: A Retrospective Cross-Sectional Study
Evaluation of Handgrip Strength Asymmetry to Assess Sarcopenia in Older Patients with Chronic Low Back Pain: A Retrospective Cross-Sectional Study
Handgrip strength (HGS) is a crucial measurement for diagnosing sarcopenia, and HGS asymmetry indicates functional impairm...
Muscle Strength Matters Most for Risk of Falling Apart from Body Mass Index in Older Adults: A Mediated-Moderation Analysis
Muscle Strength Matters Most for Risk of Falling Apart from Body Mass Index in Older Adults: A Mediated-Moderation Analysis
The primary objective of this study was to analyze the moderating effect of body mass index (BMI) on the association betwe...
The Relationship between Leisure Time Physical Activity and Cognitive Function in Older Americans
The Relationship between Leisure Time Physical Activity and Cognitive Function in Older Americans
This study aims to investigate the correlation between leisure-time physical activity (LTPA) and cognitive function in old...
Exploring the Role of Antibiotics in Hospice Care
Exploring the Role of Antibiotics in Hospice Care
The decision regarding the use of antibiotics in hospice care, whether to initiate, defer, or discontinue therapy, present...
Prevalence and natural course of incidental gastric subepithelial tumors
Table 1. Comparison of baseline demographics and clinical characteristics between the stable gastric and pro...
Jejunal Dieulafoy
Fig. 1. Push enteroscopy reveals a 2.5 cm round subepithelial mass with a large central defect covered ...
Safety and efficacy of novel oblique-viewing scope for B2-endoscopic ultrasound-guided ...
Fig. 1. Flowchart of patient selection. B2, bile duct segment 2; EUS-HGS, endoscopic ultrasound-guided ...
Development of a predictive model for hypoxia due to sedatives in gastrointestinal endoscopy: a ...
Table 1. Comparison of baseline characteristics between patients with hypoxia (+) group and hypoxia (-) grou...
Is your endoscopist qualified enough to detect Helicobacter pylori-naive status?
Department of Internal Medicine, Konkuk University School of Medicine, Seoul, Korea Corre...
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