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Impact of lifestyle factors on quantitative motor and cognitive performance: insights from a longitudinal study on healthy ageing
Impact of lifestyle factors on quantitative motor and cognitive performance: insights from a longitudinal study on healthy ageing
The process of ageing is extremely variable in progression and phenotypic features including significant variations in dis...
Synaptic pruning genes networks in Alzheimer’s disease: correlations with neuropathology and cognitive decline
Synaptic pruning genes networks in Alzheimer’s disease: correlations with neuropathology and cognitive decline
Synaptic pruning (SP) is a critical process in brain development and maintenance, essential for refining neural circuits b...
Linking sleep microstructure, blood markers of inflammation and metabolism, and cognition: mediation analysis in the osteoporotic fractures in men study
Linking sleep microstructure, blood markers of inflammation and metabolism, and cognition: mediation analysis in the osteoporotic fractures in men study
The sleep electroencephalographic (EEG) microstructure is explicitly related to brain functions, such as sleep spindle and...
Age-independent anti-angiogenic therapy for choroidal neovascularization by targeting secretogranin III
Age-independent anti-angiogenic therapy for choroidal neovascularization by targeting secretogranin III
Recent studies reported that anti-angiogenic drugs targeting vascular endothelial growth factor (VEGF) alleviate choroidal...
HealthAge: evaluation of intrinsic capacity changes in humans, mice, and killifish to explore the biology of aging
HealthAge: evaluation of intrinsic capacity changes in humans, mice, and killifish to explore the biology of aging
HealthAge was devised by a conglomerate of research groups in Toulouse, France, with the combined goal of narrowing the li...
Associations of physical frailty and polygenic score with incident heart failure in cardiovascular patients: unraveling the mediating role of inflammation
Associations of physical frailty and polygenic score with incident heart failure in cardiovascular patients: unraveling the mediating role of inflammation
Older adults with established cardiovascular diseases (CVD) are at elevated risk of heart failure (HF). Frailty, a hallmar...
Plasma p-tau231 and NfL differently associate with functional connectivity patterns in cognitively unimpaired individuals
Plasma p-tau231 and NfL differently associate with functional connectivity patterns in cognitively unimpaired individuals
Amid the rising relevance of early and non-invasive markers for neurodegenerative diseases, such as Alzheimer’s dise...
Proteoglycan-4 (PRG4) serum concentration is lower in aged mice, and genetic deficiency impacts survival probability, blood parameters, and bone during aging
Proteoglycan-4 (PRG4) serum concentration is lower in aged mice, and genetic deficiency impacts survival probability, blood parameters, and bone during aging
Proteoglycan 4 (PRG4) is a mucin-like glycoprotein best known as a boundary lubricant of articular cartilage; however, it ...
NRF2 pathway activation predicts poor prognosis in lung cancer: a cautionary note on antioxidant interventions
NRF2 pathway activation predicts poor prognosis in lung cancer: a cautionary note on antioxidant interventions
Lung cancer is a leading cause of cancer-related mortality worldwide. As an age-related disease, its pathogenesis is shape...
Cognitive decline before and after incident chronic respiratory disease
Cognitive decline before and after incident chronic respiratory disease
Few studies have comprehensively measured the changes in cognition occurring in the years before and after the onset of sp...
Rapid repetitive syllable sounds associate with episodic memory, executive function, and working memory in cognitively healthy and subjectively impaired older adults
Rapid repetitive syllable sounds associate with episodic memory, executive function, and working memory in cognitively healthy and subjectively impaired older adults
Non-invasive screening tools for Alzheimer’s disease (AD) risk are needed. Decline in episodic memory and subjective...
Indicators of mortality risk in ageing horses
Indicators of mortality risk in ageing horses
Clinical care for patients with limited life expectancy often requires adjustments, prioritizing immediate benefits over l...
Misalignment of age clocks
Misalignment of age clocks
Biological aging is a complex non-linear process, with markedly distinct starting and end points, yet the biomarkers of it...
Quinacrine and rimonabant prolong the life span of
Quinacrine and rimonabant prolong the life span of
Aging and age-related disorders are significant global health concerns, driving interest in potential preventative strateg...
Dynamics of serum exosome microRNA profile altered by chemically induced estropause and rescued by estrogen therapy in female mice
Dynamics of serum exosome microRNA profile altered by chemically induced estropause and rescued by estrogen therapy in female mice
The decline in the ovarian reserve leads to menopause and reduced serum estrogens. MicroRNAs are small non-coding RNAs, wh...
Combined aerobic and strength exercise training on biological ageing in Singaporean breast cancer patients: protocol for the Breast Cancer Exercise Intervention (BREXINT) Pilot Study
Combined aerobic and strength exercise training on biological ageing in Singaporean breast cancer patients: protocol for the Breast Cancer Exercise Intervention (BREXINT) Pilot Study
Breast cancer (BC) is the most prominent cancer amongst women, but fortunately, early diagnosis and advances in multimodal...
Neuroanatomical substrates of depression in dementia with Lewy bodies and Alzheimer’s disease
Neuroanatomical substrates of depression in dementia with Lewy bodies and Alzheimer’s disease
Dementia with Lewy bodies (DLB) and Alzheimer’s disease (AD) are often associated with depressive symptoms from the ...
Short lifespan is one’s fate, long lifespan is one’s achievement: lessons from Daphnia
Short lifespan is one’s fate, long lifespan is one’s achievement: lessons from Daphnia
Studies of longevity rely on baseline life expectancy of reference genotypes measured in standardized conditions. Variatio...
Rotating magnetic field improved cognitive and memory impairments in a sporadic ad model of mice by regulating microglial polarization
Rotating magnetic field improved cognitive and memory impairments in a sporadic ad model of mice by regulating microglial polarization
Neuroinflammation, triggered by aberrantly activated microglia, is widely recognized as a key contributor to the initiatio...
Repetitive element transcript accumulation is associated with inflammaging in humans
Repetitive element transcript accumulation is associated with inflammaging in humans
Chronic, low-grade inflammation increases with aging, contributing to functional declines and diseases that reduce healths...
Systemic metabolic benefits of 17α-estradiol are not exclusively mediated by ERα in glutamatergic or GABAergic neurons
Systemic metabolic benefits of 17α-estradiol are not exclusively mediated by ERα in glutamatergic or GABAergic neurons
17α-Estradiol (17αE2), a less-feminising enantiomer of 17β-estradiol, has been shown to prolong lifespan an...
Exploring the role of microRNAs as diagnostic and prognostic biomarkers in canine mammary tumors
Exploring the role of microRNAs as diagnostic and prognostic biomarkers in canine mammary tumors
Canine mammary tumors (CMTs) represent a significant health concern in dogs, with a high incidence among intact female dog...
Cerebrovascular dysregulation and postoperative cognitive alterations after carotid endarterectomy
Cerebrovascular dysregulation and postoperative cognitive alterations after carotid endarterectomy
There are controversial data about the effect of carotid endarterectomy regarding postoperative cognitive function. Our ai...
Modulation of neural gene networks by estradiol in old rhesus macaque females
Modulation of neural gene networks by estradiol in old rhesus macaque females
The postmenopausal decrease in circulating estradiol (E2) levels has been shown to contribute to several adverse physiolog...
Self-rated health, epigenetic ageing, and long-term mortality in older Australians
Self-rated health, epigenetic ageing, and long-term mortality in older Australians
Self-rated health (SRH) is a subjective indicator of overall health based on a single questionnaire item. Previous evidenc...
Newer treatment paradigm improves outcomes in the most common neurosurgical disease of the elderly: a literature review of middle meningeal artery embolization for chronic subdural hematoma
Newer treatment paradigm improves outcomes in the most common neurosurgical disease of the elderly: a literature review of middle meningeal artery embolization for chronic subdural hematoma
Chronic subdural hematoma (cSDH) is one of the most prevalent neurosurgical diseases, especially in the elderly. Yet, its ...
A loss of primary cilia by a reduction in mTOR signaling correlates with age-related deteriorations in condylar cartilage
A loss of primary cilia by a reduction in mTOR signaling correlates with age-related deteriorations in condylar cartilage
Age-related deterioration of condylar cartilage is an etiological factor in temporomandibular joint-osteoarthritis (TMJ-OA...
Single episode of moderate to severe traumatic brain injury leads to chronic neurological deficits and Alzheimer’s-like pathological dementia
Single episode of moderate to severe traumatic brain injury leads to chronic neurological deficits and Alzheimer’s-like pathological dementia
Traumatic brain injury (TBI) is one of the foremost causes of disability and mortality globally. While the scientific and ...
Semantic processing in older adults is associated with distributed neural activation which varies by association and abstractness of words
Semantic processing in older adults is associated with distributed neural activation which varies by association and abstractness of words
The extent to which the neural systems underlying semantic processes degrade with advanced age remains unresolved, which m...
Aging is associated with sex-specific alteration in the expression of genes encoding for neuroestradiol synthesis and signaling proteins in the mouse trigeminal somatosensory input
Aging is associated with sex-specific alteration in the expression of genes encoding for neuroestradiol synthesis and signaling proteins in the mouse trigeminal somatosensory input
Pain perception is influenced by sex and aging, with previous studies indicating the involvement of aromatase, the estradi...
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