Dimitriadis E, Menkhorst E, Saito S, Kutteh WH, Brosens JJ. Recurrent pregnancy loss. Nat Rev Dis Primers. 2020;6(1):98. https://doi.org/10.1038/s41572-020-00228-z.

Article  PubMed  Google Scholar 

Zhuang B, Shang J, Yao Y. HLA-G: an important mediator of maternal-fetal immune-tolerance. Front Immunol. 2021;12: 744324. https://doi.org/10.3389/fimmu.2021.744324.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Rosser EC, Mauri C. The emerging field of regulatory B cell immunometabolism. Cell Metab. 2021;33(6):1088–97. https://doi.org/10.1016/j.cmet.2021.05.008.

Article  PubMed  CAS  Google Scholar 

Rosser EC, Piper CJM, Matei DE, Blair PA, Rendeiro AF, Orford M, et al. Microbiota-derived metabolites suppress arthritis by amplifying aryl-hydrocarbon receptor activation in egulatory B cells. Cell Metab. 2020;31(4):837-e5110. https://doi.org/10.1016/j.cmet.2020.03.003.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Larson C, Oronsky B, Carter CA, Oronsky A, Knox SJ, Sher D, et al. TGF-beta: a master immune regulator. Expert Opin Ther Targets. 2020;24(5):427–38. https://doi.org/10.1080/14728222.2020.1744568.

Article  PubMed  CAS  Google Scholar 

Rosser EC, Mauri C, Regulatory B. Cells: origin, phenotype, and function. Immunity. 2015;42(4):607–12. https://doi.org/10.1016/j.immuni.2015.04.005.

Article  PubMed  CAS  Google Scholar 

Liu M, Li S, Li MO. TGF-β control of adaptive immune tolerance: a break from treg cells. BioEssays: News Rev Mol Cell Dev Biol. 2018;40(11):e1800063. https://doi.org/10.1002/bies.201800063.

Article  CAS  Google Scholar 

Danaii S, Ghorbani F, Ahmadi M, Abbaszadeh H, Koushaeian L, Soltani-Zangbar MS, et al. IL-10-producing B cells play important role in the pathogenesis of recurrent pregnancy loss. Int Immunopharmacol. 2020;87: 106806. https://doi.org/10.1016/j.intimp.2020.106806.

Article  PubMed  CAS  Google Scholar 

Guzel E, Arlier S, Guzeloglu-Kayisli O, Tabak MS, Ekiz T, Semerci N, et al. Endoplasmic reticulum stress and homeostasis in reproductive physiology and pathology. Int J Mol Sci. 2017;18(4). https://doi.org/10.3390/ijms18040792.

Soczewski E, Grasso E, Gallino L, Hauk V, Fernández L, Gori S, et al. Immunoregulation of the decidualization program: focus on the endoplasmic reticulum stress. Reproduction. 2020;159(4):R203-11. https://doi.org/10.1530/rep-19-0391.

Article  PubMed  CAS  Google Scholar 

Di Conza G, Ho PC. ER stress responses: an emerging modulator for innate immunity. Cells. 2020;9(3): 695. https://doi.org/10.3390/cells9030695.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Cubillos-Ruiz JR, Silberman PC, Rutkowski MR, Chopra S, Perales-Puchalt A, Song M, et al. ER stress sensor XBP1 controls anti-tumor immunity by disrupting dendritic cell homeostasis. Cell. 2015;161(7):1527–38. https://doi.org/10.1016/j.cell.2015.05.025.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Zeng X, Xiao X, Hu S, He W, Wu G, Geng X, et al. XBP1 is required in Th2 polarization induction in airway allergy. Theranostics. 2022;12(12):5337–49. https://doi.org/10.7150/thno.75100.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Yang G, Zeng XH, Geng XR, Liu JQ, Mo LH, Luo XQ, et al. The transcription factor XBP1 in dendritic cells promotes the T(H)2 cell response in airway allergy. Sci Signal. 2023;16(791): eabm9454. https://doi.org/10.1126/scisignal.abm9454.

Article  PubMed  CAS  Google Scholar 

Cui X, Liu CM, Liu QB. FCRL3 promotes IL-10 expression in B cells through the SHP-1 and p38 MAPK signaling pathways. Cell Biol Int. 2020;44(9):1811–9. https://doi.org/10.1002/cbin.11373.

Article  PubMed  CAS  Google Scholar 

Varshavsky A. The ubiquitin system, autophagy, and regulated protein degradation. Annu Rev Biochem. 2017;86:123–8. https://doi.org/10.1146/annurev-biochem-061516-044859.

Article  PubMed  CAS  Google Scholar 

Cortez JT, Montauti E, Shifrut E, Gatchalian J, Zhang Y, Shaked O, et al. CRISPR screen in regulatory T cells reveals modulators of Foxp3. Nature. 2020;582(7812):416–20. https://doi.org/10.1038/s41586-020-2246-4.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Hiwa R, Brooks JF, Mueller JL, Nielsen HV, Zikherman J. NR4A nuclear receptors in T and B lymphocytes: gatekeepers of immune tolerance(). Immunol Rev. 2022;307(1):116–33. https://doi.org/10.1111/imr.13072.

Article  PubMed  CAS  Google Scholar 

Getahun A. Role of inhibitory signaling in peripheral B cell tolerance. Immunol Rev. 2022;307(1):27–42. https://doi.org/10.1111/imr.13070.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Deshmukh H, Way SS. Immunological basis for recurrent fetal loss and pregnancy complications. Annu Rev Pathol. 2019;14:185–210. https://doi.org/10.1146/annurev-pathmechdis-012418-012743.

Article  PubMed  CAS  Google Scholar 

Liu JQ, Geng XR, Hu TY, Mo LH, Luo XQ, Qiu SY, et al. Glutaminolysis is required in maintaining immune regulatory functions in B cells. Mucosal Immunol. 2022;15(2):268–78. https://doi.org/10.1038/s41385-021-00481-9.

Article  PubMed  CAS  Google Scholar 

Yang G, Suo L, Hu S, Liu H, Wang X, Xiao X, et al. Characterization of the immune regulatory property of CD22(+) CD9(+) B cells. Immunology. 2022;167(3):328–39. https://doi.org/10.1111/imm.13539.

Article  PubMed  CAS  Google Scholar 

Sun X, Guo C, Zhao F, Zhu J, Xu Y, Liu ZQ, et al. Vasoactive intestinal peptide stabilizes intestinal immune homeostasis through maintaining interleukin-10 expression in regulatory B cells. Theranostics. 2019;9(10):2800–11. https://doi.org/10.7150/thno.34414.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Song J, Su W, Chen X, Zhao Q, Zhang N, Li MG, et al. Micro RNA-98 suppresses interleukin-10 in peripheral B cells in patient post-cardio transplantation. Oncotarget. 2017;8(17):28237–46. https://doi.org/10.18632/oncotarget.16000.

Article  PubMed  PubMed Central  Google Scholar 

Liu Y, Chen Z, Qiu J, Chen H, Zhou Z. Altered Tim-1 and IL-10 expression in regulatory B cell subsets in type 1 diabetes. Front Immunol. 2021;12: 773896. https://doi.org/10.3389/fimmu.2021.773896.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Clark DA. The importance of being a regulatory T cell in pregnancy. J Reprod Immunol. 2016;116:60–9. https://doi.org/10.1016/j.jri.2016.04.288.

Article  PubMed  CAS  Google Scholar 

Hansen IS, Schoonejans JM, Sritharan L, van Burgsteden JA, Ambarus CA, Baeten DLP, et al. ER stress abrogates the immunosuppressive effect of IL-10 on human macrophages through inhibition of STAT3 activation. Inflamm Res: Off J Eur Histamine Res Soc [et al]. 2019;68(9):775–85. https://doi.org/10.1007/s00011-019-01261-9.

Article  CAS  Google Scholar 

Zhong Y, Yang L, Guo Y, Fang F, Wang D, Li R, et al. High-temperature cultivation of recombinant Pichia pastoris increases endoplasmic reticulum stress and decreases production of human interleukin-10. Microb Cell Fact. 2014;13:163. https://doi.org/10.1186/s12934-014-0163-7.

Article  PubMed  PubMed Central  CAS