Atanasov, A. G., Zotchev, S. B., Dirsch, V. M., Orhan, I. E., Banach, M., Rollinger, J. M., Barreca, D., Weckwerth, W., Bauer, R., Bayer, E. A., Majeed, M., Bishayee, A., Bochkov, V., Bonn, G. K., Braidy, N., Bucar, F., Cifuentes, A., D’Onofrio, G., Bodkin, M.,…the International Natural Product Sciences, T. Natural products in drug discovery: advances and opportunities. Nat Rev Drug Discov. 2021;20(3):200–16. https://doi.org/10.1038/s41573-020-00114-z.

Article  CAS  Google Scholar 

Bagade T, Thapaliya K, Breuer E, Kamath R, Li Z, Sullivan E, Majeed T. Investigating the association between infertility and psychological distress using Australian Longitudinal Study on Women’s Health (ALSWH). Sci Rep. 2022;12(1):10808. https://doi.org/10.1038/s41598-022-15064-2.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Bakar MHA, Tan JS. Improvement of mitochondrial function by celastrol in palmitate-treated C2C12 myotubes via activation of PI3K-Akt signaling pathway. Biomed Pharmacother. 2017;93:903–12.

Article  PubMed  Google Scholar 

Bayoumi RR, Hurt L, Zhang N, Law YJ, Venetis C, Fatem HM, Serour GI, van der Poel S, Boivin J. A critical systematic review and meta-analyses of risk factors for fertility problems in a globalized world. Reprod Biomed Online. 2024;48(3):103217. https://doi.org/10.1016/j.rbmo.2023.04.008.

Article  PubMed  Google Scholar 

Bharath LP, Agrawal M, McCambridge G, Nicholas DA, Hasturk H, Liu J, Jiang K, Liu R, Guo Z, Deeney J, Apovian CM, Snyder-Cappione J, Hawk GS, Fleeman RM, Pihl RMF, Thompson, K., Belkina AC, Cui L, Proctor EA,…Nikolajczyk BS. Metformin Enhances Autophagy and Normalizes Mitochondrial Function to Alleviate Aging-Associated Inflammation. Cell Metab. 2020;32(1):44–55 e46. https://doi.org/10.1016/j.cmet.2020.04.015.

Bhatia P, Bihani P, Chhabra S, Sharma V, Jaju R. Ultrasound-guided bilateral subcostal TAP block for epigastric hernia repair: a case series. Indian J Anaesth. 2019. https://doi.org/10.4103/ija.IJA_594_18.

Article  PubMed  PubMed Central  Google Scholar 

Chaachouay N, Zidane L. Plant-derived natural products: a source for drug discovery and development. Drugs and Drug Candidates. 2024;3(1):184–207.

Article  Google Scholar 

Chen H, Nie P, Li J, Wu Y, Yao B, Yang Y, Lash GE, Li P. Cyclophosphamide induces ovarian granulosa cell ferroptosis via a mechanism associated with HO-1 and ROS-mediated mitochondrial dysfunction. J Ovarian Res. 2024;17(1):107. https://doi.org/10.1186/s13048-024-01434-z.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Chung IY, Jang HJ, Yoo YJ, Hur J, Oh HY, Kim SH, Cho YH. Artemisinin displays bactericidal activity via copper-mediated DNA damage. Virulence. 2022;13(1):149–59. https://doi.org/10.1080/21505594.2021.2021643.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Colella M, Cuomo D, Peluso T, Falanga I, Mallardo M, De Felice M, Ambrosino C. Ovarian aging: role of pituitary-ovarian axis hormones and ncRNAs in regulating ovarian mitochondrial activity. Front Endocrinol (Lausanne). 2021;12: 791071. https://doi.org/10.3389/fendo.2021.791071.

Article  PubMed  Google Scholar 

Cui F, He X. IGF-1 ameliorates streptozotocin-induced pancreatic β cell dysfunction and apoptosis via activating IRS1/PI3K/Akt/FOXO1 pathway. Inflamm Res. 2022;71(5–6):669–80. https://doi.org/10.1007/s00011-022-01557-3.

Article  PubMed  CAS  Google Scholar 

Dupont J, Scaramuzzi RJ. Insulin signalling and glucose transport in the ovary and ovarian function during the ovarian cycle. Biochem J. 2016;473(11):1483–501. https://doi.org/10.1042/bcj20160124.

Article  PubMed  CAS  Google Scholar 

Faheem H, Alawadhi R, Basha EH, Ismail R, Ibrahim HA, Elshamy AM, Motawea SM, Seleem MA, Elkordy A, Homouda AA, Khaled HE, Aboeida RA, Abdel Ghafar MT, Rizk FH, El-Harty YM. Ameliorating immune-dependent inflammation and apoptosis by targeting TLR4/MYD88/NF-κB pathway by celastrol mitigates the diabetic reproductive dysfunction. Physiol Genomics. 2025;57(3):103–14. https://doi.org/10.1152/physiolgenomics.00072.2024.

Article  PubMed  CAS  Google Scholar 

Feng S, Wan S, Liu S, Wang W, Tang M, Bai L, Zhu Y. LARS2 Regulates Apoptosis via ROS-Mediated Mitochondrial Dysfunction and Endoplasmic Reticulum Stress in Ovarian Granulosa Cells. Oxid Med Cell Longev. 2022;2022:5501346. https://doi.org/10.1155/2022/5501346.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Feng J, Wu Q, Liang Y, Liang Y, Bin Q. Epidemiological characteristics of infertility, 1990–2021, and 15-year forecasts: an analysis based on the global burden of disease study 2021. Reprod Health. 2025;22(1):26. https://doi.org/10.1186/s12978-025-01966-7.

Article  PubMed  PubMed Central  Google Scholar 

Gaines Das R, North D. Implications of experimental technique for analysis and interpretation of data from animal experiments: outliers and increased variability resulting from failure of intraperitoneal injection procedures. Lab Anim. 2007;41(3):312–20. https://doi.org/10.1258/002367707781282802.

Article  PubMed  CAS  Google Scholar 

Goyal R, Mittal P, Gautam RK, Kamal MA, Perveen A, Garg V, Alexiou A, Saboor M, Haque S, Farhana A, Papadakis M, Ashraf GM. Natural products in the management of neurodegenerative diseases. Nutr Metab. 2024;21(1):26. https://doi.org/10.1186/s12986-024-00800-4.

Article  Google Scholar 

Gralewska P, Gajek A, Marczak A, Rogalska A. Targeted nanocarrier-based drug delivery strategies for improving the therapeutic efficacy of PARP inhibitors against ovarian cancer. Int J Mol Sci. 2024. https://doi.org/10.3390/ijms25158304.

Article  PubMed  PubMed Central  Google Scholar 

Gwag T, Park K, Kim E, Son C, Park J, Nikawa T, Choi I. Inhibition of C2C12 myotube atrophy by a novel HSP70 inducer, celastrol, via activation of Akt1 and ERK1/2 pathways. Arch Biochem Biophys. 2013;537(1):21–30. https://doi.org/10.1016/j.abb.2013.06.006.

Article  PubMed  CAS  Google Scholar 

He Z, Lieu L, Dong Y, Afrin S, Chau D, Kabahizi A, Wallace B, Cao J, Hwang ES, Yao T, Huang Y, Okolo J, Cheng B, Gao Y, Hu L, Williams KW. PERK in POMC neurons connects celastrol with metabolism. JCI Insight. 2021. https://doi.org/10.1172/jci.insight.145306.

Article  PubMed  PubMed Central  Google Scholar 

He P, Zou M, Zhang C, Shi Y, Qin L. Celastrol-loaded hyaluronic acid/cancer cell membrane lipid nanoparticles for targeted hepatocellular carcinoma prevention. Cells. 2024. https://doi.org/10.3390/cells13211819.

Article  PubMed  PubMed Central  Google Scholar 

Horita S, Nakamura M, Suzuki M, Satoh N, Suzuki A, Seki G. Selective insulin resistance in the kidney. Biomed Res Int. 2016;2016(1):5825170.

PubMed  PubMed Central  Google Scholar 

Hoxhaj G, Ben-Sahra I, Lockwood SE, Timson RC, Byles V, Henning GT, Gao P, Selfors LM, Asara JM, Manning BD. Direct stimulation of NADP + synthesis through Akt-mediated phosphorylation of NAD kinase. Science. 2019;363(6431):1088–92. https://doi.org/10.1126/science.aau3903.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Hu W, Wang L, Du G, Guan Q, Dong T, Song L, Xia Y, Wang X. Effects of microbiota on the treatment of obesity with the natural product Celastrol in rats. Diabetes Metab J. 2020;44(5):747–63. https://doi.org/10.4093/dmj.2019.0124.

Article  PubMed  PubMed Central  Google Scholar 

Huang Q, Liu Y, Yang Z, Xie Y, Mo Z. The effects of cholesterol metabolism on follicular development and ovarian function. Curr Mol Med. 2019;19(10):719–30. https://doi.org/10.2174/1566524019666190916155004.

Article  PubMed  CAS  Google Scholar 

Huang Y, Yang Y, Liu G, Xu M. New clinical application prospects of artemisinin and its derivatives: a scoping review. Infect Dis Poverty. 2023;12(1): 115. https://doi.org/10.1186/s40249-023-01152-6.

Article  PubMed  PubMed Central  Google Scholar 

Huangfu N, Zhu X, Wang L, Zhang K, Li D, Chen L, Gao X, Niu L, Gao M, Ji J, Luo J, Cui J. Insulin receptor substrate-1 (IRS1) regulates oogenesis and vitellogenesis in Propylea japonica by mediating the FOXO transcription factor expression, independent of JH and 20E signaling pathways. J Agric Food Chem. 2023;71(1):300–10. https://doi.org/10.1021/acs.jafc.2c07433.

Article  PubMed  CAS  Google Scholar 

Jiang Y, Xin X, Pan X, Zhang A, Zhang Z, Li J, Yuan X. STAT4 targets KISS1 to promote the apoptosis of ovarian granulosa cells. J Ovarian Res. 2020;13(1):135. https://doi.org/10.1186/s13048-020-00741-5.

Article  PubMed  PubMed Central  CAS