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Conformation-tunable hydrogen-bonded calix[2]aramide macrocycles: bridging aggregation-induced emission and charge-transfer host-guest chemistry
Two novel hydrogen-bonded calix[2]aramide (C[2]A) macrocycles were successfully synthesized by linking crescent aramide tr...
Light-Promoted Cobalt-Catalyzed Radical Markovnikov Hydrothiolation of Alkenes with N-Arylsulfenyl Phthalimides
In recent years, transition-metal hydride catalysis has emerged as a powerful strategy for radical Markovnikov hydrothiola...
Diastereo- and enantioselective construction of 1,4-nonadjacent alkyne-tethered products through CuI-promoted deprotonation and addition of terminal alkynes
While catalytic asymmetric alkynylation reaction has been extensively studied, existing examples predominantly focus on th...
Pd-Catalyzed Hydroesterification of Vinyl Cyclopropanes with Aryl Formates
A Pd-catalyzed hydroesterification of vinyl cyclopropanes with aryl formates is described. A wide variety of cyclopropane-...
Harnessing the synergistic power of light and electricity: An emerging frontier in catalytic heterocycle synthesis
The strategic integration of photochemistry and electrochemistry in organic synthesis has opened new avenues for catalytic...
Recent Advances in C(sp³)–H Functionalization via Molecular Electrocatalysis
The selective functionalization of inert C(sp³)–H bonds remains a central challenge in modern organic synthesis. Mole...
Structurally Divergent Reactivity of 2,2-Disubstituted Azetidines – Mechanistic Insights and Stereochemical Implications of Amide Coupling and Ring Expansion to 5,6-dihydro-4H-1,3-oxazines
Azetidines have gained traction in drug discovery for their ability to introduce conformational constraint and modulate ph...
Core modified N-confused pentaphyrin variants with adaptive (anti)aromaticity
Retrosynthetically designed and syntheses of three unprecedented core modified N-confused pentaphyrins(sapphyrin) possessi...
Photocatalyzed Defluorinative Allylsulfonylation of Alkynes to Access gem-Difluorinated Sulfonyl-1,4-Dienes
A photocatalyzed three-component gem-difluoroallylsulfonylation of alkynes with trifluoromethyl alkenes and sodium sulfina...
Clean and Economic Synthesis of N-sulfonyl Isothioureas from Isocyanides, Sulfonamides and Disulfides
An electrochemical three-component reaction involving isocyanides, sulfonamides and disulfides was developed, using nBu4NI...
Correction: One-pot ipso-hydroxylation and ortho-/para-halogenation of (hetero)arylboronic acids under tungsten catalysis
Correction for ‘One-pot ipso-hydroxylation and ortho-/para-halogenation of (hetero)arylboronic acids under tungsten cataly...
Recent Advances of Intermolecular Carbonyloxy Radicals Addition to Alkenes
Oxygen-centered radicals are highly reactive intermediates that serve as key roles in radical-mediated organic transformat...
Nitrogen-inversion-based racemate aggregation and interenantiomer -stacking-caused solid-state fluorescence enhancement
The solid-state fluorescence of fluorophores is usually weakened or quenched by strong π-π interactions. Here, the solid-s...
Photoinduced Co-catalyzed dehydrogenative cyclization of 2-alkenylphenyl carbonyl compounds and mechanistic insights
In this work, we present a UV-induced 6π-cyclization protocol enabling the synthesis of polysubstituted naphthol skeletons...
Dearomative 2,3-Diamination of Indoles Triggered by Rh(III)-Catalyzed Csp2-H Activation
A Rh(III)-catalyzed dearomative 2,3-diamination of indoles with N-alkoxyamides has been developed. The method provides an ...
An Unexpected Lewis Acid-Catalyzed Cascade Reaction of Bicyclo[1.1.0]butanes with Triazinanes to Biscyclobutenyl Amines
An unexpected In(OTf)3-catalyzed cascade reaction of bicyclo[1.1.0]butanes with triazinanes is reported, providing a serie...
Remodelling Molecular Frameworks via Atom-Level Surgery: Recent Advances in Skeletal Editing of (Hetero)Cycles
Skeletal editing is an emerging approach in synthetic chemistry that enables precise atom-level modifications within molec...
Bridged Rings from Phenolic Feedstocks: Regio- and Diastereoselective Substitution-Hemiketalization Cyclization of Bridged Benzoxocin-4-ones with Grignard Reagents
The efficient and controllable generation of bridged polycycles of structural complexity and diversity from readily avaial...
Access to (Bridged) Bicyclic Ureas through Azocarboxamide-Enabled Enantioselective 1,2-Diamination of α-Branched Cyclic Ketones
Chiral bicyclic ureas are important multi-nitrogen-containing polycyclic frameworks and valuable building blocks in organi...
Palladium-Catalyzed Multicomponent [4+2] Cycloaddtion of 1, 4-Enynes with CO and Arylamines to Access Polycyclic γ-Lactams via Dearomative Rearrangement
Herein we report a novel palladium-catalyzed intermolecular dearomative [4+2] cycloaddition of 1, 4-enynes with CO and ary...
Supramolecular Chiroptical Sensing by Achiral AIE-active Thiols
Rapid and sensitive chiroptical sensing is of great significance for practical applications. Here, a novel rapid supramole...
Synthesis of 2-arylchromeno[2,3,4,5-lmna]phenanthridines through a sequential multicomponent assembly, oxygenation and 6πe electrocyclization reactions
A novel metal-free synthetic method is presented for the 2-arylchromeno[2,3,4,5-lmna]phenanthridines from the one-pot reac...
Giese Reaction of Alkyl Bromides using Amine Carboxyboranes
Amine carboxyborane enabled an efficient halogen atom transfer (XAT) with 1o, 2o, and 3o alkyl bromides, resulting in Gies...
Computational Study on Pd-Catalyzed ipso,meta-Dimethylation of ortho-Substituted Iodoarene: Mechanisms and the Role of Base
Density functional theory (DFT) calculations were performed to study Pd-catalyzed ipso,meta-dimethylation reaction of orth...
Progress in Catalytic Enantioselective Construction of Difluoroalkylated Stereogenic Center
Molecules bearing the difluoroalkyl groups were very important in pharmaceuticals, argrochemicals and materials. In recent...
Synthesis of a cross-chain bridging cryptand
We present two methodologies for synthesizing cross–chain bridging cryptand 1 that incorporates tri- and tetra(ethylene gl...
A domino reaction strategy for facile and modular construction of synthetically challenging functionalized ortho-fluoroanilines
The selective formation of ortho-fluoroanilines, representing versatile intermediates for the pharmaceutical and fine chem...
Asymmetric construction of spirobenzofuran indolinones via cascade reaction of 3-hydroxyoxindoles with coumarins
An interesting asymmetric organocatalytic cascade reaction of 3-hydroxyoxindoles with coumarins was accomplished by chiral...
Asymmetric Synthesis of Pyrrolo[1,2-a]indoles via Bifunctional Tertiary Amine Catalyzed [3+2] Annulation of 2-Nitrovinylindoles with Azlactones
The chiral pyrrolo[1,2-a]indole represents a privileged stuctural motif in many natual products and pharmaceutical agents....
Hypervalent Iodide(III)-Mediated Thiofluorination of Alkenes and Alkynes from Thioureas/Thiocarbamoyl Fluorides with Water and Nucleophilic Fluoride Source
Hypervalent iodines(III) mediated oxo/aza/carbon/difluorination of alkenes have made significant progress although the cor...
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