Skeletal editing is an emerging approach in synthetic chemistry that enables precise atom-level modifications within molecular cores, facilitating complex transformations and minimizing resource-intensive synthesis. This review provides a comprehensive overview of the most recent advancements in skeletal editing, with a particular focus on single atom modifications. While skeletal editing can be applied to both cyclic and acyclic compounds, this review centers on carbo- and heterocyclic systems exclusively. By integrating historical context and categorizing key developments, it highlights the major achievements in insertion, deletion, and transmutation, connecting related works and delving into mechanistic insights.

This article is Open Access

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