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TLR-4/Notch1/NF-κB pathway modulation by dapagliflozin: a novel mechanism for neuroprotection in hepatic encephalopathy
TLR-4/Notch1/NF-κB pathway modulation by dapagliflozin: a novel mechanism for neuroprotection in hepatic encephalopathy
Acute or chronic liver damage can result in Hepatic Encephalopathy (HE), a potentially fatal neuropsychiatric condition th...
Multimodal evaluation of nitazoxanide as an antidepressant: behavioral, biochemical, and molecular docking insights
Multimodal evaluation of nitazoxanide as an antidepressant: behavioral, biochemical, and molecular docking insights
This study aimed to evaluate the antidepressant potential of Nitazoxanide (NTZ), an antiprotozoal drug with known anti-inf...
The therapeutic effects of various tonic traditional Chinese medicines on demyelinating diseases
The therapeutic effects of various tonic traditional Chinese medicines on demyelinating diseases
Demyelinating diseases, a prevalent group of neurological disorders, lead to impaired nerve conduction and sensorimotor dy...
Transformations in plasma metabolic profiles of patients with major depression disorder during treatment
Transformations in plasma metabolic profiles of patients with major depression disorder during treatment
Major depression disorder (MDD) is a mental condition that significantly threatens both physical and psychological health....
Simple scoring model for predicting overt hepatic encephalopathy in geriatric cirrhosis: A multicenter retrospective cohort study
Simple scoring model for predicting overt hepatic encephalopathy in geriatric cirrhosis: A multicenter retrospective cohort study
Identifying the risk of overt hepatic encephalopathy (OHE) in geriatric patients with cirrhosis remains challenging. This ...
4-aminopyridine exerts anxiolytic and pro-cognitive effects in mice model of medial prefrontal cortex ischemia
4-aminopyridine exerts anxiolytic and pro-cognitive effects in mice model of medial prefrontal cortex ischemia
Brain ischemia is a major global cause of disability, frequently leading to psychoneurological issues. This study investig...
Impact of agmatine on cerebral astrocyte reactivity, neurodegeneration, and oxidative stress in bile duct-ligated rats
Impact of agmatine on cerebral astrocyte reactivity, neurodegeneration, and oxidative stress in bile duct-ligated rats
Hepatic encephalopathy (HE) is a severe neurological disorder arising from liver disease, often studied using the bile duc...
Curcumin treatment reduces motor impairments and protects against rotenone-induced neurodegeneration in a rat model of Parkinson disease
Curcumin treatment reduces motor impairments and protects against rotenone-induced neurodegeneration in a rat model of Parkinson disease
Parkinson’s disease (PD) is a progressive neurodegenerative disorder characterized by degeneration of dopaminergic n...
A novel modulator of the Axin/β-Catenin interaction to restore EAAT2 expression in alzheimer’s disease: an in-silico and in-vitro approach
A novel modulator of the Axin/β-Catenin interaction to restore EAAT2 expression in alzheimer’s disease: an in-silico and in-vitro approach
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder marked by synaptic dysfunction and neuronal los...
Correction to: Regulation of oxygen–glucose deprivation/reperfusion‑induced inflammatory responses and M1‑M2 phenotype switch of BV2 microglia by Lobetyolin
Correction to: Regulation of oxygen–glucose deprivation/reperfusion‑induced inflammatory responses and M1‑M2 phenotype switch of BV2 microglia by Lobetyolin
Correction to: Veterinary Research CommunicationsThe following errors are listed as f...
Prospective observational study on systemic inflammation and prognostic significance of hepatic encephalopathy
Prospective observational study on systemic inflammation and prognostic significance of hepatic encephalopathy
Hepatic encephalopathy (HE) is a common decompensating event in liver cirrhosis, with a prevalence of 10–14% in newl...
Bay leaves: the neuroprotective dietary spice inhibition of amyloid-like aggregation
Bay leaves: the neuroprotective dietary spice inhibition of amyloid-like aggregation
Aguzzi A, O’connor T (2010) Protein aggregation diseases: pathogenicity and therapeutic perspectives. Nat Rev Drug Discov ...
Umbelliferone reverses neuronal damage induced by chronic Chlorpyrifos exposure via suppressing NF-κB/STAT3/NLRP3 and boosting Keap-1/Nrf2/HO-1 signals
Umbelliferone reverses neuronal damage induced by chronic Chlorpyrifos exposure via suppressing NF-κB/STAT3/NLRP3 and boosting Keap-1/Nrf2/HO-1 signals
Chlorpyrifos (CPF), an organophosphate pesticide, is a widely used pest control chemical. Unfortunately, pesticides are kn...
Exercise training enhances myokine release and reduces brain insulin resistance: insights into muscle-CNS metabolic cross-talk
Exercise training enhances myokine release and reduces brain insulin resistance: insights into muscle-CNS metabolic cross-talk
Recent studies have demonstrated that insulin and its receptors play a vital role in the central nervous system, supportin...
Portacaval anastomosis promotes fragmentation of mitochondrial network in the cerebellum of male rats
Portacaval anastomosis promotes fragmentation of mitochondrial network in the cerebellum of male rats
Portacaval anastomosis (PCA) is a model for hypometabolic liver dysfunction. Spongiform neurodegeneration has been detecte...
Nitisinone treatment protect hereditary tyrosinemia type I patients against inflammation, DNA and protein oxidative damage by decreasing succinylacetone levels
Nitisinone treatment protect hereditary tyrosinemia type I patients against inflammation, DNA and protein oxidative damage by decreasing succinylacetone levels
Hereditary tyrosinemia type I (HT1) is an inborn error of metabolism (IEM), caused by deficiency of the enzyme fumarylacet...
From metabolic dysregulation to neurodegenerative pathology: the role of hyperglycemia, oxidative stress, and blood-brain barrier breakdown in T2D-driven Alzheimer’s disease
From metabolic dysregulation to neurodegenerative pathology: the role of hyperglycemia, oxidative stress, and blood-brain barrier breakdown in T2D-driven Alzheimer’s disease
Type 2 Diabetes (T2D) and Alzheimer’s Disease (AD) share common risk factors that can be seen through T2D nearly dou...
Impaired Synaptic Plasticity Mechanisms in Alzheimer’s Disease
Impaired Synaptic Plasticity Mechanisms in Alzheimer’s Disease
Alzheimer’s disease (AD) is the most common form of dementia, characterized by progressive cognitive decline driven ...
Epstein-Barr virus infection and vitamin D deficiency are both “causal” for multiple sclerosis (MS) - could the common denominator be their effects on hepcidin levels?
Epstein-Barr virus infection and vitamin D deficiency are both “causal” for multiple sclerosis (MS) - could the common denominator be their effects on hepcidin levels?
Multiple sclerosis (MS) is a neurological disorder characterized by damage to the myelin sheaths surrounding axons in the ...
Protective effects of against thioacetamide-induced hepatic encephalopathy: a focus on antioxidant and neuroprotective mechanisms
Protective effects of against thioacetamide-induced hepatic encephalopathy: a focus on antioxidant and neuroprotective mechanisms
Hepatic encephalopathy (HE) is a multifaceted neuropsychiatric syndrome frequently observed in patients with liver dysfunc...
The potential of alphapinene as a therapeutic agent for maternal hypoxia-induced cognitive impairments: a study on HO-1 and Nrf2 gene expression in rats
The potential of alphapinene as a therapeutic agent for maternal hypoxia-induced cognitive impairments: a study on HO-1 and Nrf2 gene expression in rats
This research seeks to address the gap in past studies by examining the role of the Nrf2 (nuclear factor erythroid 2-relat...
The protective efficacy of omega-3 polyunsaturated fatty acids on oxidative stress, inflammation, neurotransmitter perturbations, and apoptosis induced by monosodium glutamate in the brain of male rats
The protective efficacy of omega-3 polyunsaturated fatty acids on oxidative stress, inflammation, neurotransmitter perturbations, and apoptosis induced by monosodium glutamate in the brain of male rats
Exaggerated neuronal excitation by glutamate is a well-known cause of excitotoxicity, a key factor in numerous neurodegene...
2-dodecyl-6-methoxycyclohexa-2,5-diene-1,4-dione protects against MPP+-induced neurotoxicity by ameliorating oxidative stress, apoptosis and autophagy in SH-SY5Y cells
2-dodecyl-6-methoxycyclohexa-2,5-diene-1,4-dione protects against MPP+-induced neurotoxicity by ameliorating oxidative stress, apoptosis and autophagy in SH-SY5Y cells
2-dodecyl-6-methoxycyclohexa-2,5-diene-1,4-dione (DMDD) is a cyclohexanedione compound extracted from the roots of Averrho...
The effects of ursodeoxycholic acid on Parkinson’s disease, a mechanistic review of the recent evidence
The effects of ursodeoxycholic acid on Parkinson’s disease, a mechanistic review of the recent evidence
Introduction. Parkinson`s disease stands as the second-most widespread neurodegenerative disorder. Parkinson`s disease is ...
Brain interleukins and Alzheimer’s disease
Brain interleukins and Alzheimer’s disease
The central nervous system (CNS) is immune-privileged by several immuno-modulators as interleukins (ILs). ILs are cytokine...
TIPS and hepatic encephalopathy in patients with cirrhosis
TIPS and hepatic encephalopathy in patients with cirrhosis
Despite a better understanding in its prognosis and pathogenesis, hepatic encephalopathy (HE) remains one of the major com...
Altered gut microbiome and serum metabolome profiles associated with essential tremor
Altered gut microbiome and serum metabolome profiles associated with essential tremor
The genetic predisposition and environmental factors both trigger the complex neurological dyskinesia of essential tremor ...
Sodium butyrate ameliorates mitochondrial oxidative stress and alterations in membrane-bound enzyme activities in pentylenetetrazole-induced kindling rat model
Sodium butyrate ameliorates mitochondrial oxidative stress and alterations in membrane-bound enzyme activities in pentylenetetrazole-induced kindling rat model
Epilepsy is a chronic neurological disorder manifested through repeatedly recurrent unprovoked seizures. It is a debilitat...
Glutamate/GABA/glutamine ratios in intact and ischemia reperfusion challenged rat brain subregions, the effect of ischemic preconditioning
Glutamate/GABA/glutamine ratios in intact and ischemia reperfusion challenged rat brain subregions, the effect of ischemic preconditioning
The proper function of the brain is entirely dependent on intact neurotransmission, where glutamate (Glu) and γ-amino...
Gut microbiota-derived short chain fatty acids act as mediators of the gut-liver-brain axis
Gut microbiota-derived short chain fatty acids act as mediators of the gut-liver-brain axis
The gut microbiota plays a crucial role in the communication between the gut, liver, and brain through the production of s...
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