Alzheimer's disease facts and figures 2023 (2023) 2023 Alzheimer's disease facts and figures. Alzheimers Dement 19(4):1598–1695.https://doi.org/10.1002/alz.13016
Ayton S, Portbury S, Kalinowski P, Agarwal P, Diouf I, Schneider JA et al (2021) Regional brain iron associated with deterioration in Alzheimer’s disease: a large cohort study and theoretical significance. Alzheimers Dement 17(7):1244–1256. https://doi.org/10.1002/alz.12282
Babetto E, Wong KM, Beirowski B (2020) A glycolytic shift in Schwann cells supports injured axons. Nat Neurosci 23(10):1215–1228. https://doi.org/10.1038/s41593-020-0689-4
Article CAS PubMed PubMed Central Google Scholar
Baik SH, Kang S, Lee W, Choi H, Chung S, Kim JI et al (2019) A breakdown in metabolic reprogramming causes microglia dysfunction in Alzheimer’s disease. Cell Metab 30(3):493–507 e6. https://doi.org/10.1016/j.cmet.2019.06.005
Article CAS PubMed Google Scholar
Boland B, Yu WH, Corti O, Mollereau B, Henriques A, Bezard E et al (2018) Promoting the clearance of neurotoxic proteins in neurodegenerative disorders of ageing. Nat Rev Drug Discov 17(9):660–688. https://doi.org/10.1038/nrd.2018.109
Article CAS PubMed PubMed Central Google Scholar
Butterfield DA, Halliwell B (2019) Oxidative stress, dysfunctional glucose metabolism and Alzheimer disease. Nat Rev Neurosci 20(3):148–160. https://doi.org/10.1038/s41583-019-0132-6
Article CAS PubMed PubMed Central Google Scholar
Chang H, Xu Q, Li J, Li M, Zhang Z, Ma H et al (2021) Lactate secreted by PKM2 upregulation promotes Galectin-9-mediated immunosuppression via inhibiting NF-kappaB pathway in HNSCC. Cell Death Dis 12(8):725. https://doi.org/10.1038/s41419-021-03990-4
Article CAS PubMed PubMed Central Google Scholar
Cohn W, Melnik M, Huang C, Teter B, Chandra S, Zhu C et al (2021) Multi-omics analysis of microglial extracellular vesicles from human Alzheimer’s disease brain tissue reveals disease-associated signatures. Front Pharmacol 12:766082. https://doi.org/10.3389/fphar.2021.766082
Article CAS PubMed PubMed Central Google Scholar
da Costa IB, de Labio RW, Rasmussen LT, Viani GA, Chen E, Villares J et al (2017) Change in INSR, APBA2 and IDE gene expressions in brains of Alzheimer’s disease patients. Curr Alzheimer Res 14(7):760–765. https://doi.org/10.2174/1567205014666170203100734
Article CAS PubMed Google Scholar
Dang Y, He Q, Yang S, Sun H, Liu Y, Li W et al (2022) FTH1- and SAT1-Induced astrocytic ferroptosis is involved in Alzheimer’s disease: evidence from single-cell transcriptomic analysis. Pharmaceuticals (Basel) 15(10):1177. https://doi.org/10.3390/ph15101177
Article CAS PubMed Google Scholar
Du Y, Chen L, Jiao Y, Cheng Y (2019) Cerebrospinal fluid and blood Abeta levels in Down syndrome patients with and without dementia: a meta-analysis study. Aging (Albany NY) 11(24):12202–12212. https://doi.org/10.18632/aging.102560
Article CAS PubMed Google Scholar
Jia L, Liao M, Mou A, Zheng Q, Yang W, Yu Z et al (2021) Rheb-regulated mitochondrial pyruvate metabolism of Schwann cells linked to axon stability. Dev Cell 56(21):2980–94 e6. https://doi.org/10.1016/j.devcel.2021.09.013
Article CAS PubMed Google Scholar
Kellar D, Craft S (2020) Brain insulin resistance in Alzheimer’s disease and related disorders: mechanisms and therapeutic approaches. Lancet Neurol 19(9):758–766. https://doi.org/10.1016/S1474-4422(20)30231-3
Article CAS PubMed PubMed Central Google Scholar
Li X, Yang Y, Zhang B, Lin X, Fu X, An Y et al (2022) Lactate metabolism in human health and disease. Signal Transduct Target Ther 7(1):305. https://doi.org/10.1038/s41392-022-01151-3
Article CAS PubMed PubMed Central Google Scholar
Liu X, Nie L, Zhang Y, Yan Y, Wang C, Colic M et al (2023) Actin cytoskeleton vulnerability to disulfide stress mediates disulfidptosis. Nat Cell Biol 25(3):404–414. https://doi.org/10.1038/s41556-023-01091-2
Article CAS PubMed PubMed Central Google Scholar
Long HZ, Cheng Y, Zhou ZW, Luo HY, Wen DD, Gao LC (2021) PI3K/AKT signal pathway: a target of natural products in the prevention and treatment of Alzheimer’s disease and Parkinson’s disease. Front Pharmacol 12:648636. https://doi.org/10.3389/fphar.2021.648636
Article CAS PubMed PubMed Central Google Scholar
Ma S, Wang D, Xie D (2023) Identification of disulfidptosis-related genes and subgroups in Alzheimer’s disease. Front Aging Neurosci 15:1236490. https://doi.org/10.3389/fnagi.2023.1236490
Article CAS PubMed PubMed Central Google Scholar
Monsorno K, Buckinx A, Paolicelli RC (2022) Microglial metabolic flexibility: emerging roles for lactate. Trends Endocrinol Metab 33(3):186–195. https://doi.org/10.1016/j.tem.2021.12.001
Article CAS PubMed Google Scholar
Moreno-Yruela C, Zhang D, Wei W, Baek M, Liu W, Gao J et al (2022) Class I histone deacetylases (HDAC1-3) are histone lysine delactylases. Sci Adv. 8(3):eabi6696. https://doi.org/10.1126/sciadv.abi6696
Article CAS PubMed PubMed Central Google Scholar
Moujalled D, Strasser A, Liddell JR (2021) Molecular mechanisms of cell death in neurological diseases. Cell Death Differ 28(7):2029–2044. https://doi.org/10.1038/s41418-021-00814-y
Article PubMed PubMed Central Google Scholar
Nagao H, Jayavelu AK, Cai W, Pan H, Dreyfuss JM, Batista TM et al (2023) Unique ligand and kinase-independent roles of the insulin receptor in regulation of cell cycle, senescence and apoptosis. Nat Commun 14(1):57. https://doi.org/10.1038/s41467-022-35693-5
Article CAS PubMed PubMed Central Google Scholar
Pan RY, He L, Zhang J, Liu X, Liao Y, Gao J et al (2022) Positive feedback regulation of microglial glucose metabolism by histone H4 lysine 12 lactylation in Alzheimer’s disease. Cell Metab. 34(4):634–48 e6. https://doi.org/10.1016/j.cmet.2022.02.013
Article CAS PubMed Google Scholar
Perkins M, Wolf AB, Chavira B, Shonebarger D, Meckel JP, Leung L et al (2016) Altered energy metabolism pathways in the posterior cingulate in young adult apolipoprotein E varepsilon4 carriers. J Alzheimers Dis 53(1):95–106. https://doi.org/10.3233/JAD-151205
Article CAS PubMed PubMed Central Google Scholar
Ramasubbu K, Devi RV (2023) Impairment of insulin signaling pathway PI3K/Akt/mTOR and insulin resistance induced AGEs on diabetes mellitus and neurodegenerative diseases: a perspective review. Mol Cell Biochem 478(6):1307–1324. https://doi.org/10.1007/s11010-022-04587-x
Article CAS PubMed Google Scholar
Rhea EM, Leclerc M, Yassine HN, Capuano AW, Tong H, Petyuk VA et al (2023) State of the science on brain insulin resistance and cognitive decline due to Alzheimer’s disease. Aging Dis. https://doi.org/10.14336/AD.2023.0814
Ryan SK, Zelic M, Han Y, Teeple E, Chen L, Sadeghi M et al (2023) Microglia ferroptosis is regulated by SEC24B and contributes to neurodegeneration. Nat Neurosci 26(1):12–26. https://doi.org/10.1038/s41593-022-01221-3
Article CAS PubMed Google Scholar
Saltiel AR, Kahn CR (2001) Insulin signalling and the regulation of glucose and lipid metabolism. Nature 414(6865):799–806. https://doi.org/10.1038/414799a
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