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Glucose variability measured by continuous glucose monitoring is associated with skin autofluorescence: the Maastricht Study
Glucose variability measured by continuous glucose monitoring is associated with skin autofluorescence: the Maastricht Study
Glucose variability in people with type 2 diabetes has been associated with increased risk of CVD, and AGEs might be an un...
A type 1 diabetes genetic risk score discriminates between type 1 diabetes and type 2 diabetes in a Chinese population
A type 1 diabetes genetic risk score discriminates between type 1 diabetes and type 2 diabetes in a Chinese population
We aimed to generate a population-specific type 1 diabetes genetic risk score (GRS) and assess whether it could improve di...
Differences in biopsy-proven diabetic kidney disease in individuals from Polynesia vs mainland France: a retrospective cohort study
Differences in biopsy-proven diabetic kidney disease in individuals from Polynesia vs mainland France: a retrospective cohort study
Māori, a Polynesian population, have an earlier age of onset of type 2 diabetes and higher risk of diabetes-related c...
Steatotic liver disease interacts with a polygenic risk score for triglyceride clearance to impact the risk of hypertriglyceridaemia: The Maastricht Study
Steatotic liver disease interacts with a polygenic risk score for triglyceride clearance to impact the risk of hypertriglyceridaemia: The Maastricht Study
The pathogenesis of hypertriglyceridaemia is explained by a complex interplay between genetic and environmental factors. W...
Diabetogenic elevated childhood total fat in South Asian and Black African/Caribbean people relates to adverse early life growth and low socioeconomic position compared with White people in the UK
Diabetogenic elevated childhood total fat in South Asian and Black African/Caribbean people relates to adverse early life growth and low socioeconomic position compared with White people in the UK
Excess type 2 diabetes mellitus in minority ethnic groups remains unexplained, although greater fat mass makes a strong co...
Inflammatory markers and blood glucose are higher after morning vs afternoon exercise in type 2 diabetes
Inflammatory markers and blood glucose are higher after morning vs afternoon exercise in type 2 diabetes
The aim of this study was to investigate effects of time of day on glucose management in individuals with type 2 diabetes ...
Raising the bar for publication of Mendelian randomisation studies in
Raising the bar for publication of Mendelian randomisation studies in
Bours MJL (2020) A nontechnical explanation of the counterfactual definition of confounding. J Clin Epidemiol 121:91–100. ...
The role of variants in the wide spectrum of non-autoimmune abnormalities of glucose homeostasis
The role of variants in the wide spectrum of non-autoimmune abnormalities of glucose homeostasis
Biallelic pathogenic variants in SLC19A2 (the solute carrier family 19 member 2, which encodes thiamine transporter 1, res...
Stem-cell-derived beta cells mature metabolically upon murine engraftment
Stem-cell-derived beta cells mature metabolically upon murine engraftment
The use of stem-cell-derived islets (SC-islets) as a source for cell-based therapy of type 1 diabetes shows great potentia...
Association between maternal glucose levels in pregnancy and offspring’s metabolism and adiposity: an 18-year birth cohort study
Association between maternal glucose levels in pregnancy and offspring’s metabolism and adiposity: an 18-year birth cohort study
The study aimed to explore the association between maternal glucose levels in pregnancy and offspring’s metabolism a...
Rethinking the link between gestational diabetes and dementia risk
Rethinking the link between gestational diabetes and dementia risk
Acknowledgments We thank the contributors of the Alzheimer’s Disease Genetics Co...
Biomarkers of inflammation and improvement in depressive symptoms in type 1 and type 2 diabetes: differential associations with depressive symptom clusters
Biomarkers of inflammation and improvement in depressive symptoms in type 1 and type 2 diabetes: differential associations with depressive symptom clusters
People with diabetes and depression show large heterogeneity in their response to depression treatment. This study aimed t...
Dapagliflozin’s impact on hormonal regulation and ketogenesis in type 1 diabetes: a randomised controlled crossover trial
Dapagliflozin’s impact on hormonal regulation and ketogenesis in type 1 diabetes: a randomised controlled crossover trial
This study aimed to assess the impact of adding dapagliflozin to insulin therapy on key hormonal determinants of glucose r...
In Memoriam Werner Waldhäusl, 27 September 1937–22 May 2025
In Memoriam Werner Waldhäusl, 27 September 1937–22 May 2025
A leading figure in European diabetology, o. Univ. Prof. em. Dr. Werner Waldhäusl pa...
Early worsening of diabetic retinopathy in individuals with type 2 diabetes treated with tirzepatide: a real-world cohort study
Early worsening of diabetic retinopathy in individuals with type 2 diabetes treated with tirzepatide: a real-world cohort study
Early worsening of diabetic retinopathy (EWDR) has been described during treatment with glucagon-like peptide-1 receptor a...
Verapamil and low-dose anti-mouse thymocyte globulin combination therapy stably reverses recent-onset type 1 diabetes in NOD mice by acting on the beta cell and immune axes
Verapamil and low-dose anti-mouse thymocyte globulin combination therapy stably reverses recent-onset type 1 diabetes in NOD mice by acting on the beta cell and immune axes
Verapamil, a calcium channel blocker, and low doses of anti-thymocyte globulin (ATG) have individually shown efficacy in p...
Societal and biological approaches to diabetes prevention and care for Inuit populations: a narrative review
Societal and biological approaches to diabetes prevention and care for Inuit populations: a narrative review
The Inuit populations that inhabit the Arctic regions have adapted to survive in extreme conditions. However, recent socie...
Global perspectives on monogenic forms of diabetes
Global perspectives on monogenic forms of diabetes
Monogenic forms of diabetes represent an uncommon but very heterogeneous subset of the disease, with variable associated c...
Oxidised phosphatidylcholine induces sarcolemmal ceramide accumulation and insulin resistance in skeletal muscle
Oxidised phosphatidylcholine induces sarcolemmal ceramide accumulation and insulin resistance in skeletal muscle
Intracellular ceramide accumulation in specific cellular compartments is a potential mechanism explaining muscle insulin r...
Deletion of RFX6 impairs iPSC-derived islet organoid development and survival, with no impact on PDX1+/NKX6.1+ progenitors
Deletion of RFX6 impairs iPSC-derived islet organoid development and survival, with no impact on PDX1+/NKX6.1+ progenitors
Homozygous mutations in RFX6 lead to neonatal diabetes accompanied by a hypoplastic pancreas, whereas heterozygous mutatio...
Novel secreted regulators of glucose and lipid metabolism in the development of metabolic diseases
Novel secreted regulators of glucose and lipid metabolism in the development of metabolic diseases
The tight regulation of glucose and lipid metabolism is crucial for maintaining metabolic health. Dysregulation of these p...
Addressing disparities in the long-term mortality risk in individuals with non-ST segment myocardial infarction (NSTEMI) by diabetes mellitus status: a nationwide cohort study
Addressing disparities in the long-term mortality risk in individuals with non-ST segment myocardial infarction (NSTEMI) by diabetes mellitus status: a nationwide cohort study
The aim of this study was to investigate how diabetes mellitus affects longer term outcomes in individuals presenting to h...
Identification of proteins associated with type 2 diabetes risk in diverse racial and ethnic populations
Identification of proteins associated with type 2 diabetes risk in diverse racial and ethnic populations
Several studies have reported associations between specific proteins and type 2 diabetes risk in European populations. To ...
Metformin and small for gestational age babies: findings of a randomised placebo-controlled clinical trial of metformin in gestational diabetes (EMERGE)
Metformin and small for gestational age babies: findings of a randomised placebo-controlled clinical trial of metformin in gestational diabetes (EMERGE)
Gestational diabetes mellitus (GDM) is associated with adverse perinatal outcomes because of suboptimal glucose management...
Accuracy of continuous glucose monitoring in the hospital setting: an observational study
Accuracy of continuous glucose monitoring in the hospital setting: an observational study
Continuous glucose monitoring (CGM) improves glycaemic outcomes in the outpatient setting; however, there are limited data...
Mortality rates in people presenting with a new diabetes-related foot ulcer: a cohort study with implications for management
Mortality rates in people presenting with a new diabetes-related foot ulcer: a cohort study with implications for management
People with diabetes-related foot ulcers (DFUs) have high mortality rates. This analysis assesses the impact of selected r...
Evidence on the effectiveness and equity of population-based policies to reduce the burden of type 2 diabetes: a narrative review
Evidence on the effectiveness and equity of population-based policies to reduce the burden of type 2 diabetes: a narrative review
There is increasing evidence for the effectiveness of population-based policies to reduce the burden of type 2 diabetes. Y...
Metabolomics profiling in multi-ancestral individuals with type 2 diabetes in Singapore identified metabolites associated with renal function decline
Metabolomics profiling in multi-ancestral individuals with type 2 diabetes in Singapore identified metabolites associated with renal function decline
This study aims to explore the association between plasma metabolites and chronic kidney disease progression in individual...
The effect of vitamin D3 supplementation on the incidence of type 2 diabetes in healthy older adults not at high risk for diabetes (FIND): a randomised controlled trial
The effect of vitamin D3 supplementation on the incidence of type 2 diabetes in healthy older adults not at high risk for diabetes (FIND): a randomised controlled trial
Vitamin D insufficiency is associated with an elevated risk of type 2 diabetes, but evidence from randomised trials on the...
A critique of measurement of defective insulin secretion and insulin sensitivity as a precision approach to gestational diabetes
A critique of measurement of defective insulin secretion and insulin sensitivity as a precision approach to gestational diabetes
Precision medicine approaches to gestational diabetes mellitus (GDM) have categorised patients according to disease pathop...
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