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Oxidised phosphatidylcholine induces sarcolemmal ceramide accumulation and insulin resistance in skeletal muscle
Oxidised phosphatidylcholine induces sarcolemmal ceramide accumulation and insulin resistance in skeletal muscle
Intracellular ceramide accumulation in specific cellular compartments is a potential mechanism explaining muscle insulin r...
Deletion of RFX6 impairs iPSC-derived islet organoid development and survival, with no impact on PDX1+/NKX6.1+ progenitors
Deletion of RFX6 impairs iPSC-derived islet organoid development and survival, with no impact on PDX1+/NKX6.1+ progenitors
Homozygous mutations in RFX6 lead to neonatal diabetes accompanied by a hypoplastic pancreas, whereas heterozygous mutatio...
Novel secreted regulators of glucose and lipid metabolism in the development of metabolic diseases
Novel secreted regulators of glucose and lipid metabolism in the development of metabolic diseases
The tight regulation of glucose and lipid metabolism is crucial for maintaining metabolic health. Dysregulation of these p...
Addressing disparities in the long-term mortality risk in individuals with non-ST segment myocardial infarction (NSTEMI) by diabetes mellitus status: a nationwide cohort study
Addressing disparities in the long-term mortality risk in individuals with non-ST segment myocardial infarction (NSTEMI) by diabetes mellitus status: a nationwide cohort study
The aim of this study was to investigate how diabetes mellitus affects longer term outcomes in individuals presenting to h...
Identification of proteins associated with type 2 diabetes risk in diverse racial and ethnic populations
Identification of proteins associated with type 2 diabetes risk in diverse racial and ethnic populations
Several studies have reported associations between specific proteins and type 2 diabetes risk in European populations. To ...
Metformin and small for gestational age babies: findings of a randomised placebo-controlled clinical trial of metformin in gestational diabetes (EMERGE)
Metformin and small for gestational age babies: findings of a randomised placebo-controlled clinical trial of metformin in gestational diabetes (EMERGE)
Gestational diabetes mellitus (GDM) is associated with adverse perinatal outcomes because of suboptimal glucose management...
Accuracy of continuous glucose monitoring in the hospital setting: an observational study
Accuracy of continuous glucose monitoring in the hospital setting: an observational study
Continuous glucose monitoring (CGM) improves glycaemic outcomes in the outpatient setting; however, there are limited data...
Mortality rates in people presenting with a new diabetes-related foot ulcer: a cohort study with implications for management
Mortality rates in people presenting with a new diabetes-related foot ulcer: a cohort study with implications for management
People with diabetes-related foot ulcers (DFUs) have high mortality rates. This analysis assesses the impact of selected r...
Evidence on the effectiveness and equity of population-based policies to reduce the burden of type 2 diabetes: a narrative review
Evidence on the effectiveness and equity of population-based policies to reduce the burden of type 2 diabetes: a narrative review
There is increasing evidence for the effectiveness of population-based policies to reduce the burden of type 2 diabetes. Y...
Metabolomics profiling in multi-ancestral individuals with type 2 diabetes in Singapore identified metabolites associated with renal function decline
Metabolomics profiling in multi-ancestral individuals with type 2 diabetes in Singapore identified metabolites associated with renal function decline
This study aims to explore the association between plasma metabolites and chronic kidney disease progression in individual...
The effect of vitamin D3 supplementation on the incidence of type 2 diabetes in healthy older adults not at high risk for diabetes (FIND): a randomised controlled trial
The effect of vitamin D3 supplementation on the incidence of type 2 diabetes in healthy older adults not at high risk for diabetes (FIND): a randomised controlled trial
Vitamin D insufficiency is associated with an elevated risk of type 2 diabetes, but evidence from randomised trials on the...
A critique of measurement of defective insulin secretion and insulin sensitivity as a precision approach to gestational diabetes
A critique of measurement of defective insulin secretion and insulin sensitivity as a precision approach to gestational diabetes
Precision medicine approaches to gestational diabetes mellitus (GDM) have categorised patients according to disease pathop...
Inhibition of CD226 co-stimulation suppresses diabetes development in the NOD mouse by augmenting regulatory T cells and diminishing effector T cell function
Inhibition of CD226 co-stimulation suppresses diabetes development in the NOD mouse by augmenting regulatory T cells and diminishing effector T cell function
Immunotherapeutics targeting T cells are crucial for inhibiting autoimmune disease progression proximal to disease onset i...
Dietary patterns during pregnancy and maternal and birth outcomes in women with type 1 diabetes: the Environmental Determinants of Islet Autoimmunity (ENDIA) study
Dietary patterns during pregnancy and maternal and birth outcomes in women with type 1 diabetes: the Environmental Determinants of Islet Autoimmunity (ENDIA) study
Dietary patterns characterised by high intakes of vegetables may lower the risk of pre-eclampsia and premature birth in th...
Comment on the role of interferons in the pathology of beta cell destruction in type 1 diabetes. Reply to Lenzen S [letter]
Comment on the role of interferons in the pathology of beta cell destruction in type 1 diabetes. Reply to Lenzen S [letter]
Acknowledgements We are grateful to M. Cnop (Université Libre de Bruxelles, Belg...
Lifetime history of gestational diabetes and cognitive function in parous women in midlife
Lifetime history of gestational diabetes and cognitive function in parous women in midlife
We aimed to determine whether a history of gestational diabetes mellitus (GDM) is associated with cognitive function in mi...
Implicating type 2 diabetes effector genes in relevant metabolic cellular models using promoter-focused Capture-C
Implicating type 2 diabetes effector genes in relevant metabolic cellular models using promoter-focused Capture-C
Genome-wide association studies (GWAS) have identified hundreds of type 2 diabetes loci, with the vast majority of signals...
An antifibrotic compound that ameliorates hyperglycaemia and fat accumulation in cell and HFD mouse models
An antifibrotic compound that ameliorates hyperglycaemia and fat accumulation in cell and HFD mouse models
Appropriate management of blood glucose levels and the prevention of complications are important in the treatment of diabe...
Metabolic health in people living with type 1 diabetes in Belgium: a repeated cross-sectional study
Metabolic health in people living with type 1 diabetes in Belgium: a repeated cross-sectional study
Metabolic abnormalities such as central obesity, insulin resistance, dyslipidaemia and hypertension, often referred to as ...
Risk factors for Charcot foot development in individuals with diabetes mellitus
Risk factors for Charcot foot development in individuals with diabetes mellitus
Charcot foot is a complication of diabetes mellitus that has potentially disastrous consequences. Although it was first de...
Genetic evidence for efficacy of targeting IL-2, IL-6 and TYK2 signalling in the prevention of type 1 diabetes: a Mendelian randomisation study
Genetic evidence for efficacy of targeting IL-2, IL-6 and TYK2 signalling in the prevention of type 1 diabetes: a Mendelian randomisation study
We aimed to investigate the genetic evidence that supports the repurposing of drugs already licensed or in clinical phases...
The DPP-4 inhibitor sitagliptin improves glycaemic control and early-stage diabetic nephropathy in adolescents with type 1 diabetes using the MiniMed 780G advanced hybrid closed-loop system: a randomised controlled trial
The DPP-4 inhibitor sitagliptin improves glycaemic control and early-stage diabetic nephropathy in adolescents with type 1 diabetes using the MiniMed 780G advanced hybrid closed-loop system: a randomised controlled trial
Dipeptidyl peptidase-4 (DPP-4) inhibition has beneficial effects on various metabolic indicators in diabetes. Stromal cell...
The association of chronic complications with time in tight range and time in range in people with type 1 diabetes: a retrospective cross-sectional real-world study
The association of chronic complications with time in tight range and time in range in people with type 1 diabetes: a retrospective cross-sectional real-world study
The aim of this study was to evaluate the association of chronic complications with time in tight range (TITR: 3.9–7...
Risk factors and prediction of hypoglycaemia using the Hypo-RESOLVE cohort: a secondary analysis of pooled data from insulin clinical trials
Risk factors and prediction of hypoglycaemia using the Hypo-RESOLVE cohort: a secondary analysis of pooled data from insulin clinical trials
The objective of the Hypoglycaemia REdefining SOLutions for better liVES (Hypo-RESOLVE) project is to use a dataset of poo...
Differential CpG methylation at Nnat in the early establishment of beta cell heterogeneity
Differential CpG methylation at Nnat in the early establishment of beta cell heterogeneity
Beta cells within the pancreatic islet represent a heterogenous population wherein individual sub-groups of cells make dis...
A 3D atlas of the human developing pancreas to explore progenitor proliferation and differentiation
A 3D atlas of the human developing pancreas to explore progenitor proliferation and differentiation
Rodent pancreas development has been described in great detail. On the other hand, there are still gaps in our understandi...
Cardiovascular risk management among individuals with type 2 diabetes and severe mental illness: a cohort study
Cardiovascular risk management among individuals with type 2 diabetes and severe mental illness: a cohort study
The aim of this study was to compare cardiovascular risk management among people with type 2 diabetes according to severe ...
The INNODIA Type 1 Diabetes Natural History Study: a European cohort of newly diagnosed children, adolescents and adults
The INNODIA Type 1 Diabetes Natural History Study: a European cohort of newly diagnosed children, adolescents and adults
Type 1 diabetes is an heterogenous condition. Characterising factors explaining differences in an individual’s clini...
Surveillance of the liver in type 2 diabetes: important but unfeasible?
Surveillance of the liver in type 2 diabetes: important but unfeasible?
Fatty liver plays a pivotal role in the pathogenesis of the metabolic syndrome and type 2 diabetes. According to an update...
A ketone monoester drink reduces postprandial blood glucose concentrations in adults with type 2 diabetes: a randomised controlled trial
A ketone monoester drink reduces postprandial blood glucose concentrations in adults with type 2 diabetes: a randomised controlled trial
The aim of the present study was to conduct a randomised, placebo-controlled, double-blind, crossover trial to determine w...
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