Ajoolabady A, Chiong M, Lavandero S, Klionsky DJ, Ren J (2022) Mitophagy in cardiovascular diseases: molecular mechanisms, pathogenesis, and treatment. Trends Mol Med 28:836–849

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ali NAM, Abdelhamid AM, El-Sayed NM, Radwan A (2024) Alpha-asarone attenuates alcohol-induced hepatotoxicity in a murine model by ameliorating oxidative stress, inflammation, and modulating apoptotic-autophagic cell death. Toxicol Appl Pharmacol 490:117041

Article  CAS  PubMed  Google Scholar 

Alwaili MA, Elhoby AH, El-Sayed NM, Mahmoud IZ, Alharthi A, El-Nablaway M, Khodeer DM (2024) Cardioprotective effects of alpha-asarone against Hexavalent Chromium-Induced oxidative damage in mice. Drug Des Devel Ther 18:3383–3397

Article  PubMed  PubMed Central  Google Scholar 

Bao Z, Bao L, Han N, Hou Y, Feng F (2021) rTMS alleviates AD-induced cognitive impairment by inhibitng apoptosis in SAMP8 mouse. Aging 13:26034–26045

Article  CAS  PubMed  PubMed Central  Google Scholar 

Belenichev I, Aliyeva O, Popazova O, Bukhtiyarova N (2023) Molecular and biochemical mechanisms of diabetic encephalopathy. Acta Biochim Pol 70:751–760

CAS  PubMed  Google Scholar 

Bergamini C, Bonora E, Moruzzi N (2023) Editorial: mitochondrial bioenergetics impairments in genetic and metabolic diseases. Front Physiol 14:1228926

Article  PubMed  PubMed Central  Google Scholar 

Carroll RG, Hollville E, Martin SJ (2014) Parkin sensitizes toward apoptosis induced by mitochondrial depolarization through promoting degradation of Mcl-1. Cell Rep 9:1538–1553

Article  CAS  PubMed  Google Scholar 

Chomova M, Balazova M, Muchova J (2017) Diabetes-induced abnormalities of mitochondrial function in rat brain cortex: the effect of n-3 fatty acid diet. Mol Cell Biochem 435:109–131

Article  CAS  PubMed  Google Scholar 

D’Amico AG, Maugeri G, Magri B, Bucolo C, D’Agata V (2024) Targeting the PINK1/Parkin pathway: a new perspective in the prevention and therapy of diabetic retinopathy. Exp Eye Res 247:110024

Article  PubMed  Google Scholar 

Dash UK, Mazumdar D, Singh S (2024) High mobility Group Box protein (HMGB1): a potential therapeutic target for Diabetic Encephalopathy. Mol Neurobiol 61:8188–8205

Article  CAS  PubMed  Google Scholar 

Gao X, Li R, Luo L, Liao C, Yang H, Mao S (2024) Alpha-asarone ameliorates neurological dysfunction of Subarachnoid hemorrhagic rats in both Acute and Recovery Phases via regulating the CaMKII-Dependent pathways. Transl Stroke Res 15:476–494

Article  CAS  PubMed  Google Scholar 

Harper JW, Ordureau A, Heo JM (2018) Building and decoding ubiquitin chains for mitophagy. Nat Rev Mol Cell Biol 19:93–108

Article  CAS  PubMed  Google Scholar 

Hirota Y, Yamashita S, Kurihara Y, Jin X, Aihara M, Saigusa T, Kang D, Kanki T (2015) Mitophagy is primarily due to alternative autophagy and requires the MAPK1 and MAPK14 signaling pathways. Autophagy 11:332–343

Article  PubMed  PubMed Central  Google Scholar 

Hollville E, Carroll RG, Cullen SP, Martin SJ (2014) Bcl-2 family proteins participate in mitochondrial quality control by regulating Parkin/PINK1-dependent mitophagy. Mol Cell 55:451–466

Article  CAS  PubMed  Google Scholar 

Huang T, Pu Q, Zhou C, Lin P, Gao P, Zhang X, Chu Y, Yue B, Wu M (2020) MicroRNA-302/367 cluster impacts host Antimicrobial Defense via Regulation of Mitophagic Response Against Pseudomonas aeruginosa infection. Front Immunol 11:569173

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lazarou M, Jin SM, Kane LA, Youle RJ (2012) Role of PINK1 binding to the TOM complex and alternate intracellular membranes in recruitment and activation of the E3 ligase Parkin. Dev Cell 22:320–333

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lee HJ, Ahn SM, Pak ME, Jung DH, Lee SY, Shin HK, Choi BT (2018) Positive effects of alpha-asarone on transplanted neural progenitor cells in a murine model of ischemic stroke. Phytomedicine 51:151–161

Article  CAS  PubMed  Google Scholar 

Li Y, Li Z, Grillo E, Desler C, Navarro C, Bohr VA, Berliocchi L, Rasmussen LJ (2024a) Human fibroblasts from sporadic Alzheimer’s disease (AD) patients show mitochondrial alterations and lysosome dysfunction. Free Radic Biol Med 222:569–578

Article  CAS  PubMed  Google Scholar 

Li Y, Wei X, Xiao R, Chen Y, Xiong T, Fang ZM, Huo B, Guo X, Luo H, Wu X, Liu L, Zhu XH, Hu Q, Jiang DS, Yi X (2024b) SMYD2-Methylated PPARgamma facilitates Hypoxia-Induced Pulmonary hypertension by activating Mitophagy. Circ Res 135:93–109

Article  CAS  PubMed  Google Scholar 

Lin X, Yang M, Huang Y, Huang X, Shi H, Chen B, Kang J, Ke S (2024) Gene signatures of endoplasmic reticulum stress and mitophagy for prognostic risk prediction in lung adenocarcinoma. IET Syst Biol 18:103–117

Article  PubMed  PubMed Central  Google Scholar 

Mailloux RJ (2021) An update on methods and approaches for interrogating mitochondrial reactive oxygen species production. Redox Biol 45:102044

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mikami M, Takuya O, Yoshino Y, Nakamura S, Ito K, Kojima H, Takahashi T, Iddamalgoda A, Inoue S, Shimazawa M, Hara H (2021) Acorus calamus extract and its component alpha-asarone attenuate murine hippocampal neuronal cell death induced by l-glutamate and tunicamycin. Biosci Biotechnol Biochem 85:493–501

Article  PubMed  Google Scholar 

Nan X, Sun Q, Xu X, Yang Y, Zhen Y, Zhang Y, Zhou H, Fang H (2022) Forsythoside B ameliorates diabetic cognitive dysfunction by inhibiting hippocampal neuroinflammation and reducing synaptic dysfunction in ovariectomized mice. Front Aging Neurosci 14:974690

Article  CAS  PubMed  PubMed Central  Google Scholar 

Qi Z, Peng J, Wang H, Wang L, Su Y, Ding L, Cao B, Zhao Y, Xing Q, Yang JJ (2024) Modulating neuroinflammation and cognitive function in postoperative cognitive dysfunction via CCR5-GPCRs-Ras-MAPK pathway targeting with microglial EVs. CNS Neurosci Ther 30:e14924

Article  CAS  PubMed  PubMed Central  Google Scholar 

Shi J, Li R, Yang Y, Ji L, Li C (2021) Protective effect of alpha-asarone and beta-asarone on Abeta -induced inflammatory response in PC12 cells and its. Zhejiang Da Xue Xue Bao Yi Xue Ban 50:591–600

PubMed  PubMed Central  Google Scholar 

Strand N, Anderson MA, Attanti S, Gill B, Wie C, Dawodu A, Pagan-Rosado R, Harbell MW, Maloney JA (2024) Diabetic Neuropathy: Pathophysiology Review. Curr Pain Headache Rep 28:481–487

Article  PubMed  Google Scholar 

Sun W, Chen X, Mei Y, Li X, Yang Y, An L (2022) Co-exposure of melamine and cyanuric acid as a risk factor for oxidative stress and energy metabolism: adverse effects on hippocampal neuronal and synaptic function induced by excessive ROS production. Ecotoxicol Environ Saf 247:114230

Article  CAS  PubMed  Google Scholar 

Tang W, Yan C, He S, Du M, Cheng B, Deng B, Zhu S, Li Y, Wang Q (2023) Neuron-targeted overexpression of caveolin-1 alleviates diabetes-associated cognitive dysfunction via regulating mitochondrial fission-mitophagy axis. Cell Commun Signal 21:357

Article  CAS  PubMed  PubMed Central  Google Scholar 

van Sloten TT, Sedaghat S, Carnethon MR, Launer LJ, Stehouwer CDA (2020) Cerebral microvascular complications of type 2 diabetes: stroke, cognitive dysfunction, and depression. Lancet Diabetes Endocrinol 8:325–336

Article  PubMed  PubMed Central  Google Scholar 

Venkatesan K (2022) Anti-amnesic and anti-cholinesterase activities of alpha-asarone against scopolamine-induced memory impairments in rats. Eur Rev Med Pharmacol Sci 26:6344–6350