Bachmann M, Li W, Edwards MJ, Ahmad SA, Patel S, Szabo I, Gulbins E (2020) Voltage-gated potassium channels as regulators of cell death. Front Cell Dev Biol 8:611853. https://doi.org/10.3389/fcell.2020.611853

Article  PubMed  PubMed Central  Google Scholar 

Baculis BC, Zhang J, Chung HJ (2020) The role of Kv7 channels in neural plasticity and behavior. Front Physiol 11:568667. https://doi.org/10.3389/fphys.2020.568667

Article  PubMed  PubMed Central  Google Scholar 

Bari BA, Grossman CD, Lubin EE, Rajagopalan AE, Cressy JI, Cohen JY (2019) Stable representations of decision variables for flexible behavior. Neuron 103:922–933 e927

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bretón RR, Rodríguez JCG (2012) Excitotoxicity and oxidative stress in acute ischemic stroke. Acute Ischemic Stroke 200:29–50

Google Scholar 

Broicher SD, Filli L, Geisseler O, Germann N, Zörner B, Brugger P, Linnebank M (2018) Positive effects of Fampridine on cognition, fatigue and depression in patients with multiple sclerosis over 2 years. J Neurol 265:1016–1025. https://doi.org/10.1007/s00415-018-8796-9

Article  CAS  PubMed  Google Scholar 

Brus-Ramer M, Carmel JB, Martin JH (2009) Motor cortex bilateral motor representation depends on subcortical and interhemispheric interactions. J Neurosci 29:6196–6206

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chamorro Á, Dirnagl U, Urra X, Planas AM (2016) Neuroprotection in acute stroke: targeting excitotoxicity, oxidative and nitrosative stress, and inflammation. Lancet Neurol 15:869–881. https://doi.org/10.1016/S1474-4422(16)00114-9

Article  CAS  PubMed  Google Scholar 

Chen YJ, Nguyen HM, Maezawa I, Jin LW, Wulff H (2018) Inhibition of the potassium channel Kv1.3 reduces infarction and inflammation in ischemic stroke. Ann Clin Transl Neurol 5:147–161. https://doi.org/10.1002/acn3.513

Article  CAS  PubMed  Google Scholar 

Dalley JW, Cardinal RN, Robbins TW (2004) Prefrontal executive and cognitive functions in rodents: neural and neurochemical substrates. Neurosci Biobehav Rev 28:771–784. https://doi.org/10.1016/j.neubiorev.2004.09.006

Article  CAS  PubMed  Google Scholar 

Déziel RA, Tasker RA (2018) Bilateral ischaemic lesions of the medial prefrontal cortex are anxiogenic in the rat. Acta Neuropsychiatr 30:181–186. https://doi.org/10.1017/neu.2017.32

Article  PubMed  Google Scholar 

Dietrich M, Hartung H-P, Albrecht P (2021) Neuroprotective properties of 4-aminopyridine. Neurol Neuroimmunol Neuroinflamm 8:e976. https://doi.org/10.1212/NXI.0000000000000976

Article  PubMed  PubMed Central  Google Scholar 

Doyle KP, Simon RP, Stenzel-Poore MP (2008) Mechanisms of ischemic brain damage. Neuropharmacology 55:310–318. https://doi.org/10.1016/j.neuropharm.2008.01.005

Article  CAS  PubMed  PubMed Central  Google Scholar 

Elsayed WM, Abdel-Gawad E-HA, Mesallam DI, El-Serafy TS (2020) The relationship between oxidative stress and acute ischemic stroke severity and functional outcome. Egypt J Neurol Psychiatr Neurosurg 56:1–6. https://doi.org/10.1186/s41983-020-00206-y

Article  Google Scholar 

Elzawahry H, Hernandez-Frau P, Behrouz R, Clark M (2009) Reperfusion injury in stroke

Farokhi–Sisakht F, Farhoudi M, Mahmoudi J, Kahfi–Ghaneh F, Sadigh–Eteghad S (2022) Effect of intranasal administration of caffeine on mPFC ischemia–induced cognitive impairment in balb/c mice. Acta Neurobiol Exp 82:295–303. https://doi.org/10.55782/ane-2022-028

Article  Google Scholar 

Ferrer I, Friguls B, Dalfo E, Justicia C, Planas A (2003) Caspase-dependent and caspase‐independent signalling of apoptosis in the penumbra following middle cerebral artery occlusion in the adult rat. Neuropathol Appl Neurobiol 29:472–481. https://doi.org/10.1046/j.1365-2990.2003.00485.x

Article  CAS  PubMed  Google Scholar 

Franciosi S, Ryu JK, Choi HB, Radov L, Kim SU, McLarnon JG (2006) Broad-spectrum effects of 4-aminopyridine to modulate amyloid β1–42-induced cell signaling and functional responses in human microglia. J Neurosci 26:11652–11664. https://doi.org/10.1523/JNEUROSCI.2490-06.2006

Article  CAS  PubMed  PubMed Central  Google Scholar 

Galligan NG, Hevey D, Coen RF, Harbison JA (2016) Clarifying the associations between anxiety, depression and fatigue following stroke. J Health Psychol 21:2863–2871. https://doi.org/10.1177/1359105315587140

Article  PubMed  Google Scholar 

Gao S, Mo J, Chen L, Wang Y, Mao X, Shi Y, Zhang X, Yu R, Zhou X (2016) Astrocyte GGTI-mediated Rac1 prenylation upregulates NF-κB expression and promotes neuronal apoptosis following hypoxia/ischemia. Neuropharmacology 103:44–56. https://doi.org/10.1016/j.neuropharm.2015.12.002

Article  CAS  PubMed  Google Scholar 

Govindappa PK, Rahul V, Ellur G, Gaber AA, Elfar J (2024) 4-aminopyridine attenuates inflammation and apoptosis and increases angiogenesis to promote skin regeneration following a burn injury. Res Sq. https://doi.org/10.21203/rs.3.rs-4669610/v1

Article  PubMed  PubMed Central  Google Scholar 

Haghdoost-Yazdi H, Piri H, Faraji A, Fraidouni N, Dargahi T, Mahmudi M, Alipour Heidari M (2016) Pretreatment with potassium channel blockers of 4-aminopyridine and tetraethylammonium attenuates behavioural symptoms of parkinsonism induced by intrastriatal injection of 6-hydroxydopamine; the role of lipid peroxidation. Neurol Res 38:294–300. https://doi.org/10.1080/01616412.2015.1114290

Article  CAS  PubMed  Google Scholar 

Heidbreder CA, Groenewegen HJ (2003) The medial prefrontal cortex in the rat: evidence for a dorso-ventral distinction based upon functional and anatomical characteristics. Neurosci Biobehav Rev 27:555–579

Article  PubMed  Google Scholar 

Hu C-L, Liu Z, Zeng X-M, Liu Z-Q, Chen X-H, Zhang Z-H, Mei Y-A (2006) 4-aminopyridine, a Kv channel antagonist, prevents apoptosis of rat cerebellar granule neurons. Neuropharmacology 51:737–746. https://doi.org/10.1016/j.neuropharm.2006.05.013

Article  CAS  PubMed  Google Scholar 

Hupperts R, Lycke J, Short C, Gasperini C, McNeill M, Medori R, Tofil-Kaluza A, Hovenden M, Mehta LR, Elkins J (2016) Prolonged-release Fampridine and walking and balance in MS: randomised controlled MOBILE trial. Mult Scler 22:212–221. https://doi.org/10.1177/1352458515581436

Article  CAS  PubMed  PubMed Central  Google Scholar 

Iaci JF, Parry TJ, Huang Z, Finklestein SP, Ren J, Barrile DK, Davenport MD, Wu R, Blight AR, Caggiano AO (2013) Dalfampridine improves sensorimotor function in rats with chronic deficits after middle cerebral artery occlusion. Stroke 44:1942–1950. https://doi.org/10.1161/STROKEAHA.111.000147

Article  CAS  PubMed  Google Scholar 

Imlach WL, Beck ES, Choi BJ, Lotti F, Pellizzoni L, McCabe BD (2012) SMN is required for sensory-motor circuit function in drosophila. Cell 151:427–439

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jacobson L (2011) Hypothalamic-pituitary‐adrenocortical axis: neuropsychiatric aspects. Compr Physiol 4:715–738. https://doi.org/10.1002/cphy.c130036

Article  Google Scholar 

Ji M-h, Lei L, Gao D-p, Tong J-h, Wang Y, Yang J-j (2020) Neural network disturbance in the medial prefrontal cortex might contribute to cognitive impairments induced by neuroinflammation. Brain Behav Immun 89:133–144. https://doi.org/10.1016/j.bbi.2020.06.001

Article  CAS  PubMed  Google Scholar 

Kamal FZ, Lefter R, Jaber H, Balmus I-M, Ciobica A, Iordache A-C (2023) The role of potential oxidative biomarkers in the prognosis of acute ischemic stroke and the exploration of antioxidants as possible preventive and treatment options. Int J Mol Sci 24:6389. https://doi.org/10.3390/ijms24076389

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kesner RP, Churchwell JC (2011) An analysis of rat prefrontal cortex in mediating executive function. Neurobiol Learn Mem 96:417–431