Hallek M (2019) Chronic lymphocytic leukemia: 2020 update on diagnosis, risk stratification and treatment. Am J Hematol 94(11):1266–1287
Kawasaki BT, Farrar WL (2008) Cancer stem cells, CD200 and immunoevasion. Trends Immunol 29(10):464–468
Article CAS PubMed Google Scholar
Riches JC, Ramsay AG, Gribben JG (2010) T-cell function in chronic lymphocytic leukaemia. Semin Cancer Biol 20(6):431–438
Article CAS PubMed Google Scholar
McWhirter JR, Kretz-Rommel A, Saven A, Maruyama T, Potter KN, Mockridge CI et al (2006) Antibodies selected from combinatorial libraries block a tumor antigen that plays a key role in immunomodulation. Proc Natl Acad Sci USA 103(4):1041–1046
Article CAS PubMed PubMed Central Google Scholar
Staub RB, Marcondes NA, Rotta LN (2021) CD200 expression in hematopoietic neoplasms: beyond a marker for diagnosis of B-cell neoplasms. Crit Rev Oncol Hematol 167:103509
D’Arena G, De Feo V, Pietrantuono G, Seneca E, Mansueto G, Villani O et al (2020) CD200 and chronic lymphocytic leukemia: biological and clinical relevance. Front Oncol 10:584427
Article PubMed PubMed Central Google Scholar
Pallasch CP, Ulbrich S, Brinker R, Hallek M, Uger RA, Wendtner CM (2009) Disruption of T cell suppression in chronic lymphocytic leukemia by CD200 blockade. Leuk Res 33(3):460–464
Article CAS PubMed Google Scholar
Conticello C, Giuffrida R, Parrinello N, Buccheri S, Adamo L, Sciuto MR et al (2013) CD200 expression in patients with multiple myeloma: another piece of the puzzle. Leuk Res 37(12):1616–1621
Article CAS PubMed Google Scholar
Damiani D, Tiribelli M, Raspadori D, Sirianni S, Meneghel A, Cavalllin M et al (2015) Clinical impact of CD200 expression in patients with acute myeloid leukemia and correlation with other molecular prognostic factors. Oncotarget 6(30):30212–30221
Article PubMed PubMed Central Google Scholar
Zahavi D, Weiner L (2020) Monoclonal antibodies in cancer therapy. Antibodies 9(3):34
Article CAS PubMed PubMed Central Google Scholar
Burger JA, Tedeschi A, Barr PM, Robak T, Owen C, Ghia P et al (2015) Ibrutinib as initial therapy for patients with chronic lymphocytic leukemia. N Engl J Med 373(25):2425–2437
Article CAS PubMed PubMed Central Google Scholar
Fischer K, Al-Sawaf O, Bahlo J, Fink A-M, Tandon M, Dixon M et al (2019) Venetoclax and obinutuzumab in patients with CLL and coexisting conditions. N Engl J Med 380(23):2225–2236
Article CAS PubMed Google Scholar
Zelenetz AD, Barrientos JC, Brown JR, Coiffier B, Delgado J, Egyed M et al (2017) Idelalisib or placebo in combination with bendamustine and rituximab in patients with relapsed or refractory chronic lymphocytic leukaemia: interim results from a phase 3, randomised, double-blind, placebo-controlled trial. Lancet Oncol 18(3):297–311
Article CAS PubMed PubMed Central Google Scholar
Kretz-Rommel A, Bowdish KS (2008) Rationale for anti-CD200 immunotherapy in B-CLL and other hematologic malignancies: new concepts in blocking immune suppression. Expert Opin Biol Ther 8(1):5–15
Article CAS PubMed Google Scholar
Challagundla P, Medeiros LJ, Kanagal-Shamanna R, Miranda RN, Jorgensen JL (2014) Differential expression of CD200 in B-cell neoplasms by flow cytometry can assist in diagnosis, subclassification, and bone marrow staging. Am J Clin Pathol 142(6):837–844
Mora A, Bosch R, Cuellar C, Vicente EP, Blanco L, Martino R et al (2019) CD200 is a useful marker in the diagnosis of chronic lymphocytic leukemia. Cytometry B Clin Cytom 96(2):143–148
Article CAS PubMed Google Scholar
Rai KR, Sawitsky A, Cronkite EP, Chanana AD, Levy RN, Pasternack BS (1975) Clinical staging of chronic lymphocytic leukemia. Blood 46(2):219–234
Article CAS PubMed Google Scholar
Moreaux J, Veyrune JL, Reme T, De Vos J, Klein B (2008) CD200: a putative therapeutic target in cancer. Biochem Biophys Res Commun 366(1):117–122
Article CAS PubMed Google Scholar
Aref S, El Agdar M, El Sebaie A, Abouzeid T, Sabry M, Ibrahim L (2020) Prognostic value of CD200 expression and soluble CTLA-4 concentrations in intermediate and high-risk myelodysplastic syndrome patients. Asian Pac J Cancer Prev 21(8):2225–2230
Article CAS PubMed PubMed Central Google Scholar
D'Arena G, Vitale C, Coscia M, Lamorte D, Pietrantuono G, Perutelli F, D'Auria F, Statuto T, Valvano L, Tomasso A, Griggio V, Jones R, Mansueto G, Villani O, D'Agostino S, Viglioglia V, De Feo V, Calapai F, Mannucci C, Sgambato A, Efremov DG, Laurenti L (2021) CD200 baseline serum levels predict prognosis of chronic lymphocytic leukemia. Cancers (Basel) 13(16):1–9
Hazzaa AA, Azab MM, Elnaggar AM, Elshorbagy SM (2022) Role Of CD200 in adult patients with acute myeloid leukemia. Zagazig Univ Med J 28(6.1):104–14
Aref S, Azmy E, El-Bakry K, Ibrahim L, Abdel AS (2017) Prognostic impact of CD200 and CD56 expression in pediatric B-cell acute lymphoblastic leukemia patients. Pediatr Hematol Oncol 34(5):275–285
Article CAS PubMed Google Scholar
Aref S, Azmy E, El-Bakry K, Ibrahim L, Mabed M (2018) Prognostic impact of CD200 and CD56 expression in adult acute lymphoblastic leukemia patients. Hematology (Amsterdam, Netherlands) 23(5):263–270
Kandeel EZ, Madney Y, Eldin DN, Shafik NF (2021) Overexpression of CD200 and CD123 is a major influential factor in the clinical course of pediatric acute myeloid leukemia. Exp Mol Pathol 118:104597
Article CAS PubMed Google Scholar
Zahran AM, Mohammed Saleh MF, Sayed MM, Rayan A, Ali AM, Hetta HF (2018) Up-regulation of regulatory T cells, CD200 and TIM3 expression in cytogenetically normal acute myeloid leukemia. Cancer Biomark 22(3):587–595
Article CAS PubMed Google Scholar
Molina-Aguilar R, Montiel-Cervantes LA, Anguiano-Peñaloza SV, Lezama R, Vela-Ojeda J, Reyes-Maldonado E (2020) γδ T cells number, CD200, and Flt3 expression is associated with higher progression free survival in patients with chronic myeloid leukemia. Arch Med Res 51(3):194–203
Article CAS PubMed Google Scholar
El Din Fouad NB, Ibrahim NY, Abdel Aziz RS, Ibrahim SK (2018) CD200 expression in diagnostic and prognostic assessment of mature B cell lymphophoproliferative neoplasms. Asian Pac J Cancer Prev 19(12):3383–3392
Tiribelli M, Raspadori D, Geromin A, Cavallin M, Sirianni S, Simeone E et al (2017) High CD200 expression is associated with poor prognosis in cytogenetically normal acute myeloid leukemia, even in FlT3-ITD-/NPM1+ patients. Leuk Res 58:31–38
Article CAS PubMed Google Scholar
Wong KK, Shaha S, Spaner D, Gorczynski R (2009) Potential role for serum soluble CD200 in human Chronic Lymphocytic Leukemia. Am Assoc Immnol (131):144–5
Miao Y, Fan L, Wu YJ, Xia Y, Qiao C, Wang Y et al (2016) Low expression of CD200 predicts shorter time-to-treatment in chronic lymphocytic leukemia. Oncotarget 7(12):13551–13562
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