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Exploring castleman disease in a cohort of hispanic patients: a recognition to its histopathology
Exploring castleman disease in a cohort of hispanic patients: a recognition to its histopathology
Castleman disease is a clinicopathological entity that shares features with hematological, rheumatological, and infectious...
CD5-positive B-cell acute lymphoblastic leukemia/lymphoma with mimicking aggressive mature B-cell lymphoma: a case report of a newly described entity and potential diagnostic pitfall
CD5-positive B-cell acute lymphoblastic leukemia/lymphoma with mimicking aggressive mature B-cell lymphoma: a case report of a newly described entity and potential diagnostic pitfall
Here, we present a challenging diagnostic case of a B-cell acute lymphoblastic leukemia (B-ALL) presenting as a rare extra...
Primary myelofibrosis with concurrent and atypical mutations
Primary myelofibrosis with concurrent and atypical mutations
Distinct bone marrow morphology is considered the primary basis for the diagnosis of BCR::ABL1-negative myeloprol...
Evaluation of CD200 marker variations and its correlation with clinicopathological features of chronic lymphocytic leukemia patients: a case–control study
Evaluation of CD200 marker variations and its correlation with clinicopathological features of chronic lymphocytic leukemia patients: a case–control study
Given its strong correlation with disease progression and risk stratification, CD200 has emerged as a pivotal biomarker in...
A novel homozygous frameshift mutation (p.Lys365Glnfs*69) in a family with hereditary factor XII deficiency: a case report
A novel homozygous frameshift mutation (p.Lys365Glnfs*69) in a family with hereditary factor XII deficiency: a case report
Factor XII (FXII) deficiency is a rare autosomal recessive disorder characterized by prolonged activated partial thrombopl...
EGLN1-positive familial erythrocytosis: a rare variant with an unusually aggressive clinical course
EGLN1-positive familial erythrocytosis: a rare variant with an unusually aggressive clinical course
Familial erythrocytosis type 3 (ECYT3) is a rare condition caused by loss of function germline mutations in the prolyl hyd...
Unicentric Castleman disease following POEMS syndrome remission
Unicentric Castleman disease following POEMS syndrome remission
POEMS syndrome is a rare paraneoplastic disorder characterized by polyneuropathy, organomegaly, endocrinopathy, monoclonal...
Granulomas in bone marrow: is it always tuberculosis?
Granulomas in bone marrow: is it always tuberculosis?
Granulomas in a bone marrow biopsy are like gold dust. Numerous studies have reported that the incidence of granu...
Masked by eosinophils: a cryptic presentation of pediatric B-ALL with IGH rearrangement
Masked by eosinophils: a cryptic presentation of pediatric B-ALL with IGH rearrangement
Hypereosinophilia is uncommon in the pediatric population and may be associated with either primary or secondary condition...
Discovery of a germline deletion in a B-lymphoblastic leukemia post-induction bone marrow specimen: a case report and review of the literature
Discovery of a germline deletion in a B-lymphoblastic leukemia post-induction bone marrow specimen: a case report and review of the literature
Somatic IKZF1 alterations are common in B-lymphoblastic leukemia (B-ALL) and are generally associated with poor outcomes. ...
Plasmablastic plasmacytoma followed by a plasmacytic plasma cell myeloma: insights into discordant extramedullary transformation—a case report and literature review
Plasmablastic plasmacytoma followed by a plasmacytic plasma cell myeloma: insights into discordant extramedullary transformation—a case report and literature review
Plasma cell neoplasms encompass a spectrum of disorders characterized by the clonal proliferation of plasma cells. Plasmab...
A rare alpha globin chain variant hemoglobin Fontainebleau poses diagnostic challenges by yielding different results in two different HPLC systems
A rare alpha globin chain variant hemoglobin Fontainebleau poses diagnostic challenges by yielding different results in two different HPLC systems
Alpha globin chain variants constitute a very small fraction of the total hemoglobinopathy cases. Their rarity and the oft...
A rare case of Hodgkin lymphoma transformed from follicular lymphoma demonstrating 14;18 translocation
A rare case of Hodgkin lymphoma transformed from follicular lymphoma demonstrating 14;18 translocation
Ethical approval Following the institutional ethical guidel...
Where are the immunoglobulins? A review of non-secretory multiple myeloma
Where are the immunoglobulins? A review of non-secretory multiple myeloma
Multiple myeloma (MM) is a malignant neoplasm of clonal plasma cells, typically associated with the production of a monocl...
Application of capillary gel electrophoresis in detection of Factor VIII gene intron 22 inversion of hemophilia A
Application of capillary gel electrophoresis in detection of Factor VIII gene intron 22 inversion of hemophilia A
Intron 22 inversion (Inv22) of the factor VIII gene (F8) accounts for approximately 45% of severe hemophilia A (HA) cases....
Immune cell subset variations in immune thrombocytopenia: a prospective observational study
Immune cell subset variations in immune thrombocytopenia: a prospective observational study
This study evaluated immune cell subset variations in immune thrombocytopenia (ITP) by comparing frequencies at diagnosis ...
Validation of clinicopathologic features of a genetic myelodysplastic syndrome classification in an independent cohort
Validation of clinicopathologic features of a genetic myelodysplastic syndrome classification in an independent cohort
Current classification systems for myelodysplastic syndromes (MDS) incorporate morphologic findings, blast percentage, and...
A rare case of in situ follicular B-cell neoplasm involving sebaceous lymphadenoma
A rare case of in situ follicular B-cell neoplasm involving sebaceous lymphadenoma
In situ follicular neoplasia (ISFN) is characterized by a monoclonal proliferation of BCL2-positive B cells harboring the ...
Perifollicular concentric granulomas: A clue to IgG4-related lymphadenopathy
Perifollicular concentric granulomas: A clue to IgG4-related lymphadenopathy
A 69-year-old with well-controlled HIV was evaluated for persistent cough, in the context of years of fatigue and...
Quantification of the median fluorescence intensity of CD3 and CD4 in mycosis fungoides/Sezary syndrome versus non-neoplastic control cases in peripheral blood
Quantification of the median fluorescence intensity of CD3 and CD4 in mycosis fungoides/Sezary syndrome versus non-neoplastic control cases in peripheral blood
Peripheral blood involvement by MF/SS has significant implications for prognosis and treatment. Flow cytometry is commonly...
Macrothrombocytopenia and granulopoieitic Döhle body-like inclusions in a MYH9-related disorder
Macrothrombocytopenia and granulopoieitic Döhle body-like inclusions in a MYH9-related disorder
Ethical approval All procedures performed in studies involv...
Clinicopathologic features of primary central nervous system anaplastic large cell lymphoma: a multicenter study identifies age and ALK status as prognostic factors
Clinicopathologic features of primary central nervous system anaplastic large cell lymphoma: a multicenter study identifies age and ALK status as prognostic factors
Anaplastic large cell lymphoma with primary presentation in, and disease limited to, the central nervous system (primary C...
Follicular dendritic cell sarcoma involving the parotid gland with expression of the melanocytic marker PRAME
Follicular dendritic cell sarcoma involving the parotid gland with expression of the melanocytic marker PRAME
Follicular dendritic cell sarcoma is a rare mesenchymal neoplasm arising from follicular dendritic cells (FDC) of lymphoid...
Extra-adrenal myelolipoma involved by plasma cell neoplasm: homing of neoplastic plasma cells to a site of ectopic hematopoiesis
Extra-adrenal myelolipoma involved by plasma cell neoplasm: homing of neoplastic plasma cells to a site of ectopic hematopoiesis
Ethical approval All procedures performed in studies involv...
Paraneoplastic glomerulonephritis and kidney infiltration by mantle cell lymphoma: A diagnostic challenge
Paraneoplastic glomerulonephritis and kidney infiltration by mantle cell lymphoma: A diagnostic challenge
Mantle cell lymphoma (MCL) is a rare and aggressive type of lymphoma that can affect the kidneys. The disease can lead to ...
Misdiagnosis of Hodgkin disease as histiocytosis is associated with adverse consequences
Misdiagnosis of Hodgkin disease as histiocytosis is associated with adverse consequences
Conflict of interest The authors declare no competing inter...
Bridging dermatology and hematology: a case of lepromatous leprosy with bone marrow involvement and pancytopenia
Bridging dermatology and hematology: a case of lepromatous leprosy with bone marrow involvement and pancytopenia
Leprosy, caused by Mycobacterium leprae (M. leprae), primarily manifests with cutaneous and peripheral nerve invo...
Navigating diagnostic dilemmas: a rare presentation of extramedullary T-lymphoblastic leukemia/lymphoma with chronic myeloid leukemia
Navigating diagnostic dilemmas: a rare presentation of extramedullary T-lymphoblastic leukemia/lymphoma with chronic myeloid leukemia
Chronic myeloid leukemia (CML) typically presents in the chronic phase. The blast crisis phase in CML predominantly compri...
Concurrent involvement of the bone marrow by BRAF V600E–mutant melanoma and hairy cell leukemia
Concurrent involvement of the bone marrow by BRAF V600E–mutant melanoma and hairy cell leukemia
Ethical approval This case review was performed in accordan...
Systemic ALK-negative anaplastic large cell lymphoma with NPM1::TYK2 rearrangement
Systemic ALK-negative anaplastic large cell lymphoma with NPM1::TYK2 rearrangement
Anaplastic large cell lymphoma (ALCL) is a rare subtype of non-Hodgkin lymphoma, with most cases harboring ALK gene rearra...
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