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My approach to assessing for colorectal polyp cancer
My approach to assessing for colorectal polyp cancer
Assessing a locally excised colorectal adenoma for malignancy is a common but often challenging scenario. This article out...
Systematic literature review of published cases of reactive plasmacytosis in peripheral blood and bone marrow
Systematic literature review of published cases of reactive plasmacytosis in peripheral blood and bone marrow
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Intraductal carcinoma of the prostate: conflicting recommendations confuse clinicians
Intraductal carcinoma of the prostate: conflicting recommendations confuse clinicians
Intraductal carcinoma of the prostate (IDCP) generally represents a growth pattern of invasive aggressive acinar prostate ...
The highs and lows of grading intraductal carcinoma of the prostate
The highs and lows of grading intraductal carcinoma of the prostate
Accurate histological diagnosis and grading are essential for appropriate management of prostate cancer (PCa), yet there r...
Low interobserver agreement among subspecialised breast pathologists in evaluating HER2-low breast cancer
Low interobserver agreement among subspecialised breast pathologists in evaluating HER2-low breast cancer
IntroductionInvasive breast carcinomas with amplification of human epidermal growth factor receptor 2 (ERBB2) gene or over...
SSTR2 positively associates with EGFR and predicts poor prognosis in nasopharyngeal carcinoma
SSTR2 positively associates with EGFR and predicts poor prognosis in nasopharyngeal carcinoma
WHAT IS ALREADY KNOWN ON THIS TOPICRecent studies have highlighted the effectiveness of epidermal growth factor receptor (...
Tumour-infiltrating lymphocyte subsets and their individual prognostic impact in oral squamous cell carcinoma
Tumour-infiltrating lymphocyte subsets and their individual prognostic impact in oral squamous cell carcinoma
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Unravelling interobserver variability in gastrointestinal glandular neoplasia: a contemporary study of US and Korean pathologists
Unravelling interobserver variability in gastrointestinal glandular neoplasia: a contemporary study of US and Korean pathologists
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Idiopathic granulomatous mastitis: a 5-year retrospective review of cases in a tertiary centre in Dublin, Ireland
Idiopathic granulomatous mastitis: a 5-year retrospective review of cases in a tertiary centre in Dublin, Ireland
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Performance evaluation of a CRISPR Cas9-based selective exponential amplification assay for the detection of KRAS mutations in plasma of patients with advanced pancreatic cancer
Performance evaluation of a CRISPR Cas9-based selective exponential amplification assay for the detection of KRAS mutations in plasma of patients with advanced pancreatic cancer
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Optimal carcinoembryonic antigen (CEA) cutoff values in the diagnosis of neoplastic mucinous pancreatic cysts differ among assays
Optimal carcinoembryonic antigen (CEA) cutoff values in the diagnosis of neoplastic mucinous pancreatic cysts differ among assays
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Rosai-Dorfman Disease of pancreas: rare aetiology mimicking malignancy
Rosai-Dorfman Disease of pancreas: rare aetiology mimicking malignancy
Rosai-Dorfman disease (RDD) is a non-Langerhans cell histiocytosis which usually presents as painless lymphadenopathy. Ext...
Laboratory investigation of peritoneal fluids: an updated practical approach based on the available evidence
Laboratory investigation of peritoneal fluids: an updated practical approach based on the available evidence
Even though analysis of peritoneal fluids (PF) is often requested to medical laboratories for biochemical and morphologica...
Discerning clinicopathological features of congenital neutropenia syndromes: an approach to diagnostically challenging differential diagnoses
Discerning clinicopathological features of congenital neutropenia syndromes: an approach to diagnostically challenging differential diagnoses
Many congenital neutropenic conditions have been defined, but given their rarity, at a combined estimated prevalence of te...
Enteroblastic gastric cancer subtype holds therapeutic clues
Enteroblastic gastric cancer subtype holds therapeutic clues
In this issue of the Journal of Clinical Pathology, Pu and colleagues from the Nanjing University Medical School, China, r...
NTRK gene alterations were enriched in hepatoid or enteroblastic differentiation type of gastric cancer
NTRK gene alterations were enriched in hepatoid or enteroblastic differentiation type of gastric cancer
BackgroundGastric cancer (GC) ranks as the fifth most common cancer and the third-leading cause of cancer-related deaths w...
HER2/ERBB2 overexpression in advanced gallbladder carcinoma: comprehensive evaluation by immunocytochemistry and fluorescence in situ hybridisation on fine-needle aspiration cytology samples
HER2/ERBB2 overexpression in advanced gallbladder carcinoma: comprehensive evaluation by immunocytochemistry and fluorescence in situ hybridisation on fine-needle aspiration cytology samples
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Accuracy and validity of determined cause of death and manner of death following forensic autopsy prosection
Accuracy and validity of determined cause of death and manner of death following forensic autopsy prosection
WHAT IS ALREADY KNOWN ON THIS TOPICCurrently, death certificates are routinely inaccurate, often contain multiple errors a...
Autopsy findings from patients diagnosed with COVID-19 demonstrate unique morphological patterns in bone marrow and lymph node
Autopsy findings from patients diagnosed with COVID-19 demonstrate unique morphological patterns in bone marrow and lymph node
Material and methodsPatients and study designInternal review boards of each participating institution approved collection ...
High-resolution melting assay for rapid, simultaneous detection of JAK2, MPL and CALR variants
High-resolution melting assay for rapid, simultaneous detection of JAK2, MPL and CALR variants
WHAT IS ALREADY KNOWN ON THIS TOPICIdentification of recurrent mutations is crucial for the diagnosis of myeloproliferativ...
Learning at a distance: results of an international survey on the adoption of virtual conferences and whole slide imaging by pathologists
Learning at a distance: results of an international survey on the adoption of virtual conferences and whole slide imaging by pathologists
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How many mislabelled samples go unidentified? Results of a pilot study to determine the occult mislabelled sample rate
How many mislabelled samples go unidentified? Results of a pilot study to determine the occult mislabelled sample rate
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Sudden cardiac death with morphologically normal heart: always do toxicology
Sudden cardiac death with morphologically normal heart: always do toxicology
BackgroundSudden cardiac death (SCD) is defined as natural unexpected death occurring within <1 hour in witnessed cases...
Gene of the month: the uroplakins
Gene of the month: the uroplakins
Uroplakins are a family of membrane-spanning proteins highly specific to the urothelium. There are four uroplakin proteins...
Sudden unexpected death in a middle-aged woman
Sudden unexpected death in a middle-aged woman
Clinical presentationThe patient was a woman in her 50s with a history of migraine and Raynaud’s disease. She had episodes...
Commentary on sudden unexpected death in a middle-aged woman: spontaneous coronary artery dissection (SCAD), myocardial infarction and cardiac biomarkers
Commentary on sudden unexpected death in a middle-aged woman: spontaneous coronary artery dissection (SCAD), myocardial infarction and cardiac biomarkers
Spontaneous coronary artery dissection (SCAD) is an uncommon cause of myocardial infarction (MI). It presents clinically e...
Invited commentary on: sudden cardiac death
Invited commentary on: sudden cardiac death
Postmortem examination holds a pivotal role in our society. The implications of this procedure are vast, ranging from medi...
Investigating the relative frequencies of unascertained causes of death and advanced decomposition at autopsy
Investigating the relative frequencies of unascertained causes of death and advanced decomposition at autopsy
IntroductionAn established dogma of autopsy pathology is that it is not possible to ascertain a cause of death in about 2–...
Reducing workload in malignant melanoma sentinel node examination: a national study of pathology reports from 507 melanoma patients
Reducing workload in malignant melanoma sentinel node examination: a national study of pathology reports from 507 melanoma patients
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Cystic neutrophilic granulomatous mastitis: sensitivity and specificity of 16s rRNA and Sanger sequencing for Corynebacterium spp
Cystic neutrophilic granulomatous mastitis: sensitivity and specificity of 16s rRNA and Sanger sequencing for Corynebacterium spp
WHAT IS ALREADY KNOWN ON THIS TOPICHOW THIS STUDY MIGHT AFFECT RESEARCH, PRACTICE OR POLICYNo optimal testing modality cur...
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