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SUV39H1 maintains cancer stem cell chromatin state and properties in glioblastoma
Research ArticleCell biologyOncologyStem cells Open Access | 10.1172/jci.insight.186344 Chuny...
Altered inflammatory mucosal signatures within their spatial and cellular context during active ileal Crohn’s disease
Research ArticleGastroenterologyInflammation Open Access | 10.1172/jci.insight.171783 Vasanth...
Permanent defects in renal medullary structure and function after reversal of urinary obstruction
Persistent decline in renal function and UCC To study the effects of prolonged ureteric obstruction on the kidney, male B...
Impaired axonal transport contributes to neurodegeneration in a Cre-inducible mouse model of myocilin-associated glaucoma
Research ArticleGeneticsNeuroscienceOphthalmology Open Access | 10.1172/jci.insight.188710 Ba...
Multimodal integration of blood RNA and ctDNA reflects response to immunotherapy in metastatic urothelial cancer
Clinical Research and Public HealthImmunologyOncology Open Access | 10.1172/jci.insight.186062 ...
Neutrophils initiate proinflammatory immune responses in early endometriosis lesion development
Aged neutrophil populations in menstrual effluent from women with endometriosis. Previous findings using our in vivo SDME...
Leveraging complementary multi-omics data integration methods for mechanistic insights in kidney diseases
Research ArticleNephrology Open Access | 10.1172/jci.insight.186070 Fadhl Alakwaa,1 Vivek...
Metabolic shifts in tryptophan pathways during acute pancreatitis infections
Research ArticleGastroenterology Open Access | 10.1172/jci.insight.186745 Daosheng Wang,1,2 ...
APOBEC3A drives ovarian cancer metastasis by altering epithelial-mesenchymal transition
Research ArticleCell biologyOncology Open Access | 10.1172/jci.insight.186409 Jessica M. Deve...
Orchestrated response from heterogenous fibroblast subsets contributes to repair from surgery-induced stress after airway reconstruction
SIS results in Fb accumulation in the reconstructed airway. In our previous work, we showed that ECM turnover and remodel...
Fibroblast growth factor–inducible 14 regulates satellite cell self-renewal and expansion during skeletal muscle repair
Activation of Fn14 signaling in satellite cells during muscle regeneration. We first investigated how the expression of F...
The AURKA inhibitor alters the immune microenvironment and enhances targeting B7-H3 immunotherapy in glioblastoma
Increased B7-H3 expression in GBM and the correlation between AURKA and B7-H3. First, we investigated the differentially ...
A single-cell atlas of normal and KRASG12D-malformed lymphatic vessels
Sex as a biological variable. Our study examined male and female animals, and similar findings are reported for both sexe...
Characterization of cognitive decline in long-duration type 1 diabetes by cognitive, neuroimaging, and pathological examinations
Clinical Research and Public HealthAgingEndocrinology Open Access | 10.1172/jci.insight.180226 ...
Aerobic exercise prevents renal osteodystrophy via irisin-activated osteoblasts
Research ArticleBone biologyCell biologyMetabolism Open Access | 10.1172/jci.insight.184468 M...
NAD+ prevents chronic kidney disease by activating renal tubular metabolism
Research ArticleNephrology Open Access | 10.1172/jci.insight.181443 Bryce A. Jones,1 Debo...
Neurofilament accumulation disrupts autophagy in giant axonal neuropathy
Proteomic analysis of mouse dorsal root ganglia with gigaxonin silenced. Gan-null mice recapitulate the neurofilament agg...
ROCK1 promotes B cell differentiation and proteostasis under stress through the heme-regulated proteins, BACH2 and HRI
Research ArticleAgingImmunology Open Access | 10.1172/jci.insight.180507 Juan Rivera-Correa,1...
Involvement of lncRNA MIR205HG in idiopathic pulmonary fibrosis and IL-33 regulation via Alu elements
Research ArticleInflammationPulmonology Open Access | 10.1172/jci.insight.187172 Tsuyoshi Tak...
Map2k6 is a potent genetic modifier of arterial rupture in vascular Ehlers-Danlos syndrome mice
Research ArticleCardiologyGeneticsVascular biology Open Access | 10.1172/jci.insight.187315 C...
NKG2C and NKG2A coexpression defines a highly functional antiviral NK population in spontaneous HIV control
Cohort characteristics. PBMCs from 34 ECs were obtained from the Spanish AIDS Research Network (RIS) cohort of HIV Contro...
The contribution of neutrophils to bacteriophage clearance and pharmacokinetics in vivo
Research ArticleInfectious disease Open Access | 10.1172/jci.insight.181309 Arne Echterhof,1,...
The STAT3/SETDB2 axis dictates NF-κB–mediated inflammation in macrophages during wound repair
Research ArticleInflammation Open Access | 10.1172/jci.insight.179017 Kevin D. Mangum,1,2 ...
CREB-binding protein/P300 bromodomain inhibition reduces neutrophil accumulation and activates antitumor immunity in triple-negative breast cancer
IACS-70654 inhibited the growth of neutrophil-enriched syngeneic mammary tumor models. To examine the effects of CBP/P300...
Epstein-Barr virus infection induces tissue-resident memory T cells in mucosal lymphoid tissues
Sex as a biological variable. For all experiments, animals (described below) were distributed into different experimental...
Development of a humanized mouse model with functional human materno-fetal interface immunity
Establishment of a pregnant HIS mouse model. We first examined whether Thy/HSC HIS mice generated using the conventional ...
CXCL9, CXCL10, and CCL19 synergistically recruit T lymphocytes to skin in lichen planus
Immune cell landscape in LP skin consists predominantly of CD8+ T cells. We collected 4-millimeter skin biopsies from les...
Distinct strategies for intravascular triglyceride metabolism in hearts of mammals and lower vertebrate species
Research ArticleCardiologyMetabolism Open Access | 10.1172/jci.insight.184940 Le Phuong Nguye...
Human breastmilk memory T cells throughout lactation manifest activated tissue-oriented profile with prominent regulation
General composition of the breastmilk T cell compartment throughout lactation. Live T cells were present in human breastm...
Targeted long-read sequencing enriches disease-relevant genomic regions of interest to provide complete Mendelian disease diagnostics
Research ArticleGeneticsOphthalmology Open Access | 10.1172/jci.insight.183902 Kenji Nakamich...
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