Research ArticleBone biologyCell biologyMetabolism Open Access | 10.1172/jci.insight.184468

Meng Wu,1,2 Huilan Li,2,3 Xiaoting Sun,4 Rongrong Zhong,5 Linli Cai,5 Ruibo Chen,6 Madiya Madeniyet,6 Kana Ren,6 Zhen Peng,6 Yujie Yang,7 Weiqin Chen,2 Yanling Tu,2 Miaoxin Lai,2 Jinxiu Deng,2 Yuting Wu,5 Shumin Zhao,5 Qingyan Ruan,5 Mei Rao,5 Sisi Xie,5 Ying Ye,8 and Jianxin Wan1,9,10

1Department of Nephrology, Blood Purification Research Center, the First Affiliated Hospital, Fujian Medical University, Fuzhou, China.

2Department of Nephrology, Longyan First Affiliated Hospital of Fujian Medical University, Longyan, China.

3Department of Nephrology, Xuanwu Hospital, Capital Medical University, Beijing, China.

4School of Pharmaceutical Science, Wenzhou Medical University, Wenzhou, China.

5Department of Cardiology, Basic Scientific Research Center, Longyan First Affiliated Hospital of Fujian Medical University, Longyan, China.

6Department of Cellular and Genetic Medicine, School of Basic Medical Sciences, Fudan University, Shanghai, China.

7Fundamental Research Center, Shanghai Yangzhi Rehabilitation Hospital (Shanghai Sunshine Rehabilitation Center), School of Medicine, Tongji University, Shanghai, China.

8Department of Oral Implantology, Stomatological Hospital and Dental School of Tongji University, Shanghai Engineering Research Center of Tooth Restoration and Regeneration, Shanghai, China.

9Fujian Clinical Research Center for Metabolic Chronic Kidney Disease, the First Affiliated Hospital, and

10Department of Nephrology, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, China.

Address correspondence to: Sisi Xie, Department of Cardiology, Basic Scientific Research Center, Longyan First Affiliated Hospital of Fujian Medical University, Longyan, 364000, China. Email: 18111010026@fudan.edu.cn. Or to: Ying Ye, Department of Oral Implantology, Stomatological Hospital and Dental School of Tongji University, Shanghai Engineering Research Center of Tooth Restoration and Regeneration, Shanghai 200072, China. Email: ying.ye@tongji.edu.cn. Or to: Jianxin Wan, Department of Nephrology, Blood Purification Research Center, the First Affiliated Hospital, Fujian Medical University, Chazhong Road 20, Fuzhou, 350005, China. Email: wanjx@fjmu.edu.cn.

Authorship note: MW, HL, and XS contributed equally to this work and are co–first authors.

Find articles by Wu, M. in: JCI | PubMed | Google Scholar

1Department of Nephrology, Blood Purification Research Center, the First Affiliated Hospital, Fujian Medical University, Fuzhou, China.

2Department of Nephrology, Longyan First Affiliated Hospital of Fujian Medical University, Longyan, China.

3Department of Nephrology, Xuanwu Hospital, Capital Medical University, Beijing, China.

4School of Pharmaceutical Science, Wenzhou Medical University, Wenzhou, China.

5Department of Cardiology, Basic Scientific Research Center, Longyan First Affiliated Hospital of Fujian Medical University, Longyan, China.

6Department of Cellular and Genetic Medicine, School of Basic Medical Sciences, Fudan University, Shanghai, China.

7Fundamental Research Center, Shanghai Yangzhi Rehabilitation Hospital (Shanghai Sunshine Rehabilitation Center), School of Medicine, Tongji University, Shanghai, China.

8Department of Oral Implantology, Stomatological Hospital and Dental School of Tongji University, Shanghai Engineering Research Center of Tooth Restoration and Regeneration, Shanghai, China.

9Fujian Clinical Research Center for Metabolic Chronic Kidney Disease, the First Affiliated Hospital, and

10Department of Nephrology, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, China.

Address correspondence to: Sisi Xie, Department of Cardiology, Basic Scientific Research Center, Longyan First Affiliated Hospital of Fujian Medical University, Longyan, 364000, China. Email: 18111010026@fudan.edu.cn. Or to: Ying Ye, Department of Oral Implantology, Stomatological Hospital and Dental School of Tongji University, Shanghai Engineering Research Center of Tooth Restoration and Regeneration, Shanghai 200072, China. Email: ying.ye@tongji.edu.cn. Or to: Jianxin Wan, Department of Nephrology, Blood Purification Research Center, the First Affiliated Hospital, Fujian Medical University, Chazhong Road 20, Fuzhou, 350005, China. Email: wanjx@fjmu.edu.cn.

Authorship note: MW, HL, and XS contributed equally to this work and are co–first authors.

Find articles by Li, H. in: JCI | PubMed | Google Scholar

1Department of Nephrology, Blood Purification Research Center, the First Affiliated Hospital, Fujian Medical University, Fuzhou, China.

2Department of Nephrology, Longyan First Affiliated Hospital of Fujian Medical University, Longyan, China.

3Department of Nephrology, Xuanwu Hospital, Capital Medical University, Beijing, China.

4School of Pharmaceutical Science, Wenzhou Medical University, Wenzhou, China.

5Department of Cardiology, Basic Scientific Research Center, Longyan First Affiliated Hospital of Fujian Medical University, Longyan, China.

6Department of Cellular and Genetic Medicine, School of Basic Medical Sciences, Fudan University, Shanghai, China.

7Fundamental Research Center, Shanghai Yangzhi Rehabilitation Hospital (Shanghai Sunshine Rehabilitation Center), School of Medicine, Tongji University, Shanghai, China.

8Department of Oral Implantology, Stomatological Hospital and Dental School of Tongji University, Shanghai Engineering Research Center of Tooth Restoration and Regeneration, Shanghai, China.

9Fujian Clinical Research Center for Metabolic Chronic Kidney Disease, the First Affiliated Hospital, and

10Department of Nephrology, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, China.

Address correspondence to: Sisi Xie, Department of Cardiology, Basic Scientific Research Center, Longyan First Affiliated Hospital of Fujian Medical University, Longyan, 364000, China. Email: 18111010026@fudan.edu.cn. Or to: Ying Ye, Department of Oral Implantology, Stomatological Hospital and Dental School of Tongji University, Shanghai Engineering Research Center of Tooth Restoration and Regeneration, Shanghai 200072, China. Email: ying.ye@tongji.edu.cn. Or to: Jianxin Wan, Department of Nephrology, Blood Purification Research Center, the First Affiliated Hospital, Fujian Medical University, Chazhong Road 20, Fuzhou, 350005, China. Email: wanjx@fjmu.edu.cn.

Authorship note: MW, HL, and XS contributed equally to this work and are co–first authors.

Find articles by Sun, X. in: JCI | PubMed | Google Scholar

1Department of Nephrology, Blood Purification Research Center, the First Affiliated Hospital, Fujian Medical University, Fuzhou, China.

2Department of Nephrology, Longyan First Affiliated Hospital of Fujian Medical University, Longyan, China.

3Department of Nephrology, Xuanwu Hospital, Capital Medical University, Beijing, China.

4School of Pharmaceutical Science, Wenzhou Medical University, Wenzhou, China.

5Department of Cardiology, Basic Scientific Research Center, Longyan First Affiliated Hospital of Fujian Medical University, Longyan, China.

6Department of Cellular and Genetic Medicine, School of Basic Medical Sciences, Fudan University, Shanghai, China.

7Fundamental Research Center, Shanghai Yangzhi Rehabilitation Hospital (Shanghai Sunshine Rehabilitation Center), School of Medicine, Tongji University, Shanghai, China.

8Department of Oral Implantology, Stomatological Hospital and Dental School of Tongji University, Shanghai Engineering Research Center of Tooth Restoration and Regeneration, Shanghai, China.

9Fujian Clinical Research Center for Metabolic Chronic Kidney Disease, the First Affiliated Hospital, and

10Department of Nephrology, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, China.

Address correspondence to: Sisi Xie, Department of Cardiology, Basic Scientific Research Center, Longyan First Affiliated Hospital of Fujian Medical University, Longyan, 364000, China. Email: 18111010026@fudan.edu.cn. Or to: Ying Ye, Department of Oral Implantology, Stomatological Hospital and Dental School of Tongji University, Shanghai Engineering Research Center of Tooth Restoration and Regeneration, Shanghai 200072, China. Email: ying.ye@tongji.edu.cn. Or to: Jianxin Wan, Department of Nephrology, Blood Purification Research Center, the First Affiliated Hospital, Fujian Medical University, Chazhong Road 20, Fuzhou, 350005, China. Email: wanjx@fjmu.edu.cn.

Authorship note: MW, HL, and XS contributed equally to this work and are co–first authors.

Find articles by Zhong, R. in: JCI | PubMed | Google Scholar

1Department of Nephrology, Blood Purification Research Center, the First Affiliated Hospital, Fujian Medical University, Fuzhou, China.

2Department of Nephrology, Longyan First Affiliated Hospital of Fujian Medical University, Longyan, China.

3Department of Nephrology, Xuanwu Hospital, Capital Medical University, Beijing, China.

4School of Pharmaceutical Science, Wenzhou Medical University, Wenzhou, China.

5Department of Cardiology, Basic Scientific Research Center, Longyan First Affiliated Hospital of Fujian Medical University, Longyan, China.

6Department of Cellular and Genetic Medicine, School of Basic Medical Sciences, Fudan University, Shanghai, China.

7Fundamental Research Center, Shanghai Yangzhi Rehabilitation Hospital (Shanghai Sunshine Rehabilitation Center), School of Medicine, Tongji University, Shanghai, China.

8Department of Oral Implantology, Stomatological Hospital and Dental School of Tongji University, Shanghai Engineering Research Center of Tooth Restoration and Regeneration, Shanghai, China.

9Fujian Clinical Research Center for Metabolic Chronic Kidney Disease, the First Affiliated Hospital, and

10Department of Nephrology, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, China.

Address correspondence to: Sisi Xie, Department of Cardiology, Basic Scientific Research Center, Longyan First Affiliated Hospital of Fujian Medical University, Longyan, 364000, China. Email: 18111010026@fudan.edu.cn. Or to: Ying Ye, Department of Oral Implantology, Stomatological Hospital and Dental School of Tongji University, Shanghai Engineering Research Center of Tooth Restoration and Regeneration, Shanghai 200072, China. Email: ying.ye@tongji.edu.cn. Or to: Jianxin Wan, Department of Nephrology, Blood Purification Research Center, the First Affiliated Hospital, Fujian Medical University, Chazhong Road 20, Fuzhou, 350005, China. Email: wanjx@fjmu.edu.cn.

Authorship note: MW, HL, and XS contributed equally to this work and are co–first authors.

Find articles by Cai, L. in: JCI | PubMed | Google Scholar

1Department of Nephrology, Blood Purification Research Center, the First Affiliated Hospital, Fujian Medical University, Fuzhou, China.

2Department of Nephrology, Longyan First Affiliated Hospital of Fujian Medical University, Longyan, China.

3Department of Nephrology, Xuanwu Hospital, Capital Medical University, Beijing, China.

4School of Pharmaceutical Science, Wenzhou Medical University, Wenzhou, China.

5Department of Cardiology, Basic Scientific Research Center, Longyan First Affiliated Hospital of Fujian Medical University, Longyan, China.

6Department of Cellular and Genetic Medicine, School of Basic Medical Sciences, Fudan University, Shanghai, China.

7Fundamental Research Center, Shanghai Yangzhi Rehabilitation Hospital (Shanghai Sunshine Rehabilitation Center), School of Medicine, Tongji University, Shanghai, China.

8Department of Oral Implantology, Stomatological Hospital and Dental School of Tongji University, Shanghai Engineering Research Center of Tooth Restoration and Regeneration, Shanghai, China.

9Fujian Clinical Research Center for Metabolic Chronic Kidney Disease, the First Affiliated Hospital, and

10Department of Nephrology, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, China.

Address correspondence to: Sisi Xie, Department of Cardiology, Basic Scientific Research Center, Longyan First Affiliated Hospital of Fujian Medical University, Longyan, 364000, China. Email: 18111010026@fudan.edu.cn. Or to: Ying Ye, Department of Oral Implantology, Stomatological Hospital and Dental School of Tongji University, Shanghai Engineering Research Center of Tooth Restoration and Regeneration, Shanghai 200072, China. Email: ying.ye@tongji.edu.cn. Or to: Jianxin Wan, Department of Nephrology, Blood Purification Research Center, the First Affiliated Hospital, Fujian Medical University, Chazhong Road 20, Fuzhou, 350005, China. Email: wanjx@fjmu.edu.cn.

Authorship note: MW, HL, and XS contributed equally to this work and are co–first authors.

Find articles by Chen, R. in: JCI | PubMed | Google Scholar

1Department of Nephrology, Blood Purification Research Center, the First Affiliated Hospital, Fujian Medical University, Fuzhou, China.

2Department of Nephrology, Longyan First Affiliated Hospital of Fujian Medical University, Longyan, China.

3Department of Nephrology, Xuanwu Hospital, Capital Medical University, Beijing, China.

4School of Pharmaceutical Science, Wenzhou Medical University, Wenzhou, China.

5Department of Cardiology, Basic Scientific Research Center, Longyan First Affiliated Hospital of Fujian Medical University, Longyan, China.

6Department of Cellular and Genetic Medicine, School of Basic Medical Sciences, Fudan University, Shanghai, China.

7Fundamental Research Center, Shanghai Yangzhi Rehabilitation Hospital (Shanghai Sunshine Rehabilitation Center), School of Medicine, Tongji University, Shanghai, China.

8Department of Oral Implantology, Stomatological Hospital and Dental School of Tongji University, Shanghai Engineering Research Center of Tooth Restoration and Regeneration, Shanghai, China.

9Fujian Clinical Research Center for Metabolic Chronic Kidney Disease, the First Affiliated Hospital, and

10Department of Nephrology, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, China.

Address correspondence to: Sisi Xie, Department of Cardiology, Basic Scientific Research Center, Longyan First Affiliated Hospital of Fujian Medical University, Longyan, 364000, China. Email: 18111010026@fudan.edu.cn. Or to: Ying Ye, Department of Oral Implantology, Stomatological Hospital and Dental School of Tongji University, Shanghai Engineering Research Center of Tooth Restoration and Regeneration, Shanghai 200072, China. Email: ying.ye@tongji.edu.cn. Or to: Jianxin Wan, Department of Nephrology, Blood Purification Research Center, the First Affiliated Hospital, Fujian Medical University, Chazhong Road 20, Fuzhou, 350005, China. Email: wanjx@fjmu.edu.cn.

Authorship note: MW, HL, and XS contributed equally to this work and are co–first authors.

Find articles by Madeniyet, M. in: JCI | PubMed | Google Scholar

1Department of Nephrology, Blood Purification Research Center, the First Affiliated Hospital, Fujian Medical University, Fuzhou, China.

2Department of Nephrology, Longyan First Affiliated Hospital of Fujian Medical University, Longyan, China.

3Department of Nephrology, Xuanwu Hospital, Capital Medical University, Beijing, China.

4School of Pharmaceutical Science, Wenzhou Medical University, Wenzhou, China.

5Department of Cardiology, Basic Scientific Research Center, Longyan First Affiliated Hospital of Fujian Medical University, Longyan, China.

6Department of Cellular and Genetic Medicine, School of Basic Medical Sciences, Fudan University, Shanghai, China.

7Fundamental Research Center, Shanghai Yangzhi Rehabilitation Hospital (Shanghai Sunshine Rehabilitation Center), School of Medicine, Tongji University, Shanghai, China.

8Department of Oral Implantology, Stomatological Hospital and Dental School of Tongji University, Shanghai Engineering Research Center of Tooth Restoration and Regeneration, Shanghai, China.

9Fujian Clinical Research Center for Metabolic Chronic Kidney Disease, the First Affiliated Hospital, and

10Department of Nephrology, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, China.

Address correspondence to: Sisi Xie, Department of Cardiology, Basic Scientific Research Center, Longyan First Affiliated Hospital of Fujian Medical University, Longyan, 364000, China. Email: 18111010026@fudan.edu.cn. Or to: Ying Ye, Department of Oral Implantology, Stomatological Hospital and Dental School of Tongji University, Shanghai Engineering Research Center of Tooth Restoration and Regeneration, Shanghai 200072, China. Email: ying.ye@tongji.edu.cn. Or to: Jianxin Wan, Department of Nephrology, Blood Purification Research Center, the First Affiliated Hospital, Fujian Medical University, Chazhong Road 20, Fuzhou, 350005, China. Email: wanjx@fjmu.edu.cn.

Authorship note: MW, HL, and XS contributed equally to this work and are co–first authors.

Find articles by Ren, K. in: JCI | PubMed | Google Scholar

1Department of Nephrology, Blood Purification Research Center, the First Affiliated Hospital, Fujian Medical University, Fuzhou, China.

2Department of Nephrology, Longyan First Affiliated Hospital of Fujian Medical University, Longyan, China.

3Department of Nephrology, Xuanwu Hospital, Capital Medical University, Beijing, China.

4School of Pharmaceutical Science, Wenzhou Medical University, Wenzhou, China.

5Department of Cardiology, Basic Scientific Research Center, Longyan First Affiliated Hospital of Fujian Medical University, Longyan, China.

6Department of Cellular and Genetic Medicine, School of Basic Medical Sciences, Fudan University, Shanghai, China.

7Fundamental Research Center, Shanghai Yangzhi Rehabilitation Hospital (Shanghai Sunshine Rehabilitation Center), School of Medicine, Tongji University, Shanghai, China.

8Department of Oral Implantology, Stomatological Hospital and Dental School of Tongji University, Shanghai Engineering Research Center of Tooth Restoration and Regeneration, Shanghai, China.

9Fujian Clinical Research Center for Metabolic Chronic Kidney Disease, the First Affiliated Hospital, and

10Department of Nephrology, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, China.

Address correspondence to: Sisi Xie, Department of Cardiology, Basic Scientific Research Center, Longyan First Affiliated Hospital of Fujian Medical University, Longyan, 364000, China. Email: 18111010026@fudan.edu.cn. Or to: Ying Ye, Department of Oral Implantology, Stomatological Hospital and Dental School of Tongji University, Shanghai Engineering Research Center of Tooth Restoration and Regeneration, Shanghai 200072, China. Email: ying.ye@tongji.edu.cn. Or to: Jianxin Wan, Department of Nephrology, Blood Purification Research Center, the First Affiliated Hospital, Fujian Medical University, Chazhong Road 20, Fuzhou, 350005, China. Email: wanjx@fjmu.edu.cn.

Authorship note: MW, HL, and XS contributed equally to this work and are co–first authors.

Find articles by Peng, Z. in: JCI | PubMed | Google Scholar

1Department of Nephrology, Blood Purification Research Center, the First Affiliated Hospital, Fujian Medical University, Fuzhou, China.

2Department of Nephrology, Longyan First Affiliated Hospital of Fujian Medical University, Longyan, China.

3Department of Nephrology, Xuanwu Hospital, Capital Medical University, Beijing, China.

4School of Pharmaceutical Science, Wenzhou Medical University, Wenzhou, China.

5Department of Cardiology, Basic Scientific Research Center, Longyan First Affiliated Hospital of Fujian Medical University, Longyan, China.

6Department of Cellular and Genetic Medicine, School of Basic Medical Sciences, Fudan University, Shanghai, China.

7Fundamental Research Center, Shanghai Yangzhi Rehabilitation Hospital (Shanghai Sunshine Rehabilitation Center), School of Medicine, Tongji University, Shanghai, China.

8Department of Oral Implantology, Stomatological Hospital and Dental School of Tongji University, Shanghai Engineering Research Center of Tooth Restoration and Regeneration, Shanghai, China.

9Fujian Clinical Research Center for Metabolic Chronic Kidney Disease, the First Affiliated Hospital, and

10Department of Nephrology, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, China.

Address correspondence to: Sisi Xie, Department of Cardiology, Basic Scientific Research Center, Longyan First Affiliated Hospital of Fujian Medical University, Longyan, 364000, China. Email: 18111010026@fudan.edu.cn. Or to: Ying Ye, Department of Oral Implantology, Stomatological Hospital and Dental School of Tongji University, Shanghai Engineering Research Center of Tooth Restoration and Regeneration, Shanghai 200072, China. Email: ying.ye@tongji.edu.cn. Or to: Jianxin Wan, Department of Nephrology, Blood Purification Research Center, the First Affiliated Hospital, Fujian Medical University, Chazhong Road 20, Fuzhou, 350005, China. Email: wanjx@fjmu.edu.cn.

Authorship note: MW, HL, and XS contributed equally to this work and are co–first authors.

Find articles by Yang, Y. in: JCI | PubMed | Google Scholar

1Department of Nephrology, Blood Purification Research Center, the First Affiliated Hospital, Fujian Medical University, Fuzhou, China.

2Department of Nephrology, Longyan First Affiliated Hospital of Fujian Medical University, Longyan, China.

3Department of Nephrology, Xuanwu Hospital, Capital Medical University, Beijing, China.

4School of Pharmaceutical Science, Wenzhou Medical University, Wenzhou, China.

5Department of Cardiology, Basic Scientific Research Center, Longyan First Affiliated Hospital of Fujian Medical University, Longyan, China.

6Department of Cellular and Genetic Medicine, School of Basic Medical Sciences, Fudan University, Shanghai, China.

7Fundamental Research Center, Shanghai Yangzhi Rehabilitation Hospital (Shanghai Sunshine Rehabilitation Center), School of Medicine, Tongji University, Shanghai, China.

8Department of Oral Implantology, Stomatological Hospital and Dental School of Tongji University, Shanghai Engineering Research Center of Tooth Restoration and Regeneration, Shanghai, China.

9Fujian Clinical Research Center for Metabolic Chronic Kidney Disease, the First Affiliated Hospital, and

10Department of Nephrology, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, China.

Address correspondence to: Sisi Xie, Department of Cardiology, Basic Scientific Research Center, Longyan First Affiliated Hospital of Fujian Medical University, Longyan, 364000, China. Email: 18111010026@fudan.edu.cn. Or to: Ying Ye, Department of Oral Implantology, Stomatological Hospital and Dental School of Tongji University, Shanghai Engineering Research Center of Tooth Restoration and Regeneration, Shanghai 200072, China. Email: ying.ye@tongji.edu.cn. Or to: Jianxin Wan, Department of Nephrology, Blood Purification Research Center, the First Affiliated Hospital, Fujian Medical University, Chazhong Road 20, Fuzhou, 350005, China. Email: wanjx@fjmu.edu.cn.

Authorship note: MW, HL, and XS contributed equally to this work and are co–first authors.

Find articles by Chen, W. in: JCI | PubMed | Google Scholar

1Department of Nephrology, Blood Purification Research Center, the First Affiliated Hospital, Fujian Medical University, Fuzhou, China.

2Department of Nephrology, Longyan First Affiliated Hospital of Fujian Medical University, Longyan, China.

3Department of Nephrology, Xuanwu Hospital, Capital Medical University, Beijing, China.

4School of Pharmaceutical Science, Wenzhou Medical University, Wenzhou, China.

5Department of Cardiology, Basic Scientific Research Center, Longyan First Affiliated Hospital of Fujian Medical University, Longyan, China.

6Department of Cellular and Genetic Medicine, School of Basic Medical Sciences, Fudan University, Shanghai, China.

7Fundamental Research Center, Shanghai Yangzhi Rehabilitation Hospital (Shanghai Sunshine Rehabilitation Center), School of Medicine, Tongji University, Shanghai, China.

8Department of Oral Implantology, Stomatological Hospital and Dental School of Tongji University, Shanghai Engineering Research Center of Tooth Restoration and Regeneration, Shanghai, China.

9Fujian Clinical Research Center for Metabolic Chronic Kidney Disease, the First Affiliated Hospital, and

10Department of Nephrology, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, China.

Address correspondence to: Sisi Xie, Department of Cardiology, Basic Scientific Research Center, Longyan First Affiliated Hospital of Fujian Medical University, Longyan, 364000, China. Email: 18111010026@fudan.edu.cn. Or to: Ying Ye, Department of Oral Implantology, Stomatological Hospital and Dental School of Tongji University, Shanghai Engineering Research Center of Tooth Restoration and Regeneration, Shanghai 200072, China. Email: ying.ye@tongji.edu.cn. Or to: Jianxin Wan, Department of Nephrology, Blood Purification Research Center, the First Affiliated Hospital, Fujian Medical University, Chazhong Road 20, Fuzhou, 350005, China. Email: wanjx@fjmu.edu.cn.

Authorship note: MW, HL, and XS contributed equally to this work and are co–first authors.

Find articles by Tu, Y. in: JCI | PubMed | Google Scholar

1Department of Nephrology, Blood Purification Research Center, the First Affiliated Hospital, Fujian Medical University, Fuzhou, China.

2Department of Nephrology, Longyan First Affiliated Hospital of Fujian Medical University, Longyan, China.

3Department of Nephrology, Xuanwu Hospital, Capital Medical University, Beijing, China.

4School of Pharmaceutical Science, Wenzhou Medical University, Wenzhou, China.

5Department of Cardiology, Basic Scientific Research Center, Longyan First Affiliated Hospital of Fujian Medical University, Longyan, China.

6Department of Cellular and Genetic Medicine, School of Basic Medical Sciences, Fudan University, Shanghai, China.

7Fundamental Research Center, Shanghai Yangzhi Rehabilitation Hospital (Shanghai Sunshine Rehabilitation Center), School of Medicine, Tongji University, Shanghai, China.

8Department of Oral Implantology, Stomatological Hospital and Dental School of Tongji University, Shanghai Engineering Research Center of Tooth Restoration and Regeneration, Shanghai, China.

9Fujian Clinical Research Center for Metabolic Chronic Kidney Disease, the First Affiliated Hospital, and

10Department of Nephrology, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, China.

Address correspondence to: Sisi Xie, Department of Cardiology, Basic Scientific Research Center, Longyan First Affiliated Hospital of Fujian Medical University, Longyan, 364000, China. Email: 18111010026@fudan.edu.cn. Or to: Ying Ye, Department of Oral Implantology, Stomatological Hospital and Dental School of Tongji University, Shanghai Engineering Research Center of Tooth Restoration and Regeneration, Shanghai 200072, China. Email: ying.ye@tongji.edu.cn. Or to: Jianxin Wan, Department of Nephrology, Blood Purification Research Center, the First Affiliated Hospital, Fujian Medical University, Chazhong Road 20, Fuzhou, 350005, China. Email: wanjx@fjmu.edu.cn.

Authorship note: MW, HL, and XS contributed equally to this work and are co–first authors.

Find articles by Lai, M. in: JCI | PubMed | Google Scholar

1Department of Nephrology, Blood Purification Research Center, the First Affiliated Hospital, Fujian Medical University, Fuzhou, China.

2Department of Nephrology, Longyan First Affiliated Hospital of Fujian Medical University, Longyan, China.

3Department of Nephrology, Xuanwu Hospital, Capital Medical University, Beijing, China.

4School of Pharmaceutical Science, Wenzhou Medical University, Wenzhou, China.

5Department of Cardiology, Basic Scientific Research Center, Longyan First Affiliated Hospital of Fujian Medical University, Longyan, China.

6Department of Cellular and Genetic Medicine, School of Basic Medical Sciences, Fudan University, Shanghai, China.

7Fundamental Research Center, Shanghai Yangzhi Rehabilitation Hospital (Shanghai Sunshine Rehabilitation Center), School of Medicine, Tongji University, Shanghai, China.

8Department of Oral Implantology, Stomatological Hospital and Dental School of Tongji University, Shanghai Engineering Research Center of Tooth Restoration and Regeneration, Shanghai, China.

9Fujian Clinical Research Center for Metabolic Chronic Kidney Disease, the First Affiliated Hospital, and

10Department of Nephrology, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, China.

Address correspondence to: Sisi Xie, Department of Cardiology, Basic Scientific Research Center, Longyan First Affiliated Hospital of Fujian Medical University, Longyan, 364000, China. Email: 18111010026@fudan.edu.cn. Or to: Ying Ye, Department of Oral Implantology, Stomatological Hospital and Dental School of Tongji University, Shanghai Engineering Research Center of Tooth Restoration and Regeneration, Shanghai 200072, China. Email: ying.ye@tongji.edu.cn. Or to: Jianxin Wan, Department of Nephrology, Blood Purification Research Center, the First Affiliated Hospital, Fujian Medical University, Chazhong Road 20, Fuzhou, 350005, China. Email: wanjx@fjmu.edu.cn.

Authorship note: MW, HL, and XS contributed equally to this work and are co–first authors.

Find articles by Deng, J. in: JCI | PubMed | Google Scholar

1Department of Nephrology, Blood Purification Research Center, the First Affiliated Hospital, Fujian Medical University, Fuzhou, China.

2Department of Nephrology, Longyan First Affiliated Hospital of Fujian Medical University, Longyan, China.

3Department of Nephrology, Xuanwu Hospital, Capital Medical University, Beijing, China.

4School of Pharmaceutical Science, Wenzhou Medical University, Wenzhou, China.

5Department of Cardiology, Basic Scientific Research Center, Longyan First Affiliated Hospital of Fujian Medical University, Longyan, China.

6Department of Cellular and Genetic Medicine, School of Basic Medical Sciences, Fudan University, Shanghai, China.

7Fundamental Research Center, Shanghai Yangzhi Rehabilitation Hospital (Shanghai Sunshine Rehabilitation Center), School of Medicine, Tongji University, Shanghai, China.

8Department of Oral Implantology, Stomatological Hospital and Dental School of Tongji University, Shanghai Engineering Research Center of Tooth Restoration and Regeneration, Shanghai, China.

9Fujian Clinical Research Center for Metabolic Chronic Kidney Disease, the First Affiliated Hospital, and

10Department of Nephrology, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, China.

Address correspondence to: Sisi Xie, Department of Cardiology, Basic Scientific Research Center, Longyan First Affiliated Hospital of Fujian Medical University, Longyan, 364000, China. Email: 18111010026@fudan.edu.cn. Or to: Ying Ye, Department of Oral Implantology, Stomatological Hospital and Dental School of Tongji University, Shanghai Engineering Research Center of Tooth Restoration and Regeneration, Shanghai 200072, China. Email: ying.ye@tongji.edu.cn. Or to: Jianxin Wan, Department of Nephrology, Blood Purification Research Center, the First Affiliated Hospital, Fujian Medical University, Chazhong Road 20, Fuzhou, 350005, China. Email: wanjx@fjmu.edu.cn.

Authorship note: MW, HL, and XS contributed equally to this work and are co–first authors.

Find articles by Wu, Y. in: JCI | PubMed | Google Scholar

1Department of Nephrology, Blood Purification Research Center, the First Affiliated Hospital, Fujian Medical University, Fuzhou, China.

2Department of Nephrology, Longyan First Affiliated Hospital of Fujian Medical University, Longyan, China.

3Department of Nephrology, Xuanwu Hospital, Capital Medical University, Beijing, China.

4School of Pharmaceutical Science, Wenzhou Medical University, Wenzhou, China.

5Department of Cardiology, Basic Scientific Research Center, Longyan First Affiliated Hospital of Fujian Medical University, Longyan, China.

6Department of Cellular and Genetic Medicine, School of Basic Medical Sciences, Fudan University, Shanghai, China.

7Fundamental Research Center, Shanghai Yangzhi Rehabilitation Hospital (Shanghai Sunshine Rehabilitation Center), School of Medicine, Tongji University, Shanghai, China.

8Department of Oral Implantology, Stomatological Hospital and Dental School of Tongji University, Shanghai Engineering Research Center of Tooth Restoration and Regeneration, Shanghai, China.

9Fujian Clinical Research Center for Metabolic Chronic Kidney Disease, the First Affiliated Hospital, and

10Department of Nephrology, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, China.

Address correspondence to: Sisi Xie, Department of Cardiology, Basic Scientific Research Center, Longyan First Affiliated Hospital of Fujian Medical University, Longyan, 364000, China. Email: 18111010026@fudan.edu.cn. Or to: Ying Ye, Department of Oral Implantology, Stomatological Hospital and Dental School of Tongji University, Shanghai Engineering Research Center of Tooth Restoration and Regeneration, Shanghai 200072, China. Email: ying.ye@tongji.edu.cn. Or to: Jianxin Wan, Department of Nephrology, Blood Purification Research Center, the First Affiliated Hospital, Fujian Medical University, Chazhong Road 20, Fuzhou, 350005, China. Email: wanjx@fjmu.edu.cn.

Authorship note: MW, HL, and XS contributed equally to this work and are co–first authors.

Find articles by Zhao, S. in: JCI | PubMed | Google Scholar

1Department of Nephrology, Blood Purification Research Center, the First Affiliated Hospital, Fujian Medical University, Fuzhou, China.

2Department of Nephrology, Longyan First Affiliated Hospital of Fujian Medical University, Longyan, China.

3Department of Nephrology, Xuanwu Hospital, Capital Medical University, Beijing, China.

4School of Pharmaceutical Science, Wenzhou Medical University, Wenzhou, China.

5Department of Cardiology, Basic Scientific Research Center, Longyan First Affiliated Hospital of Fujian Medical University, Longyan, China.

6Department of Cellular and Genetic Medicine, School of Basic Medical Sciences, Fudan University, Shanghai, China.

7Fundamental Research Center, Shanghai Yangzhi Rehabilitation Hospital (Shanghai Sunshine Rehabilitation Center), School of Medicine, Tongji University, Shanghai, China.

8Department of Oral Implantology, Stomatological Hospital and Dental School of Tongji University, Shanghai Engineering Research Center of Tooth Restoration and Regeneration, Shanghai, China.

9Fujian Clinical Research Center for Metabolic Chronic Kidney Disease, the First Affiliated Hospital, and

10Department of Nephrology, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, China.

Address correspondence to: Sisi Xie, Department of Cardiology, Basic Scientific Research Center, Longyan First Affiliated Hospital of Fujian Medical University, Longyan, 364000, China. Email: 18111010026@fudan.edu.cn. Or to: Ying Ye, Department of Oral Implantology, Stomatological Hospital and Dental School of Tongji University, Shanghai Engineering Research Center of Tooth Restoration and Regeneration, Shanghai 200072, China. Email: ying.ye@tongji.edu.cn. Or to: Jianxin Wan, Department of Nephrology, Blood Purification Research Center, the First Affiliated Hospital, Fujian Medical University, Chazhong Road 20, Fuzhou, 350005, China. Email: wanjx@fjmu.edu.cn.

Authorship note: MW, HL, and XS contributed equally to this work and are co–first authors.

Find articles by Ruan, Q. in: JCI | PubMed | Google Scholar

1Department of Nephrology, Blood Purification Research Center, the First Affiliated Hospital, Fujian Medical University, Fuzhou, China.

2Department of Nephrology, Longyan First Affiliated Hospital of Fujian Medical University, Longyan, China.

3Department of Nephrology, Xuanwu Hospital, Capital Medical University, Beijing, China.

4School of Pharmaceutical Science, Wenzhou Medical University, Wenzhou, China.

5Department of Cardiology, Basic Scientific Research Center, Longyan First Affiliated Hospital of Fujian Medical University, Longyan, China.

6Department of Cellular and Genetic Medicine, School of Basic Medical Sciences, Fudan University, Shanghai, China.

7Fundamental Research Center, Shanghai Yangzhi Rehabilitation Hospital (Shanghai Sunshine Rehabilitation Center), School of Medicine, Tongji University, Shanghai, China.

8Department of Oral Implantology, Stomatological Hospital and Dental School of Tongji University, Shanghai Engineering Research Center of Tooth Restoration and Regeneration, Shanghai, China.

9Fujian Clinical Research Center for Metabolic Chronic Kidney Disease, the First Affiliated Hospital, and

10Department of Nephrology, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, China.

Address correspondence to: Sisi Xie, Department of Cardiology, Basic Scientific Research Center, Longyan First Affiliated Hospital of Fujian Medical University, Longyan, 364000, China. Email: 18111010026@fudan.edu.cn. Or to: Ying Ye, Department of Oral Implantology, Stomatological Hospital and Dental School of Tongji University, Shanghai Engineering Research Center of Tooth Restoration and Regeneration, Shanghai 200072, China. Email: ying.ye@tongji.edu.cn. Or to: Jianxin Wan, Department of Nephrology, Blood Purification Research Center, the First Affiliated Hospital, Fujian Medical University, Chazhong Road 20, Fuzhou, 350005, China. Email: wanjx@fjmu.edu.cn.

Authorship note: MW, HL, and XS contributed equally to this work and are co–first authors.

Find articles by Rao, M. in: JCI | PubMed | Google Scholar

1Department of Nephrology, Blood Purification Research Center, the First Affiliated Hospital, Fujian Medical University, Fuzhou, China.

2Department of Nephrology, Longyan First Affiliated Hospital of Fujian Medical University, Longyan, China.

3Department of Nephrology, Xuanwu Hospital, Capital Medical University, Beijing, China.

4School of Pharmaceutical Science, Wenzhou Medical University, Wenzhou, China.

5Department of Cardiology, Basic Scientific Research Center, Longyan First Affiliated Hospital of Fujian Medical University, Longyan, China.

6Department of Cellular and Genetic Medicine, School of Basic Medical Sciences, Fudan University, Shanghai, China.

7Fundamental Research Center, Shanghai Yangzhi Rehabilitation Hospital (Shanghai Sunshine Rehabilitation Center), School of Medicine, Tongji University, Shanghai, China.

8Department of Oral Implantology, Stomatological Hospital and Dental School of Tongji University, Shanghai Engineering Research Center of Tooth Restoration and Regeneration, Shanghai, China.

9Fujian Clinical Research Center for Metabolic Chronic Kidney Disease, the First Affiliated Hospital, and

10Department of Nephrology, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, China.

Address correspondence to: Sisi Xie, Department of Cardiology, Basic Scientific Research Center, Longyan First Affiliated Hospital of Fujian Medical University, Longyan, 364000, China. Email: 18111010026@fudan.edu.cn. Or to: Ying Ye, Department of Oral Implantology, Stomatological Hospital and Dental School of Tongji University, Shanghai Engineering Research Center of Tooth Restoration and Regeneration, Shanghai 200072, China. Email: ying.ye@tongji.edu.cn. Or to: Jianxin Wan, Department of Nephrology, Blood Purification Research Center, the First Affiliated Hospital, Fujian Medical University, Chazhong Road 20, Fuzhou, 350005, China. Email: wanjx@fjmu.edu.cn.

Authorship note: MW, HL, and XS contributed equally to this work and are co–first authors.

Find articles by Xie, S. in: JCI | PubMed | Google Scholar

1Department of Nephrology, Blood Purification Research Center, the First Affiliated Hospital, Fujian Medical University, Fuzhou, China.

2Department of Nephrology, Longyan First Affiliated Hospital of Fujian Medical University, Longyan, China.

3Department of Nephrology, Xuanwu Hospital, Capital Medical University, Beijing, China.

4School of Pharmaceutical Science, We