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GeneCompass: deciphering universal gene regulatory mechanisms with a knowledge-informed cross-species foundation model
GeneCompass: deciphering universal gene regulatory mechanisms with a knowledge-informed cross-species foundation model
Deciphering universal gene regulatory mechanisms in diverse organisms holds great potential for advancing our knowledge of...
Fine-tuning protein hunger: sex- and mating-dependent setpoint control
Fine-tuning protein hunger: sex- and mating-dependent setpoint control
While a balanced intake of macronutrients — carbohydrates, fats, and proteins — is essential for meta...
Knowing when to stop: MICL self-regulates neutrophil NETosis
In a recent study published in Nature, Malamud et al. identified how neutrophil MICL recognizes neutr...
Fueling metabolic adaptation: lysosomal AMPK ignites glutaminolysis
Fueling metabolic adaptation: lysosomal AMPK ignites glutaminolysis
The capacity to effectively adapt metabolism to environmental demands is crucial for cell viability, ...
Immunity hubs orchestrating antiviral defense
Immunity hubs orchestrating antiviral defense
Understanding the intricate dynamics of the immune response to SARS-CoV-2 is crucial for developing e...
Population-wide DNA methylation polymorphisms at single-nucleotide resolution in 207 cotton accessions reveal epigenomic contributions to complex traits
Population-wide DNA methylation polymorphisms at single-nucleotide resolution in 207 cotton accessions reveal epigenomic contributions to complex traits
DNA methylation plays multiple regulatory roles in crop development. However, the relationships of methylation polymorphis...
Nucleophagy repairs toxic DNA lesions
Nucleophagy repairs toxic DNA lesions
In a recent study in Cell, Lascaux et al. revealed a novel pathway to repair toxic DNA lesions, provi...
The mechanism of bacterial defense system DdmDE from Lactobacillus casei
The mechanism of bacterial defense system DdmDE from Lactobacillus casei
The atomic coordinates of LcDdmD-fork DNA, LcDdmE-gDNA-bubbleDNA, and LcDdmDE-guide-bubbleDNA ha...
AMPK targets PDZD8 to trigger carbon source shift from glucose to glutamine
AMPK targets PDZD8 to trigger carbon source shift from glucose to glutamine
The shift of carbon utilization from primarily glucose to other nutrients is a fundamental metabolic adaptation to cope wi...
ANT2: the first mammalian mitochondrial RNA transport translocon
ANT2: the first mammalian mitochondrial RNA transport translocon
Despite the crucial roles of mitochondrial RNA transport in maintaining mitochondrial functionality, ...
Combination therapy of KRAS G12V mRNA vaccine and pembrolizumab: clinical benefit in patients with advanced solid tumors
Combination therapy of KRAS G12V mRNA vaccine and pembrolizumab: clinical benefit in patients with advanced solid tumors
mRNA-based therapeutics have gained the public’s attention in the post-COVID era. The application of ...
Localized, highly efficient secretion of signaling proteins by migrasomes
Localized, highly efficient secretion of signaling proteins by migrasomes
Migrasomes, enriched with signaling molecules such as chemokines, cytokines and angiogenic factors, play a pivotal role in...
Molecular insights into the inhibition of proton-activated chloride channel by transfer RNA
Molecular insights into the inhibition of proton-activated chloride channel by transfer RNA
We thank SKLB West China Cryo-EM Center of Sichuan University, Cryo-EM Facility of Westlake University, and Kobilka Cryo-E...
Bitter taste receptor TAS2R14 activation and G protein assembly by an intracellular agonist
Bitter taste receptor TAS2R14 activation and G protein assembly by an intracellular agonist
The cryo-EM data were collected at the Advanced Center for Electron Microscopy, Shanghai Institute of Materia Medica. The ...
Zero-shot prediction of mutation effects with multimodal deep representation learning guides protein engineering
Zero-shot prediction of mutation effects with multimodal deep representation learning guides protein engineering
Mutations in amino acid sequences can provoke changes in protein function. Accurate and unsupervised prediction of mutatio...
Perenniality: the tale of three MADS-box genes
Perenniality: the tale of three MADS-box genes
Perennial and annual lifestyles represent two main life strategies in the plant kingdom, and they are...
MRE11 mobilizes CGAS and drives ZBP1-dependent necroptosis
MRE11 mobilizes CGAS and drives ZBP1-dependent necroptosis
Recent data from Cho et al. demonstrate that the DNA repair protein MRE11 liberates CGAS from nucleos...
T follicular regulatory cells keep B cell-directed autoreactivity in check
T follicular regulatory cells keep B cell-directed autoreactivity in check
The immune system well illustrates the need for balance between aggression and tolerance: mechanisms ...
Complement(ing) the microbiome in infants through breastmilk
Complement(ing) the microbiome in infants through breastmilk
Breastfeeding has a major impact on the health of infants. In a recent study published in Cell, Xu et...
Structural basis for different ω-agatoxin IVA sensitivities of the P-type and Q-type Cav2.1 channels
Structural basis for different ω-agatoxin IVA sensitivities of the P-type and Q-type Cav2.1 channels
We thank Xiaomin Li and Jianlin Lei for technical support during EM image acquisition. We thank the Tsinghua University Br...
The rapid proximity labeling system PhastID identifies ATP6AP1 as an unconventional GEF for Rheb
The rapid proximity labeling system PhastID identifies ATP6AP1 as an unconventional GEF for Rheb
Rheb is a small G protein that functions as the direct activator of the mechanistic target of rapamycin complex 1 (mTORC1)...
Treating insomnia with 40 Hz light flicker
A new study published in Cell Research reports that 40 Hz light flicker induces a somnogenic effect m...
Multiple cancer cell types release LIF and Gal3 to hijack neural signals
Multiple cancer cell types release LIF and Gal3 to hijack neural signals
Neural signals can significantly influence cancer prognosis. However, how cancer cells may proactively modulate the nervou...
Metabolic engineering of the paclitaxel anticancer drug
Metabolic engineering of the paclitaxel anticancer drug
In a recently published Science article, Jiang et al. unraveled a couple of missing enzymes achieving...
Publisher Correction: Sanofi-Cell Research outstanding paper award of 2022
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Caught in the middle: MARCH5 mediates PD-1-induced IL-2R degradation
Caught in the middle: MARCH5 mediates PD-1-induced IL-2R degradation
Blockade of the PD-L1/PD-1 pathway in combination of IL-2 therapy appears to yield synergistic anti-t...
A precision counterstrike on central nervous system autoimmunity
A precision counterstrike on central nervous system autoimmunity
Autoantibodies targeting the N-methyl-D-aspartate receptor (NMDAR) induce debilitating neuropsychiatr...
Sanofi-Cell Research outstanding paper award of 2022
Sanofi-Cell Research outstanding paper award of 2022
We are pleased to announce the winners of the 2022 Sanofi-Cell Research Outstanding Research Article ...
Rpd3S meets the nucleosome
Rpd3S meets the nucleosome
Two recent reports in Cell Research present cryo-electron microscopy structures of the Rpd3S HDAC com...
Flooding plant apoplast through water and solute channels
Flooding plant apoplast through water and solute channels
Inducing water-soaking symptoms is a key early step during the pathogenesis of many fungal, oomycete,...
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