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The role of Gαq in regulating NLRP3 inflammasome activation
The role of Gαq in regulating NLRP3 inflammasome activation
G proteins are a class of important signal transducers in mammalians. G proteins can corpoarated with G proteincoupled rec...
Inhibition of neuroinflammation and neuronal damage by the selective non-steroidal ERβ agonist AC-186
Inhibition of neuroinflammation and neuronal damage by the selective non-steroidal ERβ agonist AC-186
AC-186 (4-[4-4-Difluoro-1-(2-fluorophenyl) cyclohexyl] phenol) is a neuroprotective non-steroidal selective oestrogen rece...
Macrophage activation syndrome in Sepsis: from pathogenesis to clinical management
Macrophage activation syndrome in Sepsis: from pathogenesis to clinical management
Sepsis represents a significant global health and hygiene challenge. Excessive activation of macrophages in sepsis can res...
Immune cells mediate the causal pathway linking circulating complements to cancer: A Mendelian randomization study
Immune cells mediate the causal pathway linking circulating complements to cancer: A Mendelian randomization study
The role of complement in cancer remains controversial. Whether immune cells and inflammatory factors mediate the pathway ...
CD90’s role in vascularization and healing of rib fractures: insights from Dll4/notch regulation
CD90’s role in vascularization and healing of rib fractures: insights from Dll4/notch regulation
Vascularization after rib fracture is a crucial physiological process that is essential for the repair and healing of the ...
Modulation of Plet1 expression by N-Acetylglucosamine through the IL-17 A-MAPK pathway in an imiquimod-induced psoriasis mouse model
Modulation of Plet1 expression by N-Acetylglucosamine through the IL-17 A-MAPK pathway in an imiquimod-induced psoriasis mouse model
Psoriasis (Ps) is a chronic inflammatory disorder marked by skin plaque formation, driven by immune dysregulation and gene...
Environmental and inflammatory factors influencing concurrent gut and lung inflammation
Environmental and inflammatory factors influencing concurrent gut and lung inflammation
Crohn’s disease and chronic obstructive pulmonary disease (COPD) are chronic inflammatory diseases that affect the g...
Pentoxifylline in COVID-19 and considerations for its research in long COVID
Pentoxifylline in COVID-19 and considerations for its research in long COVID
Pentoxifylline (PTX) affects most blood components and the blood vessels, potentially modulating various conditions. Due t...
Single-cell transcriptome analysis of the mouse lungs during the injury and recovery periods after lipopolysaccharide administration
Single-cell transcriptome analysis of the mouse lungs during the injury and recovery periods after lipopolysaccharide administration
This study sought to investigate the cellular and molecular alterations during the injury and recovery periods of ALI and ...
Molecular mechanism of mechanical pressure induced changes in the microenvironment of intervertebral disc degeneration
Molecular mechanism of mechanical pressure induced changes in the microenvironment of intervertebral disc degeneration
Lower back pain, as a typical clinical symptom of spinal degenerative diseases, is emerging as a major social problem. Acc...
5-oxoETE promote thrombosis in antiphospholipid syndrome by triggering NETs formation through PLC/PKC/ERK pathway
5-oxoETE promote thrombosis in antiphospholipid syndrome by triggering NETs formation through PLC/PKC/ERK pathway
One mechanism by which antiphospholipid syndrome (APS) IgG contribute to thrombotic events in patients with APS is through...
Systemic immune inflammation index with all-cause and cause-specific mortality: a meta-analysis
Systemic immune inflammation index with all-cause and cause-specific mortality: a meta-analysis
Studies have reported an association among systemic immune inflammation index (SII), all-cause and cause-specific mortalit...
Function of unconventional T cells in oral lichen planus revealed by single-cell RNA sequencing
Function of unconventional T cells in oral lichen planus revealed by single-cell RNA sequencing
We intended to map the single-cell profile of OLP, explore the molecular characteristics of unconventional T cells in OLP ...
Exploring the therapeutic potential of monoclonal antibodies targeting TSLP and IgE in asthma management
Exploring the therapeutic potential of monoclonal antibodies targeting TSLP and IgE in asthma management
In recent years, there has been a growing interest in the utilization of biologic therapies for the management of asthma. ...
Alpha-galactosylceramide pre-treatment attenuates clinical symptoms of LPS-induced acute neuroinflammation by converting pathogenic iNKT cells to anti-inflammatory iNKT10 cells in the brain
Alpha-galactosylceramide pre-treatment attenuates clinical symptoms of LPS-induced acute neuroinflammation by converting pathogenic iNKT cells to anti-inflammatory iNKT10 cells in the brain
Invariant natural killer T (iNKT) cells play protective or pathogenic roles in a variety of immune and inflammatory diseas...
Fibroblast growth factor receptor 4 deficiency in macrophages aggravates experimental colitis by promoting M1-polarization
Fibroblast growth factor receptor 4 deficiency in macrophages aggravates experimental colitis by promoting M1-polarization
Compelling evidence indicates that dysregulated macrophages may play a key role in driving inflammation in inflammatory bo...
Shifting phenotype and differentiation of CD11b+Gr.1+ immature heterogeneous myeloid derived adjuster cells support inflammation and induce regulators of IL17A in imiquimod induced psoriasis
Shifting phenotype and differentiation of CD11b+Gr.1+ immature heterogeneous myeloid derived adjuster cells support inflammation and induce regulators of IL17A in imiquimod induced psoriasis
The exact immunological mechanism of widespread chronic inflammatory skin disorder psoriasis has not been fully establishe...
A novel molecular classification based on efferocytosis-related genes for predicting clinical outcome and treatment response in acute myeloid leukemia
A novel molecular classification based on efferocytosis-related genes for predicting clinical outcome and treatment response in acute myeloid leukemia
Previous studies have shown that macrophage-mediated efferocytosis is involved in immunosuppression in acute myeloid leuke...
DGA ameliorates severe acute pancreatitis through modulating macrophage pyroptosis
DGA ameliorates severe acute pancreatitis through modulating macrophage pyroptosis
Severe acute pancreatitis (SAP) is an inflammatory disease with varying severity, ranging from mild local inflammation to ...
Stored RBC transfusions leads to the systemic inflammatory response syndrome in anemic murine neonates
Stored RBC transfusions leads to the systemic inflammatory response syndrome in anemic murine neonates
RBC transfusions (RBCT) are life-saving treatment for premature and critically ill infants. However, the procedure has bee...
Probiotic nucleotides increase IL-10 expression in airway macrophages to mitigate airway allergy
Probiotic nucleotides increase IL-10 expression in airway macrophages to mitigate airway allergy
Dysfunctional immune regulation plays a crucial role in the pathogenesis of airway allergies. Macrophages are one of the c...
Simultaneously blocking ANGPTL3 and IL-1β for the treatment of atherosclerosis through lipid-lowering and anti-inflammation
Simultaneously blocking ANGPTL3 and IL-1β for the treatment of atherosclerosis through lipid-lowering and anti-inflammation
Blood lipid levels play a critical role in the progression of atherosclerosis. However, even with adequate lipid reduction...
Angiotensin-(1–7) decreases inflammation and lung damage caused by betacoronavirus infection in mice
Angiotensin-(1–7) decreases inflammation and lung damage caused by betacoronavirus infection in mice
Pro-resolving molecules, including the peptide Angiotensin-(1–7) [Ang-(1–7)], have potential adjunctive therap...
The protective role of RACK1 in hepatic ischemia‒reperfusion injury-induced ferroptosis
The protective role of RACK1 in hepatic ischemia‒reperfusion injury-induced ferroptosis
Although ferroptosis plays a crucial role in hepatic ischemia‒reperfusion injury (IRI), the molecular mechanisms und...
Corynoline alleviates hepatic ischemia–reperfusion injury by inhibiting NLRP3 inflammasome activation through enhancing Nrf2/HO-1 signaling
Corynoline alleviates hepatic ischemia–reperfusion injury by inhibiting NLRP3 inflammasome activation through enhancing Nrf2/HO-1 signaling
Corynoline has displayed pharmacological effects in reducing oxidative stress and inflammatory responses in many disorders...
Cyclic adenosine monophosphate critically modulates cardiac GLP-1 receptor’s anti-inflammatory effects
Cyclic adenosine monophosphate critically modulates cardiac GLP-1 receptor’s anti-inflammatory effects
Glucagon-like peptide (GLP)-1 receptor (GLP1R) agonists exert a multitude of beneficial cardiovascular effects beyond cont...
Olink proteomics and lipidomics analysis of serum from patients infected with non-tuberculous mycobacteria and Mycobacterium tuberculosis
Olink proteomics and lipidomics analysis of serum from patients infected with non-tuberculous mycobacteria and Mycobacterium tuberculosis
Non-tuberculous mycobacterial (NTM) and Mycobacterium tuberculosis (MTB) infections are difficult to diagnose and treat, s...
Trained immunity of synovial macrophages is associated with exacerbated joint inflammation and damage after Staphylococcus aureus infection
Trained immunity of synovial macrophages is associated with exacerbated joint inflammation and damage after Staphylococcus aureus infection
Investigate whether and which synoviocytes would acquire trained immunity characteristics that could exacerbate joint infl...
Plant extracts and omega-3 supplementation modulate hippocampal oxylipin profile in response to LPS-induced neuroinflammation
Plant extracts and omega-3 supplementation modulate hippocampal oxylipin profile in response to LPS-induced neuroinflammation
Neuroinflammation is a protective mechanism but can become harmful if chronic and/or unregulated, leading to neuronal dama...
Cynarin inhibits microglia-induced pyroptosis and neuroinflammation via Nrf2/ROS/NLRP3 axis after spinal cord injury
Cynarin inhibits microglia-induced pyroptosis and neuroinflammation via Nrf2/ROS/NLRP3 axis after spinal cord injury
Cynarin decreases neuroinflammation levels and attenuates microglial pyroptosis. Cynarin hinders the formation of NLRP3 in...
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