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Seeing tension in cells
Non-muscle myosin II (NMII) generates contractile forces, and Förster resonance energy transfer (FRET)-based tension senso...
To eat or not to eat
During development, haematopoietic stem and progenitor cells (HSPCs) experiencing high cellular stress produce increased l...
Lipid droplet messengers
Group 2 innate lymphoid cells (ILC2s) serve important roles in airway inflammation in asthma. After being activated, ILC2s...
A systemic effect for liver senescence
A systemic effect for liver senescence
A study shows that senescence induced in the liver can spread systemically to precipitate multi-organ dysfunction. The wor...
Hepatocellular senescence induces multi-organ senescence and dysfunction via TGFβ
Hepatocellular senescence induces multi-organ senescence and dysfunction via TGFβ
Cellular senescence is not only associated with ageing but also impacts physiological and pathological processes, such as ...
FMRP gains mitochondrial fission control
FMRP gains mitochondrial fission control
Mitochondrial fission and fusion are crucial for neurons. The RNA-binding protein FMRP regulates mitochondrial dynamics, i...
Chromatin remodelling in damaged intestinal crypts orchestrates redundant TGFβ and Hippo signalling to drive regeneration
Chromatin remodelling in damaged intestinal crypts orchestrates redundant TGFβ and Hippo signalling to drive regeneration
Cell state dynamics underlying successful tissue regeneration are undercharacterized. In the intestine, damage prompts epi...
FMRP regulates MFF translation to locally direct mitochondrial fission in neurons
FMRP regulates MFF translation to locally direct mitochondrial fission in neurons
Fragile X messenger ribonucleoprotein (FMRP) is a critical regulator of translation, whose dysfunction causes fragile X sy...
Cleavage-independent GSDME activation by UVC
Cleavage-independent GSDME activation by UVC
Gasdermins (GSDMs) are mediators of cell death that trigger membrane lysis. A study shows that full-length GSDME induces p...
Systematic loss-of-function screens identify pathway-specific functional circular RNAs
Systematic loss-of-function screens identify pathway-specific functional circular RNAs
Circular RNA (circRNA) is covalently closed, single-stranded RNA produced by back-splicing. A few circRNAs have been impli...
p16-dependent increase of PD-L1 stability regulates immunosurveillance of senescent cells
p16-dependent increase of PD-L1 stability regulates immunosurveillance of senescent cells
The accumulation of senescent cells promotes ageing and age-related diseases, but molecular mechanisms that senescent cell...
Spermidine is essential for fasting-mediated autophagy and longevity
Spermidine is essential for fasting-mediated autophagy and longevity
Caloric restriction and intermittent fasting prolong the lifespan and healthspan of model organisms and improve human heal...
TorsinA is essential for neuronal nuclear pore complex localization and maturation
TorsinA is essential for neuronal nuclear pore complex localization and maturation
As lifelong interphase cells, neurons face an array of unique challenges. A key challenge is regulating nuclear pore compl...
Spindle architecture constrains karyotype evolution
Spindle architecture constrains karyotype evolution
The eukaryotic cell division machinery must rapidly and reproducibly duplicate and partition the cell’s chromosomes ...
A fatty acid switch drives ferroptosis in EMT
A fatty acid switch drives ferroptosis in EMT
Ferroptosis is mediated by toxic accumulation of lipid peroxides. A new study reports that the transcription factor ZEB1 d...
Docking a flexible basket onto the core of the nuclear pore complex
Docking a flexible basket onto the core of the nuclear pore complex
The nuclear basket attaches to the nucleoplasmic side of the nuclear pore complex (NPC), coupling transcription to mRNA qu...
Fatty acyl-coenzyme A activates mitochondrial division through oligomerization of MiD49 and MiD51
Fatty acyl-coenzyme A activates mitochondrial division through oligomerization of MiD49 and MiD51
Mitochondrial fission occurs in many cellular processes, but the regulation of fission is poorly understood. We show that ...
Adding a transcription-coupled repair pathway
Adding a transcription-coupled repair pathway
When transcription by RNA polymerase II is stalled by ultraviolet-induced DNA damage, it recruits repair factors, leading ...
Tissue pressure and YAP during organogenesis
Tissue pressure and YAP during organogenesis
Organ morphogenesis begins with proliferation, which results in tissue pressures and site-specific YAP expression, nuclear...
Transcription-coupled DNA–protein crosslink repair by CSB and CRL4CSA-mediated degradation
Transcription-coupled DNA–protein crosslink repair by CSB and CRL4CSA-mediated degradation
DNA–protein crosslinks (DPCs) arise from enzymatic intermediates, metabolism or chemicals like chemotherapeutics. DP...
Endogenous aldehyde-induced DNA–protein crosslinks are resolved by transcription-coupled repair
Endogenous aldehyde-induced DNA–protein crosslinks are resolved by transcription-coupled repair
DNA–protein crosslinks (DPCs) induced by aldehydes interfere with replication and transcription. Hereditary deficien...
Transcription-coupled repair of DNA–protein cross-links depends on CSA and CSB
Transcription-coupled repair of DNA–protein cross-links depends on CSA and CSB
Covalent DNA–protein cross-links (DPCs) are toxic DNA lesions that block replication and require repair by multiple ...
A CRISPRi/a screening platform to study cellular nutrient transport in diverse microenvironments
A CRISPRi/a screening platform to study cellular nutrient transport in diverse microenvironments
Blocking the import of nutrients essential for cancer cell proliferation represents a therapeutic opportunity, but it is u...
Accelerating data sharing and reuse in volume electron microscopy
Accelerating data sharing and reuse in volume electron microscopy
Volume electron microscopy (vEM) generates large 3D volumes of cells or tissues at nanoscale resolutions, enabling analyse...
Author Correction: Co-option of epidermal cells enables touch sensing
Author Correction: Co-option of epidermal cells enables touch sensing
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which...
Author Correction: Phase separation of EB1 guides microtubule plus-end dynamics
Author Correction: Phase separation of EB1 guides microtubule plus-end dynamics
These authors contributed equally: Xiaoyu Song, Fengrui Yang, Tongtong Yang, Yong Wang, Mingrui Ding, Linge Li.These autho...
Pyruvate metabolism regulates prostate cell fate and response to cancer therapy
Pyruvate metabolism regulates prostate cell fate and response to cancer therapy
Lineage transitions are a central feature of prostate development, tumorigenesis and treatment resistance. We discovered t...
Metabolically regulated lineages in prostate cancer
Metabolically regulated lineages in prostate cancer
Lineage plasticity and epigenetic changes underlie prostate development and cancer evolution. A new study shows that basal...
Prostate lineage-specific metabolism governs luminal differentiation and response to antiandrogen treatment
Prostate lineage-specific metabolism governs luminal differentiation and response to antiandrogen treatment
Lineage transitions are a central feature of prostate development, tumourigenesis and treatment resistance. While epigenet...
Breast cancer remotely imposes a myeloid bias on haematopoietic stem cells by reprogramming the bone marrow niche
Breast cancer remotely imposes a myeloid bias on haematopoietic stem cells by reprogramming the bone marrow niche
Myeloid cell infiltration of solid tumours generally associates with poor patient prognosis and disease severity1–13...
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