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Metabolites in tumour interstitial fluid directly suppress T cells
Metabolites in tumour interstitial fluid directly suppress T cells
Cancers evade immunity in many ways, including by generating a metabolically hostile tumour microenvironment. Exposure of ...
Effects of embryonic origin, tissue cues and pathological signals on fibroblast diversity in humans
Effects of embryonic origin, tissue cues and pathological signals on fibroblast diversity in humans
Fibroblasts, once perceived as a uniform cell type, are now recognized as a mosaic of distinct populations with specialize...
Metastatic medulloblastoma remodels the local leptomeningeal microenvironment to promote further metastatic colonization and growth
Metastatic medulloblastoma remodels the local leptomeningeal microenvironment to promote further metastatic colonization and growth
Leptomeningeal metastases are the major source of morbidity and mortality for patients with medulloblastoma. The biology o...
α-Ketoglutarate promotes trophectoderm induction and maturation from naive human embryonic stem cells
α-Ketoglutarate promotes trophectoderm induction and maturation from naive human embryonic stem cells
Development and lineage choice are driven by interconnected transcriptional, epigenetic and metabolic changes. Specific me...
Targeting redox-sensitive MBD2–NuRD condensate in cancer cells
Targeting redox-sensitive MBD2–NuRD condensate in cancer cells
Transcriptional silencing of hypermethylated tumour suppressor genes is a hallmark of tumorigenesis but the underlying mec...
Regulation of RIG-I activity by phase separation reveals new therapeutic opportunities
Regulation of RIG-I activity by phase separation reveals new therapeutic opportunities
After virus infection, RIG-I forms disulfide-linked oligomers that are resistant to degradation and able to enter liquid-l...
Import mechanism of peroxisomal proteins with an N-terminal signal sequence
Import mechanism of peroxisomal proteins with an N-terminal signal sequence
Most proteins imported into peroxisomes use a carboxy-terminal PTS1 signal, which is recognized by soluble receptors that ...
ALDH4A1 functions as an active component of the MPC complex maintaining mitochondrial pyruvate import for TCA cycle entry and tumour suppression
ALDH4A1 functions as an active component of the MPC complex maintaining mitochondrial pyruvate import for TCA cycle entry and tumour suppression
MPC1 and MPC2 are two well-known components of the mitochondrial pyruvate carrier (MPC) complex maintaining MPC activity t...
Seeing tension in cells
Non-muscle myosin II (NMII) generates contractile forces, and Förster resonance energy transfer (FRET)-based tension senso...
To eat or not to eat
During development, haematopoietic stem and progenitor cells (HSPCs) experiencing high cellular stress produce increased l...
Lipid droplet messengers
Group 2 innate lymphoid cells (ILC2s) serve important roles in airway inflammation in asthma. After being activated, ILC2s...
A systemic effect for liver senescence
A systemic effect for liver senescence
A study shows that senescence induced in the liver can spread systemically to precipitate multi-organ dysfunction. The wor...
Hepatocellular senescence induces multi-organ senescence and dysfunction via TGFβ
Hepatocellular senescence induces multi-organ senescence and dysfunction via TGFβ
Cellular senescence is not only associated with ageing but also impacts physiological and pathological processes, such as ...
FMRP gains mitochondrial fission control
FMRP gains mitochondrial fission control
Mitochondrial fission and fusion are crucial for neurons. The RNA-binding protein FMRP regulates mitochondrial dynamics, i...
Chromatin remodelling in damaged intestinal crypts orchestrates redundant TGFβ and Hippo signalling to drive regeneration
Chromatin remodelling in damaged intestinal crypts orchestrates redundant TGFβ and Hippo signalling to drive regeneration
Cell state dynamics underlying successful tissue regeneration are undercharacterized. In the intestine, damage prompts epi...
FMRP regulates MFF translation to locally direct mitochondrial fission in neurons
FMRP regulates MFF translation to locally direct mitochondrial fission in neurons
Fragile X messenger ribonucleoprotein (FMRP) is a critical regulator of translation, whose dysfunction causes fragile X sy...
Cleavage-independent GSDME activation by UVC
Cleavage-independent GSDME activation by UVC
Gasdermins (GSDMs) are mediators of cell death that trigger membrane lysis. A study shows that full-length GSDME induces p...
Systematic loss-of-function screens identify pathway-specific functional circular RNAs
Systematic loss-of-function screens identify pathway-specific functional circular RNAs
Circular RNA (circRNA) is covalently closed, single-stranded RNA produced by back-splicing. A few circRNAs have been impli...
p16-dependent increase of PD-L1 stability regulates immunosurveillance of senescent cells
p16-dependent increase of PD-L1 stability regulates immunosurveillance of senescent cells
The accumulation of senescent cells promotes ageing and age-related diseases, but molecular mechanisms that senescent cell...
Spermidine is essential for fasting-mediated autophagy and longevity
Spermidine is essential for fasting-mediated autophagy and longevity
Caloric restriction and intermittent fasting prolong the lifespan and healthspan of model organisms and improve human heal...
TorsinA is essential for neuronal nuclear pore complex localization and maturation
TorsinA is essential for neuronal nuclear pore complex localization and maturation
As lifelong interphase cells, neurons face an array of unique challenges. A key challenge is regulating nuclear pore compl...
Spindle architecture constrains karyotype evolution
Spindle architecture constrains karyotype evolution
The eukaryotic cell division machinery must rapidly and reproducibly duplicate and partition the cell’s chromosomes ...
A fatty acid switch drives ferroptosis in EMT
A fatty acid switch drives ferroptosis in EMT
Ferroptosis is mediated by toxic accumulation of lipid peroxides. A new study reports that the transcription factor ZEB1 d...
Docking a flexible basket onto the core of the nuclear pore complex
Docking a flexible basket onto the core of the nuclear pore complex
The nuclear basket attaches to the nucleoplasmic side of the nuclear pore complex (NPC), coupling transcription to mRNA qu...
Fatty acyl-coenzyme A activates mitochondrial division through oligomerization of MiD49 and MiD51
Fatty acyl-coenzyme A activates mitochondrial division through oligomerization of MiD49 and MiD51
Mitochondrial fission occurs in many cellular processes, but the regulation of fission is poorly understood. We show that ...
Adding a transcription-coupled repair pathway
Adding a transcription-coupled repair pathway
When transcription by RNA polymerase II is stalled by ultraviolet-induced DNA damage, it recruits repair factors, leading ...
Tissue pressure and YAP during organogenesis
Tissue pressure and YAP during organogenesis
Organ morphogenesis begins with proliferation, which results in tissue pressures and site-specific YAP expression, nuclear...
Transcription-coupled DNA–protein crosslink repair by CSB and CRL4CSA-mediated degradation
Transcription-coupled DNA–protein crosslink repair by CSB and CRL4CSA-mediated degradation
DNA–protein crosslinks (DPCs) arise from enzymatic intermediates, metabolism or chemicals like chemotherapeutics. DP...
Endogenous aldehyde-induced DNA–protein crosslinks are resolved by transcription-coupled repair
Endogenous aldehyde-induced DNA–protein crosslinks are resolved by transcription-coupled repair
DNA–protein crosslinks (DPCs) induced by aldehydes interfere with replication and transcription. Hereditary deficien...
Transcription-coupled repair of DNA–protein cross-links depends on CSA and CSB
Transcription-coupled repair of DNA–protein cross-links depends on CSA and CSB
Covalent DNA–protein cross-links (DPCs) are toxic DNA lesions that block replication and require repair by multiple ...
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