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Targeting A2M-LRP1 reverses uterine spiral artery remodeling disorder and alleviates the progression of preeclampsia
Targeting A2M-LRP1 reverses uterine spiral artery remodeling disorder and alleviates the progression of preeclampsia
Patients with early-onset preeclampsia (EOPE) have a most severe disease state. a2-macroglobulin (A2M) play a crucial role...
LRSAM1 mediated the degradation of intracellular Vibrio through the ubiquitination-autophagy-lysosome pathway in oyster
LRSAM1 mediated the degradation of intracellular Vibrio through the ubiquitination-autophagy-lysosome pathway in oyster
The leucine rich repeat and sterile alpha motif containing 1 (LRSAM1) as E3 ligase recognizes bacteria and generates a ubi...
Emerging functions of Plakophilin 4 in the control of cell contact dynamics
Emerging functions of Plakophilin 4 in the control of cell contact dynamics
Plakophilin 4 (PKP4, also called p0071) is a unique armadillo family protein localized at adherens junctions that acts as ...
CXXC5 function blockade promotes diabetic wound healing through stimulating fibroblast and vascular endothelial cell activation
CXXC5 function blockade promotes diabetic wound healing through stimulating fibroblast and vascular endothelial cell activation
Extracellular matrix (ECM) and angiogenesis are critical controls of wound regeneration, and their dysfunction delays diab...
Spatial-transcriptomic profiling: a new lens for understanding myelofibrosis pathophysiology
Spatial-transcriptomic profiling: a new lens for understanding myelofibrosis pathophysiology
Myelofibrosis (MF) is a complex myeloproliferative neoplasm characterized by abnormal hematopoietic stem cell proliferatio...
The crosstalk between copper-induced oxidative stress and cuproptosis: a novel potential anticancer paradigm
The crosstalk between copper-induced oxidative stress and cuproptosis: a novel potential anticancer paradigm
Copper is a crucial trace element that plays a role in various pathophysiological processes in the human body. Copper also...
Hainanenin-1, an oncolytic peptide, triggers immunogenic cell death via STING activation in triple-negative breast cancer
Hainanenin-1, an oncolytic peptide, triggers immunogenic cell death via STING activation in triple-negative breast cancer
In triple-negative breast cancer (TNBC) therapy, insufficient tumor infiltration by lymphocytes significantly hinders the ...
tRF-His-GTG-1 enhances NETs formation and interferon-α production in lupus by extracellular vesicle
tRF-His-GTG-1 enhances NETs formation and interferon-α production in lupus by extracellular vesicle
Hyperactive neutrophil extracellular traps (NETs) formation plays a crucial role in active severe systemic lupus erythemat...
Applications of lung cancer organoids in precision medicine: from bench to bedside
Applications of lung cancer organoids in precision medicine: from bench to bedside
As the leading cause of cancer-related mortality, lung cancer continues to pose a menacing threat to human health worldwid...
Correction: Extracellular vesicles of the probiotic bacteria E. coli O83 activate innate immunity and prevent allergy in mice
Correction: Extracellular vesicles of the probiotic bacteria E. coli O83 activate innate immunity and prevent allergy in mice
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Polyamines: their significance for maintaining health and contributing to diseases
Polyamines: their significance for maintaining health and contributing to diseases
Polyamines are essential for the growth and proliferation of mammalian cells and are intimately involved in biological mec...
New insights into the stemness of adoptively transferred T cells by γc family cytokines
New insights into the stemness of adoptively transferred T cells by γc family cytokines
T cell-based adoptive cell therapy (ACT) has exhibited excellent antitumoral efficacy exemplified by the clinical breakthr...
A missense mutant of ocrl1 promotes apoptosis of tubular epithelial cells and disrupts endocytosis and the cell cycle of podocytes in Dent-2 Disease
A missense mutant of ocrl1 promotes apoptosis of tubular epithelial cells and disrupts endocytosis and the cell cycle of podocytes in Dent-2 Disease
This study aimed to identify an orcl1 mutation in a patient with Dent-2 Disease and investigate the underlying mechanisms....
Novel roles of PIWI proteins and PIWI-interacting RNAs in human health and diseases
Novel roles of PIWI proteins and PIWI-interacting RNAs in human health and diseases
Non-coding RNA has aroused great research interest recently, they play a wide range of biological functions, such as regul...
Overcoming BCR::ABL1 dependent and independent survival mechanisms in chronic myeloid leukaemia using a multi-kinase targeting approach
Overcoming BCR::ABL1 dependent and independent survival mechanisms in chronic myeloid leukaemia using a multi-kinase targeting approach
Despite improved patient outcome using tyrosine kinase inhibitors (TKIs), chronic myeloid leukaemia (CML) patients require...
Natural killer cells in the central nervous system
Natural killer cells in the central nervous system
Natural killer (NK) cells are essential components of the innate lymphoid cell family that work as both cytotoxic effector...
CP-25 inhibits the hyperactivation of rheumatic synoviocytes by suppressing the switch in Gαs-Gαi coupling to the β2-adrenergic receptor
CP-25 inhibits the hyperactivation of rheumatic synoviocytes by suppressing the switch in Gαs-Gαi coupling to the β2-adrenergic receptor
In essence, the β2 adrenergic receptor (β2AR) plays an antiproliferative role by increasing the intracellular cy...
The SMYD3-dependent H3K4me3 status of IGF2 intensifies local Th2 differentiation in CRSwNP via positive feedback
The SMYD3-dependent H3K4me3 status of IGF2 intensifies local Th2 differentiation in CRSwNP via positive feedback
Chronic rhinosinusitis with nasal polyps (CRSwNP) is a heterogeneous and common upper airway disease divided into various ...
Mechanisms underlying linear ubiquitination and implications in tumorigenesis and drug discovery
Mechanisms underlying linear ubiquitination and implications in tumorigenesis and drug discovery
Linear ubiquitination is a distinct type of ubiquitination that involves attaching a head-to-tail polyubiquitin chain to a...
Targeting ferroptosis in melanoma: cancer therapeutics
Targeting ferroptosis in melanoma: cancer therapeutics
Melanoma is an aggressive kind of skin cancer; its rate has risen rapidly over the past few decades. Melanoma reports for ...
Preeclampsia impedes foetal kidney development by delivering placenta-derived exosomes to glomerular endothelial cells
Preeclampsia impedes foetal kidney development by delivering placenta-derived exosomes to glomerular endothelial cells
Foetal renal dysplasia is still the main cause of adult renal disease. Placenta-derived exosomes are an important communic...
P2X7 receptor activation leads to NLRP3-independent IL-1β release by human macrophages
P2X7 receptor activation leads to NLRP3-independent IL-1β release by human macrophages
The purinergic receptor P2X7 plays a crucial role in infection, inflammation, and cell death. It is thought that P2X7 rece...
New insights into the regulation of METTL3 and its role in tumors
New insights into the regulation of METTL3 and its role in tumors
As one of the most abundant epigenetic modifications in RNA, N6-methyladenosine (m6A) affects RNA transcription, splicing,...
Inhibition of Dickkopf-1 enhances the anti-tumor efficacy of sorafenib via inhibition of the PI3K/Akt and Wnt/β-catenin pathways in hepatocellular carcinoma
Inhibition of Dickkopf-1 enhances the anti-tumor efficacy of sorafenib via inhibition of the PI3K/Akt and Wnt/β-catenin pathways in hepatocellular carcinoma
Sorafenib improves the overall survival in patients with advanced hepatocellular carcinoma (HCC). Dickkopf-1 (DKK1) is com...
Machine learning-based analysis of cancer cell-derived vesicular proteins revealed significant tumor-specificity and predictive potential of extracellular vesicles for cell invasion and proliferation – A meta-analysis
Machine learning-based analysis of cancer cell-derived vesicular proteins revealed significant tumor-specificity and predictive potential of extracellular vesicles for cell invasion and proliferation – A meta-analysis
Although interest in the role of extracellular vesicles (EV) in oncology is growing, not all potential aspects have been i...
IL-1β mediates the induction of immune checkpoint regulators IDO1 and PD-L1 in lung adenocarcinoma cells
IL-1β mediates the induction of immune checkpoint regulators IDO1 and PD-L1 in lung adenocarcinoma cells
Inflammation plays a significant role in various cancers, including lung cancer, where the inflammatory cytokine IL-1β...
The impact of erythroblast enucleation efficiency on the severity of anemia in patients with myelodysplastic syndrome
The impact of erythroblast enucleation efficiency on the severity of anemia in patients with myelodysplastic syndrome
Anemia is the most common manifestation in myelodysplastic syndrome (MDS) patients, but the cause of ineffective hematopoi...
PKCδ regulates the vascular biology in diabetic atherosclerosis
PKCδ regulates the vascular biology in diabetic atherosclerosis
Diabetes mellitus, known for its complications, especially vascular complications, is becoming a globally serious social p...
Epigenetic-focused CRISPR/Cas9 screen identifies (absent, small, or homeotic)2-like protein (ASH2L) as a regulator of glioblastoma cell survival
Epigenetic-focused CRISPR/Cas9 screen identifies (absent, small, or homeotic)2-like protein (ASH2L) as a regulator of glioblastoma cell survival
Glioblastoma is the most common and aggressive primary brain tumor with extremely poor prognosis, highlighting an urgent n...
Simvastatin induces pyroptosis via ROS/caspase-1/GSDMD pathway in colon cancer
Simvastatin induces pyroptosis via ROS/caspase-1/GSDMD pathway in colon cancer
The outcome of patients with colon cancer is still unsatisfied nowadays. Simvastatin is a type of statins with anti-cancer...
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