SCI Abstract

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Human-specific genetic hallmarks in neocortical development: focus on neural progenitors
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How our brains are built: emerging approaches to understand human-specific features
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Exploiting the plasticity of cholangiocytes to repair the biliary tree
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Engineering immune organoids to regenerate host immune system
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Diversity of human skin three-dimensional organotypic cultures
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Cell–cell interactions between transplanted retinal organoid cells and recipient tissues
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Circuit integration by transplanted human neurons
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Control of cell fate upon transcription factor–driven cardiac reprogramming
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Unveiling the potential: implications of successful somatic cell-to-ganglion organoid reprogramming
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The power of proximity: mechanisms and biological roles of transvection
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Genome folding and zygotic genome activation in mammalian preimplantation embryos
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Better together: how cooperativity influences transcriptional bursting
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Emerging interactions between RNA methylation and chromatin architecture
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Editorial overview: Epitranscriptomics: Exploring a new frontier in health and disease
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Strategies for programmable manipulation of alternative splicing
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Editorial overview: Drivers, droplets, and deeds of nuclear genome organization
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Archaic hominin admixture and its consequences for modern humans
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Novelty versus innovation of gene regulatory elements in human evolution and disease
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Genetic factors mediating long-range enhancer–promoter communication in mammalian development
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In vitro dynamics of DNA loop extrusion by structural maintenance of chromosomes complexes
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Therapeutic targeting of BET bromodomain and other epigenetic acetylrecognition domain–containing factors
Therapeutic targeting of BET bromodomain and other epigenetic acetylrecognition domain–containing factors
In this perspective, we discuss the emerging class of epigenetic cancer therapies targeting acetylrecognition domain–conta...
Chromatin and aberrant enhancer activity in KMT2A rearranged acute lymphoblastic leukemia
Chromatin and aberrant enhancer activity in KMT2A rearranged acute lymphoblastic leukemia
To make a multicellular organism, genes need to be transcribed at the right developmental stages and in the right tissues....
Hijacked enhancer–promoter and silencer–promoter loops in cancer
Hijacked enhancer–promoter and silencer–promoter loops in cancer
The three-dimensional (3D) spatial organization of the human genome plays a crucial role in maintaining normal cellular fu...
Mitochondrial metabolism and the continuing search for ultimate regulators of developmental rate
Mitochondrial metabolism and the continuing search for ultimate regulators of developmental rate
A fundamental question in developmental biology is how the pace of developmental processes is controlled from a cell biolo...
Temporal patterning of the vertebrate developing neural tube
Temporal patterning of the vertebrate developing neural tube
scRNAseq data has been obtained from the indicated references (forebrain, midbrain, hindbrain: [34], spinal cord: [31], re...
The significance of ultradian oscillations in development
The significance of ultradian oscillations in development
Embryos develop autonomously under a predetermined schedule. While the genes involved in these processes have been charact...
Linking mitochondria metabolism, developmental timing, and human brain evolution
Linking mitochondria metabolism, developmental timing, and human brain evolution
Changes in developmental timing are an important factor of evolution in organ shape and function. This is particularly str...
New insights into how to induce and maintain embryonic diapause in the blastocyst
New insights into how to induce and maintain embryonic diapause in the blastocyst
Embryonic diapause in mammals is a period of developmental pause of the embryo at the blastocyst stage. During diapause, t...
Timing mechanisms: insights from comparative neural differentiation systems
Timing mechanisms: insights from comparative neural differentiation systems
Temporal control is central to deploy and coordinate genetic programs during development. At present, there is limited und...
Timing and Tempo in Development
Timing and Tempo in Development
James Briscoe is a group leader at the Francis Crick Institute, London. His laboratory’s research interests include the mo...
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