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Causal inference for epigenetic ageing
Causal inference for epigenetic ageing
In this Tools of the Trade article, Kejun Ying describes epigenome-wide Mendelian randomization, which integrates Mendelia...
The phenotypic consequences of enhancer evolution
In this Journal Club, Julie Jung and Thomas King recount a paper by Chan et al. that identified the regulatory changes und...
Slide-tags enables spatial single-nucleus sequencing
Slide-tags enables spatial single-nucleus sequencing
In this Tools of the Trade article, Andrew Russell describes Slide-tags, a method for scalable, spatially resolved single-...
Exploring biodiversity through museomics
Natural history collections are unparalleled resources for studying biodiversity across multiple dimensions. As multi-omic...
Genetic conflict and its resolution between the sexes
Abderrahman Khila highlights an important 2015 paper by Barson et al. that demonstrated how sexual conflict in Atlantic sa...
The design and engineering of synthetic genomes
The design and engineering of synthetic genomes
Synthetic genomics seeks to design and construct entire genomes to mechanistically dissect fundamental questions of genome...
Plant pattern recognition receptors: from evolutionary insight to engineering
Plant pattern recognition receptors: from evolutionary insight to engineering
The plant immune system relies on germline-encoded pattern recognition receptors (PRRs) that sense foreign and plant-deriv...
Biobanking with genetics shapes precision medicine and global health
Biobanking with genetics shapes precision medicine and global health
Precision medicine provides patients with access to personally tailored treatments based on individual-level data. However...
Genetic variation across and within individuals
Genetic variation across and within individuals
Germline variation and somatic mutation are intricately connected and together shape human traits and disease risks. Germl...
Pleiotropy, epistasis and the genetic architecture of quantitative traits
Pleiotropy, epistasis and the genetic architecture of quantitative traits
Pleiotropy (whereby one genetic polymorphism affects multiple traits) and epistasis (whereby non-linear interactions betwe...
Human embryonic genetic mosaicism and its effects on development and disease
Human embryonic genetic mosaicism and its effects on development and disease
Nearly every mammalian cell division is accompanied by a mutational event that becomes fixed in a daughter cell. When carr...
A developmental exit from totipotency
A developmental exit from totipotency
A paper in Nature Genetics identifies a mechanism involving the transcription factor DUXBL that controls the development o...
SIMPLE-seq to decode DNA methylation dynamics in single cells
SIMPLE-seq to decode DNA methylation dynamics in single cells
In this Tools of the Trade article, Dongsheng Bai and Chenxu Zhu describe SIMPLE-seq, a scalable single-cell sequencing me...
Understanding human uniqueness in the pre-genomic era
In this Journal Club article, Jenny Tung reflects on a 1975 paper from King and Wilson that emphasized the importance of g...
Natural antisense transcripts as versatile regulators of gene expression
Natural antisense transcripts as versatile regulators of gene expression
Long non-coding RNAs (lncRNAs) are emerging as a major class of gene products that have central roles in cell and developm...
Nuclear mRNA decay: regulatory networks that control gene expression
Nuclear mRNA decay: regulatory networks that control gene expression
Proper regulation of mRNA production in the nucleus is critical for the maintenance of cellular homoeostasis during adapta...
Decoding human genetic variation using a synthetic paradigm
Aashiq Kachroo highlights a recent paper by van Loggerenberg et al. that demonstrates the experimental power of &...
Divergence and conservation of the meiotic recombination machinery
Divergence and conservation of the meiotic recombination machinery
Sexually reproducing eukaryotes use recombination between homologous chromosomes to promote chromosome segregation during ...
Including diverse populations enhances the discovery of type 2 diabetes loci
Segun Fatumo highlights a paper by Mahajan et al. that uses a multi-ancestry genome-wide association studies approach to u...
Mouse genome rewriting with human DNA for disease modelling
Mouse genome rewriting with human DNA for disease modelling
Zhang et al. describe mSwAP-In, a platform for large-scale, efficient, biallelic and ‘scarless’ genome editing...
Weaponized genomics: potential threats to international and human security
Genetic technologies are revolutionizing human health. In parallel, geopolitical instability has prompted renewed discussi...
Context-specific functions of chromatin remodellers in development and disease
Context-specific functions of chromatin remodellers in development and disease
Chromatin remodellers were once thought to be highly redundant and nonspecific in their actions. However, recent human gen...
SWI/SNF function compensated by another chromatin remodeller
SWI/SNF function compensated by another chromatin remodeller
Martin et al. report that the EP400/TIP60 complex can compensate for function of the SWI/SNF complex to remodel chromatin ...
Translating genomic advances into biodiversity conservation
Translating genomic advances into biodiversity conservation
A key action of the new Global Biodiversity Framework is the maintenance of genetic diversity in all species to safeguard ...
Interrogating epigenetic mechanisms with chemically customized chromatin
Interrogating epigenetic mechanisms with chemically customized chromatin
Genetic and genomic techniques have proven incredibly powerful for identifying and studying molecular players implicated i...
Non-coding RNAs in disease: from mechanisms to therapeutics
Non-coding RNAs in disease: from mechanisms to therapeutics
Non-coding RNAs (ncRNAs) are a heterogeneous group of transcripts that, by definition, are not translated into proteins. S...
Controlling organoid gene expression with light
Controlling organoid gene expression with light
Legnini et al. report in Nature Methods their new optogenetic method for controlling gene expression in organoids that can...
De novo genes: from non-genic to genic
Li Zhao recalls a 2006 paper by Levine et al. that, by identifying a handful of de novo genes, outlined a potentially univ...
A genetic atlas of the human blood proteome
A genetic atlas of the human blood proteome
Three papers in Nature report on the largest open-access plasma proteomics dataset to date, a valuable resource for unders...
Scrambling the genome in cancer: causes and consequences of complex chromosome rearrangements
Scrambling the genome in cancer: causes and consequences of complex chromosome rearrangements
Complex chromosome rearrangements, known as chromoanagenesis, are widespread in cancer. Based on large-scale DNA sequencin...
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