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Microbiota in tumors: new factor influencing cancer development
Microbiota in tumors: new factor influencing cancer development
Tumor microbiota research is a new field in oncology. With the advancement of high-throughput sequencing, there is growing...
Targeting CREB-binding protein (CBP) abrogates colorectal cancer stemness through epigenetic regulation of C-MYC
Targeting CREB-binding protein (CBP) abrogates colorectal cancer stemness through epigenetic regulation of C-MYC
Colorectal cancer (CRC) is a common cancer worldwide with an increasing annual incidence. Cancer stem cells (CSCs) play im...
Correction: PARD6A promotes lung adenocarcinoma cell proliferation and invasion through Serpina3
These authors contributed equally: Lanlin Hu, Mingxin Liu, Bo Tang.These authors jointly supervised this work: Sijia Liu, ...
AMIGO2 enhances the invasive potential of colorectal cancer by inducing EMT
AMIGO2 enhances the invasive potential of colorectal cancer by inducing EMT
In our previous studies, we identified amphoterin-inducible gene and open reading frame 2 (AMIGO2) as a driver gene for li...
Systemic delivery of tannic acid-ferric-masked oncolytic adenovirus reprograms tumor microenvironment for improved therapeutic efficacy in glioblastoma
Systemic delivery of tannic acid-ferric-masked oncolytic adenovirus reprograms tumor microenvironment for improved therapeutic efficacy in glioblastoma
Glioblastoma (GBM) represents the most aggressive primary brain tumor, and urgently requires effective treatments. Oncolyt...
AAV-mediated combination gene therapy of inducible Caspase 9 and miR-199a-5p is therapeutic in hepatocellular carcinoma
AAV-mediated combination gene therapy of inducible Caspase 9 and miR-199a-5p is therapeutic in hepatocellular carcinoma
Advanced-stage hepatocellular carcinoma (HCC) remains an untreatable disease with an overall survival of less than one yea...
Intraperitoneal administration of adeno-associated virus encoding microRNA-29b for the treatment of peritoneal metastasis
Intraperitoneal administration of adeno-associated virus encoding microRNA-29b for the treatment of peritoneal metastasis
This study explores a novel therapeutic approach for peritoneal metastasis (PM) using AAV-mediated delivery of tumor suppr...
γ-Glutamylcyclotransferase is transcriptionally regulated by c-Jun and controls proliferation of glioblastoma stem cells through Notch1 levels
γ-Glutamylcyclotransferase is transcriptionally regulated by c-Jun and controls proliferation of glioblastoma stem cells through Notch1 levels
Glioblastoma stem cells (GSCs) have been reported to cause poor prognosis of glioblastoma by contributing to therapy resis...
Lower ratio of IMPDH1 to IMPDH2 sensitizes gliomas to chemotherapy
Lower ratio of IMPDH1 to IMPDH2 sensitizes gliomas to chemotherapy
Gliomas are the most common primary tumors of the central nervous system, with approximately half of patients presenting w...
ScRNA-seq revealed the tumor microenvironment heterogeneity related to the occurrence and metastasis in upper urinary tract urothelial carcinoma
ScRNA-seq revealed the tumor microenvironment heterogeneity related to the occurrence and metastasis in upper urinary tract urothelial carcinoma
Metastasis is the greatest clinical challenge for UTUCs, which may have distinct molecular and cellular characteristics fr...
Deciphering the role of post-translational modifications in fanconi anemia proteins and their influence on tumorigenesis
Deciphering the role of post-translational modifications in fanconi anemia proteins and their influence on tumorigenesis
Fanconi anemia (FA) is an autosomal or X-linked human disease, characterized by bone marrow failure, cancer susceptibility...
Gut microbiota-mediated activation of GSDMD ignites colorectal tumorigenesis
Gut microbiota-mediated activation of GSDMD ignites colorectal tumorigenesis
Activation of Gasdermin D (GSDMD) results in its cleavage, oligomerization, and subsequent formation of plasma membrane po...
Correction: TRIM58 downregulation maintains stemness via MYH9-GRK3-YAP axis activation in triple-negative breast cancer stem cells
Correction: TRIM58 downregulation maintains stemness via MYH9-GRK3-YAP axis activation in triple-negative breast cancer stem cells
Author notesThese authors contributed equally: Xujun Li, Jing Jiang.Authors and AffiliationsDepartment of Oncology, Ningbo...
Extracellular vesicles from type-2 macrophages increase the survival of chronic lymphocytic leukemia cells ex vivo
Extracellular vesicles from type-2 macrophages increase the survival of chronic lymphocytic leukemia cells ex vivo
The resistance of Chronic Lymphocytic Leukemia (CLL) B-cells to cell death is mainly attributed to interactions within the...
Anti-angiogenesis and anti-immunosuppression gene therapy through targeting COUP-TFII in an in situ glioblastoma mouse model
Anti-angiogenesis and anti-immunosuppression gene therapy through targeting COUP-TFII in an in situ glioblastoma mouse model
Glioblastoma (GBM) is the most common and aggressive primary brain cancer; angiogenesis and immunosuppression exacerbate G...
Correction: H3.3-G34W in giant cell tumor of bone functionally aligns with the exon choice repressor hnRNPA1L2
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which...
Modification of the tumor microenvironment enhances immunity with plasmid gene therapy
Modification of the tumor microenvironment enhances immunity with plasmid gene therapy
Local intratumor delivery with electroporation of low levels of plasmids encoding molecules, induces an antitumor effect w...
The golden key to open mystery boxes of SMARCA4-deficient undifferentiated thoracic tumor: focusing immunotherapy, tumor microenvironment and epigenetic regulation
The golden key to open mystery boxes of SMARCA4-deficient undifferentiated thoracic tumor: focusing immunotherapy, tumor microenvironment and epigenetic regulation
SMARCA4-deficient undifferentiated thoracic tumor is extremely invasive. This tumor with poor prognosis is easily confused...
Cancer-associated fibroblast exosomes promote prostate cancer metastasis through miR-500a-3p/FBXW7/HSF1 axis under hypoxic microenvironment
Cancer-associated fibroblast exosomes promote prostate cancer metastasis through miR-500a-3p/FBXW7/HSF1 axis under hypoxic microenvironment
Metastasis is the main cause of deaths in prostate cancer (PCa). However, the exact mechanisms underlying PCa metastasis a...
Emerging role of RNA modification and long noncoding RNA interaction in cancer
Emerging role of RNA modification and long noncoding RNA interaction in cancer
RNA modification, especially N6-methyladenosine, 5-methylcytosine, and N7-methylguanosine methylation, participates in the...
Transactivation of Met signaling by oncogenic Gnaq drives the evolution of melanoma in Hgf-Cdk4 mice
Transactivation of Met signaling by oncogenic Gnaq drives the evolution of melanoma in Hgf-Cdk4 mice
Recent pan-cancer genomic analyses have identified numerous oncogenic driver mutations that occur in a cell-type and tissu...
A guardian turned rogue: TP53 promoter translocations rewire stress responses to oncogenic effectors in osteosarcoma
A guardian turned rogue: TP53 promoter translocations rewire stress responses to oncogenic effectors in osteosarcoma
Osteosarcoma is the most prevalent malignant bone tumour in children, adolescents and young adults. Despite a multitude of...
Recent progress of CDK4/6 inhibitors’ current practice in breast cancer
Recent progress of CDK4/6 inhibitors’ current practice in breast cancer
Dysregulated cellular proliferation represents a hallmark feature across all cancers. Aberrant activation of the cyclin-de...
PLK1 and its substrate MISP facilitate intrahepatic cholangiocarcinoma progression by promoting lymphatic invasion and impairing E-cadherin adherens junctions
PLK1 and its substrate MISP facilitate intrahepatic cholangiocarcinoma progression by promoting lymphatic invasion and impairing E-cadherin adherens junctions
Intrahepatic cholangiocarcinoma (iCCA) is a subtype of CCA and has a high mortality rate and a relatively poor prognosis. ...
SPP1+ TAM subpopulations in tumor microenvironment promote intravasation and metastasis of head and neck squamous cell carcinoma
SPP1+ TAM subpopulations in tumor microenvironment promote intravasation and metastasis of head and neck squamous cell carcinoma
Macrophages are heterogeneous cells that play multifaceted roles in cancer progression and metastasis. However, the phenot...
Cancer-associated fibroblast exosome LINC00355 promotes epithelial-mesenchymal transition and chemoresistance in colorectal cancer through the miR-34b-5p/CRKL axis
Cancer-associated fibroblast exosome LINC00355 promotes epithelial-mesenchymal transition and chemoresistance in colorectal cancer through the miR-34b-5p/CRKL axis
This study was designed to investigate the role and mechanism of cancer-associated fibroblasts (CAFs)-derived exosomes (CA...
Leveraging synthetic lethality to uncover potential therapeutic target in gastric cancer
Leveraging synthetic lethality to uncover potential therapeutic target in gastric cancer
Since trastuzumab was approved in 2012 for the first-line treatment of gastric cancer (GC), no significant advancement in ...
Cell fusion upregulates PD-L1 expression for evasion from immunosurveillance
Cell fusion upregulates PD-L1 expression for evasion from immunosurveillance
MSCs (mesenchymal stem cells), responsible for tissue repair, rarely undergo cell fusion with somatic cells. Here, we show...
TNFRSF19 promotes endoplasmic reticulum stress-induced paraptosis via the activation of the MAPK pathway in triple-negative breast cancer cells
TNFRSF19 promotes endoplasmic reticulum stress-induced paraptosis via the activation of the MAPK pathway in triple-negative breast cancer cells
TNFRSF19 is a member of the tumor necrosis factor receptor superfamily, and its function exhibits variability among differ...
Chimeric TβRII-SE/Fc overexpression by a lentiviral vector exerts strong antitumoral activity on colorectal cancer-derived cell lines in vitro and on xenografts
Chimeric TβRII-SE/Fc overexpression by a lentiviral vector exerts strong antitumoral activity on colorectal cancer-derived cell lines in vitro and on xenografts
The TGF signaling pathway is a key regulator of cancer progression. In this work, we report for the first time the antitum...
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