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Milletomics: a metabolomics centered integrated omics approach toward genetic progression
Milletomics: a metabolomics centered integrated omics approach toward genetic progression
Producing alternative staple foods like millet will be essential to feeding ten billion people by 2050. The increased dema...
Revolutionizing soybean genomics: How CRISPR and advanced sequencing are unlocking new potential
Revolutionizing soybean genomics: How CRISPR and advanced sequencing are unlocking new potential
Soybean Glycine max L., paleopolyploid genome, poses challenges to its genetic improvement. However, the development of re...
Genomic profiling of pan-drug resistant proteus mirabilis Isolates reveals antimicrobial resistance and virulence gene landscape
Genomic profiling of pan-drug resistant proteus mirabilis Isolates reveals antimicrobial resistance and virulence gene landscape
Proteus mirabilis is a gram-negative pathogen that caused significant opportunistic infections. In this study we aimed to ...
Microproteins unveiling new dimensions in cancer
Microproteins unveiling new dimensions in cancer
In the complex landscape of cancer biology, the discovery of microproteins has triggered a paradigm shift, thereby, challe...
Integrative analyses of long and short-read RNA sequencing reveal the spliced isoform regulatory network of seedling growth dynamics in upland cotton
Integrative analyses of long and short-read RNA sequencing reveal the spliced isoform regulatory network of seedling growth dynamics in upland cotton
The polyploid genome of cotton has significantly increased the transcript complexity. Recent advances in full-length trans...
Biotechnological frontiers in harnessing allelopathy for sustainable crop production
Biotechnological frontiers in harnessing allelopathy for sustainable crop production
Allelopathy, the phenomenon in which plants release biochemical compounds that influence the growth and development of nei...
AC092100.1 promotes angiogenesis in pre-eclampsia through YTHDC2/VEGFA signaling
AC092100.1 promotes angiogenesis in pre-eclampsia through YTHDC2/VEGFA signaling
Aberrant long non-coding RNA (lncRNA) expression has been shown to be involved in the pathological process of pre-eclampsi...
Long non-coding RNA MAGEA4-AS1 binding to p53 enhances MK2 signaling pathway and promotes the proliferation and metastasis of oral squamous cell carcinoma
Long non-coding RNA MAGEA4-AS1 binding to p53 enhances MK2 signaling pathway and promotes the proliferation and metastasis of oral squamous cell carcinoma
Long non-coding RNAs (lncRNAs) regulate the occurrence, development and progression of oral squamous cell carcinoma (OSCC)...
Exploring the transcription start sites and other genomic features facilitates the accurate identification and annotation of small RNAs across multiple stress conditions in Mycobacterium tuberculosis
Exploring the transcription start sites and other genomic features facilitates the accurate identification and annotation of small RNAs across multiple stress conditions in Mycobacterium tuberculosis
Mycobacterium tuberculosis (MTB) is a pathogen that is known for its ability to persist in harsh environments and cause ch...
LncRNA XIST/miR-455-3p/HOXC4 axis promotes breast cancer development by activating TGF-β/SMAD signaling pathway
LncRNA XIST/miR-455-3p/HOXC4 axis promotes breast cancer development by activating TGF-β/SMAD signaling pathway
Breast cancer is the second primary cause of cancer death among women. Long non-coding RNA (lncRNA) X-inactive specific tr...
Tet1-mediated activation of the Ampk signaling by Trpv1 DNA hydroxymethylation exerts neuroprotective effects in a rat model of Parkinson’s disease
Tet1-mediated activation of the Ampk signaling by Trpv1 DNA hydroxymethylation exerts neuroprotective effects in a rat model of Parkinson’s disease
Epigenetic regulation plays a role in Parkinson’s disease (PD), and ten-eleven translocation methylcytosine dioxygen...
C-FOS inhibition promotes pancreatic cancer cell ferroptosis by transcriptionally regulating the expression of SLC7A11
C-FOS inhibition promotes pancreatic cancer cell ferroptosis by transcriptionally regulating the expression of SLC7A11
Cellular proto-oncogene C-Fos forms the AP-1 transcription factor by dimerizing with proto-oncogene c-Jun; this factor upr...
Advances in targeting cancer epigenetics using CRISPR-dCas9 technology: A comprehensive review and future prospects
Advances in targeting cancer epigenetics using CRISPR-dCas9 technology: A comprehensive review and future prospects
Cancer, a complex and multifaceted group of diseases, continues to challenge the boundaries of medical science and healthc...
Is the voltage-gated sodium channel β3 subunit (SCN3B) a biomarker for glioma?
Is the voltage-gated sodium channel β3 subunit (SCN3B) a biomarker for glioma?
Recent studies suggest a need for reliable biomarkers enhancing prognosis prediction and treatment strategies in cancer. H...
Deciphering the role of FOXP4 in long COVID: exploring genetic associations, evolutionary conservation, and drug identification through bioinformatics analysis
Deciphering the role of FOXP4 in long COVID: exploring genetic associations, evolutionary conservation, and drug identification through bioinformatics analysis
Long COVID (LC) refers to a condition characterized by a variety of lingering symptoms that persist for more than 4 to 12 ...
Cancer pharmacoinformatics: Databases and analytical tools
Cancer pharmacoinformatics: Databases and analytical tools
Cancer is a subject of extensive investigation, and the utilization of omics technology has resulted in the generation of ...
lncRNA HOTAIR and Cardiovascular diseases
lncRNA HOTAIR and Cardiovascular diseases
Cardiovascular diseases (CVDs) a major contributor to global mortality rates, with a steadily rising prevalence observed a...
Ischemic cardiac stromal fibroblast-derived protein mediators in the infarcted myocardium and transcriptomic profiling at single cell resolution
Ischemic cardiac stromal fibroblast-derived protein mediators in the infarcted myocardium and transcriptomic profiling at single cell resolution
This article focuses on screening the major secreted proteins by the ischemia-challenged cardiac stromal fibroblasts (CF),...
Whole blood transcriptome signature predicts severe forms of COVID-19: Results from the COVIDeF cohort study
Whole blood transcriptome signature predicts severe forms of COVID-19: Results from the COVIDeF cohort study
COVID-19 is associated with heterogeneous outcome. Early identification of a severe progression of the disease is essentia...
Genome-wide identification and expression-pattern analysis of sulfate transporter (SULTR) gene family in cotton under multiple abiotic stresses and fiber development
Genome-wide identification and expression-pattern analysis of sulfate transporter (SULTR) gene family in cotton under multiple abiotic stresses and fiber development
Sulfate transporter (SULTR) proteins are in charge of the transport and absorption on sulfate substances, and have been re...
Analysis of chloroplast genome characteristics and codon usage bias in 14 species of Annonaceae
Analysis of chloroplast genome characteristics and codon usage bias in 14 species of Annonaceae
For the study of species evolution, chloroplast gene expression, and transformation, the chloroplast genome is an invaluab...
Identification of flowering genes in Camellia perpetua by comparative transcriptome analysis
Identification of flowering genes in Camellia perpetua by comparative transcriptome analysis
Camellia perpetua has the excellent characteristic of flowering multiple times throughout the year, which is of great impo...
Knockdown of ADAMDEC1 ameliorates ox-LDL-induced endothelial cell injury and atherosclerosis progression
Knockdown of ADAMDEC1 ameliorates ox-LDL-induced endothelial cell injury and atherosclerosis progression
This study was designed to investigate the role of a disintegrin and metalloproteinase domain-like protein decysin 1 (ADAM...
Hypoxia-induced circRTN4IP1 promotes progression and glycolysis of hepatocellular carcinoma cells
Hypoxia-induced circRTN4IP1 promotes progression and glycolysis of hepatocellular carcinoma cells
Hypoxia is one of the hallmarks of solid tumors, especially in hepatocellular carcinoma (HCC). CircRNAs are reported to be...
IGF2 is upregulated by its antisense RNA to potentiate pancreatic cancer progression
IGF2 is upregulated by its antisense RNA to potentiate pancreatic cancer progression
Pancreatic cancer is a deadly cancer. More and more long noncoding RNAs (lncRNAs) have received confirmation to be dysregu...
Benchmarking of bioinformatics tools for NGS-based microRNA profiling with RT-qPCR method
Benchmarking of bioinformatics tools for NGS-based microRNA profiling with RT-qPCR method
MicroRNAs are vital gene expression regulators, extensively studied worldwide. The large-scale characterization of miRNAom...
CFAP61 knockdown aggravates male infertility by inhibiting testosterone secretion by Leydig cells via the MAPK/COX-2 pathway
CFAP61 knockdown aggravates male infertility by inhibiting testosterone secretion by Leydig cells via the MAPK/COX-2 pathway
This study aimed to elucidate the roles of cilia- and flagella-associated protein 61 (CFAP61) in male infertility and its ...
3′-tRF-CysGCA overexpression in HEK-293 cells alters the global expression profile and modulates cellular processes and pathways
3′-tRF-CysGCA overexpression in HEK-293 cells alters the global expression profile and modulates cellular processes and pathways
tRNA fragments (tRFs) are small non-coding RNAs generated through specific cleavage of tRNAs and involved in various biolo...
NLRP3/miR-223-3p axis attenuates neuroinflammation induced by chronic intermittent hypoxia
NLRP3/miR-223-3p axis attenuates neuroinflammation induced by chronic intermittent hypoxia
Obstructive sleep apnea (OSA) is mainly characterized by chronic intermittent hypoxia (CIH) with multiple brain injuries. ...
The cellular trajectories of tumor-associated macrophages decipher the heterogeneity of pancreatic cancer
The cellular trajectories of tumor-associated macrophages decipher the heterogeneity of pancreatic cancer
Emerging evidence indicates that the interactions and dynamic changes among tumor-associated macrophages (TAMs) are pivota...
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