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Novel polymorphic and copy number diversity in the antibody IGH locus of South African individuals
Novel polymorphic and copy number diversity in the antibody IGH locus of South African individuals
The heavy chain of an antibody is crucial for mediating antigen binding. IGHV genes, which partially encode the heavy chai...
VaxOptiML: leveraging machine learning for accurate prediction of MHC-I and II epitopes for optimized cancer immunotherapy
VaxOptiML: leveraging machine learning for accurate prediction of MHC-I and II epitopes for optimized cancer immunotherapy
Cancer immunotherapy hinges on accurate epitope prediction for advancing vaccine development. VaxOptiML (available at http...
Syndecan-1: a key player in health and disease
Syndecan-1: a key player in health and disease
Syndecan-1 (SDC-1) is a transmembrane protein localized on the basolateral surface of epithelial cells, encompassing a cor...
Uncovering selection pressures on the IRF gene family in bats’ immune system
Uncovering selection pressures on the IRF gene family in bats’ immune system
Unlike other mammals, bats serve as natural reservoirs for several highly pathogenic viruses without exhibiting symptoms o...
AMPed up immunity: 418 whole genomes reveal intraspecific diversity of koala antimicrobial peptides
AMPed up immunity: 418 whole genomes reveal intraspecific diversity of koala antimicrobial peptides
Characterising functional diversity is a vital element to understanding a species’ immune function, yet many immunog...
functional analysis of the human, chimpanzee, and gorilla MHC-A repertoires
functional analysis of the human, chimpanzee, and gorilla MHC-A repertoires
T cells recognize peptides displayed on the surface of cells on MHC molecules. Genetic variation in MHC genes alters their...
HCV immunodominant peptide mapping reveals unique HLA-A*02-restricted signatures: insights for CD8 T-cell-based vaccines and immunotherapies
HCV immunodominant peptide mapping reveals unique HLA-A*02-restricted signatures: insights for CD8 T-cell-based vaccines and immunotherapies
Several barriers for the development of an HCV vaccine still exist, including the genetic diversity of the virus, and the ...
Primary regulatory T cell activator FOXP3 is present across Amphibia
Primary regulatory T cell activator FOXP3 is present across Amphibia
The overall structure of the immune system is highly conserved across jawed vertebrates, but characterization and descript...
Suppressed activation of the and by V617F gold nanoparticles
Suppressed activation of the and by V617F gold nanoparticles
Philadelphia chromosome-negative myeloproliferative neoplasms (Ph-MPNs) are characterized by the overproduction of myeloid...
Kirsten Falk 1963-2024
Kirsten Falk 1963-2024
Kirsten Falk working at the HPLC system, ca. 1990. Copyright Olaf RötzschkeKirsten F...
Phylogenetic and structural insights into the origin of C-type lectin Mincle in vertebrates
Phylogenetic and structural insights into the origin of C-type lectin Mincle in vertebrates
Our bodies are continuously exposed to injurious insults by infection and tissue damage, which are primarily sensed by inn...
Allele co-segregation and haplotype diversity of MHC IIβ genes in the small-spotted catshark
Allele co-segregation and haplotype diversity of MHC IIβ genes in the small-spotted catshark
The major histocompatibility complex (MHC) constitutes a functionally relevant multigene family playing an essential role ...
Correction to: HCV immunodominant peptide mapping reveals unique HLA‑A* 02‑restricted signatures: insights for CD8 T‑cell‑based vaccines and immunotherapies
Correction to: HCV immunodominant peptide mapping reveals unique HLA‑A* 02‑restricted signatures: insights for CD8 T‑cell‑based vaccines and immunotherapies
Laboratório de Virologia Básica E Aplicada, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Avenid...
Genome-wide diversity and MHC characterisation in a critically endangered freshwater turtle susceptible to disease
Genome-wide diversity and MHC characterisation in a critically endangered freshwater turtle susceptible to disease
Small, isolated populations are often vulnerable to increased inbreeding and genetic drift, both of which elevate the risk...
Histocompatibility in and the origins of adaptive immunity
Histocompatibility in and the origins of adaptive immunity
The basal chordate, Botryllus schlosseri, undergoes a natural transplantation reaction that is controlled by a single, hig...
HLA diversity and signatures of selection in the Maniq, a nomadic hunter-gatherer population in Southern Thailand
HLA diversity and signatures of selection in the Maniq, a nomadic hunter-gatherer population in Southern Thailand
The Maniq, a small and isolated nomadic hunter-gatherer population from the rainforests of Southern Thailand, offer a uniq...
Epistatic effects of IGHG and FCGRIIB genes on the development of Alzheimer’s disease in African Americans
Epistatic effects of IGHG and FCGRIIB genes on the development of Alzheimer’s disease in African Americans
Genome-wide association studies (GWAS) of Alzheimer’s disease (AD) have identified a large number of susceptibility ...
A novel mutation in FNIP1 associated with a syndromic immunodeficiency and cardiomyopathy
A novel mutation in FNIP1 associated with a syndromic immunodeficiency and cardiomyopathy
Genetic variants in Folliculin interacting protein 1 (FNIP1) were recently discovered as monogenic causes for immunodefici...
Exploring the therapeutic potential of interleukin-6 receptor blockade in autoimmune diseases using drug target mendelian randomization
Exploring the therapeutic potential of interleukin-6 receptor blockade in autoimmune diseases using drug target mendelian randomization
The blockade of the interleukin 6 receptor (IL-6R) demonstrates significant potential in various autoimmune diseases (ADs)...
Analysis of Complement Factor H gene polymorphisms and their association with clinical manifestations ofleptospirosis
Analysis of Complement Factor H gene polymorphisms and their association with clinical manifestations ofleptospirosis
Leptospirosis is caused by pathogenic leptospires, posing a significant public health problem. Host susceptibility to Lept...
Spatial variation in toll-like receptor diversity in koala populations across their geographic distribution
Spatial variation in toll-like receptor diversity in koala populations across their geographic distribution
The koala (Phascolarctos cinereus) is an iconic Australian species that is listed as endangered in the northern parts of i...
Sequence variants underlying severe combined immunodeficiency and leukocyte adhesion deficiency type 1 in six consanguineous families
Sequence variants underlying severe combined immunodeficiency and leukocyte adhesion deficiency type 1 in six consanguineous families
Inborn errors of immunity (IEI) are defined as genetic disorders affecting the immune system and resulting in diverse clin...
Using bioinformatics to investigate functional diversity: a case study of MHC diversity in koalas
Using bioinformatics to investigate functional diversity: a case study of MHC diversity in koalas
Conservation genomics can greatly improve conservation outcomes of threatened populations, including those impacted by dis...
Evolutionary diversity of CXCL16-CXCR6: Convergent substitutions and recurrent gene loss in sauropsids
Evolutionary diversity of CXCL16-CXCR6: Convergent substitutions and recurrent gene loss in sauropsids
The CXCL16-CXCR6 axis is crucial for regulating the persistence of CD8 tissue-resident memory T cells (TRM). CXCR6 deficie...
A genome assembly and transcriptome atlas of the inbred Babraham pig to illuminate porcine immunogenetic variation
A genome assembly and transcriptome atlas of the inbred Babraham pig to illuminate porcine immunogenetic variation
The inbred Babraham pig serves as a valuable biomedical model for research due to its high level of homozygosity, includin...
Bioinformatic analysis predicts the regulatory function of noncoding SNPs associated with Long COVID-19 syndrome
Bioinformatic analysis predicts the regulatory function of noncoding SNPs associated with Long COVID-19 syndrome
Long or Post COVID-19 is a condition of collected symptoms persisted after recovery from COVID-19. Host genetic factors pl...
Decoding the genetic landscape of juvenile dermatomyositis: insights from phosphorylation-associated single nucleotide polymorphisms
Decoding the genetic landscape of juvenile dermatomyositis: insights from phosphorylation-associated single nucleotide polymorphisms
Genome-wide association studies (GWASs) have identified genetic susceptibility loci associated with juvenile dermatomyosit...
Associations between immune cell traits and autoimmune thyroid diseases: a bidirectional two-sample mendelian randomization study
Associations between immune cell traits and autoimmune thyroid diseases: a bidirectional two-sample mendelian randomization study
Autoimmune thyroid diseases (AITDs), mainly including Graves’ disease (GD) and Hashimoto’s thyroiditis (HT), a...
HLA alleles, haplotypes frequencies, and their association with hematological disorders: a report from 1550 families whose patients underwent allogeneic bone marrow transplantation in Egypt
HLA alleles, haplotypes frequencies, and their association with hematological disorders: a report from 1550 families whose patients underwent allogeneic bone marrow transplantation in Egypt
HLA alleles are representative of ethnicities and may play important roles in predisposition to hematological disorders. W...
A possible role of lncRNA MEG3 and lncRNA MAFG-AS1 on miRNA 147-b in the pathogenesis of Behcet’s disease
A possible role of lncRNA MEG3 and lncRNA MAFG-AS1 on miRNA 147-b in the pathogenesis of Behcet’s disease
Behcet’s disease (BD) is a multisystem disease with altered Toll-like receptors (TLRs) on macrophages. Long noncodin...
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