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Optimization in the HIV treatment: economic and organizational impact analysis of Bictegravir/Emtricitabine/Tenofovir Alafenamide
Introduzione L’innovazione terapeutica nel contesto del trattamento del virus dell’immunodeficienza umana (HIV), in ter...
D.I.Ri.M.O. project: deprescription, inappropriateness evaluation and therapeutic reconciliation in hospital medicine
Introduction The rising average age of the Italian population and the growing number of patients with multiple health c...
Cost per responder of upadacitinib 30 mg and dupilumab 300 mg in patients with moderate-to-severe atopic dermatitis in italy
Introduzione La dermatite atopica (DA) è una malattia infiammatoria cutanea caratterizzata da un decorso cronico e reci...
Assessing the economic burden of Waldenström’s Macroglobulinemia (WM), Marginal Zone Lymphoma (MZL), and Chronic Lymphocytic Leukemia (CLL)
Introduction B-cell malignancies are the most common types of blood cancer and encompass over 40 different diseases cau...
Management and utilization of the Fund for Innovative Medicines: a multistakeholder qualitative survey on regional and local practices
Introduzione Il Fondo Farmaci Innovativi (FFI) riveste un ruolo cruciale per finanziare e garantire un accesso rapido a...
Regional tools for the governance of prescribing behaviour and pharmaceutical spending: from literature to concrete experiences and prospects for change
Introduzione Il mercato globale dei farmaci è in costante crescita e se ne prevede un aumento del 5-8% in termini di sp...
Cost-effectiveness of Brentuximab Vedotin plus chemotherapy as frontline treatment of systemic anaplastic large cell lymphoma in Italy
Introduzione Il linfoma anaplastico a grandi cellule sistemico (sALCL) rappresenta una forma rara, severa e aggressiva ...
Cost-effectiveness of cenobamate as a therapeutic alternative for the treatment of focal epilepsy in adults with inadequate seizure control
Introduction Epilepsy is one of the most common neurological disorders, affecting approximately 50 million people world...
Healthcare of patients with immunoglobulin A nephropathy through a retrospective observational study of Italian administrative data
Introduction Immunoglobulin A nephropathy (IgAN) is a rare disease that, by accumulating IgA-containing immune complexe...
Time to market evaluation for new chemical entities in Italy: a critical analysis of the period 2018-2024
Introduzione In Italia, l’analisi relativa alle tempistiche di autorizzazione delle procedure di prezzo e rimborso dei ...
Cost-analysis from real-world REDS study on dalbavancin in inpatient treatment of acute bacterial skin and skin structure infections
Introduction Acute bacterial skin and soft tissue infections (ABSSSIs) are among the most common infections in the gene...
C(nn) and compassionate use: two approaches for early access. Proposals for a better management
Introduzione In Italia, esistono molteplici strumenti regolatori di Early Access Program (EAP), che offrono ai pazienti...
Real-World Evidence and Managed Entry Agreements
Introduzione Con il termine Real-World Evidence (RWE) si indicano le evidenze scientifiche sui possibili effetti di una...
Cost-effectiveness analysis of nirmatrelvir/ritonavir in adult patients at high risk of progressing to severe COVID-19
Introduzione La malattia da Coronavirus 2019 (COVID-19) provocata dal Coronavirus-2, agente eziologico della sindrome r...
Health technology assessment (HTA) of prostatic urethral lift (PUL) for the treatment of benign prostatic hyperplasia (BPH) in the Italian context
Background Health Technology Assessment (HTA) is a multidisciplinary process that synthesizes information on clinical, ...
Micro-costing analysis from Italian Guidelines for the management of sporadic primary hyperparathyroidism
Introduction Primary hyperparathyroidism (PHPT) is the third most frequent endocrine disorder and the leading cause of ...
Paving the road for a successful EU HTA Reform implementation
Introduction In May 2024 the ETTHICS think thank (European Think Tank on Health Innovation and Competitiveness for Sust...
RWE in oncology: use of databases to identify molecular subtypes of metastatic breast cancer in Italy
Introduzione Negli ultimi anni, il panorama della ricerca oncologica ha subito una trasformazione significativa grazie ...
The economic impact of multimorbidity in Italy: evaluation of direct costs and scenario analysis of patients with type 2 diabetes, heart failure, and chronic kidney disease using real-world data
The economic impact of multimorbidity in Italy: evaluation of direct costs and scenario analysis of patients with type ...
Spending caps for pharmaceuticals within the pharmaceutical policies framework: critical issues and reform options
Introduzione Le evidenze empiriche sul governo dell’assistenza farmaceutica e, nello specifico, sull’accesso ai farmaci...
The length of price&reimbursement negotiation procedures in Italy in the period 2021-2023 was independent from the price of medicines
Cocciolo, R., Turella, P., Pilunni, D., & Navarra, P. (2025). The length of price&reimbursement negotiation pro...
What is needed to successfully implement the EU HTA Regulation enabling broad patient access in Europe
Solà-Morales, O., Lipska, I., Meyer, F., Canonico, P.-L., & Altmann, H. (2025). What is needed to successfully impl...
Value contribution of leniolisib in the Treatment of Activated PI3Kδ syndrome (APDS) in Spain using Multi-Criteria Decision Analysis (MCDA)
Angulo I, Vadas O, Garçon F, et al. Phosphoinositide 3-kinase δ gene mutation predisposes to respira...
Economic and clinical burden associated with respiratory syncytial virus and impact of universal immunization with nirsevimab in Italy
Cutrera R, Wolfler A, Picone S, et al. Impact of the 2014 American Academy of Pediatrics recommendat...
Towards a Green Health Technology Assessment: embedding Life Cycle Assessment for sustainable choices
Goodland R. The Concept of Environmental Sustainability. Annu Rev Ecol Syst. 1995;26(1):1-24. https:...
Assessment of innovativeness, and price and reimbursement negotiation of medicines: recommendations of an expert panel
Garattini L, Cornago D, De Compadri P. Pricing and reimbursement of in-patent drugs in seven Europea...
Budget impact analysis on the Italian healthcare system of roxadustat for the treatment of anemia due to chronic kidney disease
WHO. Haemoglobin concentrations for the diagnosis of anaemia and assessment of severity Vitamin and ...
Drug utilization and medication adherence for the treatment of psoriatic arthritis: an Italian study
Coates LC, Helliwell PS. Psoriatic arthritis: state of the art review. Clin Med (Lond). 2017;17(1):6...
HTA regulation: how is Italy moving?
Authors Francesca Patarnello Vice-President Market Access ...
Cost per Number Needed to Treat (NNT) for upadacitinib in the treatment of bio-exposed patients with moderately-severely active ulcerative rectocolitis
Burr NE, Gracie DJ, Black CJ, Ford AC. Efficacy of biological therapies and small molecules in moder...
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